Liquid chromatographic-mass spectrometric determination of the metabolism and disposition of the anti-retroviral nucleoside analogs zidovudine and lamivudine in C57BL/6N and B6C3F1 mice

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 798, Issue 1, 2003, Pages 55-62

  Williams, Lee D ^a   Von Tungeln, Linda S ^a   Beland, Frederick A ^a   Doerge, Daniel R ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

Author keywords

Lamivudine; Zidovudine

Indexed keywords

BIOMEDICAL ENGINEERING; DETOXIFICATION; DRUG PRODUCTS; MASS SPECTROMETRY; PHOSPHORUS COMPOUNDS;

GENOTOXICITY; SERUM CONCENTRATIONS;

LIQUID CHROMATOGRAPHY;

3' AMINO 3' DEOXYTHYMIDINE; ANTIRETROVIRUS AGENT; GLUCURONIDE; LAMIVUDINE; NUCLEOSIDE DERIVATIVE; PHOSPHATE; ZIDOVUDINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DETOXIFICATION; DOSE RESPONSE; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG DISPOSITION; DRUG METABOLISM; DRUG STRUCTURE; FEMALE; FETUS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; SOLID PHASE EXTRACTION;

EID: 0242664024     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2003.08.051     Document Type: Article

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