Tnfa and Il-10 Deficiencies Have Contrasting Effects on Lung Tumor Susceptibility: Gender-Dependent Modulation of IL-10 Haploinsufficiency

Molecular Carcinogenesis

Volumn 38, Issue 3, 2003, Pages 117-123

  Bernert, Heike ^a   Sekikawa, Kenji ^b   Radcliffe, Richard A ^c   Iraqi, Fuad ^d   You, Ming ^e   Malkinson, Alvin M ^c,f  

^a OHIO STATE UNIVERSITY   (United States)

^b NATIONAL INSTITUTE OF AGROBIOLOGICAL SCIENCES   (Japan)

^c UNIVERSITY OF COLORADO   (United States)

^d INTERNATIONAL LIVESTOCK RESEARCH INSTITUTE   (Kenya)

^e WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF COLORADO CANCER CENTER   (United States)

Author keywords

Cytokines; Haploinsufficiency; Inflammation; Lung tumors; Quantitative trait loci

Indexed keywords

INTERLEUKIN 10; TUMOR NECROSIS FACTOR ALPHA; URETHAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER RISK; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CHRONIC INFLAMMATION; CONTROLLED STUDY; FEMALE; GENDER; HAPLOTYPE; HEMIZYGOSITY; LUNG TUMOR; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS;

EID: 0242658493     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/mc.10151     Document Type: Article

References (65)

1. Balmain A. Cancer as a complex genetic trait: Tumor susceptibility in humans and mouse models. Cell 2002;108:145-152.
2. Cormier RT, Bilger A, Lillich AJ, et al. The Moro 1AKR intestinal tumor resistance region consists of Pla2g2a and a locus distal to D4Mit64. Oncogene 2000;19:3182-3192.
3. Cohen BH, Diamond EL, Graves CG, et al. A common familial component in lung cancer and chronic obstructive pulmonary disease. Lancet 1977;2:523-526.
4. Malkinson AM. Primary lung tumors in mice: An experimentally manipulable model of human adenocarcinoma. Cancer Res 1992;52:2670s-2676s.
5. Malkinson AM. Molecular comparison of human and mouse pulmonary adenocarcinomas. Exp Lung Res 1998;24:541-555.
6. Malkinson AM. Primary lung tumors in mice as an aid for understanding, preventing, and treating human adenocarcinoma of the lung. Lung Cancer 2001;32:265-279.
7. Shimkin MB, Stoner GD. Lung tumors in mice: Application to carcinogenesis bioassay. Adv Cancer Res 1975;21:1-58.
8. Malkinson AM. The genetic basis of susceptibility to lung tumors in mice. Toxicology 1989;54:241-271.
9. Den Engelse L, Oomen LC, van der Valk MA, Hart AA, Dux A, Emmelot P. Studies on lung tumours. V. Susceptibility of mice to dimethylnitrosamine-induced tumour formation in relation to H-2 haplotype. Int J Cancer 1981;28:199-208.
10. Miyashita N, Moriwaki K, Migita S. The H-2 class II genes and the susceptibility to the development of pulmonary adenoma in mice. Immunogenetics 1989;29:14-18.
11. Malkinson AM, Nesbitt MN, Skamene E. Susceptibility to urethan-induced pulmonary adenomas between A/J and C57BL/6J mice: Use of AXB and BXA recombinant inbred lines indicating a three-locus genetic model. J Natl Cancer Inst 1985;75:971-974.
12. Lin L, Festing MF, Devereux TR, et al. Additional evidence that the K-ras protooncogene is a candidate for the major mouse pulmonary adenoma susceptibility (Pas-1) gene. Exp Lung Res 1998;24:481-497.
13. Fijneman RJ, Oomen LC, Snoek M, Demant P. A susceptibility gene for alveolar lung tumors in the mouse maps between Hsp70.3 and G7 within the H2 complex. Immunogenetics 1995;41:106-109.
14. Gariboldi M, Manenti G, Canzian F, et al. A major susceptibility locus to murine lung carcinogenesis maps on chromosome 6. Nat Genet 1993;3:132-136.
15. Festing MF, Yang A, Malkinson AM. At least four genes and sex are associated with susceptibility to urethane-induced pulmonary adenomas in mice. Genet Res 1994;64:99-106.
16. Devereux TR, Wiseman RW, Kaplan N, et al. Assignment of a locus for mouse lung tumor susceptibility to proximal chromosome 19. Mamm Genome 1994;5:749-755.
17. You M, Wang Y, Stoner G, et al. Parental bias of Ki-ras oncogenes detected in lung tumors from mouse hybrids. Proc Natl Acad Sci USA 1992;89:5804-5808.
18. Malkinson AM, You M. The intronic structure of cancer-related genes regulates susceptibility to cancer. Mol Carcinog 1994;10:61-65.
19. You M, Candrian U, Maronpot RR, Stoner GD, Anderson MW. Activation of the Ki-ras protooncogene in spontaneously occurring and chemically induced lung tumors of the strain A mouse. Proc Natl Acad Sci USA 1989;86:3070-3074.
20. Horio Y, Chen A, Rice P, Roth JA, Malkinson AM, Schrump DS. Ki-ras and p53 mutations are early and late events, respectively, in urethane-induced pulmonary carcinogenesis in A/J mice. Mol Carcinog 1996;17:217-223.
21. Chen B, Johanson L, Wiest JS, Anderson MW, You M. The second intron of the K-ras gene contains regulatory elements associated with mouse lung tumor susceptibility. Proc Natl Acad Sci USA 1994;91:1589-1593.
22. Zhang Z, Wang Y, Vikis HG, et al. Wildtype Kras2 can inhibit lung carcinogenesis in mice. Nat Genet 2001;29:25-33.
23. Wewers MD, Gadek JE, Marsh CB. Proinflammatory cytokines. In: Crystal RG, Barnes PJ, West JB, Weibel ER, editors. The lung. New York: Lippincott-Raven; 1997. p 117-132.
24. Whitsett JA, Gerard C. Transgenic mice for study of pulmonary disease. In: Crystal RG, West JB, editors. The lung: Scientific foundations. Philadelphia: Lippincott-Raven; 1997. p 383-393.
25. Kang Y, Ozbun LL, Angdisen J, et al. Altered expression of G1/S regulatory genes occurs early and frequently in lung carcinogenesis in transforming growth factor-beta1 heterozygous mice. Carcinogenesis 2002;23:1217-1227.
26. Huffman JA, Hull WM, Dranoff G, Mulligan RC, Whitsett JA. Pulmonary epithelial cell expression of GM-CSF corrects the alveolar proteinosis in GM-CSF-deficient mice. J Clin Invest 1996;97:649-655.
27. Siegfried JM. Women and lung cancer: Does oestrogen play a role? Lancet Oncol 2001;2:506-513.
28. Taniguchi T, Takata M, Ikeda A, Momotani E, Sekikawa K. Failure of germinal center formation and impairment of response to endotoxin in tumor necrosis factor alpha-deficient mice. Lab Invest 1997;77:647-658.
29. Iraqi F, Sekikawa K, Rowlands J, Teale A. Susceptibility of tumour necrosis factor-alpha genetically deficient mice to Trypanosoma congolense infection. Parasite Immunol 2001;23:445-451.
30. Kuhn R, Lohler J, Rennick D, Rajewsky K, Muller W. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 1993;75:263-274.
31. Malkinson AM, Beer DS. Major effect on susceptibility to urethan-induced pulmonary adenoma by a single gene in BALB/cBy mice. J Natl Cancer Inst 1983;70:931-936.
32. + TH1-like responses. J Clin Invest 1996;98:1010-1020.
33. Zangrilli JG, Peters SP. Cytokines in allergic airway disease. In: Busse WW, Holgate ST, editors. Asthma and rhinitis. London: Blackwell; 2000. p 577-596.
34. Pfeffer K, Matsuyama T, Kundig TM, et al. Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell 1993;73:457-467.
35. Marino MW, Dunn A, Grail D, et al. Characterization of tumor necrosis factor-deficient mice. Proc Natl Acad Sci USA 1997;94:8093-8098.
36. Lawson GW, Van Winkle LS, Toskala E, Senior RM, Parks WC, Plopper CG. Mouse strain modulates the role of the ciliated cell in acute tracheobronchial airway injury-distal airways. Am J Pathol 2002;160:315-327.
37. Bienvenu JA, Monneret G, Gutowski MC, Fabien N. Cytokine assays in human sera and tissues. Toxicology 1998;129:55-61.
38. Warzocha K, Salles G, Bienvenu J, et al. Tumor necrosis factor ligand-receptor system can predict treatment outcome in lymphoma patients. J Clin Oncol 1997;15:499-508.
39. Noguchi E, Yokouchi Y, Shibasaki M, et al. Association between TNFA polymorphism and the development of asthma in the Japanese population. Am J Respir Crit Care Med 2002;166:43-46.
40. Staelens J, Wielockx B, Puimege L, Van Roy F, Guenet JL, Libert C. Hyporesponsiveness of SPRET/Ei mice to lethal shock induced by tumor necrosis factor and implications for a TNF-based antitumor therapy. Proc Natl Acad Sci USA 2002;99:9340-9345.
41. Munker M, Munker R, Saxton RE, Koeffler HP. Effect of recombinant monokines, lymphokines, and other agents on clonal proliferation of human lung cancer cell lines. Cancer Res 1987;47:4081-4085.
42. Blankenstein T, Qin ZH, Uberla K, et al. Tumor suppression after tumor cell-targeted tumor necrosis factor alpha gene transfer. J Exp Med 1991;173:1047-1052.
43. Fodde R, Smits R. Cancer biology. A matter of dosage. Science 2002;298:761-763.
44. Moore RJ, Owens DM, Stamp G, et al. Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis. Nat Med 1999;5:828-831.
45. Fajardo LF, Kwan HH, Kowalski J, Prionas SD, Allison AC. Dual role of tumor necrosis factor-alpha in angiogenesis. Am J Pathol 1992;140:539-544.
46. Frater-Schroder M, Risau W, Hallmann R, Gautschi P, Bohlen P. Tumor necrosis factor type alpha, a potent inhibitor of endothelial cell growth in vitro, is angiogenic in vivo. Proc Natl Acad Sci USA 1987;84:5277-5281.
47. Tartaglia LA, Ayres TM, Wong GH, Goeddel DV. A novel domain within the 55 kd TNF receptor signals cell death. Cell 1993;74:845-853.
48. Kisley LR, Barrett BS, Bauer AK, et al. Genetic ablation of inducible nitric oxide synthase decreases mouse lung tumorigenesis. Cancer Res 2002;62:6850-6856.
49. de Waal MR, Abrams J, Bennett B, Figdor CG, de Vries JE. Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: An autoregulatory role of IL-10 produced by monocytes. J Exp Med 1991;174:1209-1220.
50. Joyce DA, Gibbons DP, Green P, Steer JH, Feldmann M, Brennan FM. Two inhibitors of pro-inflammatory cytokine release, interleukin-10 and interleukin-4, have contrasting effects on release of soluble p75 tumor necrosis factor receptor by cultured monocytes. Eur J Immunol 1994;24:2699-2705.
51. Cassatella MA, Meda L, Gasperini S, Calzetti F, Bonora S. Interleukin 10 (IL-10) upregulates IL-1 receptor antagonist production from lipopolysaccharide-stimulated human polymorphonuclear leukocytes by delaying mRNA degradation. J Exp Med 1994;179:1695-1699.
52. Rogy MA, Auffenberg T, Espat NJ, et al. Human tumor necrosis factor receptor (p55) and interleukin 10 gene transfer in the mouse reduces mortality to lethal endotoxemia and also attenuates local inflammatory responses. J Exp Med 1995;181:2289-2293.
53. Fiorentino DF, Bond MW, Mosmann TR. Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J Exp Med 1989;170:2081-2095.
54. Bonfield TL, Konstan MW, Burfeind P, Panuska JR, Hilliard JB, Berger M. Normal bronchial epithelial cells constitutively produce the anti-inflammatory cytokine interleukin-10, which is downregulated in cystic fibrosis. Am J Respir Cell Mol Biol 1995;13:257-261.
55. Shimkin MB, Sasaki T, McDonough M, Baserga R, Thatcher D, Wieder R. Relation of thymidine index to pulmonary tumor response in mice receiving urethan and other carcinogens. Cancer Res 1969;29:994-998.
56. Grady HG, Stewart HL. Histogenesis of induced pulmonary tumors in strain A mice. Am J Pathol 1940;16:417-432.
57. Go NF, Castle BE, Barrett R, et al. Interleukin 10, a novel B cell stimulatory factor: Unresponsiveness of X chromosome-linked immunodeficiency B cells. J Exp Med 1990;172:1625-1631.
58. Geng Y, Gulbins E, Altman A, Lotz M. Monocyte deactivation by interleukin 10 via inhibition of tyrosine kinase activity and the Ras signaling pathway. Proc Natl Acad Sci USA 1994;91:8602-8606.
59. Schwartz AG, Yang P, Swanson GM. Familial risk of lung cancer among nonsmokers and their relatives. Am J Epidemiol 1996;144:554-562.
60. Chen WY, Zeng X, Carter MG, et al. Heterozygous disruption of Hi1 predisposes mice to a gender-dependent spectrum of malignant tumors. Nat Genet 2003;33:197-202.
61. Van Winkle LS, Gunderson AD, Shimizu JA, Baker GL, Brown CD. Gender differences in naphthalene metabolism and naphthalene-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol 2002;282:L1122-L1134.
62. Watanobe H. Sexual dimorphism in the pituitary-adrenal response to tumor necrosis factor-alpha, but not to interleukin-6, in the rat. Brain Res Bull 2002;57:151-155.
63. + T lymphocytes to increase IL-10 production. J Immunol 2001;167:2060-2067.
64. Ikejima K, Enomoto N, Iimuro Y, et al. Estrogen increases sensitivity of hepatic Kupffer cells to endotoxin. Am J Physiol 1998;274:G669-G676.
65. Stabile LP, Davis AL, Gubish CT, et al. Human non-small cell lung tumors and cells derived from normal lung express both estrogen receptor alpha and beta and show biological responses to estrogen. Cancer Res 2002;62:2141-2150.