A Toolkit for Dermal Risk Assessment: Toxicological Approach for Hazard Characterization

Annals of Occupational Hygiene

Volumn 47, Issue 8, 2003, Pages 641-652

  Schuhmacher Wolz, U ^a   Kalberlah, F ^a   Oppl, R ^b   Van Hemmen, J J ^c  

^a FoBiG GmbH   (Germany)

^b Eurofins Medinet Inc   (United States)

^c TNO   (Netherlands)

Author keywords

Dermal; Exposure; Hazard assessment; Occupational; Risk assessment; Skin

Indexed keywords

HAZARDOUS MATERIALS; HEALTH RISKS; RISK ASSESSMENT; SKIN; TOXICITY; CHEMICAL HAZARDS; HAZARDS; HEALTH; OCCUPATIONAL RISKS;

INTRINSIC TOXICITY (IT) SCORES;

OCCUPATIONAL RISKS; RISK ASSESSMENT;

ARTICLE; CONTROLLED STUDY; DROWSINESS; HAZARD ASSESSMENT; HEALTH HAZARD; HUMAN; LIVER INJURY; OCCUPATIONAL EXPOSURE; OCCUPATIONAL HEALTH; PRIORITY JOURNAL; RISK ASSESSMENT; SKIN DEFECT; SKIN IRRITATION; SKIN PENETRATION;

HAZARDOUS SUBSTANCES; HUMANS; MODELS, THEORETICAL; OCCUPATIONAL EXPOSURE; RISK ASSESSMENT; SKIN; SKIN ABSORPTION;

ADDITIONAL DATUM; DERMAL; DERMAL EXPOSURE; EXPOSURE; HAZARD ASSESSMENT; HEALTH EFFECTS; OCCUPATIONAL; PURE CHEMICALS;

EID: 0242628984     PISSN: 00034878     EISSN: None     Source Type: Journal    
DOI: 10.1093/annhyg/meg091     Document Type: Article

References (34)

1. Agner T, Serup J. (1990) Sodium lauryl sulphate for irritant patch testing - a dose-response study using bioengineering methods for determination of skin irritation. J Invest Dermatol; 95: 543-7.
2. Andersen PH, Maibach HI. (1995) Skin irritation in man: a comparative bioengineering study using improved reflectance spectroscopy. Contact Dermatitis; 33: 315-22.
3. Basketter DA, Balikie, L Dearman RJ et al. (2000) Use of the local lymph node assay for the estimation of relative contact allergenic potency. Contact Dermatitis; 42: 344-8.
4. Bronaugh RL, Maibach HI. (1985) Percutaneous penetration of nitroaromatic compounds: in vivo and in vitro in the human and monkey. J Invest Dermatol; 84: 180-3.
5. Brooke I, Cocker J, Delic JI et al. (1998) Dermal uptake of solvents from the vapour phase: an experimental study in humans. Ann Occup Hyg; 42: 531-40.
6. Cardin CW, Weaver JE, Bailey PT. (1986) Dose-response assessments of Kathon biocide. II. Threshold prophetic patch testing. Contact Dermatitis; 15: 10-6.
7. Dearman RJ, Basketter DA, Kimber I. (1999) Local lymph node assay: use in hazard and risk assessment. J Appl Toxicol; 19: 299-306.
8. de Heer C, Wilschut A, Stevenson H, Hakkert BC. (1999) Guidance document on the estimation of dermal absorption according to a tiered approach: an update. TNO Report V98.1237. Zeist, The Netherlands: TNO Nutrition and Food Research Institute.
9. ECETOC. (1993) Monograph no. 20 - Percutaneous Absorption. Brussels, Belgium: European Centre for Ecotoxicology and Toxicology of Chemicals.
10. Feldmann RJ, Maibach HJ. (1970) Absorption of some organic compounds through the skin in man. J Invest Dermatol; 54: 399-404.
11. Feldmann RJ, Maibach HJ. (1974) Percutaneous penetration of some pesticides and herbicides in man. Toxicol Appl Pharmacol; 28: 126-32.
12. Goede HA, Tijssen SCHA, Schipper HJ, Warren N, Oppl R, Kalberlah F, van Hemmen JJ. (2003) Classification of dermal exposure modifiers and assignment of values for a risk assessment toolkit. Ann Occup Hyg; 47: 609-18.
13. Grandjean P. (1990) Skin penetration: hazardous chemicals at work. London, UK: Taylor & Francis.
14. Hall-Manning TJ, Holland GH, Rennie G, Revell P, Hines J, Barratt MD, Basketter DA. (1998) Skin irritation potential of mixed surfactant systems. Food Chem Toxicol; 36: 233-8.
15. Henschler D. (1978) Gesundheitsschädliche Arbeitsstoffe, Toxikologisch-arbeitsmedizinische Begründungen von MAK-Werten, Loseblattsammlung, 6. Lfg. DFG, Deutsche Forschungsgemeinschaft. Weinheim, Germany: VCH Verlag.
16. Honma T, Suda M. (1998) Correlation of lethal doses of industrial chemicals between oral or intrarperitoneal administration and inhalation exposure. Ind Health; 36: 273-81.
17. Hughes MF, Shrivastava SP, Sumler MR, Edwards BC, Goodwin JH, Shah PV, Fisher HL, Hall LL. (1992) Dermal absorption of chemicals: effect of application of chemicals as a solid, aqueous paste, suspension, or in volatile vehicle. J Toxicol Environ Health; 37: 57-71.
18. Johanson G, Boman A. (1991) Percutaneous absorption of 2-butoxyethanol vapour in human subjects. Br J Ind Med; 48: 788-92.
19. Kalberlah F, Wriedt H. (1998) Bewertung und Fortentwicklung der Regelsetzung: Anwendbarkeit der TRGS 440. Fb 784. Dortmund, Germany: Schriftenreihe der Bundesanstalt für Arbeitsschutz und Arbeitsmedizin.
20. Kezic S, Monster AC, Krüse J, Verberk MM. (2000) Skin absorption of some vaporous solvents in volunteers. Int Arch Occup Environ Health; 73: 415-22.
21. Kligman AM. (1966) The identification of contact allergens by human assay. II. Factors influencing the induction and measurement of allergic contact dermatitis. J Invest Dermatol; 47: 375-92.
22. Loizou GD, Jones K, Akrill P, Dyne D, Cocker J. (1999) Estimation of the dermal absorption of m-xylene vapor in humans using breath sampling and physiologically based pharmacokinetic analysis. Toxicol Sci; 49: 170-9.
23. Magnusson B, Kligman AM. (1969) The identification of contact allergens by animal assay, the guinea pig maximization test method. J Invest Dermatol; 52: 268-76.
24. Marquart J, Brouwer DH, Gijsbers JHJ, Links IHM, Warren N, van Hemmen JJ. (2003) Determinants of dermal exposure relevant for exposure modelling in regulatory risk assessment. Ann Occup Hyg; 47: 599-607.
25. Nangia A, Camel E, Berner B, Maibach H. (1993) Influence of skin irritants on percutaneous absorption. Pharm Res; 10: 1756-9.
26. Oppl R, Kalberlah F, Evans PG, van Hemmen JJ. (2003) A toolkit for dermal risk assessment and management: an overview. Ann Occup Hyg; 47: 629-40.
27. Sartorelli P, Aprea C, Cenni A, Novelli MT, Orsi D, Palmi S, Matteucci G. (1998) Prediction of percutaneous absorption from physicochemical data: a model based on data of in vitro experiments. Ann Occup Hyg; 42: 267-76.
28. Schnitzler A. (1942) Beitrag zur Frage des Mechanismus der Sensibilisierung. Dermatologica; 85: 339-47.
29. Treffel P, Gabard B. (1996) Measurement of sodium lauryl sulfate-induced skin irritation. Acta Derm Venereol; 76: 342-3.
30. Ursin C, Hansen CM, Van Dyk JW, Jensen PO, Christensen IJ, Ebbehoej J. (1995) Permeability of commercial solvents through living human skin. Am Ind Hyg Assoc J; 56: 651-60.
31. Warren N, Goede HA, Tijssen SCHA, Oppl R, Schipper HJ, van Hemmen JJ. (2003) Deriving default dermal exposure values for use in a risk assessment toolkit for small and medium-sized enterprises. Ann Occup Hyg; 47: 619-27.
32. White SI, Friedman PS, Moss C, Simpson JM. (1986) The effect of altering area of application and dose per unit area on sensitization by DNCB. Br J Dermatol; 115: 663-8.
33. Wilschut A, Houben GF, Hakkert BC. (1998) Evaluation of route-to-route extrapolation in helath risk assessment for dermal and respiratory exposure to chemicals. TNO Report V97.520. Zeist, The Netherlands: TNO Nutrition and Food Research Institute.
34. Wilschut A, ten Berge WF, Robinson PJ, McKone TE. (1995) Estimating skin permeation. The validation of five mathematical skin permeation models. Chemosphere; 30: 1275-96.