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Volumn 27, Issue 5, 2003, Pages 1131-1140

Histopathologic Changes in Liver and Renal Tissues Induced by Different Doses of Diclofenac Sodium in Rats

Author keywords

Diclofenac sodium; Histopathologic changes; Kidney; Liver

Indexed keywords

DICLOFENAC; EOSIN; HEMATOXYLIN; NONSTEROID ANTIINFLAMMATORY AGENT;

EID: 0242606267     PISSN: 13000128     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (66)

References (42)
  • 1
    • 0034048997 scopus 로고    scopus 로고
    • Zidovudine, diclofenac and ketoprofen pharmacokinetic interactions in rats
    • Radwan, M.A.: Zidovudine, diclofenac and ketoprofen pharmacokinetic interactions in rats.: J. Pharm. Pharmacol., 2000; 52: 665-669.
    • (2000) J. Pharm. Pharmacol. , vol.52 , pp. 665-669
    • Radwan, M.A.1
  • 2
    • 0028286337 scopus 로고
    • Actions and toxic effects of the nonsteroidal anti-inflammatory drugs
    • Simon, L.S.: Actions and toxic effects of the nonsteroidal anti-inflammatory drugs. Curr. Opin. Rheumatol., 1994; 6: 238-251.
    • (1994) Curr. Opin. Rheumatol. , vol.6 , pp. 238-251
    • Simon, L.S.1
  • 3
    • 0029990706 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drug-induced hepatic disorders. Incidence and prevention
    • Manoukian, A.V., Carson, J.L.: Nonsteroidal anti-inflammatory drug-induced hepatic disorders. Incidence and prevention. Drug Saf., 1996; 15: 64-71.
    • (1996) Drug Saf. , vol.15 , pp. 64-71
    • Manoukian, A.V.1    Carson, J.L.2
  • 5
  • 6
    • 0242652322 scopus 로고    scopus 로고
    • Rasyonel tedavi yönünden tibbi farmakoloji
    • 8. baski. Ankara., Hacettepe Taş Kitapcilik, Ltd. Şti.
    • Kayaalp, S.O.: Rasyonel tedavi yönünden tibbi farmakoloji. Medicine Pharmacology. 8. baski. Ankara., Hacettepe Taş Kitapcilik, Ltd. Şti., pp. 1032-1046, 1998.
    • (1998) Medicine Pharmacology , pp. 1032-1046
    • Kayaalp, S.O.1
  • 7
    • 0033709079 scopus 로고    scopus 로고
    • Current problems with non-specific COX inhibitors
    • Gettigan, M. P., Henry, D.: Current problems with non-specific COX inhibitors. Curr. Pharm. Des., 2000; 6: 1693-1724.
    • (2000) Curr. Pharm. Des. , vol.6 , pp. 1693-1724
    • Gettigan, M.P.1    Henry, D.2
  • 9
    • 0029027732 scopus 로고
    • NSAID-induced hepatotoxicity: Aceclofenac and diclofenac
    • Zaragoza, M. A., Alfonso, M.V., Roig, C.E.: NSAID-induced hepatotoxicity: aceclofenac and diclofenac. Rev. Esp. Enferm. Dig., 1995; 87: 472-475.
    • (1995) Rev. Esp. Enferm. Dig. , vol.87 , pp. 472-475
    • Zaragoza, M.A.1    Alfonso, M.V.2    Roig, C.E.3
  • 11
    • 0030875708 scopus 로고    scopus 로고
    • The use of cultured hepatocytes to investigate the mechanism of drug hepatotoxicity
    • Review
    • Castel, J.V., Gomez-Lechon, M.J., Ponsoda, X., Bort, R.: The use of cultured hepatocytes to investigate the mechanism of drug hepatotoxicity. Cell Biol. Toxicol., (Review), 1997; 13: 331-338.
    • (1997) Cell Biol. Toxicol. , vol.13 , pp. 331-338
    • Castel, J.V.1    Gomez-Lechon, M.J.2    Ponsoda, X.3    Bort, R.4
  • 12
    • 0034755172 scopus 로고    scopus 로고
    • Effect of diclofenac sodium administration during pregnancy in the postnatal period
    • Gökçimen, A., Aydin, G., Karaöz, E, Malas, M.A., Öncü, M.: Effect of diclofenac sodium administration during pregnancy in the postnatal period. Fetal Diagn. Ther., 2001; 16: 417-422.
    • (2001) Fetal Diagn. Ther. , vol.16 , pp. 417-422
    • Gökçimen, A.1    Aydin, G.2    Karaöz, E.3    Malas, M.A.4    Öncü, M.5
  • 13
    • 0034508178 scopus 로고    scopus 로고
    • Structural and biochemical changes in liver and renal tissues induced by an acute high dose of diclofenac sodium in rats
    • Gökçimen, A., Akdoǧan, M., Karaöz, E.: Structural and biochemical changes in liver and renal tissues induced by an acute high dose of diclofenac sodium in rats. Biomed. Res., 2000; 11: 293-302.
    • (2000) Biomed. Res. , vol.11 , pp. 293-302
    • Gökçimen, A.1    Akdoǧan, M.2    Karaöz, E.3
  • 14
    • 0027269444 scopus 로고
    • Diclofenac covalent protein binding is dependent on acyl glucuronide formation and is inversely related to P 450-mediated acute cell injury in cultured rat hepatocytes
    • Kertz-Rommel, D.A., Boelsteri, U.A.: Diclofenac covalent protein binding is dependent on acyl glucuronide formation and is inversely related to P 450-mediated acute cell injury in cultured rat hepatocytes. Toxicol. Appl. Pharmacol., 1993; 120: 155-161.
    • (1993) Toxicol. Appl. Pharmacol. , vol.120 , pp. 155-161
    • Kertz-Rommel, D.A.1    Boelsteri, U.A.2
  • 15
    • 0027930364 scopus 로고
    • Metabolic activation and immunochemical localization of liver protein adducts of the nonsteroidal anti-inflammatory drug diclofenac
    • Hargus, S.J., Amouzedeh, H.R., Pumford, N.R.: Metabolic activation and immunochemical localization of liver protein adducts of the nonsteroidal anti-inflammatory drug diclofenac. Chem. Res. Toxicol., 1994; 7: 575-582.
    • (1994) Chem. Res. Toxicol. , vol.7 , pp. 575-582
    • Hargus, S.J.1    Amouzedeh, H.R.2    Pumford, N.R.3
  • 16
    • 0032572572 scopus 로고    scopus 로고
    • Hepatotoxicity of non-narcotic analgesics
    • Review
    • Tolman, K.G.: Hepatotoxicity of non-narcotic analgesics. Am. J. Med., (Review)., 1998; 105: 13S-19S.
    • (1998) Am. J. Med. , vol.105
    • Tolman, K.G.1
  • 17
    • 0030875708 scopus 로고    scopus 로고
    • The use of cultured hepatocytes to investigate the mechanism of drug hepatotoxicity
    • Castel, J.V., Gomez-Lechon, M.J., Ponsoda, X., Bort, R.: The use of cultured hepatocytes to investigate the mechanism of drug hepatotoxicity. Cell Biol. Toxicol., 1997; 13: 331-338.
    • (1997) Cell Biol. Toxicol. , vol.13 , pp. 331-338
    • Castel, J.V.1    Gomez-Lechon, M.J.2    Ponsoda, X.3    Bort, R.4
  • 19
    • 0031570791 scopus 로고    scopus 로고
    • Diclofenac sodium and mefenamic acid: Potent inducers of the membrane permeability transition in renal cortex mitochondria
    • Sergio, A.U., Antonio, C.S.: Diclofenac sodium and mefenamic acid: Potent inducers of the membrane permeability transition in renal cortex mitochondria. Arch. Biochem. Biophys., 1997; 342: 231-235.
    • (1997) Arch. Biochem. Biophys. , vol.342 , pp. 231-235
    • Sergio, A.U.1    Antonio, C.S.2
  • 20
    • 0344097396 scopus 로고    scopus 로고
    • Inhibition and uncoupling of oxidative phosphorylation by nonsteroidal anti-inflammatory drugs: Study in mitochondria, submitochondrial particles, cells, and whole heart
    • Moreno-Sanchez, R., Bravo, C., Vasquez, C., Ayala, G., Silveira, LH., Martinez-Lavin, M.: Inhibition and uncoupling of oxidative phosphorylation by nonsteroidal anti-inflammatory drugs: Study in mitochondria, submitochondrial particles, cells, and whole heart. Biochem. Pharmacol., 1999; 57: 743-752.
    • (1999) Biochem. Pharmacol. , vol.57 , pp. 743-752
    • Moreno-Sanchez, R.1    Bravo, C.2    Vasquez, C.3    Ayala, G.4    Silveira, L.H.5    Martinez-Lavin, M.6
  • 23
    • 0022573017 scopus 로고
    • Overview of enzyme systems involved in bioreduction of drugs and redox cycling
    • Kappus, H.: Overview of enzyme systems involved in bioreduction of drugs and redox cycling. Biochem. Pharmacol., 1986; 35: 1-6.
    • (1986) Biochem. Pharmacol. , vol.35 , pp. 1-6
    • Kappus, H.1
  • 25
  • 26
    • 0035062985 scopus 로고    scopus 로고
    • Investigation of erythrocyte antioxidant enzymes activities in high dose diclofenac sodium applied rats
    • Akdoǧan, M., Akkuş, S.: Investigation of erythrocyte antioxidant enzymes activities in high dose diclofenac sodium applied rats. Biomed. Res., 2001; 12: 53-57.
    • (2001) Biomed. Res. , vol.12 , pp. 53-57
    • Akdoǧan, M.1    Akkuş, S.2
  • 27
    • 0021352405 scopus 로고
    • Renal syndromes associated with nonsteroidal anti-inflammatory drugs
    • Clive, D.M., Stoff, J.S.: Renal syndromes associated with nonsteroidal anti-inflammatory drugs. N. Engl. J. Med., 1984; 310: 563-572.
    • (1984) N. Engl. J. Med. , vol.310 , pp. 563-572
    • Clive, D.M.1    Stoff, J.S.2
  • 28
    • 0027478126 scopus 로고
    • Renal toxicity of nonsteroidal anti-inflammatory drugs
    • Murray, M.D., Brater, D.C.: Renal toxicity of nonsteroidal anti-inflammatory drugs. Annu. Rev. Pharmacol. Toxicol., 1993; 32: 435-465.
    • (1993) Annu. Rev. Pharmacol. Toxicol. , vol.32 , pp. 435-465
    • Murray, M.D.1    Brater, D.C.2
  • 29
    • 0029445164 scopus 로고
    • Renal complications associated with use of nonsteroidal anti-inflammatory agents
    • Palmer, B.F.: Renal complications associated with use of nonsteroidal anti-inflammatory agents. J. Invest. Med., 1995; 43: 516-553.
    • (1995) J. Invest. Med. , vol.43 , pp. 516-553
    • Palmer, B.F.1
  • 30
    • 0024528916 scopus 로고
    • The mechanism of action of nonsteroidal anti-inflammatory drugs
    • Abromson, S.B., Weissmann, G.: The mechanism of action of nonsteroidal anti-inflammatory drugs. Arth. Rheum., 1988; 32: 1.
    • (1988) Arth. Rheum. , vol.32 , pp. 1
    • Abromson, S.B.1    Weissmann, G.2
  • 31
    • 71849104860 scopus 로고
    • Protein measurement with the Folin phenol reagent
    • Lowry, O.H., Rosebrough, N.J., Randall, R.J.: Protein measurement with the Folin phenol reagent. J. Biol. Chem., 1951; 182: 265-268.
    • (1951) J. Biol. Chem. , vol.182 , pp. 265-268
    • Lowry, O.H.1    Rosebrough, N.J.2    Randall, R.J.3
  • 32
    • 0027162796 scopus 로고
    • Ferous-iron-induced oxidation in chicken liver slices as measured by hemichrome formation and thiobarbituric acid reactive substances: Effect of dietary vitamin e and beta-carotene
    • Anderson, H.C., Chen, H., Pellet, LT., Tappel, A.L.: Ferous-iron-induced oxidation in chicken liver slices as measured by hemichrome formation and thiobarbituric acid reactive substances: Effect of dietary vitamin E and beta-carotene. Free Radic. Biol. Med., 1993; 15: 35-48.
    • (1993) Free Radic. Biol. Med. , vol.15 , pp. 35-48
    • Anderson, H.C.1    Chen, H.2    Pellet, L.T.3    Tappel, A.L.4
  • 33
    • 0343075899 scopus 로고
    • Beregmeyer, H.U., London, New York, Academic Press
    • Aebi, H.: Catalase. Methods of enzymatic analysis. In: Beregmeyer, H.U., London, New York, Academic Press, p. 673, 1974.
    • (1974) Catalase. Methods of Enzymatic Analysis , pp. 673
    • Aebi, H.1
  • 34
    • 0029078059 scopus 로고
    • Changes in energy homeostasis and GSH-depletion as possible mechanisms of diclofenac induced cytotoxicity on isolated rat hepatocytes
    • Schmitz, G., Lepper, H., Estler, C.J.: Changes in energy homeostasis and GSH-depletion as possible mechanisms of diclofenac induced cytotoxicity on isolated rat hepatocytes. Naunyn Schmied Eberas. Arch. Pharmacol., 1995; 77: 32-35.
    • (1995) Naunyn Schmied Eberas. Arch. Pharmacol. , vol.77 , pp. 32-35
    • Schmitz, G.1    Lepper, H.2    Estler, C.J.3
  • 36
    • 0021244916 scopus 로고
    • Pirprofen induced hepatitis with favourable outcome
    • Castot, A., Netter, P., Arnaudo, J.P.: Pirprofen induced hepatitis with favourable outcome. Therapie, 1984; 3: 297-303.
    • (1984) Therapie , vol.3 , pp. 297-303
    • Castot, A.1    Netter, P.2    Arnaudo, J.P.3
  • 38
    • 0018332596 scopus 로고
    • 2+ induced membrane transition in mitochondria. I. The protective mechanisms
    • 2+ induced membrane transition in mitochondria. I. The protective mechanisms. Arch. Biochem. Biophys, 1979; 195: 453-459.
    • (1979) Arch. Biochem. Biophys , vol.195 , pp. 453-459
    • Hunter, D.R.1    Haworth, R.A.2
  • 39
    • 0028941372 scopus 로고
    • 2+ ions is stimulated byt-butyl hydroperoxide and mediated by reactive oxygen species generated by mitochondria
    • 2+ ions is stimulated byt-butyl hydroperoxide and mediated by reactive oxygen species generated by mitochondria. Free Radical. Biol. Med., 1995; 18: 479-486.
    • (1995) Free Radical. Biol. Med. , vol.18 , pp. 479-486
    • Castilho, R.F.1    Kowaltowski, A.J.2    Meinjcke, A.R.3
  • 40
    • 0030047794 scopus 로고    scopus 로고
    • 2+ is dependent on mitochondrial generated reactive oxygen species
    • 2+ is dependent on mitochondrial generated reactive oxygen species. FEBS Lett., 1996; 378: 150-152.
    • (1996) FEBS Lett. , vol.378 , pp. 150-152
    • Kawaltovski, A.J.1    Castilho, R.F.2
  • 41
    • 0028053663 scopus 로고
    • Recent progress on regulation of the mitochondrial permeability transition pore, a cyclosporin-sensitive pore in the inner mitochondrial membrane
    • Bernardi, P., Broekemeier, K.M., Pfeiffer, D.R.: Recent progress on regulation of the mitochondrial permeability transition pore, a cyclosporin-sensitive pore in the inner mitochondrial membrane. J. Bioenerg. Biomembr., 1994; 26: 509-517.
    • (1994) J. Bioenerg. Biomembr. , vol.26 , pp. 509-517
    • Bernardi, P.1    Broekemeier, K.M.2    Pfeiffer, D.R.3
  • 42
    • 0030588297 scopus 로고    scopus 로고
    • In vitro interaction of nonsteroidal anti-inflammatory drugs on oxidative phosphorylation of rat
    • Mingatto, F.E., Santor, A.C., Uyemura, S.A.: In vitro interaction of nonsteroidal anti-inflammatory drugs on oxidative phosphorylation of rat. Arch. Biochem. Biophy., 1996; 334: 303-308.
    • (1996) Arch. Biochem. Biophy. , vol.334 , pp. 303-308
    • Mingatto, F.E.1    Santor, A.C.2    Uyemura, S.A.3


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