Structural and biochemical changes in liver and renal tissues induced by an acute high dose of diclofenac sodium in rats

Biomedical Research

Volumn 11, Issue 3, 2000, Pages 293-302

  Gokcimen A ^a   Akdogan, M ^a   Karaoz E ^a   Ozguner F ^a   Malas, M A ^a   Cicek E ^a  

^a SULEYMAN DEMIREL UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

Author keywords

Diclofenac sodium; Kidney; Liver; Structural and biochemical changes

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; CATALASE; CREATINE KINASE; CREATININE; DICLOFENAC; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; LACTATE DEHYDROGENASE; LIPID PEROXIDASE; MALONALDEHYDE; SUPEROXIDE DISMUTASE; UREA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT; CELL DEGENERATION; CELL INFILTRATION; CELL PROLIFERATION; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DRUG MEGADOSE; HISTOPATHOLOGY; KIDNEY TUBULE EPITHELIUM; LACTATE DEHYDROGENASE BLOOD LEVEL; LIVER CELL DAMAGE; LIVER TOXICITY; MALE; NEPHROTOXICITY; NONHUMAN; RAT; UREA NITROGEN BLOOD LEVEL;

ANIMALIA; FELIS CATUS;

EID: 0034508178     PISSN: 0970938X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Review of diclofenac and evaluation of its place in therapy as a nonsteroidal anti-inflammatory agent
2. Effect on neonate of maternal treatment with indomethacin
3. Medicine Pharmacology
4. Hepatotoxicity of non-narcotic analgesic
5. Diclofenac covalent protein binding is dependent on acyl glucuronide formation and is inversely related to P 450-mediated acute cell injury in cultured rat hepatocytes
6. Metabolic activation and immunochemical localization of liver protein adducts of the nonsteroidal anti-inflammatory drug diclofenac
7. The use of cultured hepatocytes to investigate the mechanism of drug hepatotoxicity
8. The mechanism of action of nonsteroidal anti-inflammatory drugs
9. Protein measurement with the Folin phenol reagent
10. Ferous-iron-induced oxidation in chicken liver slices as measured by hemichrome formation and thiobarbituric acid reactive substances: Effect of dietary vitamin E and beta-carotene
11. Catalase
12. Diclofenac hepatitis
13. Diclofenac sodium and mefenamic acid: Potent inducers of the membrane permeality transition in renal cortex mitochondria
14. Changes in energy homostasis and GSH-depletion as possible mechanism of diclofenac induced cytotoxicity on isolated rat hepatocytes
15. Hepatite fulminante che une femme prenant de la glafenine et du diclofenac
16. Pirprofen induced hepatitis with favourable outcome
17. Side effects of anti-inflammatory drugs
18. Overview of enzyme systems involved in bioreduction of drugs and redox cycling
19. Toxic and drug induced hepatitis
20. 4 induced liver injury and concentrations after inhalation or oral administration
21. Report on a long-term tolerability study of up to two years with diclofenac sodium
22. Pharmacokinetics and hepatotoxicity of diclofenac using an isolated perfused rat liver
23. Renal syndromes associated with nonsteroidal anti-inflammatory drugs
24. Renal toxicity of nonsteroidal anti-inflammatory drugs
25. Renal complications associated with use of nonsteroidal anti-inflammatory agents
26. 2+ induced membrane transition in mitochondrial. The protective mechanisms
27. 2+ ions is stimulated byt-butyl hydroperoxide and mediated by reactive oxygen species generated by mitochodria
28. 2+ is dependent on mitochondrial generated reactive oxygen species
29. Recent progress on regulation of the mitochodrial permeability transition pore; a cyclosporin-sensitive in the inner mitochondrial membrane
30. In vitro interaction of nonsteroidal anti-inflammatory drugs on oxidative phosphorylation of rat