Novel treatment of short stature with aromatase inhibitors

Journal of Steroid Biochemistry and Molecular Biology

Volumn 86, Issue 3-5, 2003, Pages 345-356

  Dunkel, Leo ^a   Wickman, Sanna ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Androgens; Aromatase; Bone; Estrogens; Gonadotropins; Growth; Insulin; Lipids; Puberty

Indexed keywords

ANDROGEN; AROMATASE INHIBITOR; CYTOCHROME P450 INHIBITOR; ESTRADIOL; ESTROGEN; LETROZOLE; PLACEBO; TESTOSTERONE ENANTATE;

ADOLESCENT; BODY HEIGHT; BONE MATURATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DELAYED PUBERTY; DRUG DOSE REGIMEN; DRUG POTENCY; DRUG SPECIFICITY; ESTROGEN SYNTHESIS; EVALUATION; FOLLOW UP; HUMAN; INHIBITION KINETICS; MALE; PREDICTION; PROSPECTIVE STUDY; PUBERTY; RANDOMIZED CONTROLLED TRIAL; SHORT STATURE;

EID: 0242575852     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-0760(03)00344-3     Document Type: Conference Paper

References (62)

1. Smith E.P., Boyd J., Frank G.R., Takahashi H., Cohen R.M., Specker B., Williams T.C., Lubahn D.B., Korach K.S. Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. N. Engl. J. Med. 331:1994;1056-1061.
2. Morishima A., Grumbach M.M., Simpson E.R., Fisher C., Qin K. Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens. J. Clin. Endocrinol. Metab. 80:1995;3689-3698.
3. Carani C., Qin K., Simoni M., Faustini-Fustini M., Serpente S., Boyd J., Korach K.S., Simpson E.R. Effect of testosterone and estradiol in a man with aromatase deficiency. N. Engl. J. Med. 337:1997;91-95.
4. Bilezikian J.P., Morishima A., Bell J., Grumbach M.M. Increased bone mass as a result of estrogen therapy in a man with aromatase deficiency. N. Engl. J. Med. 339:1998;599-603.
5. Crowne E.C., Shalet S.M., Wallace W.H.B., Eminson D.M., Price D.A. Final height in boys with untreated constitutional delay in growth and puberty. Arch. Dis. Child. 65:1990;1109-1112.
6. LaFranchi S., Hanna C.E., Mandel S.H. Constitutional delay of growth: expected versus final adult height. Pediatrics. 87:1991;82-87.
7. Albanese A., Stanhope R. Does constitutional delayed puberty cause segmental disproportion and short stature? Eur. J. Pediatr. 152:1993;293-296.
8. Albanese A., Stanhope R. Predictive factors in the determination of final height in boys with constitutional delay of growth and puberty. J. Pediatr. 126:1995;545-550.
9. Martin M.M., Martin A.L.A., Mossman K.L. Testosterone treatment of constitutional delay in growth and development: effect of dose on predicted versus definitive height. Acta Endocrinol. Suppl. 279:1986;147-152.
10. Richman R.A., Kirsch L.R. Testosterone treatment in adolescent boys with constitutional delay in growth and development. N. Engl. J. Med. 319:1988;1563-1567.
11. Albanese A., Kewley G.D., Long A., Pearl K.N., Robins D.G., Stanhope R. Oral treatment for constitutional delay of growth and puberty in boys: a randomized trial of an anabolic steroid or testosterone undecanoate. Arch. Dis. Child. 71:1994;315-317.
12. Blethen S.L., Gaines S., Weldon V. Comparison of predicted and adult heights in short boys: effect of androgen therapy. Pediatr. Res. 18:1984;467-469.
13. Wickman S., Sipilä I., Ankarberg-Lindgren C., Norjavaara E., Dunkel L. A specific aromatase inhibitor and potential increase in adult height in boys with delayed puberty: a randomized controlled trial. Lancet. 357:2001;1743-1748.
14. Wickman S., Saukkonen T., Dunkel L. The role of sex steroids in the regulation of insulin and lipid metabolism in boys during puberty: a prospective study with a P450-aromatase inhibitor. Eur. J. Endocrinol. 146:2002;339-346.
15. Wickman S., Dunkel L. Inhibition of P450 aromatase enhances gonadotropin secretion in early and midpubertal boys: evidence for a pituitary site of action of endogenous. E. J. Clin. Endocrinol. Metab. 86:2001;4887-4894.
16. P. Ojajärvi, The Adolescent Finnish Child, A Longitudinal Study of the Anthropometry, Physical Development and Physiological Changes During Puberty, University of Helsinki, Helsinki, 1982.
17. J.M. Tanner, Growth at Adolescence, second ed., Blackwell Scientific Publications, Oxford, 1962.
18. Hansen P., With T.K. Clinical measurements of the testis in boys and men. Acta Med. Scand. 142(Suppl. 266):1952;457-465.
19. W.W. Greulich, S.I. Pyle, Radiographic Atlas of Skeletal Development of the Hand and Wrist, second ed., Stanford University Press, Stanford, 1959.
20. Bayley N., Pinneau S.R. Tables for predicting adult height from skeletal age: revised for use with the Greulich-Pyle hand standards. J. Pediatr. 40:1952;423-441.
21. Norjavaara E., Ankarberg C., Albertsson-Wikland K. Diurnal rhythm of 17β-estradiol secretion throughout pubertal development in healthy girls: evaluation by a sensitive radioimmunoassay. J. Clin. Endocrinol. Metab. 81:1996;4095-4102.
22. Apter D., Jänne O., Karvonen P., Vihko R. Simultaneous determination of five sex hormones in human serum by radioimmunoassay after chromatography on Lipidex-5000. Clin. Chem. 22:1976;32-38.
23. Blum W.F., Albertsson-Wikland K., Rosberg S., Ranke M.B. Serum levels of insulin-like growth factor I (IGF-I) and IGF-binding protein 3 reflect spontaneous growth hormone secretion. J. Clin. Endocrinol. Metab. 76:1993;1610-1616.
24. Friedewald W.T., Levy R.I., Fredrickson D.S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin. Chem. 18:1972;499-502.
25. Dunkel L., Alfthan H., Stenman U.H., Perheentupa J. Gonadal control of pulsatile secretion of luteinizing hormone and follicle-stimulating hormone in prepubertal boys evaluated by ultrasensitive time-resolved immunofluorometric assays. J. Clin. Endocrinol. Metab. 70:1990;107-114.
26. Trunet P.F., Mueller P., Bhatnagar A.S., Dickes I., Monnet G., White G. Open dose-finding study of a new potent and selective nonsteroidal aromatase inhibitor, CGS 20 267, in healthy male subjects. J. Clin. Endocrinol. Metab. 77:1993;319-323.
27. Pentikäinen V., Erkkilä K., Suomalainen L., Parvinen M., Dunkel L. Estradiol acts as a germ cell survival factor in the human testis in vitro. J. Clin. Endocrinol. Metab. 85:2000;2057-2067.
28. Metzger D.L., Kerrigan J.R. Estrogen receptor blockade with tamoxifen diminishes growth hormone secretion in boys: evidence for a stimulatory role of endogenous estrogens during male adolescence. J. Clin. Endocrinol. Metab. 79:1994;513-518.
29. Kuiper G.G.J.M., Carlsson B., Grandien K., Enmark E., Häggblad J., Nilsson S., Gustafsson J.-Å. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology. 138:1997;863-870.
30. Bertelloni S., Baroncelli G.I., Federico G., Cappa M., Lala R., Saggese G. Altered bone mineral density in patients with complete androgen insensitivity syndrome. Horm. Res. 50:1998;309-314.
31. Marcus R., Leary D., Schneider D.L., Shane E., Favus M., Quigley C.A. The contribution of testosterone to skeletal development and maintenance: lessons from the androgen insensitivity syndrome. J. Clin. Endocrinol. Metab. 85:2000;1032-1037.
32. Morrison J.A., Sprecher D.L., Biro F.M., Hansen C.A., Lucky A.W., Wride K. Sex hormones and lipoproteins in adolescent male offspring of parents with premature coronary heart disease and a control group. J. Pediatr. 133:1998;526-532.
33. Morrison J.A., Sprecher D.L., Biro F.M., Apperson-Hansen C., Lucky A.W., DiPaola L.M. Estradiol and testosterone effects on lipids in black and white boys aged 10-15 years. Metabolism. 49:2000;1124-1129.
34. Kirkland R.T., Keenan B.S., Probstfield J.L., Patsch W., Lin T.L., Clayton G.W., Insull W. Jr. Decrease in plasma high-density lipoprotein cholesterol levels at puberty in boys with delayed adolescence. Correlation with plasma testosterone levels. JAMA. 257:1987;502-507.
35. Arslanian S., Suprasongsin C. Testosterone treatment in adolescents with delayed puberty: changes in body composition, protein, fat, and glucose metabolism. J. Clin. Endocrinol. Metab. 82:1997;3213-3220.
36. Saad R.J., Keenan B.S., Danadian K., Lewy V.D., Arslanian S.A. Dihydrotestosterone treatment in adolescents with delayed puberty: does it explain insulin resistance of puberty? J. Clin. Endocrinol. Metab. 86:2001;4881-4886.
37. Applebaum D.M., Goldberg A.P., Pykälistö O.J., Brunzell J.D., Hazzard W.R. Effect of estrogen on post-heparin lipolytic activity. Selective decline in hepatic triglyceride lipase. J. Clin. Invest. 59:1977;601-608.
38. Laskarzewski P.M., Morrison J.A., Gutai J., Khoury P.R., Glueck C.J. Longitudinal relationships among endogenous testosterone, estradiol, and Quetelet index with high- and low-density lipoprotein cholesterols in adolescent boys. Pediatr. Res. 17:1983;689-698.
39. Laskarzewski P.M., Morrison J.A., Gutai J., Orchard T., Khoury P.R., Glueck C.J. High- and low-density lipoprotein cholesterols in adolescent boys: relationships with endogenous testosterone, estradiol, and Quetelet index. Metabolism. 32:1983;262-271.
40. Amiel S.A., Sherwin R.S., Simonson D.C., Lauritano A.A., Tamborlane W.V. Impaired insulin action in puberty. A contributing factor to poor glycemic control in adolescents with diabetes. N. Engl. J. Med. 315:1986;215-219.
41. Bloch C.A., Clemons P., Sperling M.A. Puberty decreases insulin sensitivity. J. Pediatr. 110:1987;481-487.
42. Caprio S., Plewe G., Diamond M.P., Simonson D.C., Boulware S.D., Sherwin R.S., Tamborlane W.V. Increased insulin secretion in puberty: a compensatory response to reductions in insulin sensitivity. J. Pediatr. 114:1989;963-967.
43. Smith C.P., Dunger D.B., Williams A.J.K., Taylor A.M., Perry L.A., Gale E.A.M., Preece M.A., Savage M.O. Relationship between insulin, insulin-like growth factor I, and dehydroepiandrosterone sulfate concentrations during childhood, puberty, and adult life. J. Clin. Endocrinol. Metab. 68:1989;932-937.
44. Amiel S.A., Caprio S., Sherwin R.S., Plewe G., Haymond M.W., Tamborlane W.V. Insulin resistance of puberty: a defect restricted to peripheral glucose metabolism. J. Clin. Endocrinol. Metab. 72:1991;277-282.
45. Goran M.I., Gower B.A. Longitudinal study on pubertal insulin resistance. Diabetes. 50:2001;2444-2450.
46. Cook J.S., Hoffman R.P., Stene M.A., Hansen J.R. Effects of maturational stage on insulin sensitivity during puberty. J. Clin. Endocrinol. Metab. 77:1993;725-730.
47. Heptulla R.A., Boulware S.D., Caprio S., Silver D., Sherwin R.S., Tamborlane W.V. Decreased insulin sensitivity and compensatory hyperinsulinemia after hormone treatment in children with short stature. J. Clin. Endocrinol. Metab. 82:1997;3234-3238.
48. Santen R.J., Kulin H.E., Loriaux D.L., Friend J. Spironolactone stimulation of gonadotropin secretion in boys with delayed adolescence. J. Clin. Endocrinol. Metab. 43:1976;1386-1390.
49. Kletter G.B., Padmanabhan V., Beitins I.Z., Marshall J.C., Kelch R.P., Foster C.M. Acute effects of estradiol infusion and naloxone on luteinizing hormone secretion in pubertal boys. J. Clin. Endocrinol. Metab. 82:1997;4010-4014.
50. Hayes F.J., Seminara S.B., DeCruz S., Boepple P.A., Crowley W.F. Jr. Aromatase inhibition in the human male reveals a hypothalmic site of estrogen feedback. J. Clin. Endocrinol. Metab. 85:2000;3027-3035.
51. Clarke I.J., Cummins J.T. The temporal relationship between gonadotropin releasing hormone (GnRH) and luteinizing hormone (LH) secretion in ovariectomized ewes. Endocrinology. 111:1982;1737-1739.
52. Levine J.E., Pau K.Y., Ramirez V.D., Jackson G.L. Simultaneous measurement of luteinizing hormone-releasing hormone and luteinizing hormone release in unanesthetized, ovariectomized sheep. Endocrinology. 111:1982;1449-1455.
53. Hayes F.J., Crowley W.F. Jr. Gonadotropin pulsations across development. Horm. Res. 49:1998;163-168.
54. Andersson A.M., Juul A., Petersen J.H., Muller J., Groome N.P., Skakkebaek N.E. Serum inhibin B in healthy pubertal and adolescent boys: relation to age, stage of puberty, and follicle-stimulating hormone, luteinizing hormone, testosterone, and estradiol levels. J. Clin. Endocrinol. Metab. 82:1997;3976-3981.
55. Byrd W., Bennett M.J., Carr B.R., Dong Y., Wians F., Rainey W. Regulation of biologically active dimeric inhibin A and B from infancy to adulthood in the male. J. Clin. Endocrinol. Metab. 83:1998;2849-2854.
56. Raivio T., Saukkonen S., Jääskeläinen J., Komulainen J., Dunkel L. Signaling between the pituitary gland and the testes: inverse relationship between serum follicle-stimulating hormone and inhibin B concentrations in boys in early puberty. Eur. J. Endocrinol. 142:2000;150-156.
57. Nachtigall L.B., Boepple P.A., Seminara S.B., Khoury R.H., Sluss P.M., Lecain A.E., Crowley W.F. Jr. Inhibin B secretion in males with gonadotropin-releasing hormone (GnRH) deficiency before and during long-term GnRH replacement: relationship to spontaneous puberty, testicular volume, and prior treatment - a clinical research center study. J. Clin. Endocrinol. Metab. 81:1996;3520-3525.
58. Hayes F.J., Pitteloud N., DeCruz S., Crowley W.F. Jr., Boepple P.A. Importance of inhibin B in the regulation of FSH secretion in the human male. J. Clin. Endocrinol. Metab. 86:2001;5541-5546.
59. Boyar R., Finkelstein J., Roffwarg H., Kapen S., Weitzman E., Hellman L. Synchronization of augmented luteinizing hormone secretion with sleep during puberty. N. Engl. J. Med. 287:1972;582-586.
60. Beck W., Wuttke W. Diurnal variations of plasma luteinizing hormone, follicle-stimulating hormone, and prolactin in boys and girls from birth to puberty. J. Clin. Endocrinol. Metab. 50:1980;635-639.
61. Boyar R.M., Finkelstein J.W., Roffwarg H., Kapen S., Weitzman E.D., Hellman L. Twenty-four-hour luteinizing hormone and follicle-stimulating hormone secretory patterns in gonadal dysgenesis. J. Clin. Endocrinol. Metab. 37:1973;521-525.
62. Ross J.L., Loriaux D.L., Cutler G.B. Jr. Developmental changes in neuroendocrine regulation of gonadotropin secretion in gonadal dysgenesis. J. Clin. Endocrinol. Metab. 57:1983;288-293.