Effects of 6-aminonicotinamide gliotoxin on blood-brain barrier differentiation in the chick embryo cerebellum

Anatomy and Embryology

Volumn 207, Issue 3, 2003, Pages 209-219

  Bertossi, Mirella ^a   Girolamo, Francesco ^b   Errede, Mariella ^b   Virgintino, Daniela ^b   Roncali, Luisa ^b  

^a UNIVERSITY OF FOGGIA   (Italy)

^b UNIVERSITY OF BARI MEDICAL SCHOOL   (Italy)

Author keywords

3CB2; Astroglia degeneration; Brain endothelial cells; Embryonic CNS; HT7

Indexed keywords

6 AMINONICOTINAMIDE; GLIOTOXIN; HORSERADISH PEROXIDASE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BLOOD VESSEL PERMEABILITY; BRAIN BLOOD VESSEL; CELL DIFFERENTIATION; CELL ULTRASTRUCTURE; CENTRAL NERVOUS SYSTEM; CEREBELLUM; CHICK EMBRYO; CHORIOALLANTOIS; DRUG EFFECT; EMBRYO DEVELOPMENT; ENDOTHELIUM CELL; MACROGLIA; MICROVASCULATURE; NONHUMAN; PRIORITY JOURNAL;

6-AMINONICOTINAMIDE; ANIMALS; ANTIGENS, CD; ANTIGENS, CD147; ANTIGENS, NEOPLASM; ANTIGENS, SURFACE; ASTROCYTES; AVIAN PROTEINS; BLOOD PROTEINS; BLOOD-BRAIN BARRIER; CELL DIFFERENTIATION; CEREBELLUM; CHICK EMBRYO; ENDOTHELIUM, VASCULAR; HORSERADISH PEROXIDASE; IMMUNOHISTOCHEMISTRY; MEMBRANE GLYCOPROTEINS; MICROCIRCULATION; NEUROGLIA;

ANIMALIA; ARMORACIA RUSTICANA; GALLUS GALLUS;

EID: 0242572050     PISSN: 03402061     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00429-003-0335-4     Document Type: Article

References (44)

1. Abbott NJ, Revest PA, Romero IA (1992) Astrocyte-endothelial interaction: physiology and pathology. Neuropathol Appl Neurobiol 18:424-433
2. Abbott NJ (2002) Astrocyte-endothelial interactions and blood-brain barrier permeability. J Anat 200:629-638
3. Balabanov R, Dore-Duffy P (1998) Role of the CNS microvascular pericyte in the blood-brain barrier. J Neurosci Res 53:637-644
4. Bauer HC, Bauer H (2000) Neural induction of the blood-brain barrier: still an enigma. Cell Mol Neurobiol 20:13-28
5. Bertossi M, Girolamo F, Errede M, Benagiano V, Virgintino D, Roncali L (2002) Developmental changes of HT7 expression in the microvessels of the chick embryo brain. Anat Embryol (Berl) 205:229-233
6. Budihardjo II, Walker DL, Svingen PA, Buckwalter CA, Desnoyers S, Eckdahl S, Shah GM, Poirier GG, Reid JM, Ames MM, Kaufmann SH (1998) 6-Aminonicotinamide sensitizes human tumor cell lines to cisplatin. Clin Cancer Res 4:117-130
7. Davson H, Oldendorf WH (1967) Symposium on membrane transport. Transport in the central nervous system. Proc R Soc Med 60:326-329
8. Fishell G, Kriegstein AR (2003) Neurons from radial glia: the consequences of asymmetric inheritance. Current Opinion in Neurobiology 13:34-41
9. Guérin CJ, Nolan CC, Mavroudis G, Lister T, Davidson GM, Holton JL, Ray DE (2001) The dynamics of blood-brain barrier breakdown in an experimental model of glial cell degeneration. Neuroscience 103:873-883
10. Herken H (1992) Neurotoxic synthesis by enzymatic error. In: Herken H, Hucho F (eds) Selective Neurotoxicity. Springer-Verlag, Berlin, pp 141-192
11. Holash JA, Noden DM, Stewart PA (1993) Re-evaluating the role of astrocytes in blood-brain barrier induction. Dev Dyn 197:14-25
12. Horita N, Ishii T, Izumiyama Y (1980) Ultrastructure of 6-aminonicotinamide (6-AN)-induced lesions in the central nervous system of rats. II. Alterations of the nervous susceptibility with aging. Acta Neuropathol (Berl) 49:19-27
13. Horita N, Ishii T, Izumiyama Y (1981) Ultrastructure of 6-aminonicotinamide (6-AN)-induced lesions in the central nervous system of rats. III. Alterations of the spinal gray matter lesion with aging. Acta Neuropathol (Berl) 53:227-235
14. Joó F (1995) Isolated brain microvessels and cultured cerebral endothelial cells in blood-brain barrier research: 20 years on. In: Greenwood J, Begley DJ, Segal MB (eds) New concepts of a blood-brain barrier. Plenum Press, New York, pp 229-237
15. Krum JM (1994) Experimental gliopathy in the adult rat CNS: effect on the blood-brain barrier. Glia 11:354-366
16. Krum JM (1995) Age-dependent susceptibility of CNS glial populations in situ to the antimetabolite 6-aminonicotinamide. Mol Chem Neuropathol 26:79-94
17. Krum JM (1996) Effect of astrocyte degeneration on neonatal blood-brain barrier marker expression. Exp Neurol 142:29-35
18. Krum JM, Rosenstein JM (1993) Effect of astroglial degeneration on the blood-brain barrier to protein in neonatal rats. Brain Res Dev Brain Res 74:41-50
19. Krum JM, Kenyon KL, Rosenstein JM (1997) Expression of blood-brain barrier characteristics following neuronal loss and astroglial damage after administration of anti-Thy-1 immunotoxin. Exp Neurol 146:33-45
20. Kuchler-Bopp S, Delaunoy J, Artault JHC, Zaepfel M, Dietrich JB (1999) Astrocytes induce several blood-brain barrier properties in non-neural endothelial cells. Neuroreport 10:1347-1353
21. Malatesta P, Hack MA, Hartfuss E, Kettenmann H, Klinkert W, Kirchhoff F, Götz M (2003) Neuronal or glial progeny: regional differences in radial glia fate. Neuron 37:751-764
22. Morris G, Nadler JV, Nemeroff CB, Slotkin TA (1985) Effects of neonatal treatment with 6-aminonicotinamide on basal and isoproterenol-stimulated ornithine decarboxylase activity in cerebellum of the development rat. Biochem Pharmacol 34:3281-3284
23. Pardridge WM (1999) Blood-brain barrier biology and methodology. J Neurovirol 5:556-569
24. Penkowa M, Hidalgo J (2000) IL-6 deficiency leads to reduced metallothionein-I+II expression and increased oxidative stress in the brain stem after 6-aminonicotinamide treatment. Exp Neurol 163:72-84
25. Penkowa M, Poulsen C, Carrasco J, Hidalgo J (2002) M-CSF deficiency leads to reduced metallothioneins I and II expression and increased tissue damage in the brain stem after 6-aminonicotinamide treatment. Exp Neurol 176:308-321
26. Politis MJ (1989) 6-Aminonicotinamide selectively causes necrosis in reactive astroglia cells in vivo. Preliminary morphological observations. J Neurol Sci 92:71-79.
27. Prada AF, Dorado ME, Quesada A, Prada C, Schwarz U, De La Rosa EJ (1995) Early expression of a novel radial glia antigen in the chick embryo. Glia 15:389-400
28. Rakic P, Sidman RL (1973) Weaver mutant mouse cerebellum, defective neuronal migration secondary to abnormality of Bergmann glia. Proc Natl Acad Sci USA 70:240-244
29. Rauchfuss A (1978) Normal and 6-aminonicotinamide impaired development of capillarization in occipital cortex of rat. Anat Embryol (Berl) 154:27-37
30. Risau W, Hallman R, Albrecht U, Henke-Fahle S (1986) Brain induces the expression of an early cell surface marker for blood-brain barrier-specific endothelium. EMBO J 5:3179-3183
31. Roncali L (2001) Astrocyte and barrier-provided microvasculature in the developing brain. In: deVellis J (ed.) Neuroglia in the aging brain. Humana Press, Totowa, pp 321-335
32. Roncali L, Nico B, Ribatti D, Bertossi M, Mancini L (1986) Microscopical and ultrastructural investigations on the development of the blood-brain barrier in the chick embryo optic tectum. Acta Neuropathol 70:193-201
33. Sasaki S (1982) Brain edema and gliopathy induced by 6-aminonicotinamide intoxication in the central nervous system of rats. Am J Vet Res 43:1691-1695
34. Schaarschmidt W, Lierse W (1975) Ultrastrustrukturelle reaktion der multipotenten glia im kleinhirn der ratte nach behandlung mit 6-aminonikotinamid. Acta Anat 93:184-193
35. Schlosshauer B (1991) Neurothelin: molecular characteristics and developmental regulation in the chick CNS. Development 113:129-140
36. Schneider H, Cervos-Navarro J (1974) Acute gliopathy in spinal cord and brain stem induced by 6-aminonicotinamide. Acta Neuropathol (Berl) 27:11-23
37. Seulberger H, Lottspeich F, Risau W (1990) The inducible blood-brain barrier specific molecule HT7 is a novel immunoglobulin-like cell surface glycoprotein. EMBO J 9:2151-2158
38. Seulberger H, Unger CM, Risau W (1992) HT7, Neurothelin, Basigin, gp42 and OX-47-many names for one developmentally regulated immuno-globulin-like surface glycoprotein on blood-brain barrier endothelium, epithelial tissue barriers and neurons. Neurosci Lett 140:93-97
39. Sotelo C (1967) Cerebellar neuroglia: morphological and histochemical aspects. Prog Brain Res 25:226-250
40. Sotelo C, Rio JP (1980) Cerebellar malformation obtained in rats by early postnatal treatment with 6-aminonicotinamide. Role of neuron-glia interactions in cerebellar development. Neuroscience 5:1737-1759
41. Street JC, Alfieri AA, Koutcher JA (1997) Quantitation of metabolic and radiobiological effects of 6-aminonicotinamide in RIF-1 tumor cells in vitro. Cancer Res 57:3956-3962
42. Virgintino D, Maiorano E, Bertossi M, Pollice L, Ambrosi G, Roncali L (1993) Vimentin-and GFAP immunoreactivity in developing and mature neural microvessels. Study in the chicken tectum and cerebellum. Eur J Histochem 37:353-362
43. Walker DL, Reid JM, Svingen PA, Rios R, Covey JM, Alley MC, Hollingshead MG, Budihardjo II, Eckdahl S, Boerner SA, Kaufmann SH, Ames MM (1999) Murine pharmacokinetics of 6-aminonicotinamide (NSC 21206), a novel biochemical modulating agent. Biochem Pharmacol 58:1057-1066
44. Wolburg H, Neuhaus J, Kniesel U, Krauss B, Schmid EM, Ocalan M, Farrel C, Risau W (1994) Modulation of tight junction structure in blood-brain barrier endothelial cells. Effects of tissue culture, second messengers and cocultured astrocytes. J Cell Sci 107:1347-1357