"Top Down" Characterization Is a Complementary Technique to Peptide Sequencing for Identifying Protein Species in Complex Mixtures

Journal of Proteome Research

Volumn 2, Issue 5, 2003, Pages 495-505

  Nemeth Cawley, Jennifer F ^a,b   Tangarone, Bruce S ^a   Rouse, Jason C ^a  

^a PFIZER INC   (United States)

^b ExSAR Corporation   (United States)

Author keywords

"Bottom Up" characterization; "Top Down" characterization; Chinese hamster ovary; Mass spectrometry; Proteomics; Recombinant protein characterization

Indexed keywords

HYBRID PROTEIN; IMMUNOGLOBULIN G1; RECOMBINANT PROTEIN;

ALKYLATION; ANALYTIC METHOD; ANIMAL CELL; ARTICLE; CHO CELL; GEL PERMEATION CHROMATOGRAPHY; GLYCOSYLATION; MASS SPECTROMETRY; NONHUMAN; PEPTIDE ANALYSIS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PURIFICATION; PROTEOMICS; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

ALKYLATION; AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CHO CELLS; CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRICETINAE; CRICETULUS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; IMMUNOGLOBULIN G; MICE; PEPTIDE FRAGMENTS; PEPTIDE MAPPING; PROTEINS; PROTEOMICS; RECEPTORS, INTERLEUKIN; RECOMBINANT FUSION PROTEINS; SEQUENCE ANALYSIS;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS;

EID: 0242569357     PISSN: 15353893     EISSN: None     Source Type: Journal    
DOI: 10.1021/pr034008u     Document Type: Article

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