Pneumocystis jiroveci in Portuguese immunocompromised patients: Association of specific ITS genotypes with treatment failure, bad clinical outcome and childhood

Infection, Genetics and Evolution

Volumn 3, Issue 4, 2003, Pages 281-285

  Matos, Olga ^a   Lee, Chao Hung ^b   Jin, Shaoling ^b   Li, Baozheng ^b   Costa, Marina C ^a   Gonçalves, Luzia ^a   Antunes, Francisco ^a,c  

^a INSTITUTO DE HIGIENE E MEDICINA TROPICAL   (Portugal)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c HOSPITAL DE SANTA MARIA   (Portugal)

Author keywords

DHPS gene; Genotyping; ITS regions; Pneumocystis jiroveci pneumonia; Portuguese immunocompromised patients

Indexed keywords

ANTIBIOTIC AGENT; COTRIMOXAZOLE; DIHYDROPTEROATE SYNTHASE; INTERNAL TRANSCRIBED SPACER; NUCLEAR RNA; PENTAMIDINE;

ADULT; AGE; AGED; ARTICLE; BACTERIUM ISOLATE; CONTROLLED STUDY; DIAGNOSTIC PROCEDURE; DRUG RESPONSE; FEMALE; GENETIC VARIABILITY; GENOTYPE; HUMAN; IMMUNE DEFICIENCY; IMMUNOFLUORESCENCE; MALE; MORTALITY; OPERON; OUTCOMES RESEARCH; PNEUMOCYSTIS; PNEUMOCYSTIS JIROVECI; PNEUMONIA; PORTUGAL; PRIORITY JOURNAL; TREATMENT FAILURE; WILD TYPE;

ADULT; AGED; CHILD; CHILD, PRESCHOOL; DIHYDROPTEROATE SYNTHASE; DNA, INTERGENIC; FEMALE; HUMANS; IMMUNOCOMPROMISED HOST; INFANT; MALE; MIDDLE AGED; OPERON; PNEUMOCYSTIS JIROVECI; PNEUMONIA, PNEUMOCYSTIS; PORTUGAL; TREATMENT OUTCOME; VARIATION (GENETICS);

PNEUMOCYSTIS; PNEUMOCYSTIS JIROVECII;

EID: 0242558925     PISSN: 15671348     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1567-1348(03)00092-3     Document Type: Article

References (22)

1. Chen W. Gigliotti F. Harmsen A.G. Latency is not an inevitable outcome of infection with Pneumocystis carinii Infect. Immun. 61 1993 5406-5409
2. Costa, M.C., Helweg-Larsen, J., Lundgren, B., Antunes, F., Matos, O., in press. Mutations in the dihydropteroate synthase gene of Pneumocystis jiroveci isolates from Portuguese patients with Pneumocystis pneumonia. Int. J. Antimicrob. Agents.
3. Diop S.L. Lacube P. Latouche S. Kac G. Mayaud C. Marteau M. Poirot J.L. Maury E. Guillot J. Roux P. Contribution of dihydropteroate synthase gene typing for Pneumocystis carinii f. sp. hominis epidemiology J. Eukaryot. Microbiol. 46 1999 133S-134S
4. Hauser, P.M., Sudre, P., Nahimana, A., Francioli, P., The Study Group, 2001. Prophylaxis failure is associated with a specific Pneumocystis carinii genotype. C.I.D. 33, 1080-1082.
5. Helweg-Larsen J. Benfield T.L. Eugen-Olsen J. Lundgren J.D. Lundgren B. Effects of mutations in Pneumocystis carinii dihydropteroate synthase on outcome of AIDS-associated P. carinii pneumonia Lancet 354 1999 1347-1351
6. Helweg-Larsen J. Eugen-Olsen J. Lundgren B. Rapid detection of dihydropteroate polymorphism in AIDS-related Pneumocystis carinii pneumonia by restriction fragment length polymorphism Scand. J. Infect. Dis. 32 2000 481-483
7. Helweg-Larsen J. Lee C.H. Jin S. Hsueh J.Y.-C. Benfield T.L. Hansen J. Lundgren J.D. Lundgren B. Clinical correlation of variations in the internal transcribed spacer regions of rRNA genes in Pneumocystis carinii f. sp. Hominis AIDS 15 2001 451-459
8. Kazanjian P. Locke A.B. Hossler P.A. Lane B.R. Bartlett M.S. Smith J.W. Cannon M. Meshnick S.R. Pneumocystis carinii mutations associated with sulfa and sulfone prophylaxis failures in AIDS patients AIDS 12 1998 873-878
9. Keely S.P. Stringer J.R. Baughman R.P. Linke M.J. Walzer P.D. Smulian A.G. Genetic variation among Pneumocystis carinii hominis isolates in recurrent pneumocystosis J. Infect. Dis. 172 1995 595-598
10. Lee C. Helweg-Larsen J. Tang X. Jin S. Li B. Bartlett M.S. Lu J. Lundgren B. Lundgren J.D. Olsson M. Lucas S.B. Roux P. Cargnel A. Atzori C. Matos O. Smith J.W. Update on Pneumocystis carinii f. sp. hominis typing based on nucleotide sequence variations in internal transcribed spacer regions of rRNA genes J. Clin. Microbiol. 36 1998 734-741
11. Lu J.J. Bartlett M.S. Shaw M.M. Queener S.F. Smith J.W. Ortiz-Rivera M. Leibowitz M.J. Lee C.H. Typing of Pneumocystis carinii strains that infect humans based on nucleotide sequence variations of internal transcribed spacers of rRNA genes J. Clin. Microbiol. 32 1994 2904-2912
12. Lu J.J. Bartlett M.S. Smith J.W. Lee C.H. Typing of Pneumocystis carinii strains with type-specific oligonucleotide probes derived from nucleotide sequences of internal transcribed spacers of rRNA genes J. Clin. Microbiol. 33 1995a 2973-2977
13. Lu J. Chen C. Bartlett M.S. Smith J.W. Lee C. Comparison of six different PCR methods for detection of Pneumocystis carinii J. Clin. Microbiol. 33 1995b 2785-2788
14. Mei Q. Gurunathan S. Masur H. Kovacs J.A. Failure of co-trimoxazole in Pneumocystis carinii infection and mutations in dihydropteroate synthase gene Lancet 351 1998 1631-1632
15. Meshnick, S.R., Hossler, P.A., Enger, K.S., Kazanjian, P., Rest, J.S., Mindell, D., Li, B., Lee, C.-H., Mimri, L.F., Carter, J.L., Beard, B., Huang, L., 2001. Distribution of DHPS mutations among ITS subtypes of P. carinii f. sp. hominis. J. Eukaryot. Microbiol. Suppl. 126S-128S.
16. Miller R.F. Wakefield A.E. Pneumocystis carinii genotypes and severity of pneumonia Lancet 353 1999 2039-2040
17. Nimri L.F. Moura I.N.S. Huang L. del Rio C. Rimland D. Duchin J.S. Dotson E.M. Beard C.B. Genetic diversity of Pneumocystis carinii f. sp. hominis based on variations in nucleotide sequences of internal transcribed spacers of rRNA genes J. Clin. Microbiol. 40 2002 1146-1151
18. Stringer J.R. Walzer P.D. Molecular biology and epidemiology of Pneumocystis carinii infection in AIDS AIDS 10 1996 561-571
19. Stringer J.R. Beard C.B. Miller R.F. Wakefield A. A new name (Pneumocystis jiroveci) for Pneumocystis from humans Emerg. Infect. Dis. 8 2002 891-896
20. Tamburrini E. Mencarini P. Visconti E. Zolfo M. Luca A. Siracusano A. Ortona E. Margutti P. Wakefield A.E. Comparison of two PCR methods for detection of Pneumocystis carinii in bronchoalveolar lavage fluid J. Eukaryot. Microbiol. 43 1996 20S
21. Tsolaki A.G. Miller R.F. Underwood A.P. Banerji S. Wakefiled A.E. Genetic diversity at the internal transcribed spacer regions of the rRNA operon among isolates of Pneumocystis carinii from AIDS patients with recurrent pneumonia J. Infect. Dis. 174 1996 141-156
22. Wakefield A.E. Pixley F.J. Banerji S. Sinclair K. Miller R.F. Moxon E.R. Hopkin J.M. Amplification of mitochondrial ribosomal RNA sequences from Pneumocystis carinii DNA of rat and human origin Mol. Biochem. Parasitol. 43 1990 69-76