Adverse cardiac events in ICU patients with presumptive antidepressant overdose

Swiss Medical Weekly

Volumn 133, Issue 35-36, 2003, Pages 479-483

  Arranto, C A ^a   Mueller, C ^b   Hunziker, P R ^b   Maysch, S C ^b   Eriksson, U ^b  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b NONE

Author keywords

Antidepressant toxicity; Arrhythmia; ECG; Intoxication; Serotonin reuptake inhibitor; Tricyclic antidepressant

Indexed keywords

AMITRIPTYLINE; ANTIDEPRESSANT AGENT; CITALOPRAM; CLOMIPRAMINE; FLUOXETINE; MAPROTILINE; PAROXETINE; SEROTONIN UPTAKE INHIBITOR; SERTRALINE; TRICYCLIC ANTIDEPRESSANT AGENT; TRIMIPRAMINE; VENLAFAXINE;

ADOLESCENT; ADULT; AGED; BLOOD; CARDIOTOXICITY; COMPARATIVE STUDY; CONFERENCE PAPER; DEPRESSION; DRUG EFFECT; DRUG OVERDOSE; ELECTROCARDIOGRAPHY; FEMALE; HEART ARRHYTHMIA; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE TACHYCARDIA; HOSPITAL ADMISSION; HUMAN; HYPOTENSION; IATROGENIC DISEASE; INTENSIVE CARE UNIT; INTOXICATION; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; PROSPECTIVE STUDY; QRS COMPLEX; SEIZURE; SIDE EFFECT; SUICIDE ATTEMPT; TORSADE DES POINTES; TREATMENT OUTCOME;

EID: 0242497223     PISSN: 14247860     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (34)

1. Frommer DA, Kulig KW, Marx JA, Rumack B. Tricyclic antidepressant overdose. A review. JAMA 1987;257:521-6.
2. Dziukas LJ, Vohra J. Tricyclic antidepressant poisoning. Med J Aust 1991;154:344-50.
3. Newton EH, Shih RD, Hoffman RS. Cyclic antidepressant overdose: a review of current management strategies. Am J Emerg Med 1994;12:376-9.
4. Henderson A, Wright M, Pond SM. Experience with 732 acute overdose patients admitted to an intensive care unit over six years. Med J Aust 1993;158;28-30.
5. Bosch TM, van der Werft TS, Uges DR, Ligtenberg JJ, Fijen JW, Tulleken JE, et al. Antidepressants self-poisoning and ICU admissions in a university hospital in the Netherlands. Pharm World Sci 2000;22;92-5.
6. Jefferson JW. Cardiovascular effects and toxicity of anxiolytics and antidepressants. J Clin Psychiatry 1989;50:368-78.
7. Boehnert MT, Lovejoy FH. Value of the QRS duration versus the serum drug level in predicting seizures and ventricular arrhythmias after an acute overdose of tricyclic antidepressants. N Engl J Med 1985;313:474-9.
8. Hulten BA, Adams R, Askenasi R, Dallos V, Dawling S, Volans G, et al. Predicting severity of tricyclic antidepressant overdose. Clin Toxicol 1992;30:161-70.
9. Lavoie FW, Gansert GG, Weiss RE. Value of initial ECG findings and plasma drug levels in cyclic antidepressant overdose. Ann Emerg Med 1990;19:696-700.
10. Merigian KS, Hedges JR, Kaplan LA, Roberts JR, Stuebing RC, Pesce A, et al. Plasma catecholamine levels in cyclic antidepressant overdose. J Toxicol Clin Toxicol 1991;29:177-90.
11. Townsend E, Hawton K, Harriss L, Bale E, Bond A. Substances used in deliberate self-poisoning 1985-1997: trend and associations with age, gender, repetition and suicide intent. Soc Psychiatr Epidemiol 2001;36:228-34.
12. Foulke GE. Identifying toxicity risk early after antidepressant overdose. Am J Emerg Med 1995;13:123-6.
13. Bazett HC. An analysis of the time- relations of electrocardiograms. Heart 1920;7:352-70.
14. Chan B, Gaudry P, Grattan-Smith TM, McNeil R. The use of Glasgow Coma Scale in poisoning. J Emerg Med 1993;11: 579-82.
15. Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit Care Med 1985;13:818-29.
16. Tran TP, Panacek EA, Rhee KJ, Foulke GE. Response to dopamine vs norepinephrine in tricyclic antidepressant-induced hypotension. Acad Emerg Med 1997;4:864-8.
17. Treiman DM, Meyers PD, Walton NY, Collins JF, Colling C, Rowan AJ, et al. A comparison of four treatments for generalized convulsive status epilepticus. Veterans Affairs Status Epilepticus Cooperative Study Group. N Engl J Med 1998; 339:792-8.
18. Hoffman JR, Votey SR, Bayer M, Silver L. Effect of hypertonic sodium bicarbonate in the treatment of moderate-to-severe cyclic antidepressant overdose. Am J Emerg Med 1993;11: 336-41.
19. American Academy of Clinical Toxicology; European Association of Poisons Centres and Clinical Toxicologists. Position statement and practice guidelines on the use of multi-dose activated charcoal in the treatment of acute poisoning. J Toxicol Clin Toxicol 1999;37:731-51.
20. Pentel P, Sioris L. Incidence of arrhythmias following tricyclic antidepressant overdose. Clin Toxicol 1981;18:5438.
21. Callaham M, Kassel D. Epidemiology of fatal tricyclic antidepressant ingestion: implications for management. Ann Emerg Med 1985;14:1-9.
22. Foulke GE, Albertson TE, Walby WF. Tricyclic antidepressant overdose: Emergency department findings as predictors of clinical course. Am J Emerg Med 1986;4:496-500.
23. Dziukas LJ, Vohra J. Tricyclic antidepressant poisoning. Med J Aust 1991;154:344-50.
24. Goldberg RJ, Capone RJ, Hunt JD. Cardiac complications following tricyclic antidepressant overdose. JAMA 1985;254: 1772-5.
25. Shannon MW. Duration of QRS disturbances after severe tricyclic antidepressant intoxication. J Toxicol Clin Toxicol 1992; 30(3):377-86.
26. Marzuk PM, Tardiff K, Leon AC, Hirsch CS, Stajic M, Hartwell N, et al. Use of prescription psychotropic drugs among suicide victims in New York City. Am J Psychiatry 1995;152:1520-2.
27. Wilens TE, Stern TA, O'Gara PT. Adverse cardiac effects of combined neuroleptic ingestion and tricyclic antidepressant overdose. J Clin Psychopharmacol 1990;10:51-4.
28. McCabe JL, Cobaugh DJ, Menegazzi JJ, Fata J. Experimental tricyclic antidepressant toxicity: a randomized controlled comparison of hypertonic saline solution, sodium bicarbonate, and hyperventilation. Ann Emerg Med 1998;32:329-33.
29. Phillips S, Brent J, Kulig K, Heiligenstein J, Birkett M. Fluoxetine versus tricyclic antidepressants: A prospective multicenter study of antidepressant drug overdoses. J Emerg Med 1997;15: 439-45.
30. Buckley NA, McManus PR. Fatal toxicity of serotoninergic and other antidepressant drugs: analysis of United Kingdom mortality data. BMJ 2002;325:1332-3.
31. Henry JA, Antao CA. Suicide and fatal antidepressant poisoning. Eur J Med 1992; 1:343-8.
32. Spier SA, Frontera MA. Unexpected deaths in depressed medical inpatients treated with fluoxetine. J Clin Psychiatry 1991; 52:377-82.
33. Jefferson JW. Cardiovascular effects and toxicity of anxiolytics and antidepressants. J Clin Psychiatry 1989;50:368-78.
34. Sheline YI, Freedland KE, Carney RM. How safe are serotonin reuptake inhibitors for depression in patients with coronary heart disease? Am J Med 1997;102:54-9.