Fluoxetine versus tricyclic antidepressants: A prospective multicenter study of antidepressant drug overdoses

Journal of Emergency Medicine

Volumn 15, Issue 4, 1997, Pages 439-445

  Phillips, Scott ^a,b   Brent, Jeffrey ^a   Kulig, Kenneth ^a   Heiligenstein, John ^a   Birkett, Martin ^a  

^a ROCKY MOUNTAIN POISON AND DRUG CENTER   (United States)

^b Toxicology Associates Denver   (United States)

Author keywords

Antidepressant; Fluoxetine; Safety; Toxicity; Tricyclic

Indexed keywords

DRUG METABOLITE; FLUOXETINE; TRICYCLIC ANTIDEPRESSANT AGENT;

ADOLESCENT; ADULT; AGED; AGITATION; ARTICLE; CHILD; CLINICAL FEATURE; CLINICAL TRIAL; COMA; DISEASE COURSE; DRUG BLOOD LEVEL; DRUG OVERDOSE; ELECTROCARDIOGRAM; EMERGENCY MEDICINE; FATALITY; FEMALE; HUMAN; INFANT; INTENSIVE CARE; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PRIORITY JOURNAL; RESPIRATORY TRACT INTUBATION; TACHYCARDIA;

ADOLESCENT; ADULT; AGED; ANTIDEPRESSIVE AGENTS, TRICYCLIC; ARRHYTHMIA; CHILD; CHILD, PRESCHOOL; FEMALE; FLUOXETINE; HUMANS; INFANT; INTENSIVE CARE UNITS; MALE; MIDDLE AGED; OVERDOSE; PROSPECTIVE STUDIES; SEIZURES; SEROTONIN UPTAKE INHIBITORS; STATISTICS, NONPARAMETRIC; UNITED STATES;

EID: 0030835764     PISSN: 07364679     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0736-4679(97)00072-3     Document Type: Article

References (34)

1. Callaham M, Kassel D. Epidemiology of fatal tricyclic antidepressant ingestion: Implications for management. Ann Emerg Med. 1985;14:1-9.
2. Frommer DA, Kulig KW, Marx JA, Rumack B. Tricyclic antidepressant overdose: A review. JAMA. 1987;257:521-6.
3. Crome P. Antidepressant overdosage. Drugs. 1982;23:431-61.
4. Litovitz TL, Felberg L, White S, Klein-Schwartz W. 1995 Annual report of the American Association of Poison Control Centers Toxic Exposures Surveillance System. Am J Emerg Med. 1996; 14:487-537.
5. Borys D, Setzer SC, Ling LJ, Reisdorf JJ, Day LC, Krenzelok EP. The effects of fluoxetine in the overdose patient. Clin Toxicol. 1990;28:331-40.
6. Borys DJ, Setzer SC, Ling LJ, et al. Acute fluoxetine overdose: A report of 234 cases. Am J Emerg Med. 1992;10:115-20.
7. Linakis JG, Frederick KA. Poisoning deaths not reported to the regional poison control center. Ann Emerg Med. 1993;22:1822-8.
8. Callaham M. Tricyclics antidepressant overdose. J Am Coll Emerg Phys. 1979;8:413-23.
9. Finnegan KT, Gabiola JM. Fluoxetine overdose. Am J Psychiatr. 1988;145:12.
10. Henry JA. Toxicity of antidepressants: Comparisons with fluoxetine. Inter Clin Psychopharmacol. 1992;6(suppl. 6):22-7.
11. Guze SB, Robins E. Suicide among primary affective disorders. Br J Psychiatr. 1970;117:437-8.
12. Brent DA, Kupfer DJ, Bromet EJ, Dew AM. The assessment and treatment for patients at risk for suicide. In: Frances AJ, Hale RE, eds. Review of psychiatry VII. Washington, DC: American Psychiatric Press; 1988:353-86.
13. Bulik CM, Carpenter LL, Kupfer DJ, Frank E. Features associated with suicide attempts in recurrent major depression. J Affect Disord. 1990;18:29-37.
14. Kapour S, Mieczkowski T, Mann JJ. Antidepressant medications and the relative risk of suicide attempt and suicide. JAMA. 1992; 268:3441-5.
15. Biggs JT, Spiker DG, Petit JM, Ziegler VE. Tricyclic antidepressant overdose: Incidence of symptoms. JAMA. 1977;238: 135-8.
16. Stern TA, O'Gara PT, Mulley AG, Singer DE, Thibault GE. Complications after overdose with tricyclic antidepressants. Crit Care Med. 1985;13:672-4.
17. Wernicke JF. The side effect profile and safety of fluoxetine. J Clin Psychiatr. 1985;46:59-67.
18. Riddle MA, Brown N, Dzubinski D, Jetmalani AN, Law Y, Woolston JL. Fluoxetine overdose in an adolescent. J Am Acad Child Adol Psychiatr. 1989;28:587-8.
19. Weber JJ. Seizure activity associated with fluoxetine therapy. Clin Pharmacol. 1989;8:296-8.
20. Groleau G, Jotte R, Barish R. The electrocardiographic manifestations of cyclic antidepressant therapy and overdose: A review. J Emerg Med. 1990;8:597-605.
21. Sasyniuk BI, Jhamandas V. Mechanism of reversal of toxic effects of amitriptyline on cardiac Purkinje fibers by sodium bicarbonate. J Pharmacol Exp Ther. 1984;231:387-94.
22. Lusher TF, Buhler FR, Vanhoutte PM. Serotonin and the cardiovascular system. In: Kulbertus HF, Franck G, eds. Neurocardiology. Mount Kisco, NY: Futura Publishing; 1988:257-75.
23. Zipes DP. Specific arrhythmias: Diagnosis and treatment. In: Braunwald E, ed. Heart disease: A textbook of cardiovascular medicine, 2nd ed. Philadelphia: W.B. Saunders; 1984:683-743.
24. Ellison DW, Pentel PR. Clinical features and consequences of seizures due to cyclic antidepressant overdose. Am J Emerg Med. 1989;7:5-10.
25. Gardner SF, Rutherford WF, Munger MA, Panacek EA. Drug-induced supraventricular tachycardia: A case report of fluoxetine. Ann Emerg Med. 1991;20:194-7.
26. Roberge RJ, Martin TG. Mixed fluoxetine/loxapine overdose and atrial flutter. Ann Emerg Med. 1994;23:586-90.
27. Spier SA, Frontera MA. Unexpected deaths in depressed medical inpatients treated with fluoxetine. J Clin Psychiatr. 1991;52:377-82.
28. Buff DD, Brenner R, Kirtane SS, Gilboa R. Dysrhythmia associated with fluoxetine treatment in an elderly patient with cardiac disease. J Clin Psychiatr. 1991;52:174-6.
29. Goldberg RJ, Capone RJ, Hunt JD. Cardiac complications following tricyclic antidepressant overdose. JAMA. 1985;254:1772-5.
30. IMS America National Prescription Audit (NPA). November 1990-March 1993.
31. Price WAS, Zimmer B, Kucas P. Serotonin syndrome: A case report. J Clin Pharmacol. 1986;26:77.
32. Levy AB, Bucher P, Votolato N. Myoclonus, hyperreflexia and diaphoresis in patients on phenelzine-tryptophan combination treatment. Can J Psychiatr. 1986;30:434-6.
33. Insel TR, Roy BF, Cohen RM, Murphy DL. Possible development of the serotonin syndrome in man. Am J Psychiatr. 1982;139: 954-5.
34. Kaminski CA, Robbins MS, Weibley RE. Sertraline intoxication in a child. Ann Emerg Med. 1994, 23:1372-4.