Vascular invasion in human breast cancer is correlated to T→786 C polymorphism of NOS3 gene

Nitric Oxide - Biology and Chemistry

Volumn 9, Issue 2, 2003, Pages 118-122

  Ghilardi, Giorgio ^a   Biondi, Maria Luisa ^b   Cecchini, Federica ^b   DeMonti, Marco ^a   Guagnellini, Emma ^b   Scorza, Roberto ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b SAN PAOLO HOSPITAL   (Italy)

Author keywords

Breast cancer; Gene promoter polymorphisms; Nitric oxide synthase

Indexed keywords

NITRIC OXIDE SYNTHASE;

ADULT; AGED; ARTICLE; AXILLARY LYMPH NODE; BLOOD VESSEL; BREAST CANCER; CANCER GENETICS; CANCER INVASION; CANCER SURGERY; CONTROLLED STUDY; CORRELATION ANALYSIS; EXON; FEMALE; FOLLOW UP; GENE FREQUENCY; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROGNOSIS; PROMOTER REGION; VASCULAR ENDOTHELIUM; VASCULAR TUMOR;

EID: 0242493618     PISSN: 10898603     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.niox.2003.09.002     Document Type: Article

References (20)

1. Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat. Med. 1:1995;27-31.
2. Nicolson G.L. Organ specificity of tumor metastasis: role of preferential adhesion, invasion and growth of malignant cells at specific secondary sites. Cancer Metastasis Rev. 7:1989;143-148.
3. Kong L.P., Dunn G.D., Keefer L.K., Korthuis R.J. Nitric oxide reduces tumor cell adhesion to isolated rat postcapillary venules. Clin. Exp. Metastasis. 14:1996;335-343.
4. Umansky V., Bucur M., Schirrmacher V., Rocha M. Activated endothelial cells induce apoptosis in lymphoma cells: role of nitric oxide. Int. J. Oncol. 10:1997;465-471.
5. Mortensen K., Holck S., Christensen I.J., Skouv J., Hougaard D.M., Blom J., Larsson L.I. Endothelial cell nitric oxide synthase in peritumoral microvessels is a favorable prognostic indicator in premenopausal breast cancer patients. Clin. Cancer Res. 5:1999;1093-1097.
6. Cheon K.T., Choi K.H., Lee H.B., Park S.K., Rhee Y.K., Lee Y.C. Gene polymorphisms of endothelial Nitric Oxide Synthase and angiotensin-converting enzyme in patients with lung cancer. Lung. 178:2000;351-360.
7. ′ -flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm Circulation. 99:1999;2864-2870.
8. ′ ' flanking region of the endothelial nitric oxide synthase gene is associated with myocardial infarction, especially without coronary organic stenosis Am. J. Cardiol. 86:2000;628-634.
9. Hingorani A.D., Liang C.F., Fatibene J., Lyon A., Monteith S., Parsons Haydock S., Hopper R.V., Stephens N.G., O'Shaughnessey K.M., Brown M.J. A common variant of the endothelial nitric oxide synthase (Glu298. → Asp) is a major risk factor for coronary atherosclerosis in the UK Circulation. 100:1999;1515-1520.
10. Tesauro M., Thompson W.C., Rogliani P., Qi I., Chaudhary P.P., Moss J. Intracellular processing of endothelial nitric oxide synthase isoforms associated with differences in severity of cardiopulmonary disease: cleavage of proteins with aspartate vs. glutamate at position 298. Proc. Natl. Acad. Sci. USA. 97:2000;2832-2835.
11. Biondi M.L., Marasini B., Leviti S., Turri O., Bernini M., Seminati R., Porreca W., Guagnellini E. Genotyping method for pointy mutation detection in the endothelial nitric oxide synthase exon 7 using fluorescent probes. Clinical validation in systemic sclerosis patients. Clin. Chem. Lab. Med. 39:2001;281-282.
12. Fukumura D., Gohongi T., Kadambi A., Izumi Y., Ang J., Yun C.O., Buerk D.G., Huang P.L., Jain R.K. Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability. Proc. Natl. Acad. Sci. USA. 98:2001;2604-2609.
13. Orucevic A., Bechberger J., Green A.M., Shapiro R.A., Billiar T.R., Lala P.K. Nitric-oxide production by murine mammary adenocarcinoma cells promotes tumour-cell invasiveness. Int. J. Cancer. 81:1999;889-896.
14. Thomsen L.L., Miles D.W., Happerfield L., Bobrow L.G., Knowles R.G., Moncada S. Nitric oxide synthase activity in human breast cancer. Br. J. Cancer. 72:1995;41-44.
15. Doi C., Noguchi Y., Marat D., Saito A., Fukuzawa K., Yoshikawa T., Tsuburaya A., Ito T. Expression of nitric oxide synthase in gastric cancer. Cancer Lett. 144:1999;161-167.
16. Martin J.H., Begum S., Alalami O., Harrison A., Scott K.W. Endothelial nitric oxide synthase: correlation with histologic grade, lymph node status and estrogen receptor expression in human breast cancer. Tumour Biol. 21:2000;90-97.
17. Talbot I.C., Ritchie S., Leighton M., Hughes A.O., Bussey H.J.R., Morson B.C. Invasion of veins by carcinoma of rectum: method of detection, histological features and significance. Histopathology. 5:1981;141-163.
18. Heney N.M., Proppe K., Prout G.R., Griffin P.P., Shipley W.U. Invasive bladder cancer: tumour configuration, lymphatic invasion and survival. J. Urol. 130:1983;895-897.
19. Van Nagell J.R., Donaldson E.S., Wood E.G., Parker J.C. The significance of vascular invasion and lymphocytic infiltration in invasive cervical cancer. Cancer. 41:1978;228-234.
20. Pinder S.E., Ellus I.O., Galea M., O'Rouke S., Blamey R.W., Elston C.W. Pathological prognostic factors in breast cancer. III. Vascular invasion: relationship with recurrence and survival in a large study with long-term follow-up. Histopathology. 24:1994;41-47.