A non-peptide radioiodinated high affinity melanocortin-4 receptor ligand

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 46, Issue 11, 2003, Pages 1007-1017

  Mutulis, Felikss ^a   Yahorava, Sviatlana ^a   Mutule, Ilze ^a   Yahorau, Aleh ^a   Kopanchuk, Sergei ^a,b   Veiksina, Santa ^a   Rinken, Ago ^b   Wikberg, Jarl E S ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b UNIVERSITY OF TARTU   (Estonia)

Author keywords

Iodine 125; Iodobead; Iododestannylation; Melanocortin 4 receptor radioligand

Indexed keywords

CHELATION; IODINE; PALLADIUM COMPOUNDS;

CYCLOHEXYL; HIGH AFFINITY; IODINE-125; IODOBEAD; IODODESTANNYLATION; MELANOCORTIN-4 RECEPTOR RADIOLIGAND; MELANOCORTINS; PEPTIDE SYNTHESIS; RADIOLIGANDS; RECEPTOR LIGANDS;

PEPTIDES;

1 (DEXTRO 1,2,3,4 TETRAHYDROISOQUINOLINE 3 CARBOXY DEXTRO 4 IODOPHENYLALANYL) 4 CYCLOHEXYL 4 (1,2,4 TRIAZOL 1 YL)PIPERIDINE TRIFLUOROACETATE I 125; 1 (DEXTRO 1,2,3,4 TETRAHYDROISOQUINOLINE 3 CARBOXY DEXTRO 4 IODOPHENYLALANYL) 4 CYCLOHEXYL 4 [(1,2,4 TRIAZOL 1 YL)METHYL]PIPERIDINE TRIFLUOROACETATE; 4 CYCLOHEXYL 4 [(1,2,4, TRIAZOL 1 YL)METHYL]PIPERIDINE; ACETIC ACID DERIVATIVE; ALPHA INTERMEDIN; ALPHA MELANOCYTE STIMULATING HORMONE[4 TYROSINE 2 N LEUCINE 4 DEXTRO PHENYLALANINE] I 125; BUFFER; CARBOXYLIC ACID DERIVATIVE; CHEMICAL COMPOUND; DEXTRO 1,2,3,4 TETRAHYDROISOQUINOLINE 3 CARBOXYLIC ACID; DEXTRO 4 IODOPHENYLALANINE; HALOGEN; HEXAMETHYLDITIN; IODINE 125; MELANOCORTIN 4 RECEPTOR; METHYL GROUP; PEPTIDE; PHENYLALANINE DERIVATIVE; PHOSPHATE; PHOSPHINE DERIVATIVE; PIPERIDINE DERIVATIVE; RADIOLIGAND; SODIUM IODINE I 125; TETRAKIS(TRIPHENYLPHOSPHINE)PALLADIUM; UNCLASSIFIED DRUG;

ACIDITY; ARTICLE; BINDING AFFINITY; CHEMICAL MODIFICATION; CHEMICAL PROCEDURES; CHEMISTRY; EVALUATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; OXIDATION; PEPTIDE SYNTHESIS; PHOSPHATE BALANCE; RADIOCHEMISTRY; RADIOIODINATION;

EID: 0242492158     PISSN: 03624803     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlcr.735     Document Type: Article

References (13)

1. Van der Ploeg LHT, Martin WJ, Howard AD, Nargund RP, Austin CP, Guan X, Drisko J, Cashen D, Sebhat I, Patchett AA, Figueroa DJ, DiLella AG, Connolly BM, Weinberg DH, Tan CP, Palyha OC, Pong S-S, MacNeil T, Rosenblum C, Vongs A, Tang R, Yu H, Sailer AW, Fong TM, Huang C, Tota MR, Chang RS, Stearns R, Tamvakopoulos C, Christ G, Drazen DL, Spar BD, Nelson RJ, MacIntyre DE. Proc Natl Acad Sci USA 2002; 99: 11381-11386.
2. Cone RD. In: The melanocortin receptors, Cone (ed.), Human Press, Totowa, New Jersey 2000; 405-447.
3. Nijenhuis WAJ, Oosterom J, Adan RAH. Mol Endocrinol 2001; 15: 164-171.
4. Wikberg JES, Muceniece R, Mandrika I, Prusis P, Lindblom J, Post C, Skottner A. Pharmacol Res 2000; 42: 393-420.
5. Ujjainwalla F, Chu L, Goulet MT, Lee B, Warner D, Wyvratt MJ. WO patent # 2002068387, 6 September 2002.
6. Wikberg JES. Exp Opin Ther Patents 2001; 11: 61-76.
7. Andersson PM, Boman A, Seifert E, Skottner A, Lundstedt T. Exp Opin Ther Patents 2001; 11: 1583-1592.
8. Bakshi RK, Barakat KJ, Nargund RP, Palucki BL, Patchett AA, Sebhat I, Ye Z, Van der Ploeg LHT. WO patent # 00/74679, 31 May 2000.
9. Bolton R. J Label Compd Radiopharm 2002; 45: 485-528.
10. Angell YM, Garcia-Echeverria C, Rich DH. Tetr Lett 1994; 35: 5981-5984.
11. Schiöth HB, Kuusinen A, Muceniece R, Szardenings M, Keinänen K, Wikberg JES. Biochem Biophys Res Commun 1996; 221: 807-814.
12. Gantz I, Miwa H, Konda Y, Shimoto Y, Tashiro T, Watson SJ, DelValle J, Yamada T. J Biol Chem 1993; 268: 15174-15179.
13. Bradford MM. Anal Biochem 1976; 72: 248-254.