Tubulyzine®, a novel tri-substituted triazine, prevents the early cell death of transplanted myogenic cells and improves transplantation success

Biochemistry and Cell Biology

Volumn 81, Issue 2, 2003, Pages 81-90

  El Fahime, E ^a   Bouchentouf, M ^a   Benabdallah, B F ^a   Skuk, D ^a   Lafreniere, J F ^a   Chang, Y T ^b   Tremblay, J P ^a  

^a UNIVERSITÉ LAVAL   (Canada)

^b NEW YORK UNIVERSITY   (United States)

Author keywords

Cell death; Mdx mouse; Microtubule binding molecule; Myoblast survival; Myoblast transplantation

Indexed keywords

CELLS; DNA; GENE TRANSFER; NUCLEATION; TISSUE CULTURE;

MYOBLAST TRANSPLANTATION (MT);

BIOCHEMISTRY;

CASPASE 3; DNA; LIPOCORTIN 5; MYOSEVERIN; PURINE DERIVATIVE; STAUROSPORINE; TACROLIMUS; THYMIDINE; TRIAZINE DERIVATIVE; TUBULYZINE; UNCLASSIFIED DRUG; CASP3 PROTEIN, MOUSE; CASPASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL SURVIVAL; CELL TRANSPLANTATION; CONTROLLED STUDY; DUCHENNE MUSCULAR DYSTROPHY; EXTRACELLULAR MATRIX; FEMALE; GENE TRANSFER; IN VITRO STUDY; MICROTUBULE; MOUSE; MYOBLAST; MYOTUBE; NEWBORN; NONHUMAN; PHASE CONTRAST MICROSCOPY; STRESS; TIBIALIS ANTERIOR MUSCLE; TISSUE REGENERATION; TRANSGENIC MOUSE; WOUND HEALING; ANIMAL; ANIMAL MUSCULAR DYSTROPHY; APOPTOSIS; C57BL MOUSE; CELL CULTURE; CELL LINE; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; IMMUNOSUPPRESSIVE TREATMENT; METHODOLOGY; MUSCLE CELL; TRANSPLANTATION; X CHROMOSOME LINKED MUSCULAR DYSTROPHIC MOUSE;

ANIMALIA; MUS MUSCULUS;

ANIMALS; APOPTOSIS; CASPASE 3; CASPASES; CELL LINE; CELL SURVIVAL; CELL TRANSPLANTATION; CELLS, CULTURED; ENZYME ACTIVATION; MICE; MICE, INBRED C57BL; MICE, INBRED MDX; MICE, TRANSGENIC; MUSCLE FIBERS; MUSCULAR DYSTROPHY, ANIMAL; MYOBLASTS, SKELETAL; STAUROSPORINE; TRANSPLANTATION CONDITIONING; TRIAZINES;

EID: 0242468722     PISSN: 08298211     EISSN: None     Source Type: Journal    
DOI: 10.1139/o03-054     Document Type: Article

References (33)

1. Baroffio, A., Hamann, M., Bernheim, L., Bochaton-Piallat, M.L., Gabbiani, G., and Bader, C.R. 1996. Identification of self-renewing myoblasts in the progeny of single human muscle satellite cells. Differentiation, 60: 47-57.
2. Beauchamp, J.R., Pagel, C.N., and Partridge, T.A. 1997. A dual-marker system for quantitative studies of myoblast transplantation in the mouse. Transplantation, 63: 1794-1797.
3. Beauchamp, J.R., Morgan, J.E., Pagel, C.N., and Partridge, T.A. 1999. Dynamics of myoblast transplantation reveal a discrete minority of precursors with stem cell-like properties as the myogenic source. J. Cell Biol. 144: 1113-1122.
4. Brundin, P., Karlsson, J., Emgard, M., Schierle, G.S., Hansson, O., et al. 2000. Improving the survival of grafted dopaminergic neurons: a review over current approaches. Cell Transplant, 9: 179-195.
5. Chinni, C., de Niese, M.R., Tew, D.J., Jenkins, A.L., Bottomley, S.P., and Mackie, E.J. 1999. Thrombin, a survival factor for cultured myoblasts. J. Biol. Chem. 274: 9169-9174.
6. Di Matola, T., Mueller, F., Fenzi, G., Rossi, G., Bifulco, M., et al. 2000. Serum withdrawal-induced apoptosis in thyroid cells is caused by loss of fibronectin-integrin interaction. J. Clin. Endocrinol. Metab. 85: 1188-1193.
7. Frisch, S.M., and Francis, H. 1994. Disruption of epithelial cell-matrix interactions induces apoptosis. J. Cell Biol. 124: 619-626.
8. Green, D.R. 1998. Apoptotic pathways: the roads to ruin. Cell, 94: 695-698.
9. Griggs, R.C., and Karpati, G. 1990. Myoblast transfer therapy. Plenum Press, New York.
10. Guerette, B., Asselin, I., Skuk, D., Entman, M., and Tremblay, J.P. 1997a. Control of inflammatory damage by anti-LFA-1: increase success of myoblast transplantation. Cell Transplant, 6: 101-107.
11. Guerette, B., Skuk, D., Celestin, F., Huard, C., Tardif, F., et al. 1997b. Prevention by anti-LFA-1 of acute myoblast death following transplantation. J. Immunol. 159: 2522-2531.
12. Gussoni, E., Blau, H.M., and Kunkel, L.M. 1997. The fate of individual myoblasts after transplantation into muscles of DMD patients. Nat. Med. 3: 970-977.
13. Ho-Sang Moon, E.M.J., Khersonsky, S.M., Luzung, M.R., Walsh, D.P., Xiong, W., Lee, J.W., Parikh, P.B., Lam, J.C., Kang, T.-W., Rosania, G.R., Schier, A.F., and Chang, Y.-T. 2002. A Novel Microtubule Destabilizing Entity from Orthogonal Synthesis of Triazine Library and Zebrafish Embryo Screening. J. Am. Chem. Soc. 124: 11 608-11 609.
14. Jacobsen, M.D., Weil, M., Raff, M.C., Jacobsen, F.W., Stokke, T., and Jacobsen, S.E. 1996. Role of Ced-3/ICE-family proteases in staurosporine- induced programmed cell death. Transforming growth factor-beta potently inhibits the viability-promoting activity of stem cell factor and other cytokines and induces apoptosis of primitive murine hematopoietic progenitor cells. J. Cell Biol. 133: 1041-1051.
15. Kroemer, G., Dallaporta, B., and Resche-Rigon, M. 1998. The mitochondrial death/life regulator in apoptosis and necrosis. Annu. Rev. Physiol. 60: 619-642.
16. Moon, H.S., Jacobson, E.M., Khersonsky, S.M., Luzung, M.R., Walsh, D.P., et al. 2002. A novel microtubule destabilizing entity from orthogonal synthesis of triazine library and zebrafish embryo screening. J. Am. Chem. Soc. 124: 11 608-11 609.
17. Morgan, J.E., Beauchamp, J.R., Pagel, C.N., Peckham, M., Ataliotis, P., et al. 1994. Myogenic cell lines derived from transgenic mice carrying a thermolabile T antigen: a model system for the derivation of tissue-specific and mutation-specific cell lines. Dev. Biol. 162: 486-498.
18. Olson, E.N. 1992. Interplay between proliferation and differentiation within the myogenic lineage. Dev. Biol. 154: 261-272.
19. Ostrowska, A., Karrer, F.M., and Bilir, B.M. 1999. Histological identification of purified and cryopreserved allogeneic hepatocytes following transplantation in a murine model without host immunosuppression. Transpl. Int. 12: 188-194.
20. Partridge, T.A., Morgan, J.E., Coulton, G.R., Huffman, E.P., and Kunkel, L.M. 1989. Conversion of mdx myofibres from dystrophin-negative to -positive by injection of normal myoblasts. Nature, 337: 176-179.
21. Ferez, O.D., Chang, Y.T., Rosania, G., Sutherlin, D., and Schultz, P.G. 2002. Inhibition and reversal of myogenic differentiation by purine-based microtubule assembly inhibitors. Chem. Biol. 9: 475-483.
22. Qu, Z., Balkir, L., van Deutekom, J.C., Robbins, P.D., Pruchnic, R., and Huard, J. 1998. Development of approaches to improve cell survival in myoblast transfer therapy. J. Cell Biol. 142: 1257-1267.
23. Qu-Petersen, Z., Deasy, B., Jankowski, R., Ikezawa, M., Cummins, J., et al. 2002. Identification of a novel population of muscle stem cells in mice: potential for muscle regeneration. J. Cell Biol. 157: 851-864.
24. Raynal, P., and Pollard, H.B. 1994. Annexins: the problem of assessing the biological role for a gene family of multifunctional calcium-and phospholipid-binding proteins. Biochim. Biophys. Acta, 5: 63-93.
25. Rosania, G.R., Chang, Y.T., Perez, O., Sutherlin, D., Dong, H., et al. 2000. Myoseverin, a microtubule-binding molecule with novel cellular effects. Nat. Biotechnol. 18: 304-308.
26. Skuk, D., and Tremblay, J.P. 1998. Complement deposition and cell death after myoblast transplantation. Cell Transplant, 7: 427-434.
27. Skuk, D., and Tremblay, J.P. 2000. Progress in myoblast transplantation: a potential treatment of dystrophies. Microsc. Res. Tech. 48: 213-222.
28. Smythe, G.M., Hodgetts, S.I., and Grounds, M.D. 2000. Immunobiology and the future of myoblast transfer therapy. Mol. Ther. 1: 304-313.
29. Strater, J., Wedding, U., Barth, T.F., Koretz, K., Elsing, C., and Moller, P. 1996. Rapid onset of apoptosis in vitro follows disruption of beta 1-integrin/matrix interactions in human colonic crypt cells. Gastroenterology, 110: 1776-1784.
30. Swift, S.M., Clayton, H.A., London, N.J., and James, R.F. 1998. The potential contribution of rejection to survival of transplanted human islets. Cell Transplant, 7: 599-606.
31. Vermes, I., Haanen, C., Steffens-Nakken, H., and Reutelingsperger, C. 1995. A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. J. Immunol. Methods, 184: 39-51.
32. Vilquin, J.T., Wagner, E., Kinoshita, I., Roy, R., and Tremblay, J.P. 1995. Successful histocompatible myoblast transplantation in dystrophin-deficient mdx mouse despite the production of antibodies against dystrophin. J. Cell Biol. 131: 975-988.
33. Wang, J., and Walsh, K. 1996. Resistance to apoptosis conferred by Cdk inhibitors during myocyte differentiation. Science, 273: 359-361.