The effects of cure of Helicobacter pylori infection on the signal transduction of gastric epithelial cells

Alimentary Pharmacology and Therapeutics, Supplement

Volumn 18, Issue 1, 2003, Pages 39-44

  Azuma, T ^a   Yamazaki, S ^a   Yamakawa, A ^a   Ito, Y ^a   Ohtani, M ^a   Dojo, M ^a   Yamazaki, Y ^a   Higashi, H ^b   Hatakeyama, M ^b  

^a UNIVERSITY OF FUKUI   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CAGA PROTEIN; PROTEIN TYROSINE PHOSPHATASE SHP 2; REGULATOR PROTEIN; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; DNA BINDING PROTEIN; DROSOPHILA PROTEIN; HOMEODOMAIN PROTEIN; PROTEIN TYROSINE PHOSPHATASE; SIGNAL PEPTIDE; SRC HOMOLOGY 2 (SH2) DOMAIN CONTAINING PHOSPHATASES; SRC HOMOLOGY-2 (SH2) DOMAIN-CONTAINING PHOSPHATASES; TRANSCRIPTION FACTOR; TRL PROTEIN, DROSOPHILA;

ADULT; ATROPHIC GASTRITIS; CANCER RISK; CELL SECRETION; CELL STIMULATION; CLINICAL ARTICLE; COMPLEX FORMATION; CONFERENCE PAPER; CONTROLLED STUDY; EPITHELIUM CELL; ERADICATION THERAPY; FEMALE; HELICOBACTER PYLORI; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; INFECTION CONTROL; MALE; MITOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAIN; STOMACH BIOPSY; STOMACH EPITHELIUM; STRAIN IDENTIFICATION; ARTICLE; HELICOBACTER INFECTION; METABOLISM; METHODOLOGY; MICROBIOLOGY; MIDDLE AGED; PHOSPHORYLATION; PHYSIOLOGY; POLYMERASE CHAIN REACTION; SERODIAGNOSIS; STOMACH MUCOSA;

BACTERIAL PROTEINS; DNA-BINDING PROTEINS; DROSOPHILA PROTEINS; EPITHELIAL CELLS; FEMALE; GASTRIC MUCOSA; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOBLOTTING; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MIDDLE AGED; PHOSPHORYLATION; POLYMERASE CHAIN REACTION; PRECIPITIN TESTS; PROTEIN-TYROSINE-PHOSPHATASE; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 0242432366     PISSN: 09530673     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2036.18.s1.2.x     Document Type: Conference Paper

References (22)

1. Warren JR, Marshall BJ. Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet 1983; 1: 1273-5.
2. Parsonnet J, Friedman GD, Vandersteen DP, et al. Helicobacter pylori infection and the risk of gastric carcinoma. N Engl J Med 1991; 325: 11127-31.
3. The Eurogast Study Group. An association between Helicobacter pylori infection and gastric cancer. Lancet 1993; 341: 1359-62.
4. IARC. Schistosomes, liver flukes and Helicobacter pylori. Monographs on the evaluation of carcinogenic risks to humans. IARC Sci Publ 1994; 61: 1-241.
5. Censini S, Lange C, Xiang Z, et al. Cag, a pathogenicity island of Helicobacter pylori. encodes type I-specific and disease-associated virulence factors. Proc Natl Acad Sci USA 1996; 93: 14648-53.
6. Blaser MJ, Perez-Perez GI, Kleanthous H, et al. Infection with Helicobcter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach. Cancer Res 1995; 55: 2111-5.
7. Parsonnet J, Friedman CD, Orentreich N, Vogelman H. Risk for gastric cancer in people with CagA positive or CagA negative Helicobacter pylori infection. Gut 1997; 40: 297-301.
8. Segal ED, Cha J, Lo J, Falkow S, Tompkins LS. Altered states: involvement of phosphorylated CagA in the induction of host cellular growth changes by Helicobacter pylori. Proc Natl Acad Sci USA 1999; 96: 14559-64.
9. Stein M, Rappuoli R, Covacci A. Tyrosine phosphorylation of the Helicobacter pylori CagA antigen after cag-driven host cell translocation. Proc Natl Acad Sci USA 2000; 97: 1263-8.
10. Asahi M, Azuma T, Ito S, et al. Helicobacter pylori cagA protein can be tyrosine phosphorylated in gastric epithelial cells. J Exp Med 2000; 191: 593-602.
11. Odenbreit S, Puls J, Sedlmaier B, Gerland E, Fischer W, Haas R. Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion. Science 2000; 287: 1497-500.
12. Higashi H, Tsutsumi R, Muto S, et al. SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein. Science 2002; 295: 683-6.
13. Feng G, Hui C, Pawson T. SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases. Science 1993; 259: 1607-11.
14. Freeman R, Plutzky J, Neel BG. Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew. Proc Natl Acad Sci USA 1992; 89: 11239-43.
15. Yu D, Qu C, Henegariu O, Lu X, Feng C. Protein-tyrosine phosphatase Shp-2 regulates cell spreading, migration, and focal adhesion. J Biol Chem 1998; 273: 21125-31.
16. Anti M, Armuzzi A, Gasbarrini A, Casbarrini C. Importance of changes in epithelial cell turnover during Helicobacter pylori infection in gastric carcinogenesis. Gut 1998; 43(Suppl. 1): 27-32(S).
17. Ito Y, Azuma T, Ito S, et al. Analysis and typing of the vacA gene from cagA-positive strains of Helicobacter pylori isolated in Japan. J Clin Microbiol 1997; 35: 1710-14.
18. Watanabe T, Tada M, Nagai H, Sasaki S, Nakao M. Helicobacter pylori infection induces gastric cancer in Mongolian gerbils. Gastroenterology 1998; 115: 642-8.
19. Sugiyama A, Maruta F, Ikeno T, et al. Helicobacter pylori infection enhances N-methyl-N-nitrosourea-induced stomach carcinogenesis in Mongolian gerbil. Cancer Res 1998; 58: 2067-9.
20. Shimizu N, Ikehara Y, Inada K, et al. Eradication diminishes enhancing effects of Helicobacter pylori infection on glandular stomach carcinogenesis in Mongolian Gerbils. Cancer Res 2000; 60: 1512-4.
21. Uemura N, Mukai T, Okamoto S, et al. Effect of Helicobacter pylori eradication on subsequent development of cancer after endoscopic resection of early gastric cancer. Cancer Epidemiol Biomarkers Prev 1997; 6: 639-42.
22. Saito K, Arai K, Mori M, Kobayashi R, Ohki I. Effect of Helicobacter pylori eradication on malignant transformation of gastric adenoma. Castrointest Endosc 2000; 52: 27-32.