Catalytic Implications from the Drosophila Protein L-Isoaspartyl Methyltransferase Structure and Site-Directed Mutagenesis

Biochemistry

Volumn 42, Issue 44, 2003, Pages 12844-12853

  Bennett, Eric J ^a   Bjerregaard, Jens ^a   Knapp, James E ^b   Chavous, David A ^a   Friedman, Alan M ^c   Royer Jr , William E ^b   O'Connor, Clare M ^a  

^a BOSTON COLLEGE   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^c PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CRYSTAL STRUCTURE; MUTAGENESIS; POLYPEPTIDES;

NUCLEOTIDE-BINDING FOLDS;

ENZYMES;

ALANINE; GLUTAMINE; INSECT PROTEIN; ISOASPARTIC ACID; NUCLEOTIDE; POLYPEPTIDE; PROTEIN ISOASPARTYL METHYLTRANSFERASE; S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE; SERINE; THREONINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CRYSTAL STRUCTURE; DROSOPHILA MELANOGASTER; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME STRUCTURE; GENE OVEREXPRESSION; LIFESPAN; LONGEVITY; METHYLATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN METHYLATION; SITE DIRECTED MUTAGENESIS; TRANSGENIC ANIMAL;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; CATALYSIS; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; PROTEIN D-ASPARTATE-L-ISOASPARTATE METHYLTRANSFERASE; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SERINE; SUBSTRATE SPECIFICITY;

ANIMALIA; DROSOPHILA MELANOGASTER; INSECTA; MELANOGASTER;

EID: 0242424144     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi034891+     Document Type: Article

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