Crystal structure of human L-isoaspartyl-O-methyltransferase with S-adenosyl homocysteine at 1.6-Å resolution and modeling of an isoaspartyl-containing peptide at the active site

Protein Science

Volumn 11, Issue 3, 2002, Pages 625-635

  Smith, Craig D ^a   Carson, Mike ^a   Friedman, Alan M ^b   Skinner, Matthew M ^b   Delucas, Lawrence ^a   Chantalat, Laurent ^c   Weise, Lance ^a   Shirasawa, Takuji ^d   Chattopadhyay, Debashish ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b PURDUE UNIVERSITY   (United States)

^c SANOFI   (France)

^d TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

Author keywords

Deamidation; Isoaspartyl; Methyltransferase; Protein repair

Indexed keywords

ASPARTIC ACID; METHYLTRANSFERASE; NUCLEOTIDE; S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; GENETIC CONSERVATION; METHYLATION; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN STRUCTURE; THERMOTOGA MARITIMA;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; HUMANS; ISOASPARTIC ACID; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN D-ASPARTATE-L-ISOASPARTATE METHYLTRANSFERASE; PROTEIN STRUCTURE, TERTIARY; S-ADENOSYLHOMOCYSTEINE;

BACTERIA (MICROORGANISMS); THERMOTOGA; THERMOTOGA MARITIMA;

EID: 0036176909     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.37802     Document Type: Article

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