Synthesis of [14C]-labelled vardenafil hydrochloride and metabolites

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 46, Issue 11, 2003, Pages 1019-1032

  Seidel, D ^a   Brehmer, P ^a   Schoof, Y ^a   Weinberg, U ^a   Niewohner U ^a   Nowakowski, M ^a  

^a BAYER AG   (Germany)

Author keywords

Carbon 14; Cyanation; Levitra ; Nucleophilic substitution; PDE V inhibitor; Regioselective chlorosulfonation; Semi preparative chromatography

Indexed keywords

CARBON; CHROMATOGRAPHY; METABOLISM; PHYSIOLOGY; REGIOSELECTIVITY;

CARBON 14; CYANATION; LEVITRUM®; NUCLEOPHILIC SUBSTITUTIONS; PHOSPHODIESTERASE TYPE V INHIBITOR; PHOSPHODIESTERASES; PREPARATIVE CHROMATOGRAPHY; REGIO-SELECTIVE; REGIOSELECTIVE CHLOROSULPHONATION; SEMI-PREPARATIVE CHROMATOGRAPHY;

METABOLITES;

2 IODOPHENOL; CARBON 14; CHEMICAL COMPOUND; IMIDAZOLE DERIVATIVE; IMIDAZOTRIAZINONE; PHENOL DERIVATIVE; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE V INHIBITOR; UNCLASSIFIED DRUG; VARDENAFIL;

ARTICLE; CYANATION; DRUG METABOLISM; DRUG SYNTHESIS; METABOLITE; RADIOACTIVITY;

EID: 0242408788     PISSN: 03624803     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlcr.736     Document Type: Article

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