Cushing's Syndrome in a Patient with Bilateral Macronodular Adrenal Hyperplasia Responding to Cisapride: An in Vivo and in Vitro Study

Journal of Clinical Endocrinology and Metabolism

Volumn 88, Issue 10, 2003, Pages 4616-4622

  Mannelli, Massimo ^a   Ferruzzi, Pietro ^a   Luciani, Paola ^a   Crescioli, Clara ^a   Buci, Lisa ^a   Corona, Giovanni ^a   Serio, Mario ^a   Peri, Alessandro ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CATECHOLAMINE RECEPTOR; CHORIONIC GONADOTROPIN RECEPTOR; CISAPRIDE; CORTICOTROPIN; DESMOPRESSIN; GASTRIC INHIBITORY POLYPEPTIDE; GLUCAGON; GONADORELIN; HORMONE RECEPTOR; HYDROCORTISONE; MESSENGER RNA; PROTIRELIN; RELEFACT-TRH; SEROTONIN AGONIST; SEROTONIN RECEPTOR; TETRACOSACTIDE; VASOPRESSIN; VASOPRESSIN V1 RECEPTOR;

ADRENAL GLAND; ADRENAL HYPERPLASIA; ADRENALECTOMY; ADULT; ARTICLE; CASE REPORT; CELL CULTURE; CLINICAL FEATURE; CUSHING SYNDROME; DRUG EFFECT; ECHOGRAPHY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDROCORTISONE BLOOD LEVEL; HYDROCORTISONE RELEASE; IN VITRO STUDY; IN VIVO STUDY; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADRENAL GLANDS; ADRENOCORTICOTROPIC HORMONE; CISAPRIDE; CUSHING SYNDROME; FEMALE; GENE EXPRESSION; HUMANS; HYDROCORTISONE; HYPERPLASIA; MIDDLE AGED; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTORS, ADRENERGIC, BETA-1; RECEPTORS, ANGIOTENSIN; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT4; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEROTONIN AGONISTS;

EID: 0242383408     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2002-021949     Document Type: Article

References (26)

1. Latronico AC, Chrousos GP 1997 Extensive personal experience: adrenocortical tumors. J Clin Endocrinol Metab 82:1317-1324
2. Bornstein SR, Stratakis CA, Chrousos GP 1999 Adrenocortical tumors: recent advances in basic concepts and clinical management. Ann Intern Med 130: 759-771
3. Kirschner LS, Carney A, Pack SD, Taymans S, Giatzakis C, Cho YS, ChoChung YS, Stratakis CA 2000 Mutations of the gene encoding the protein kinase A type I-α regulatory subunit in patients with the Carney complex. Nat Genet 26:89-92
4. Lacroix A, N'Diaye N, Tremblay, Hamet P 2001 Ectopic and abnormal hormone receptors in adrenal Cushing's syndrome. Endocr Rev 22:75-110
5. Lacroix A, Hamet P, Boutin J-M 1999 Leuprolide acetate therapy in luteinizing hormone-dependent Cushing's syndrome. N Engl J Med 341:1577-1581
6. Mircescu H, Jilwan J, N'Diaye N, Bourdeau I, Tremblay J, Hamet P, Lacroix A 2000 Are ectopic or abnormal membrane hormone receptors frequently present in adrenal Cushing's syndrome? J Clin Endocrinol Metab 85:3531-3536
7. 4 receptors in cisapride-responsive adrenocorticotropin-independent bilateral macronodular hyperplasia causing Cushing's syndrome. J Clin Endocrinol Metab 88:248-254
8. Bourdeau I, D'Amour P, Hamet P, Boutin J-M, Lacroix A 2001 Aberrant membrane hormone receptors in incidentally discovered bilateral macronodular adrenal hyperplasia with subclinical Cushing's syndrome. J Clin Endocrinol Metab 86:5534-5540
9. Lacroix A, Tremblay J, Rousseau G, Bouvier M, Hamet P 1997 Propranolol therapy for ectopic β-adrenergic receptors in adrenal Cushing's syndrome. N Engl J Med 337:1429-1434
10. 4 receptor cloned from human atrium. FEBS Lett 412:465-474
11. Blondel O, Gastineau M, Dahmoune Y, Langlois M, Fischmeister R 1998 Cloning, expression, and pharmacology of four human 5-hydroxytryptamine 4 receptor isoforms produced by alternative splicing in the carboxyl terminus. J Neurochem 70:2252-2261
12. 4 receptor variants. Neuropharmacology 42:60-73
13. 4 splice variant. J Neurochem 74:478-489
14. Munari-Silem Y, Lebrethon MC, Morand I, Rousset B, Saez JM 1995 Gap junction-mediated cell-to-cell communication in bovine and human adrenal cells. A process whereby cells increase their responsiveness to physiological corticotropin concentrations. J Clin Invest 95:1429-1439
15. Chomczynski P, Sacchi N 1987 Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156-159
16. 4 receptors in adrenocortical aldosterone-producing adenomas: in vivo and in vitro studies. J Clin Endocrinol Metab 87:1211-1216
17. 1-adrenergic receptors and their mRNA in neuroepithelioma SK-N-MC cells: effects of agonist, forskolin, and protein kinase A. Biochem Pharmacol 62:1211-1220
18. 2-inhibitory protein. J Clin Invest 92:2099-2109
19. Dveksler GS, Basile AA, Dieffenbach CW 1992 Analysis of gene expression: use of oligonucleotide primers for glyceraldehyde-3-phosphate dehydrogenase. PCR Methods Applic 1:283-285
20. Bustin SA 2002 Quantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems. J Mol Endocrinol 29:23-39
21. Lefebvre H, Contesse, Delarue C, Feuilloley M, Hery F, Grise P, Raynaud G, Verhofstad AA, Wolf LM, Vaudry H 1992 Serotonin-induced stimulation of cortisol secretion from human adrenocortical tissue is mediated through activation of a serotonin 4 receptor subtype. Neuroscience 47:999-1007
22. Lefebvre H, Contesse V, Delarue C, Soubrane C, Legrand A, Kuhn JM, Wolf LM, Vaudry H 1993 Effect of the serotonin-4 receptor agonist zacopride on aldosterone secretion from the human adrenal cortex. In vivo and in vitro studies. J Clin Endocrinol Metab 77:1662-1666
23. Lefebvre H, Contesse V, Delarue C, Legrand A, Kuhn JM, Vaydry H, Wolf LM 1995 The serotonin-4 receptor agonist cisapride and angiotensin-II exert additive effects on aldosterone secretion in normal man. J Clin Endocrinol Metab 80:504-507
24. Lefebvre H, Contesse V, Delarue C, Vaudry H, Kuhn JM 1998 Serotoninergic regulation of adrenocortical function. Horm Metab Res 30:398-403
25. Lefebvre H, Compagnon P, Contesse V, Delarue C, Thuillez C, Vaudry H, Kuhn JM 2001 Production and metabolism of serotonin (5-HAT) by the human adrenal cortex: paracrine stimulation of aldosterone secretion by 5-HAT. J Clin Endocrinol Metab 86:5001-5007
26. Lamas C, Alfaro JJ, Lucas T, Lecumberri B, Barcelò, Estrada J 2002 Is unilateral adrenalectomy an alternative treatment for ACTH-independent macronodular adrenal hyperplasia?: long-term follow-up of four cases. Eur J Endocrinol 146:237-240