Identification of novel polymorphisms in the AXIN1 and CDX-2 genes

Journal of Human Genetics

Volumn 45, Issue 4, 2000, Pages 254-256

  Lin, Yu Min ^a   Kato, Tatsushi ^a   Satoh, Seiji ^a   Nakamura, Yusuke ^a   Furukawa, Yoichi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Axin; Cdx 2; Colorectal cancer; Hepatocellular carcinoma; Single nucleotide polymorphism

Indexed keywords

DNA; NUCLEOTIDE;

ARTICLE; CARCINOGENESIS; COLORECTAL CANCER; DNA SEQUENCE; GENE; GENE FREQUENCY; GENETIC POLYMORPHISM; HETEROZYGOSITY LOSS; HUMAN; LIVER CANCER; NUCLEOTIDE SEQUENCE; SINGLE NUCLEOTIDE POLYMORPHISM; SINGLE STRAND CONFORMATION POLYMORPHISM;

EID: 0033911564     PISSN: 14345161     EISSN: None     Source Type: Journal    
DOI: 10.1007/s100380070036     Document Type: Article

References (10)

1. Chawengsaksophak K, James R, Hammond VE, Kontgen F, Beck F (1997) Homeosis and intestinal tumours in Cdx2 mutant mice. Nature 386:84-87
2. da Costa LT, He T-C, Yu J, Sparks AB, Morin PJ, Polyak K, Laken S, Vogelstein B, Kinzler KW (1999) CDX2 is mutated in a colorectal cancer with normal APC/β-catenin signaling. Oncogene 18:5010-5014
3. Drummond F, Putt W, Fox M, Edwards YH (1997) Cloning and chromosome assignment of the human CDX2 gene. Ann Hum Genet 61:393-400
4. Kishida S, Yamamoto H, Ikeda S, Kishida M, Sakamoto I, Koyama S, Kikuchi A (1998) Axin, a negative regulator of the Wnt signaling pathway, directly interacts with adenomatous polyposis coli and regulates the stabilization of beta-catenin. J Biol Chem 273:10823-10826
5. Laken SJ, Petersen GM, Gruber SB, Oddoux C, Ostrer H, Giardiello FM, Hamilton SR, Hampel H, Markowitz A, Klimstra D, Jhanwar S, Winawe S, Offit K, Luce MC, Kinzler KW, Vogelstein B (1997) Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC. Nat Genet 17:79-83
6. Nakamura T, Hamada F, Ishidate T, Anai K, Kawahara K, Toyoshima K, Akiyama T (1998) Axin, an inhibitor of the Wnt signaling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin level. Genes Cells 3:395-403
7. Nakamura Y (1997) Cleaning up on beta-catenin. Nat Med 3:499-500
8. Satoh S, Daigo Y, Furukawa Y, Kato T, Miwa N, Nishiwaki T, Kawasoe T, Ishiguro T, Fujita M, Tokino T, Sasaki Y, Imaoka S, Murata M, Shimano T, Yamaoka Y, Nakamura Y (2000) AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. Nat Genet 24:245-250
9. Storey A, Thomas M, Kalita A, Harwood C, Gardiol D, Mantovani F, Breuer J, Leigh IM, Matlashewski G, Banks L (1998) Role of a p53 polymorphism in the development of human papillomavirus-associated cancer. Nature 393:229-234
10. Zeng L, Fagotto F, Zhang T, Hsu W, Vasicek TJ, Perry WL 3rd, Lee JJ, Tilghman SM, Gumbiner BM, Costantini F (1997) The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation. Cell 90:181-192