Long-Term Hypoxia Changes Myometrial Responsiveness and Oxytocin Receptors in the Pregnant Ewe: Differential Effects on Longitudinal Versus Circular Smooth Muscle

Biology of Reproduction

Volumn 69, Issue 5, 2003, Pages 1500-1505

  Mlynarczyk, M ^a   Imamura, T ^a   Umezaki, H ^a   Kaushal, K M ^a   Zhang, L ^a   Ducsay, Charles A ^a  

^a LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Environment; Oxytocin; Parturition; Uterus

Indexed keywords

OXYTOCIN; OXYTOCIN RECEPTOR;

ALTITUDE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHILDBIRTH; CONCENTRATION RESPONSE; CONTROLLED STUDY; FEMALE; GESTATIONAL AGE; HORMONE ACTION; HORMONE RECEPTOR INTERACTION; HYPOXIA; IN VITRO STUDY; MUSCLE CONTRACTILITY; MYOMETRIUM; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SHEEP; SMOOTH MUSCLE; WESTERN BLOTTING;

ANIMALS; ANOXIA; BLOTTING, WESTERN; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; MYOMETRIUM; OXYTOCIN; PREGNANCY; PREGNANCY, ANIMAL; RECEPTORS, OXYTOCIN; SHEEP; UTERINE CONTRACTION;

ANIMALIA; OVIS; OVIS ARIES;

EID: 0242267117     PISSN: 00063363     EISSN: None     Source Type: Journal    
DOI: 10.1095/biolreprod.103.018556     Document Type: Article

References (29)

1. 2+ and pHi in guinea-pig ureteric smooth muscle. Pflugers Arch 1998; 435:240-246.
2. Huang SM, Chowdhury JU, Kobayashi K, Tomita T. Inhibitory effects of cyanide on mechanical and electrical activities in the circular muscle of gastric antrum of guinea-pig stomach. Jpn J Physiol 1993; 43: 229-238.
3. Sward K, Josefsson M, Lydrup ML, Hellstrand P. Effects of metabolic inhibition on cytoplasmic calcium and contraction in smooth muscle of rat portal vein. Acta Physiol Scand 1993; 148:265-272.
4. Wray S, Duggins K, Iles R, Nyman L, Osman V. The effects of metabolic inhibition and acidification on force production in the rat uterus. Exp Physiol 1992; 77:307-319.
5. Ballew C, Haas JD. Hematologic evidence of fetal hypoxia among newborn infants at high altitude in Bolivia. Am J Obstet Gynecol 1986; 155:166-169.
6. Moore LG, Rounds SS, Jahnigen D, Grover RF, Reeves JT. Infant birth weight is related to maternal arterial oxygenation at high altitude. J Appl Physiol 1982; 52:695-699.
7. Rhee JW, Longo LD, Pearce WJ, Bae NH, Valenzuela GJ, Ducsay CA. Effect of chronic hypoxia on myometrial responsiveness in the pregnant rat. Am J Physiol 1996; 270:E477-E482.
8. Rhee JW, Zhang L, Ducsay CA. Functional determination of oxytocin affinity in near-term pregnant rat myometrium: effect of chronic hypoxia. Eur J Pharmacol 1998; 356:9-14.
9. Rhee JW, Zhang LB, Ducsay CA. Suppression of myometrial contractile responses to oxytocin after different durations of chronic hypoxia in the near-term pregnant rat. Am J Obstet Gynecol 1997; 177: 639-644.
10. Rhee JW, Hull A, Valenzuela GJ, Ducsay CA. Effects of chronic long-term hypoxia on myometrial contractile response to oxytocin in the pregnant ewe. J Soc Gynecol Investig 1996; 3:344A, 573.
11. Osa T, Katase T. Physiological comparison of the longitudinal and circular muscles of the pregnant rat uterus. Jpn J Physiol 1975; 25: 153-164.
12. Crankshaw DJ. The sensitivity of the longitudinal and circular muscle layers of the rat's myometrium to oxytocin in vitro during pregnancy. Can J Physiol Pharmacol 1987; 65:773-777.
13. El Alj A, Bonoris E, Cynober E, Germain G. Heterogeneity of oxytocin receptors in the pregnant rat myometrium near parturition. Eur J Pharmacol 1990; 186:231-238.
14. 2α on circular and longitudinal myometrium from the pregnant rat. Biol Reprod 1987; 37:348-355.
15. Chow EH, Marshall JM. Effects of catecholamines on circular and longitudinal uterine muscle of the rat. Eur J Pharmacol 1981; 76:157-165.
16. Kawarabayashi T, Osa T. Comparative investigations of α- and β-effects on the longitudinal and circular muscles of the pregnant rat myometrium. Jpn J Physiol 1976; 26:403-416.
17. Challis JR, Sloboda D, Matthews SG, Holloway A, Alfaidy N, Patel FA, Whittle W, Fraser M, Moss TJ, Newnham J. The fetal placental hypothalamic-pituitary-adrenal (HPA) axis, parturition and post natal health. Mol Cell Endocrinol 2001; 185:135-144.
18. Challis JRG, Matthews SG, Gibb W, Lye SJ. Endocrine and paracrine regulation of birth at term and preterm. Endocr Rev 2000; 21:514-550.
19. Baguma-Nibasheka M, Nathanielsz PW. In vivo administration of nimesulide, a selective PGHS-2 inhibitor, increases in vitro myometrial sensitivity to prostaglandins while lowering sensitivity to oxytocin. J Soc Gynecol Investig 1998; 5:296-299.
20. 2α. Biol Reprod 1998; 58:73-78.
21. Adan RA, Van Leeuwen FW, Sonnemans MA, Brouns M, Hoffman G, Verbalis JG, Burbach JP. Rat oxytocin receptor in brain, pituitary, mammary gland, and uterus: partial sequence and immunocytochemical localization. Endocrinology 1995; 136:4022-4028.
22. Wu WX, Verbalis JG, Hoffman GE, Derks JB, Nathanielsz PW. Characterization of oxytocin receptor expression and distribution in the pregnant sheep uterus. Endocrinology 1996; 137:722-728.
23. Schrey MP, Cornford PA, Read AM, Steer PJ. A role for phosphoinositide hydrolysis in human uterine smooth muscle during parturition. Am J Obstet Gynecol 1988; 159:964-970.
24. 1-adrenergic receptors and Ins(1,4,5)P3 responses in cerebral arteries. Am J Physiol 1997; 272:R669-R674.
25. 1-adrenergic receptors in the ovine uterine artery. Am J Physiol 1996; 270:H1001-H1007.
26. 1-adrenergic receptor-stimulated cardiac hypertrophy and signaling. Circulation 1995; 92:918-925.
27. Kacimi R, Richalet JP, Corsin A, Abousahl I, Crozatier B. Hypoxia-induced downregulation of β-adrenergic receptors in rat heart. J Appl Physiol 1992; 73:1377-1382.
28. Kacimi R, Richalet JP, Crozatier B. Hypoxia-induced differential modulation of adenosinergic and muscarinic receptors in rat heart. J Appl Physiol 1993; 75:1123-1128.
29. Hu XQ, Zhang L. Chronic hypoxia suppresses pharmacomechanical coupling of the uterine artery in near-term pregnant sheep. J Physiol 1997; 499(pt 2):551-559.