A case study to evaluate the treatment of vitiligo with khellin encapsulated in L-phenylalanin stabilized phosphatidylcholine liposomes in combination with ultraviolet light therapy

European Journal of Dermatology

Volumn 13, Issue 5, 2003, Pages 474-477

  De Leeuw, Jaap ^a   Van Der Beek, Nick ^a   Maierhofer, Günther ^a   Neugebauer, Wolfgang Dieter ^a  

^a Clin Dermatol and Laser Treatm   (Netherlands)

Author keywords

Khellin; L phenylalanine; Liposomes; Ultraviolet light; Vitiligo

Indexed keywords

KHELLIN; LIPOSOME; PHENYLALANINE;

ADOLESCENT; ADULT; AGED; ARM; ARTICLE; BACK; CELL ACTIVATION; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; DRUG STABILITY; EVALUATION; FACE; FEMALE; HUMAN; LEG; MAJOR CLINICAL STUDY; MALE; MELANOCYTE; PHOTOTHERAPY; SCHOOL CHILD; SKIN PIGMENTATION; TRUNK; ULTRAVIOLET A RADIATION; ULTRAVIOLET B RADIATION; VITILIGO;

ADMINISTRATION, TOPICAL; ADOLESCENT; ADULT; AGED; CAPSULES; FEMALE; HUMANS; KHELLIN; LIPOSOMES; MALE; MIDDLE AGED; PHENYLALANINE; PHOSPHATIDYLCHOLINES; PHOTOCHEMOTHERAPY; RETROSPECTIVE STUDIES; TREATMENT OUTCOME; ULTRAVIOLET THERAPY; VASODILATOR AGENTS; VITILIGO;

EID: 0142246447     PISSN: 11671122     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Kovacs SO. Vitiligo. J Am Acad Dermatol 1998;38:647-66.
2. Westerhof W, Njoo MD, Schollreuter KU. Vitiligo. Hautarzt 1997;48:677-93.
3. Fitzpatrick TB, Eisen AZ, Wolff K. Dermatology in general medicine. New York: Mc Graw-Hill, 1993:923-4.
4. Cui J, Shen L, Wang G. Role of hair follicles in the repigmentation of vitiligo. J Invest Dermatol 1991;97:410-6.
5. Antoniou G, Katsambas A. Guidelines for the treatment of vitiligo. Drugs 1992;43:490-8.
6. Antoniou C, Schulpis H, Michas T. Vitiligo therapy with oral and topical Phenylalanine with UVA exposure. Int J Derm 1989;28:545-7.
7. Anstey A, Hawk JLM. PUVA treatment for vitiligo. Br J Dermatol 1994: 131(suppl 44): 18.
8. Camacho F, Mazuecos J. Treatment of vitiligo with oral and topical phenylalanine: 6 years of experience. Arch Dermatol 1999; 135:216-7.
9. Cormane RH, Siddiqui AH, Westerhof W. Phenylalanine and UVA light for the treatment of vitiligo. Arch Dermatol Res 1985;277:126-30.
10. Vedaldi D, Caffieri S, Dalla'acqua F. Khellin, a naturally occuring furochrome, used for the photochemotherapy of skin diseases: Mechanism of action. Il Farmaco 1987; 43: 333-46.
11. Morliere P, Honigsmann H, Averbeck D. Phototherapeutic, Photobiologic and Photosensitizing properties of khellin. J Invest Derm 1988; 90: 720-4.
12. Ortel B, Tanew A, Honigsmann H. Treatment of vitiligo with khellin and ultraviolet A. J Am Acad Dermatol 1988; 18: 693-701.
13. Hofer A, Kerl H, Wolf P. Long-term results in the treatment of vitiligo with oral khellin plus UVA. Eur J Dermatol 2001;11:225-9.
14. Orecchia G, Sangalli ME, Gazzaniga A., Giordano F. Topical photochemotherapy of vitiligo with a new khellin formulation: preliminary results. J Der Treatm 1998; 9: 65-9.
15. Hoffman RM. Topical liposome targeting of dyes, melanins, genes and proteins selectively to hair follicles. J of Drug Tarqeting 1997;3:67-74.
16. Hope MJ, Kitson C. Liposomes. A perspective for Dermatologists. Derm Ther Jan 1993; 2: 17-21.
17. Mezei M. Biodisposition of liposome encapsulated active ingredients applied on the skin. Liposome- Dermatitis. Braun Falco, Karting Maibach Springer Verlag 1992;206-14.
18. Schallreuter KU. Pseudocatalase and the depigmentation disorder vitiligo. Retinoids 1998; 14:57-9
19. Maskos Z, Rush JD, Koppenol WH. The hydroxylation of phenylalanine and tyrosine: A comparison with salicylote and tryptophan. Arch Biochem Biophys 1992;296:521-9.
20. Sarkany RPE, Anstey A, Diffey BL. Home phototherapy: report on a workshop of the British Photodermatology Group, December 1996. Br J Derm 1999;140:195-9.
21. Njoo MD, Bos JD, Westerhof W. Treatment of generalized vitiligo in children with norrow-bond (TL-01) UVB radiation therapy. J Am Acad Dermatol 2000;42:245-53.
22. Meas M, van Weelden H, van Vloten WA. Vitiligo: epidemiologie en behondeling, met name met UVB (311). Ned Tijdschr Dermatol Venerel 1999;9:30-3.