Topical photochemotherapy of vitiligo with a new khellin formulation: Preliminary clinical results

Journal of Dermatological Treatment

Volumn 9, Issue 2, 1998, Pages 65-69

  Orecchia, G ^a,d   Sangalli, M E ^b   Gazzaniga, A ^b   Giordano, F ^c  

^a UNIVERSITY OF PAVIA   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c UNIVERSITY OF PARMA   (Italy)

^d FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

Author keywords

Khellin; Psoralens; Topical treatment; UVA; Vitiligo; Water 2 propanol propylene glycol

Indexed keywords

DRUG VEHICLE; KHELLIN; PLACEBO; PROPRANOLOL DERIVATIVE; PROPYLENE GLYCOL; PSORALEN DERIVATIVE; WATER;

ADOLESCENT; ADULT; AGE; ARTICLE; CARCINOGENICITY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE DURATION; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG FORMULATION; DRUG SOLUBILITY; FEMALE; GEL; HUMAN; MALE; MUTAGENESIS; PATIENT COMPLIANCE; PHOTOCHEMOTHERAPY; PHOTOTOXICITY; PRIORITY JOURNAL; SCHOOL CHILD; SKIN PIGMENTATION; TOPICAL DRUG ADMINISTRATION; ULTRAVIOLET A RADIATION; VITILIGO;

EID: 0031927076     PISSN: 09546634     EISSN: None     Source Type: Journal    
DOI: 10.3109/09546639809161375     Document Type: Article

References (23)

1. Lindelof B, Sigurgeirsson B, Tegner E et al, Comparison of the carcinogenic potential of trioxsalen bath PUVA and oral methoxsalen PUVA. A preliminary report. Arch Dermatol (1992) 128: 1341-4.
2. Grimes PE, Minus HR, Chakrabarti SG et al, Determination of optimal topical photochemotherapy for vitiligo. J Am Acad Dermatol (1982) 7: 771-8.
3. Abdel-Fattah A, Aboul-Enein MN, Wassel GM, El-Menshawi BS, An approach to the treatment of vitiligo by khellin. Dermatologica (1982) 165: 136-40.
4. Ortel B, Tanew A, Honigsmann H, Treatment of vitiligo with khellin and ultraviolet A. J Am Acad Dermatol (1988) 18: 693-701.
5. Morliere P, Honigsmann H, Averbeck D et al. Phototherapeutic, photobiologic and photosensitizing properties of khellin. J Invest Dermatol (1988) 90: 720-4.
6. Pathak MA, Dalle Carbonare M, Melanogenetic potential of various furocoumarins in normal and vitiliginous skin. In: Fitzpatrick TB, Forlot P, Pathak MA, Urbach F (eds) Psoralens: past, present and future of photochemoprotection and other biological activities. Libbey: Paris, 1989, p 87.
7. Dell'Acqua F, Vedaldi D, Boccichetti F, Bordin F, Photochemotherapy of skin disease: comparative study of the photochemical and photobiological properties of various mono and bifunctional agents. Il Farmaco (1981) 36: 519-35.
8. Abeysekera BF, Abramowsky Z, Towers GHM, Genotoxicity of the natural furochromones, khellin and visnagin and the identification of a khellin-thymine photoadduct. Photochem Photobiol (1983) 38: 311-15.
9. Trabalzini L, Martelli P, Bovalini L et al. Photosensitization of DNA of defined sequence by furochromones, khellin and visnagin. J Photochem Photobiol B (1990) 7: 317-36.
10. Riccio ML, Coratza G, Bovalini L, Martelli P, Investigation of mutagenic activity in Salmonella typhimurium of the furochromone khellin, proposed as therapeutic agents for skin diseases. Mutat Res (1992) 279(2): 103-8.
11. Orecchia G, Perfetti L, Photochemotherapy with topical khellin and sunlight in vitiligo. Dermatology (1992) 184: 120-3.
12. Giordano F, Rillosi M, Benelli P et al, Preformulation studies and formulation strategies on khellin; an old/new antivitiligo agent: interaction with cyclodextrins, solubility in mixed solvent systems and permeation through artificial membranes. Eur J Pharm Biopharm (1994) 40(4) 232-6.
13. Delfino M, Raulo U, Sarno A et al, Fotochemioterapia della vitiligine con kellina. Ann Ital Derm Clin Sper (1987) 41: 307-10.
14. Delfino M, Procaccini EM, Monfrecola G, Fotochemioterapia della vitiligine con kellina ed esposizione alla luce solare. Dermatol Oggi (1990) 4: 11-13.
15. Kao CH, Yu HS, Comparison of the effect of 8-methoxy-psoralen (8-MOP) plus UVA (PUVA) on human melanocytes in vitiligo vulgaris and in vitro. J Invest Dermatol (1992) 98: 734-40.
16. Laskin JD, Laskin DL, Role of psoralen receptors in cell growth regulation. In: Gasparro FP (ed) Psoralen and DNA photobiology, vol 2. CRC Press: Boca Raton, 1988, p 135.
17. Distefano A, Lagaetana R, Bovalini L et al. Pertussis toxin reverses the inhibition of the adenylyl cyclase system by khellin in HeLa cells. Biochim Biophys Acta Mol Cell Res (1996) 1314(1-2): 105-8.
18. Ubeda A, Villar A, Relaxant actions of khellin on vascular smooth muscle. J Pharm Pharmacol (1989) 41(4): 236-41.
19. Shallreuter KU, Pittelkow MR, Defective calcium uptake in keratinocyte cell cultures from vitiliginous skin. Arch Dermatol Res (1988) 280: 137-9.
20. Shallreuter-Wood KU, Pittelkow MR, Swanson NN, Defective calcium transport in vitiliginous melanocytes. Arch Dermatol Res (1996) 288: 11-13.
21. 2+ movements in rat isolated aorta. J Pharm Pharmacol (1991) 43(1): 46-8.
22. Shallreuter KU, Wood JM, Ziegler I et al, Defective tetrahydrobiopterin and catecholamine biosynthesis in the depigmentation disorder vitiligo. Biochim Biophys Acta (1994) 1226: 181-92.
23. Shallreuter KU, Buttner G, Pittelkow MR et al, The cytotoxicity of 6-biopterin to human melanocytes. Biochem Biophys Res Commun (1994) 204: 432-8.