Wood Creosote, the Principal Active Ingredient of Seirogan, an Herbal Antidiarrheal Medicine: A Single-Dose, Dose-Escalation Safety and Pharmacokinetic Study

Pharmacotherapy

Volumn 23, Issue 11, 2003, Pages 1391-1400

  Kuge, Tomoo ^a,b,d   Shibata, Takashi ^a   Willett, Michael S ^c  

^a Taiko Pharmaceutical Company Ltd   (Japan)

^b NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c Advanced Biomedical Research Inc   (United States)

^d Taiko Pharmaceutical Co Ltd   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 ETHYLGUAIACOL; ANTIDIARRHEAL AGENT; ATROPINE; CREOSOL; CREOSOTE; GUAIACOL; LOPERAMIDE; ORTHO CRESOL; PLACEBO; PLANT EXTRACT; PLANT MEDICINAL PRODUCT; SEIROGAN; UNCLASSIFIED DRUG;

ABDOMINAL CRAMP; ADULT; AREA UNDER THE CURVE; ARTICLE; ASTHENIA; BACKACHE; BLOOD PRESSURE; CENTRAL NERVOUS SYSTEM DISEASE; CLINICAL TRIAL; COMPARATIVE STUDY; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG ABSORPTION; DRUG ADMINISTRATION; DRUG CONJUGATION; DRUG EFFECT; DRUG ELIMINATION; DRUG SAFETY; DRUG TOLERABILITY; ECCHYMOSIS; ELECTROCARDIOGRAM; FEMALE; HEADACHE; HEART RATE; HUMAN; HUMAN EXPERIMENT; INFECTION; MALE; NAUSEA; NORMAL HUMAN; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; RHINITIS; SEX DIFFERENCE; SOMNOLENCE; STATISTICAL MODEL; URINARY TRACT INFECTION; VERTIGO; VOMITING; WOOD;

ADULT; ANTIDIARRHEALS; AREA UNDER CURVE; BLOOD PRESSURE; CREOSOTE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; FEMALE; HEART RATE; HUMANS; LINEAR MODELS; MALE; PLANT EXTRACTS; PLANT PREPARATIONS; WOOD;

EID: 0142244680     PISSN: 02770008     EISSN: None     Source Type: Journal    
DOI: 10.1592/phco.23.14.1391.31940     Document Type: Article

References (20)

1. Cook GC. Diarrhea disease: a worldwide problem. J Royal Soc Med 1998;91:192-4.
2. Guerrant RL, Moore RA, Kirschenfeld P, Sande M. Role of toxigenic and invasive bacteria in acute diarrhea of childhood. N Engl J Med 1975;293:567-72.
3. Richards L, Claeson M, Pierce NF. Management of acute diarrhea in children: lessons learned. Pediatr Infect Dis J 1993;12:5-9.
4. Garthwright WE, Archer DL, Kvenberg JE. Estimates of incidence and cost of intestinal infectious diseases in the United States. Public Health Rep 1988;103:107-15.
5. Steffen R. Epidemiologic studies of travelers' diarrhea, severe gastrointestinal infections, and cholera. Rev Infect Dis 1986;8(suppl 2):122-30.
6. Ryan ET, Kain KC. Health advice and immunizations for travelers. N Engl J Med 2000;342:1716-25.
7. Guerrant RL, Bobak DA. Nausea, vomiting, and noninflammatory diarrhea, In: Mandell GL, Bennett JE, Dolin R, eds. Principles and practice of infectious diseases. New York: Churchill Livingstone, 1995:965-73.
8. Fine KD, Krejs GJ, Fortran JS. Diarrhea. In: Sleisenger MH, Fortran JS, eds. Gastrointestinal disease: pathophysiology, diagnosis, management. Philadelphia: WB Saunders, 1998:1043-72.
9. Anonymous. Physicians' desk reference. 54th ed. Montvale, NJ: Medical Economics Company, 2000:2923-4.
10. Gattuso JM, Kamm MA. Adverse effects of drugs used in the management of constipation and diarrhoea. Drug Saf 1994;10:47-65.
11. Haller JS. Creosote: a short history of its medicinal uses. Conn Med 1990;54:502-7.
12. Ogata N, Baba T. Analysis of beech wood creosote by gas chromatography-mass spectrometry and high performance liquid chromatography. Res Commun Chem Pathol Pharmacol 1989;66:411-23.
13. Kuge T, Shibata T, Willett MS, Turck P, Traul KA. Lack of oncogenicity of wood creosote, the principal active ingredient of Seirogan, an herbal antidiarrheal medication, in Sprague-Dawley rats. Int J Toxicol 2001;20:297-305.
14. Greenwood-Van Meerveld B, Tyler K, Kuge T, Ogata N. Antidiarrhoeal effects of Seirogan in the rat small intestine and colon examined in vitro. Aliment Pharmacol Ther 1999;13:97-102.
15. Greenwood-Van Meerveld B, Tyler KR, Venkova K, Kuge, T. Comparison of the antidiarrheal effects of wood creosote and loperamide in the rat jejunum and colon in vitro. Biol Pharm Bull 2000;23:952-6.
16. Ogata N, Shibata T. Antidiarrheal activity of wood creosote: inhibition of muscle contraction and enterotoxin-induced fluid secretion in rabbit small intestine. Pharmacology 2001;62:181-7.
17. Taiko Pharmaceutical Company, Ltd. Seirogen product labeling. Osaka, Japan; 2000.
18. Taiko Pharmaceutical Company, Ltd. Data on file. Osaka, Japan; 2002.
19. Kuge T, Shibata T, Willett MS. Multiple dose escalation, safety and tolerability study of wood creosote, the principal active ingredient of Seirogan, an herbal antidiarrheal medication, in healthy subjects. J Clin Pharmacol 2003;43:284-90.
20. Ogata N, Matsushima N, Shibata T. Pharmacokinetics of wood creosote: glucuronic acid and sulfate conjugation of phenolic compounds. Pharmacology 1995;51:195-204.