Lack of oncogenicity of wood creosote, the principal active ingredient of seirogan, an herbal antidiarrheal medication, in Sprague-Dawley rats

International Journal of Toxicology

Volumn 20, Issue 5, 2001, Pages 297-305

  Kuge, Tomoo ^a   Shibata, Takashi ^a   Willett, Michael S ^b   Turck, Patricia ^c   Traul, Karl A ^d  

^a Taiko Pharmaceutical Co Ltd   (Japan)

^b Advanced Biomedical Research Inc   (United States)

^c MPI RESEARCH   (United States)

^d Ingle Traul Pharmaceutical C   (United States)

Author keywords

Antidiarrheal; Creosol; Guaiacol; Oncogenicity; Seirogan; Wood Creosote (CAS 8021 39 4)

Indexed keywords

ANTIDIARRHEAL AGENT; CARBOXYMETHYLCELLULOSE; CREOSOTE; HERBACEOUS AGENT;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CARCINOGENICITY; CLINICAL FEATURE; CONTROLLED STUDY; FEMALE; FOOD INTAKE; LUNG ASPIRATION; LUNG EDEMA; MALE; NONHUMAN; PHYSICAL ACTIVITY; RAT; SALIVATION; SURVIVAL RATE;

ANIMALS; ANTIDIARRHEALS; BODY WEIGHT; CARCINOGENICITY TESTS; CARCINOGENS; CREOSOTE; FEEDING BEHAVIOR; FEMALE; MALE; MOTOR ACTIVITY; NEOPLASMS; ORGAN SIZE; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; RESPIRATORY SOUNDS; SALIVATION; SURVIVAL RATE;

ANIMALIA;

EID: 0035195671     PISSN: 10915818     EISSN: None     Source Type: Journal    
DOI: 10.1080/109158101753253036     Document Type: Article

References (22)

1. Gas chromatographic-mass spectrometric analysis of chlorination effects on commercial coal-tar leachate
2. Cholestatic hepatitis after ingestion of chaparral leaf: Confirmation by endoscopic retrograde cholangiopancreatography and liver biopsy
3. Illness raises concern on herbal preparations
4. A multiple comparison procedure for comparing several treatments with a control
5. Comparison of the antidiarrheal effects of wood creosote and loperamide in the rat jejunum and colon in vitro
6. In vitro effects of wood creosote on enterotoxin-induced secretion measured electrophysiologically in the rat jejunum and colon
7. Multiple cutaneous carcinoma after creosote exposure
8. Toxic chemicals in sediments and biota from a creosote-polluted harbor: Relationships with hepatic neoplasms and other hepatic lesions in English sole (Parophrys vetulus)
9. Studies on the toxicity of beechwood creosote. (2) Chronic toxicity and carcinogenicity in mice
10. Studies on the toxicity of beechwood creosote. (3) Chronic toxicity and carcinogenicity in rats
11. Analysis of beechwood creosote by gas chromatography-mass spectrometry and high performance liquid chromatography
12. Demonstration of antidiarrheal and antimotility effects of wood creosote
13. Suppression of intestinal smooth muscle contraction by phenolic compounds
14. Guidelines for simple, sensitive significance tests for carcinogenic effects in long term animal experiments
15. Gas chromatographic-mass spectrometric analysis of creosotes extracted from wooden sleepers installed in playgrounds
16. The significance of the difference between two means when the population variances are unequal