Multiple-dose escalation, safety, and tolerability study of wood creosote, the principal active ingredient of seirogan, an herbal antidiarrheal medication, in healthy subjects

Journal of Clinical Pharmacology

Volumn 43, Issue 3, 2003, Pages 284-290

  Kuge, Tomoo ^a,c   Shibata, Takashi ^a   Willett, Michael S ^b  

^a Taiko Pharmaceutical Co Ltd   (Japan)

^b Advanced Biomedical Research Inc   (United States)

^c Taiko Pharmaceutical Co Ltd   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDIARRHEAL AGENT; CAS 8021 39 4; CREOSOTE; HERBACEOUS AGENT; PLACEBO; SEIROGAN;

ABDOMINAL CRAMP; ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DOSE CALCULATION; DOSE RESPONSE; DRUG EFFECT; DRUG SAFETY; DRUG TOLERABILITY; DYSPEPSIA; ELECTROCARDIOGRAM; GASTROINTESTINAL SYMPTOM; HEADACHE; HEART ARRHYTHMIA; HEMODYNAMIC MONITORING; HUMAN; HYPERBILIRUBINEMIA; MALE; METABOLIC DISORDER; NEUROTOXICITY; NORMAL HUMAN; RANDOMIZED CONTROLLED TRIAL; SITING; SOMNOLENCE; STANDING; TASTE DISORDER; TELEMETRY; VERTIGO; WOOD;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; ANTIDIARRHEALS; BLOOD PRESSURE; COHORT STUDIES; CREOSOTE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROCARDIOGRAPHY; HEART RATE; HUMANS; MALE; MIDDLE AGED; PLANT EXTRACTS; PLANT PREPARATIONS; TELEMETRY;

EID: 0037369202     PISSN: 00912700     EISSN: None     Source Type: Journal    
DOI: 10.1177/0091270002250606     Document Type: Article

References (7)

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7. Kuge T, Shibata T, Willett MS: Safety and pharmacokinetic study of wood creosote, the principal active ingredient of Seirogan®. Pharmacotherapy; submitted for publication.