Effect of U-74389G (21-Lazaroid) on intestinal recovery after acute mesenteric ischemia and reperfusion in rats

In Vivo

Volumn 17, Issue 5, 2003, Pages 463-468

  Andreadou, Ioanna ^a   Poussios, Dimitrios ^a   Papalois, Apostolos ^b   Gavalakis, Nikolaos ^a   Aroni, Kyriaki ^c   Gazouli, Maria ^c   Gorgoulis, Vassilis G ^c   Fotiadis, Constantinos ^a  

^a SOTIRIA GENERAL HOSPITAL   (Greece)

^b ELPEN Pharmaceutical Co Inc   (Greece)

^c UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

Lazaroids; Malondialdehyde; Mesenteric ischemia; Reperfusion

Indexed keywords

21 [4 [2,6 BIS(1 PYRROLIDINYL) 4 PYRIMIDINYL] 1 PIPERAZINYL]PREGNA 1,4,9(11) TRIENE 3,20 DIONE; LAZAROID; LIPID; MALONALDEHYDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY CLAMP; ARTICLE; CELL COUNT; CONTROLLED STUDY; DISEASE MODEL; DRUG EFFECT; DRUG EFFICACY; DRUG STRUCTURE; HISTOPATHOLOGY; ILEUM; INTESTINE ISCHEMIA; INTESTINE MUCOSA; LIPID PEROXIDATION; MALE; MESENTERIC ARTERY OCCLUSION; NEUTROPHIL; NONHUMAN; OXIDATIVE STRESS; PREVENTIVE MEDICINE; RANDOMIZATION; RAT; REPERFUSION INJURY; STATISTICAL SIGNIFICANCE; STOMACH MUCOSA LESION; STOMACH PROTECTION; TISSUE LEVEL;

EID: 0142229899     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Blikslager AT, Roberts MC, Rhoads JM and Argenzio RA: Is reperfusion injury an important cause of mucosal damage after porcine intestinal ischemia? Surgery 121: 526-534, 1997.
2. Haglund U and Gerdin B: Oxygen free radicals (OFR) and circulatory shock. Circ Shock 34: 405-411, 1991.
3. Schoenberg MH, Poch B, Younes M, Swarz A, Baczako K, Lundberg C, Haglund U and Beger HG: Involvement of neutrophils in postischemic damage to the small intestine. Gut 32: 905-12, 1991.
4. Nilsson GA, Schoenberg MH, Aneman A, Poch B, Magadum S, Beger HG and Lundgren O: Free radicals and pathogenesis during ischemia and reperfusion of the cat small intestine. Gastroenterology 106: 629-636, 1994.
5. Osborne DL, Aw TY, Cepinskas G, Kvietys PR and Carter PR: Development of ischemia/reperfusion tolerance in the rat small intestine. J Clin Invest 94: 1910-8, 1994.
6. Leung FW, Su KC, Passaro E and Guth PH: Regional differences in gut blood flow and mucosal damage in response to ischemia and reperfusion. Am J Physiol 26: G301-305, 1992.
7. Cicalese L, Lee K, Schraut W, Watkins S, Borle A and Stanko R: Pyruvate prevents ischemia-reperfusion mucosal injury of rat small intestine. Am J Surg 171: 97-101, 1996.
8. Duranton B, Schleiffer R, Gosse F and Raul F: Preventive administration of ornithine a-ketoglutarine improves intestinal mucosal repair after transient ischemia in rats. Crit Care Med 26: 120-125, 1998.
9. Mustafa NA, Yandi M, Albayrak L and Yildiz K: Effect of pentoxifylline on the ischemia-reperfusion injury of the intestine. Int Surg 80: 152-155, 1995.
10. Ward T, Lawson SA, Gallagher LM, Conner WC and Shea-Donohue T: Sustained nitric oxide production via L-arginine administration ameliorates effects of intestinal ischemia-reperfusion. J Surg Res 89: 13-19, 2000.
11. Takeyoshi I, Iwanami K, Ohwada S, Takahasi T, Kobayashi J, Kawashima Y, Kamoshita N, Ohya T, Ogawa T, Yokoe T, Iino Y, Matsumoto K and Morishita Y: Effect of lazaroid U-74389G on lung ischemia-reperfusion injury. Transplant Proc 30: 3364-3365, 1998.
12. Tanaka H, Zhu Y, Zhang S, Ishizaki N, Jin MB, Azuma T, Lee R, Starzl TE and Todo S: Lazaroid U-74500A for warm ischemia and reperfusion injury of the canine small intestine. J Am Coll Surg 184: 389-396, 1997.
13. Stojadinovic A, Smallridge R, Nath J, Ding X and Shea-Donohue T: Anti-inflammatory effects of U-74389F in a rat model of intestinal ischemia/reperfusion injury. Crit Care Med 27: 764-770, 1999.
14. Horton JW and Walker PB: Oxygen radicals, lipid peroxidation, and permeability changes after intestinal ischemia and reperfusion. J Appl Physiol 74: 1515-1520, 1993.
15. Katz SM, Sun S, Schechner RS, Tellis VA, Alt ER and Greenstein SM: Improved small intestinal preservation after lazaroid U74389G treatment and cold storage in University of Wisconsin solution. Transplantation 59: 694-698, 1995.
16. Park PO, Gerdin B and Haglund U: Effects of a novel 21-aminosteroid or methylprednisolone in experimental total intestinal ischemia. Arch Surg 129: 857-860, 1994.
17. Van Ye TM, Rosa AM, Pieper GM, Henderson J, Johnson CP and Adams MB: Inhibition of intestinal peroxidation does not minimize damage. J Surg Res 55: 553-558, 1993.
18. Chiu CJ, McArdle AH and Brown R: Intestinal mucosal lesion in low-flow states. A morphological, hemodynamic and metabolic reappraisal. Arch Surg 1: 478-483, 1970.
19. Andreadou I, Tasouli A, Iliodromitis E, Tsantili-Kakoulidou A, Papalois A, Siatra T and Kremastinos DTh: Reduction of myocardial infarct size in rabbits by a novel indole derivative with antioxidant and free radical scavenging properties. Eur J Pharmacol 453: 123-129, 2002.
20. Collard CD and Gelman S: Pathophysiology, clinical manifestations, and prevention of ischemia-reperfusion injury. Anesthesiology 94: 1133-8, 2001.
21. Takahasi T, Takeyoshi I, Hasegwa Y, Koyano T, Yamagishi T, Oshima K, Ishikawa S, Ohtaki A, Matsumoto K and Morishita Y: Lazaroid U-74389G ameliorates ischemia-reperfusion injury in canine hearts: A histologic study. Transplant Proc 30: 3334-3336, 1998.
22. Bulkley GB: Reactive oxygen metabolites and reperfusion injury: Aberrant triggering of reticuloendothelial function. Lancet 344: 934-936, 1994.
23. Thomas PD, Mao GD, Rabinovitch A and Poznasky MJ: Inhibition of superoxide-generating NADPH oxidase from human neutrophils by lazaroids (21-aminosteroids and 2-methylaminochromands). Biochem Pharmacol 45: 241-251, 1993.
24. Gadaleta D, Verma M and Davis JM: Inhibition of neutrophil leukotriene generation by the 21-aminosteroid U74389G. J Surg Res 57: 233-237, 1994.
25. Cheeseman KH: Mechanism and effects of lipid peroxidation. Molec Aspects Med 14: 191-197, 1993.
26. Sato M, Maulik G, Ray PS, Bagchi D and Das DK: Cardioprotective effects grape seed pronthocyanidin against ischemic reperfusion injury. J Mol Cell Cardiol 31: 1289-1297, 1999.
27. Gonzalez AP, Sepulveda S, Massberg S, Boumeister R and Menger MD: In vivo fluorescence microscopy for the assessment of microvascular reperfusion injury in small bowel transplants in rats. Transplantation 58: 403-408, 1994.