Dopamine receptor D2 - 141C Insertion/Deletion polymorphism in a Finnish population with schizophrenia

Psychiatry Research

Volumn 121, Issue 1, 2003, Pages 89-92

  Kampman, Olli ^a,c   Anttila, Sami ^b   Illi, Ari ^a   Lehtimäki, Terho ^a,b   Mattila, Kari M ^a,b   Roivas, Markus ^d   Leinonen, Esa ^a,b  

^a TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^b TAMPERE UNIVERSITY HOSPITAL   (Finland)

^c Tampere Community Mental Health Care   (Finland)

^d Tampere Comm Mental Hlth Care Ctr ^*

Author keywords

Antipsychotic agents; Biological psychiatry; Pharmacogenetics; Psychopharmacology

Indexed keywords

DOPAMINE 2 RECEPTOR;

ARTICLE; CAUCASIAN; CONTROLLED STUDY; EUROPE; FINLAND; GENE DELETION; GENE FREQUENCY; GENE INSERTION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; HUMAN; INCIDENCE; JAPAN; MAJOR CLINICAL STUDY; MUTATIONAL ANALYSIS; POPULATION RESEARCH; PRIORITY JOURNAL; RACE DIFFERENCE; SCHIZOPHRENIA;

EID: 0142219728     PISSN: 01651781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-1781(03)00201-4     Document Type: Article

References (13)

1. Arinami T., Gao M., Hamaguchi H., Toru M. A functional polymorphism in the promoter region of the dopamine D2 receptor gene is associated with schizophrenia. Human Molecular Genetics. 6:1997;577-582.
2. Breen G., Brown J., Maude S., Fox H., Collier D., Li T., Arranz M., Shaw D., St Clair D. 141C del/ins polymorphism of the dopamine receptor 2 gene is associated with schizophrenia in a British population. American Journal of Medical Genetics. 88:1999;407-410.
3. Gelernter J., Kranzler H., Cubells J.F., Ichinose H., Nagatsu T. DRD2 allele frequencies and linkage disequilibria, including the -141C Ins/Del promoter polymorphism, in European-American, African-American, and Japanese subjects. Genomics. 51:1998;21-26.
4. Himei A., Koh J., Sakai J., Inada Y., Akabame K., Yoneda H. The influence on the schizophrenic symptoms by the DRD2Ser/Cys311 and -141CIns/Del polymorphisms. Psychiatry and Clinical Neurosciences. 56:2002;97-102.
5. Hori H., Ohmori O., Shinkai T., Kojima H., Nakamura J. Association analysis between two functional dopamine D2 receptor gene polymorphisms and schizophrenia. American Journal of Medical Genetics. 105:2001;176-178.
6. Inada T., Arinami T., Yagi G. Association between a polymorphism in the promoter region of the dopamine D2 receptor gene and schizophrenia in Japanese subjects: replication and evaluation for antipsychotic-related features. International Journal of Neuropsychopharmacology. 2:1999;181-186.
7. Jönsson E.G., Nöthen M.M., Neidt H., Forslund K., Rylander G., Mattila-Evenden M., Åsberg M., Propping P., Sedvall G.C. Association between a promoter polymorphism in the dopamine D2 receptor gene and schizophrenia. Schizophrenia Research. 40:1999;31-36.
8. Kidd K.K., Morar B., Castiglione C.M., Zhao H., Pakstis A.J., Speed W.C., Bonne-Tamir B., Lu R.B., Goldman D., Lee C., Nam Y.S., Grandy D.K., Jenkins T., Kidd J.R. A global survey of haplotype frequencies and linkage disequilibrium at the DRD2 locus. Human Genetics. 103:1998;211-227.
9. Li T., Arranz M., Aitchison K.J., Bryant C., Liu X., Kerwin R.W., Murray R., Sham P., Collier D.A. Case-control, haplotype relative risk and transmission disequilibrium analysis of a dopamine D2 receptor functional promoter polymorphism in schizophrenia. Schizophrenia Research. 32:1998;87-92.
10. Nakane Y., Ohta Y., Radford M.H. Epidemiological studies of schizophrenia in Japan. Schizophrenia Bulletin. 18:1992;75-84.
11. Ohara K., Nagai M., Tani K., Nakamura Y., Ino A., Ohara K. Functional polymorphism of -141C Ins/Del in the dopamine D2 receptor gene promoter and schizophrenia. Psychiatry Research. 81:1998;117-123.
12. Stöber G., Jatzke S., Heils A., Jungkunz G., Knapp M., Mossner R., Riederer P., Lesch K.P. Insertion/deletion variant (-141C Ins/Del) in the 5′ regulatory region of the dopamine D2 receptor gene: lack of association with schizophrenia and bipolar affective disorder. Short communication. Journal of Neural Transmission-General. 105:1998;101-109.
13. Suzuki A., Kondo T., Mihara K., Yasui-Furukori N., Ishida M., Furukori H., Kaneko S., Inoue Y., Otani K. The -141C Ins/Del polymorphism in the dopamine D2 receptor gene promoter region is associated with anxiolytic and antidepressive effects during treatment with dopamine antagonists in schizophrenic patients. Pharmacogenetics. 11:2001;545-550.