Reduced presence of tissue-repairing cells in wounds combined with whole-body irradiation injury is associated with both suppression of proliferation and increased apoptosis

Medical Science Monitor

Volumn 9, Issue 10, 2003, Pages

  Qu, Jifu ^a   Cheng, Tianmin ^a   Shi, Chunmeng ^a   Lin, Yuan ^a   Yan, Guohe ^a   Ran, Xinze ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Proliferation; Whole body irradiation Injury; Wound healing

Indexed keywords

ANTIGEN; CYCLIN DEPENDENT KINASE 4; CYCLIN E; CYCLINE; PROTEIN BAX; PROTEIN BCL 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; FIBROBLAST; HISTOLOGY; IMMUNOHISTOCHEMISTRY; INCISION; MALE; NICK END LABELING; NONHUMAN; RADIATION INJURY; RAT; TISSUE REPAIR; WHOLE BODY RADIATION; WOUND HEALING;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL DIVISION; CYCLIN E; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASES; FEMALE; FIBROBLASTS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MALE; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, WISTAR; TIME FACTORS; WHOLE-BODY IRRADIATION; WOUND HEALING;

EID: 0142184236     PISSN: 12341010     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. st ed. pp.398-428. Beijing (China), People's Liberation Army Press. 1992 (Chinese).
2. Woel RT, Munley MT, Hollis D et al: The time course of radiation therapy-induced reductions in regional perfusion: a prospective study with >5 years of follow-up. Int J Radiat Oncol Biol Phys, 2002; 52: 58-67
3. Qu JF, Gheng TM, Ran XZ: Radiation and impaired wound healing. Chin J Radiol Med Prot, 2002; 22: 245-6 (Chinese)
4. Qu JF, Cheng TM, Hao L: Retrospective study on the cells in the processes of cutaneous wound healing and their effects. Chin Clin Rehabilitation, 2001; 5: 74-5 (Chinese)
5. Moyer KE, Davis A, Saggers GC et al: Wound healing: the role of gap junctional communication in rat granulation tissue maturation. Exp Mol Pathol, 2002; 72: 10-5
6. Bouissou H, Pieraggi MT, Thiers JC: Fibrocytes and activated fibrocytes in the healing of an open skin wound. J Soc Biol, 1999; 193: 41-8
7. Yamaguchi Y, Yoshikawa KK: Cutaneous wound healing: an update. J Dermatol, 2001; 28: 521-34
8. Ben-Hur H, Gurevich P, Huszar M et al: Apoptosis and apoptosis-related proteins (Fas, Fas ligand, Blc-2, p53) in lymphoid elements of human ovarian tumors. Eur J Gynaecol Oncol, 2000; 21: 53-7
9. Toronyi E, Hamar J, Magyar K et al: Antiapoptotic effect of (-)-deprenyl in rat kidney after ischemia-reperfusion. Med Sci Monit, 2002; 8(2): BR65-68
10. Qu JF, Cheng TM, Xu LS et al: Effects of radiation on fibroblasts and their significances. Chin Clin Rehabilitation, 2001; 5: 60-1
11. Carroll LA and Koch RJ: Heparin stimulates production of bFGF and TGF-beta 1 by human normal, keloid, and fetal dermal fibroblasts. Med Sci Monit, 2003; 9(3): BR97-108
12. Zaslawski R, Surowiak P, Dziegiel P et al: Analysis of the expression of estrogen and progesteron receptors, and of PCNA and Ki67 proliferation antigens, in uterine myomata cells in relation to the phase of the menstrual cycle. Med Sci Monit, 2001; 7(5): 908-913
13. Kulldorff M, McShane LM, Schalzkin A et al: Measuring cell proliferation in the rectal mucosa. comparing bromodeoxyuridine (BrdU) and proliferating cell nuclear antigen (PCNA) assays. J Clin Epidemiol, 2000; 53: 875-83
14. Koundrioukoff S, Johsson ZO, Hasan S et al: A direct interaction between proliferating cell nuclear antigen (PCNA) and Cdk2 targets PCNA-interacting proteins for phosphorylation. J Biol Chem, 2000; 275: 22882-7
15. Arooz T, Yam CH, Siu WY et al: On the concentrations of cyclins and cyclin-dependent kinases in extracts of cultured human cells. Biochemistry, 2000; 39: 9494-501
16. Harbour JW, Luo RX, Dei Santi A et al: Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells more through G1. Cell, 1999; 98: 859-69
17. Makarevich AV and Markkula M: Apoptosis and cell proliferation potential of bovine embryos stimulated with insulin-like growth factor I during in vitro maturation and culture. Biol Reprod, 2002; 66: 386-92
18. Gabriel A, Ziolkowski A, Dziambor AP et al: Bcl-2 antigen expression in patients with chronic hepatitis C and advanced fibrosis. Med Sci Monit, 2001; 7(Suppl 1): 181-184
19. Atkinson C, Stewart S, Upton PD et al: Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor. Circulation, 2002; 105: 1672-8
20. Niklaus AL, Babischkin JS, Aberdeen GW et al: Expression of vascular endothelial growth/permeability factor by endometrial glandular epithelial and stromal cells in baboons during the menstrual cycle and after ovariectomy. Endocrinology, 2002; 143: 4007-17
21. Morykwas MJ, Faler BJ, Pearce DJ et al: Effects of varying levels of subatmospheric pressure on the rate of granulation tissue formation in experimental wounds in swine. Ann Plast Surg, 2001; 47: 547-51
22. Thomas DR: Age-Related Changes in Wound Healing. Drugs & Aging, 2001; 18: 607
23. De Ugarte DA, Roberts RL, Lerdluediiporn P et al: Treatment of chronic wounds by local delivery of granulocyte-macrophage colony-stimulating factor in patients with neutrophil dysfunction. Pediatr Surg Int, 2002; 18: 517-20
24. Thomas DW, Harding KG: Wound healing. Br J Surg, 2002; 89: 1203-5
25. Mathes SJ, Alexander J: Radiation injury. Surg Oncol Clin N Am, 1996; 5: 809-24
26. Gabka CJ, Benhaim P, Mathse SJ et al: An experimental model to determine the effect of irradiated tissue on neutrophil function. Plast Reconstr Surg, 1995; 96: 1676-88