β-thalassemia Major: Thin-Section CT Features and Correlation with Pulmonary Function and Iron Overload

Radiology

Volumn 229, Issue 2, 2003, Pages 507-512

  Khong, Pek Lan ^a   Chan, Godfrey C F ^a   Lee, So Lun ^a   Au, Wing Y ^a   Fong, Daniel Y T ^a   Tsang, Kenneth W T ^a   Ooi, Gaik Cheng ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Anemia; Liver, MR; Lung, air trapping; Lung, CT; Lung, function

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CORRELATION ANALYSIS; FEMALE; FORCED EXPIRATORY FLOW; FORCED EXPIRATORY VOLUME; HUMAN; IRON OVERLOAD; LUNG FUNCTION; MALE; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; QUANTITATIVE DIAGNOSIS; RADIODIAGNOSIS; SCHOOL CHILD; SCORING SYSTEM; SIGNAL PROCESSING; THALASSEMIA MAJOR;

ADOLESCENT; ADULT; BETA-THALASSEMIA; CHILD; FEMALE; FORCED EXPIRATORY FLOW RATES; FORCED EXPIRATORY VOLUME; HUMANS; IRON OVERLOAD; LIVER; LIVER DISEASES; LOGISTIC MODELS; LUNG; LUNG DISEASES, OBSTRUCTIVE; MAGNETIC RESONANCE IMAGING; MALE; MULTIVARIATE ANALYSIS; PULMONARY VENTILATION; TOMOGRAPHY, X-RAY COMPUTED; VITAL CAPACITY;

EID: 0142178315     PISSN: 00338419     EISSN: None     Source Type: Journal    
DOI: 10.1148/radiol.2292021805     Document Type: Article

References (39)

1. Lau YL, Chan LC, Chan YY, et al. Prevalence and genotypes of alpha- and beta-thalassemia carriers in Hong Kong: implications for population screening. N Engl J Med 1997; 336:1298-1301.
2. Factor JM, Pottipati SR, Rappoport I, Rosner IK, Lesser ML, Giardina PJ. Pulmonary function abnormalities in thalassemia major and the role of iron overload. Am J Respir Crit Care Med 1994; 149:1570-1574.
3. Dimopoulou I, Kremastinos DT, Maris TG, Mavrogeni S, Tzelepis GE. Respiratory function in patients with thalassaemia and iron overload. Eur Respir J 1999; 13:602-605.
4. Tai DYH, Wang YT, Lou J, Wang WY, Mak KH, Cheng HK. Lungs in thalassaemia major patients receiving regular transfusion. Eur Respir J 1996; 9:1389-1394.
5. Kani N, Shamseddine A, Gharzeddine W, et al. Relation of ferritin levels to pulmonary function in patients with thalassemia major and the acute effects of transfusion. Eur J Haematol 2000; 64:396-400.
6. Filosa A, Esposito V, Meoli I, Baron I, Romano L. Evidence of lymphocyte alveolitis by bronchoalveolar lavage in thalassemic patients with pulmonary dysfunction. Acta Haematol 2000; 103:90-95.
7. Fung KP, Chow OKW, So SY, Yuen PMB. Pulmonary function in thalassemia major. J Pediatr 1987; 111:534-537.
8. Li AM, Chan D, Li CK, Wong E, Chan YL, Fok, TF. Respiratory function in patients with thalassaemia major: relation with iron overload. Arch Dis Child 2002; 87:328-330.
9. Keens TG, O'Neal MH, Ortega JA, Hyman CB, Platzker ACG. Pulmonary function abnormalities in thalassemia patients on a hypertransfusion program. Pediatrics 1980; 65:1013-1017.
10. Hoyt RW, Scarpa N, Wilmott RW, Cohen A, Schwartz E. Pulmonary function abnormalities in homozygous beta-thalassemia. J Pediatr 1986; 109:452-455.
11. Ooi GC, Khong PL, Lam WK, Trendell-Smith NJ, Tsang KWT. Pulmonary iron overload in thalassemia major presenting as small airway disease. Acta Haematol 2002; 108:43-46.
12. Ng CS, Desai SR, Rubens MB, Padley SPG, Wells AU, Hansell DM. Visual quantitation and observer variation of signs of small airways disease at inspiratory and expiratory CT. J Thorac Imaging 1999; 14:279-285.
13. Chen D, Webb WR, Storto ML, Lee KN. Assessment of air trapping using postexpiratory high-resolution computed tomography. J Thorac Imaging 1998; 13:135-143.
14. Arakawa H, Webb WR. Expiratory high-resolution CT scan. Radiol Clin North Am 1998; 36:189-209.
15. Siegel MJ, Bhalla S, Gutierrez FR, Hildebolt C, Sweet S. Post-lung transplantation bronchiolitis obliterans syndrome: usefulness of expiratory thin-section CT for diagnosis. Radiology 2001; 220:455-462.
16. Webb WR, Stern EJ, Kanth N, Gamsu G. Dynamic pulmonary CT: findings in healthy adult men. Radiology 1993; 186:117-124.
17. Standardization of spirometry: 1994 update,. American Thoracic Society. Am J Respir Crit Care Med 1995; 152:1107-1136.
18. Ip MSM, Karlberg EM, Karlberg PE, Luk KDK, Leong JCY. Lung function reference values in Chinese children and adolescents in Hong Kong. Am J Respir Crit Care Med 2000; 162:424-429.
19. Chen FE, Ooi GC, Ha SY, et al. Genetic and clinical features of hemoglobin H disease in Chinese patients. N Engl J Med 2000; 343:544-550.
20. Lucidarme O, Coche E, Cluzel P, Mourey-Gerosa I, Howarth N, Grenier P. Expiratory CT scans for chronic airway disease: correlation with pulmonary function test results. AJR Am J Roentgenol 1998; 170:301-307.
21. Arakawa H, Webb WR. Air trapping on expiratory high-resolution CT scans in the absence of inspiratory scan abnormalities: correlation with pulmonary function tests and differential diagnosis. AJR Am J Roentgenol 1998; 170:1349-1353.
22. Stern E, Frank MS. Small-airway diseases of the lungs: findings at expiratory CT. AJR Am J Roentgenol 1994; 163:37-41.
23. Hansell DM, Wells AU, Rubens MB, Cole PJ. Bronchiectasis: functional significance of areas of decreased attenuation at expiratory CT. Radiology 1994; 193:369-374.
24. Pifferi M, Caramella D, Ragazzo V, Pietrobelli A, Boner AL. Low-density areas on high-resolution computed tomograms in chronic pediatric asthma. J Pediatr 2002; 141:104-108.
25. Miller WT, Kotloff RM, Blumenthal NP, Aronchick JM, Gefter WB, Miller WT. Utility of high resolution computed tomography in predicting bronchiolitis obliterans syndrome following lung transplantation: preliminary findings. J Thorac Imaging 2001; 16:76-80.
26. Ooi GC, Khong PL, Chan-Yeung M, et al. High-resolution CT quantification of bronchiectasis: clinical and functional correlation. Radiology 2002; 225:663-672.
27. Magkanas E, Voloudaki A, Bouros D, et al. Pulmonary sarcoidosis: correlation of expiratory high-resolution CT findings with inspiratory patterns and pulmonary function tests. Acta Radiol 2001; 42:494-501.
28. Perez T, Remy-Jardin M, Cortet B. Airways involvement in rheumatoid arthritis: clinical, functional and HRCT findings. Am J Respir Crit Care Med 1998; 157:1658-1665.
29. Stern EJ, Webb WR, Golden JA, Gamsu G. Cystic lung disease associated with eosinophilic granuloma and tuberous sclerosis: air trapping at dynamic ultrafast high-resolution CT. Radiology 1992; 182:325-329.
30. Cooper DM, Mansell AL, Weiner MA, et al. Low lung capacity and hypoxemia in children with thalassemia major. Am Rev Respir Dis 1980; 121:639-646.
31. Cappell DF, Hutchinson HE, Jowett M. Transfusional siderosis: the effects of excessive iron deposits on the tissues. J Pathol Bacteriol 1957; 74:245-264.
32. Santamaria F, Villa MP, Werner B, Cutrera R, Barreto M, Ronchetti R. The effect of transfusion on pulmonary function in patients with thalassemia major. Pediatr Pulmonol 1994; 18:139-143.
33. Cunningham EL, Brody JS, Jain BP. Lung growth induced by hypoxia. J Appl Physiol 1974; 37:362-366.
34. Angelucci E, Brittenham GM, McLaren CE, et al. Hepatic iron concentration and total body iron stores in thalassemia major. N Engl J Med 2000; 343:327-331.
35. Gomori JM, Horev G, Tamary H, et al. Hepatic iron overload: quantitative MR imaging. Radiology 1991; 179:367-369.
36. Ernst O, Sergent G, Bonvarlet P, Canva-Delcambre V, Paris JC, L'Herminé C. Hepatic iron overload: diagnosis and quantification with MR imaging. AJR Am J Roentgenol 1997; 168:1205-1208.
37. Ooi GC, Chen FE, Chan KN, et al. Qualitative and quantitative magnetic resonance imaging in haemoglobin H disease: screening for iron overload. Clin Radiol 1999; 54:98-102.
38. Filosa A, Esposito V, Meoli I, Stefanelli F, Cassandro R. Evidence of a restrictive spirometric pattern in older thalassemic patients. Respiration 2001; 68:273-278.
39. Villa MP, Rotili PL, Santamaria F, et al. Physical performance in patients with thalassemia before and after transfusion. Pediatr Pulmonol 1996; 21:367-372.