Lungs in thalassaemia major patients receiving regular transfusion

European Respiratory Journal

Volumn 9, Issue 7, 1996, Pages 1389-1394

  Tai, D Y H ^a   Wang, Y T ^a   Lou, J ^a   Wang, W Y ^b   Mak, K H ^a   Cheng, H K ^a  

^a TAN TOCK SENG HOSPITAL   (Singapore)

^b Advanced Imaging (Radiology)   (Singapore)

Author keywords

alveolocapillary membrane block; restrictive lung function; thalassaemia major; transfer factor

Indexed keywords

IRON;

ADOLESCENT; ADULT; ARTERIAL OXYGEN SATURATION; ARTICLE; BICYCLE ERGOMETRY; BLOOD TRANSFUSION; CHILD; CLINICAL ARTICLE; FEMALE; FORCED EXPIRATORY VOLUME; GAS DIFFUSION; HUMAN; INTERSTITIAL LUNG DISEASE; LUNG DISEASE; LUNG FIBROSIS; LUNG PARENCHYMA; LUNG TRANSFER FACTOR; MALE; PRIORITY JOURNAL; THALASSEMIA MAJOR; TOTAL LUNG CAPACITY;

ADOLESCENT; BETA-THALASSEMIA; BLOOD TRANSFUSION; BLOOD-AIR BARRIER; ECHOCARDIOGRAPHY; EXERCISE TEST; FEMALE; HUMANS; IRON OVERLOAD; LUNG; LUNG DISEASES; MALE; RESPIRATORY FUNCTION TESTS; SPIROMETRY;

EID: 0030017799     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/09031936.96.09071389     Document Type: Article

References (38)

1. Nathan DO, Gunn RB. Thalassemia: the consequences of unbalanced hemoglobin synthesis. Am J Med1966; 41:815-830.
2. Factor JM, Pottipati S, Rappaport I, Rosner IK, Lesser ML, Giardina PJ. Pulmonary function abnormalities in thalassemia major and the role of iron overload. Am J Respir Crit Care Med1994; 149: 1570-1574
3. Witzleben CL, Wyatt JP. The effect of long-term survival on the pathology of thalassemia major. J Path Bact1961; 82:1-12.
4. Cappell DP, Hutchinson HE, Jowett M. Transfusional siderosis: the effects of excessive iron deposits on the tissues. J Path Bact1957; 74:245-264.
5. Cooper DM, Mansell AL, Weiner MA, et al. Low lung capacity and hypoxemia in children with thalassemia major. Am Rev Respir Dis1980; 121:639-646.
6. Fung KP, Chow OKW, So SY, Yuen PMB. Pulmonary function in thalassemia major. J Pediatr1987; 111:543-547.
7. Keens TG, O'Neal MH, Ortega JA, Hyman CB, Platzker ACG. Pulmonary function abnormalities in thalassemia patients on a hypertransfusion program. Pediatrics1980; 65: 1013-1017.
8. Hoyt RW, Scarpa N, Wilmott RW, Cohen A, Schwartz E. Pulmonary function abnormalities in homozygous beta-thalassemia. J Pediatr1986; 109:452-455.
9. Ehlers KH, Giardina PJ, Lesser ML, Engle MA, Hilgartner MW. Prolonged survival in patients with beta-thalassemia treated with desferrioxamine. J Pediatr1991; 118:540-545.
10. Brittenham AM, Griffith PM, Nienhuis AW. Desferrioxamine use protects against heart disease and death from transfusional iron overload in thalassemia major (Abstract). Blood1988; 72 (Suppl. 1): 56a.
11. Recommendations of the British Thoracic Society and the Association of Respiratory Technicians and Physiologists. Topical review: guidelines for the measurement of respiratory function. Respir Med1994; 88:165-194.
12. Ogilvie CM, Forster RE, Blakemore WS, Motion JW. A standardised hreathholding technique for the clinical measurement of the diffusing capacity of the lung for carbon monoxide. J Clin Invest1957; 36:1-17.
13. Jones RS, Meade F. A theoretical and experimental analysis of anomalies in the estimation of pulmonary diffusing capacity by the single-breath method. Q J Exp Physiol1961; 46:131-143.
14. Cotes JE, Dabbs JM, Elwood PC, Hall AM, McDonald A, Saunders M. Iron deficiency: its effect on transfer factor. Clin Sci1972; 42:325-335.
15. Krogh M. The diffusion of gases through the lungs of man. J Physiol (Lond)1972; 49:271-300.
16. Roughton FJW, Forster RE. Relative importance of diffusion and chemical reaction rates in determining rate of exchange of gases in the human lung: with special reference to true diffusing capacity of pulmonary membrane and volume of blood in the lung capillaries. J Appl Physiol1957; 11:290-302.
17. Stam H, Kreuzer FJA, Versprille A. Effect of lung volume and positional changes on pulmonary diffusing capacity and its component. J Appl Physiol1991; 71(4): 1477-1488.
18. Frans A, Stanescu DC, Veriter C, Clerbaux T, Brasseur L. Smoking and pulmonary diffusing capacity. Scand J Respir Dis1975; 56:165-183.
19. Van Ganse WF, Ferris BG Jr, Cotes JE. Cigarette smoking and pulmonary diffusing capacity. Am Rev Respir Dis1972; 105:30-41.
20. Dujic Z, Tocilj J, Boschi S, Saric M, Eterovic D. Biphasic lung diffusing capacity: detection of early asbestos-induced changes in lung function. Br J Ind Med1992; 49:260-267.
21. Vijayan VK, Kuppurao KV, Venkatesan P, Sankaran K, Prabhakar R. Pulmonary membrane diffusing capacity and capillary blood volume in tropical eosinophilia. Chest1990; 97: 1386-1389.
22. Bucci G, Cook CD, Barrie H. Studies of respiratory physiology in children. V. Total lung diffusion, diffusing capacity of pulmonary membrane, and pulmonary capillary blood volume in normal subjects from 7 to 40 years of age. J Pediatr1961; 58:820-828.
23. Rosenthal M, Bain SH, Cramer D, et al. Lung function in white children aged 4 to19 years: I. Spirometry. Thorax1993; 48:794-802.
24. Ngiam TE, Lun KC, Vellayappan K, Wong HB, Wee PH. Ventilatory functions of normal Singapore Chinese children. I. Spirometry. J Singapore Pediatr Soc1980; 22:61-71.
25. Rosenthal M, Cramer D, Bain SH, Denison D, Bush A, Warner JO. Lung function in white children aged 4 to19 years. II. Single-breath analysis and plethysmography. Thorax1993; 48:803-808.
26. Cotes JE, Dabhs JM, Hall AM, Axford AT, Laurence KM. Lung volumes, ventilatory capacity, and transfer factor in healthy British boy and girl twins. Thorax1973; 28:709-715.
27. International Labour Office. Guidelines for the use of ILO international classification of radiographs of pneumoconioses. Geneva; International Office, 1980.
28. Marciniuk DD, Gallagher CG. Clinical exercise testing in interstitial lung disease. Clin Chest Med1994; 15:287-303.
29. Kelly MA, Daniele RP. Exercise testing in interstitial lung disease. Clin Chest Med1984; 5:145-156.
30. McLoud TC, Gaensler EA, Carrington CB. Chronic diffuse infiltrative lung disease: newer approaches. Clin Chest Med1984; 5:329-334.
31. Luyt DK, Richards GA, Roode H, Dowdeswell RJ, van Rensburg AJ, Reinach SG. Thalassemia: lung function with reference to iron studies and reactive oxidant status. Pediatr Hematol Oncol1993; 10:13-23.
32. Mansell AL, Bryan AC, Levison M. Relationship of lung recoil to lung volume and maximum expiratory flow in normal children. J Appl Physiol1977; 42:817-823.
33. Bucher U, Reid L. Development of the intrathoracic bronchial tree: the pattern of branching. Thorax1961; 16:207-218.
34. Ward PA, Remick DA. Immune mechanisms in lung injury. In: Fishman A, ed. Pulmonary Diseases and Disorders. New York, McGraw Hill. 1988; pp. 607-619.
35. Malech HL, Gallin JI. Current concepts: immunology. neutrophils and human diseases. N Engl J Med1987; 317:687-694.
36. Santamaria F, Villa MP, Werner B, Cutrera R, Barreto M, Ronchetti R. The effect of transfusion on pulmonary function in patients with thalassemia major. Pediatr Pulmonol1994; 18:139-143.
37. Freedman MH, Grisaru D, Olivieri N, MacLusky I, Thorner PS. Pulmonary syndrome in patients with thalassemia major receiving intravenous deferoxamine infusions. Am J Dis Child1990; 144:565-569.
38. Epler GR, McLoud TC, Gaensler EA, Mikus JP, Carrington CB. Normal chest roentgenograms in chronic diffuse infiltrative lung disease. AT Engl J Med1978; 298:934-939.