Immunoglobulin V(H) gene mutational analysis suggests that blastic variant of mantle cell lymphoma derives from different stages of B-cell maturation

Leukemia Research

Volumn 24, Issue 1, 2000, Pages 27-31

  László, Terézia ^a   Nagy, Mónika ^a   Kelényi, Gábor ^a   Matolcsy, András ^a  

^a UNIVERSITY OF PÉCS   (Hungary)

Author keywords

Immunoglobulin gene; Mantle cell lymphoma blastic variant; Somatic mutation

Indexed keywords

IMMUNOGLOBULIN;

ARTICLE; B LYMPHOCYTE DIFFERENTIATION; CELL LINEAGE; GENE AMPLIFICATION; GENE MUTATION; GENE SEQUENCE; HUMAN; HUMAN CELL; IMMUNOGLOBULIN VARIABLE REGION; MANTLE CELL LYMPHOMA; NUCLEOTIDE SEQUENCE; PATHOGENESIS; POINT MUTATION; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; B-LYMPHOCYTES; CELL DIFFERENTIATION; CELL TRANSFORMATION, NEOPLASTIC; DNA MUTATIONAL ANALYSIS; DNA NUCLEOTIDYLTRANSFERASES; DNA, NEOPLASM; GENE REARRANGEMENT, B-LYMPHOCYTE, HEAVY CHAIN; GENES, IMMUNOGLOBULIN; GERMINAL CENTER; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOPHENOTYPING; LYMPHOMA, MANTLE-CELL; MOLECULAR SEQUENCE DATA; NEOPLASM PROTEINS; POLYMERASE CHAIN REACTION; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; TUMOR STEM CELLS; VDJ RECOMBINASES;

EID: 0344614634     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0145-2126(99)00156-3     Document Type: Article

References (20)

1. Banks P.M., Chan J., Cleary M.L., Delsol G., De Wolf-Peeters C., Gatter K., Grogan T.M., Harris N.L., Isaacson P.G., Jaffe E.S., Mason D., Pileri S., Ralfkiaer E., Stein H., Warnke R. Mantle cell lymphoma. A proposal for unification of morphologic, immunologic, and molecular data. Am. J. Surg. Pathol. 16:1992;637-640.
2. Harris N.L., Jaffe E.S., Stein H., Banks P.M., Chan J.K.C., Cleary M.L., Delsol G., Wolf-Peeters C.D., Falini B., Gatter K.C., Grogan T.M., Isaacson P.G., Knowles D.M., Mason D.Y., Muller-Hermelink H.K., Pileri S.A., Piris M.A., Ralfkiaer E., Warnke R.A. A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood. 84:1994;1361-1392.
3. Ott G., Kalla J., Ott M.M., Schryen B., Katzenberger T., Müller J.G., Müller-Hermelink H.K. Blastoid variants of mantle cell lymphoma: frequent bcl-1 rearrangements at the major translocation cluster region and tetraploid chromosome clones. Blood. 89:1997;1421-1429.
4. Stevenson F., Shaota S., Ottensmeier C., Chapman C., Oscier D., Hamblin T. Insight into the origin and clonal history of B-cell tumors as revealed by analysis of immunoglobulin variable region genes. Immunol. Rev. 162:1998;247-259.
5. Küppers R., Zhao M., Hansmann M.L., Rajewsky K. Tracing B-cell development in human germinal centres by molecular analysis of single cells picked from histological sections. EMBO J. 12:1993;4955-4967.
6. Miller S.A., Dykes D.D., Polesky H.F. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acid Res. 16:1988;1215.
7. Deane M., Norton J.D. Immunoglobulin heavy chain variable region family usage is independent of tumor cell phenotype in human B lineage leukemias. Eur. J. Immunol. 20:1990;2209-2217.
8. H gene are inherently susceptible to amino acid replacement. Immunol. Today. 15:1994;367-373.
9. Kabat EA, Wu TT, Perry HM, Gottesmann KS, Foeller C. Sequences of proteins of immunological interest. U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, 1991.
10. H repertoire. Immunol. Today. 16:1995;237-242.
11. Matolcsy A., Casali P., Liu Y., Knowles D.M. Molecular characterization of IgA- and/or IgG-switched chronic lymphocytic leukemia B-cells. Blood. 89:1997;1732-1739.
12. Shaota S.S., Hamblin T., Oscier D.G., Stevenson F.K. Assessment of the role of clonogenic B lymphocytes in the pathogenesis of multiple myeloma. Leukemia. 8:1994;1285-1289.
13. Pittaluga S., Tierens A., Pinyol M., Campo E., Delabie J., De Wolf-Peeters C. Blastic variant of mantle cell lymphoma show a heterogenous pattern of somatic mutations of the rearranged immunoglobulin heavy chain variable genes. Br. J. Haematol. 102:1998;1301-1306.
14. H genes with no or very little somatic mutations like the physiologic cells of the follicle mantle. Blood. 84:1994;403-407.
15. Andersen N.S., Donovan J.W., Borus J.S., Poor C.M., Neuberg D., Aster J.C., Nadler L.M., Freedman A.S., Gribben J.G. Failure of immunologic purging in mantle cell lymphoma assessed by polymerase chain reaction detection of minimal residual disease. Blood. 90:1997;4212-4221.
16. Du M.Q., Diss T.C., Xu C.F., Wotherspoon A.C., Isaacson P.G., Pan L.X. Ongoing immunoglobulin gene mutations in mantle cell lymphomas. Br. J. Haematol. 96:1997;124-131.
17. Küppers R., Gause A., Rajewsky K. B-cells of chronic lymphatic leukemia express V genes in unmutated form. Leuk. Res. 15:1991;487-496.
18. + chronic lymphocytic leukemia B-cells. J. Exp. Med. 181:1995;1507-1517.
19. H5 gene in B-cell chronic lymphocytic leukemia. J. Exp. Med. 176:1992;1073-1079.
20. H gene sequences and antigen reactivity of monoclonal antibodies produced by human B-1 cells. Evidence for somatic selection. J. Immunol. 158:1997;2477-2489.