메뉴 건너뛰기




Volumn 106, Issue 1-2, 2003, Pages 91-99

Naloxone provokes similar pain facilitation as observed after short-term infusion of remifentanil in humans

Author keywords

Central sensitization; Endogenous opioids; Human; Hyperalgesia; Opioid receptor; Pain sensation

Indexed keywords

NALOXONE; REMIFENTANIL;

EID: 0142165206     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3959(03)00294-X     Document Type: Article
Times cited : (92)

References (54)
  • 1
    • 0036711509 scopus 로고    scopus 로고
    • Naloxone increases pain induced by topical capsaicin in healthy human volunteers
    • Anderson W.S., Sheth R.N., Bencherif B., Frost J.J., Campbell J.N. Naloxone increases pain induced by topical capsaicin in healthy human volunteers. Pain. 99:2002;207-216.
    • (2002) Pain , vol.99 , pp. 207-216
    • Anderson, W.S.1    Sheth, R.N.2    Bencherif, B.3    Frost, J.J.4    Campbell, J.N.5
  • 2
    • 0142196082 scopus 로고    scopus 로고
    • Short-term infusion of the μ-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal that is prevented by the NMDA-antagonist S-ketamine
    • Angst MS, Koppert W, Pahl I, Clark DJ, Schmelz M. Short-term infusion of the μ-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal that is prevented by the NMDA-antagonist S-ketamine. Pain 2003;106:49-57.
    • (2003) Pain , vol.106 , pp. 49-57
    • Angst, M.S.1    Koppert, W.2    Pahl, I.3    Clark, D.J.4    Schmelz, M.5
  • 3
    • 0026585966 scopus 로고
    • A double-blind trial of naloxone in central post-stroke pain
    • Bainton T., Fox M., Bowsher D., Wells C. A double-blind trial of naloxone in central post-stroke pain. Pain. 48:1992;159-162.
    • (1992) Pain , vol.48 , pp. 159-162
    • Bainton, T.1    Fox, M.2    Bowsher, D.3    Wells, C.4
  • 4
    • 0033135982 scopus 로고    scopus 로고
    • Somatotopic activation of opioid systems by target-directed expectations of analgesia
    • Benedetti F., Arduino C., Amanzio M. Somatotopic activation of opioid systems by target-directed expectations of analgesia. J Neurosci. 19:1999;3639-3648.
    • (1999) J Neurosci , vol.19 , pp. 3639-3648
    • Benedetti, F.1    Arduino, C.2    Amanzio, M.3
  • 5
    • 0035128485 scopus 로고    scopus 로고
    • Acute opioid receptor desensitization and tolerance: Is there a link?
    • Borgland S.L. Acute opioid receptor desensitization and tolerance: is there a link? Clin Exp Pharmacol Physiol. 28:2001;147-154.
    • (2001) Clin Exp Pharmacol Physiol , vol.28 , pp. 147-154
    • Borgland, S.L.1
  • 6
    • 0025339554 scopus 로고
    • Subcutaneous formalin induces a segmental release of Met-enkephalin-like material from the rat spinal cord
    • Bourgoin S., Le Bars D., Clot A.M., Hamon M., Cesselin F. Subcutaneous formalin induces a segmental release of Met-enkephalin-like material from the rat spinal cord. Pain. 41:1990;323-329.
    • (1990) Pain , vol.41 , pp. 323-329
    • Bourgoin, S.1    Le Bars, D.2    Clot, A.M.3    Hamon, M.4    Cesselin, F.5
  • 7
    • 0020658311 scopus 로고
    • Pain enhances naloxone-induced hyperalgesia in humans as assessed by somatosensory evoked potentials
    • Buchsbaum M.S., Davis G.C., Naber D., Pickar D. Pain enhances naloxone-induced hyperalgesia in humans as assessed by somatosensory evoked potentials. Psychopharmacology (Berl). 79:1983;99-103.
    • (1983) Psychopharmacology (Berl) , vol.79 , pp. 99-103
    • Buchsbaum, M.S.1    Davis, G.C.2    Naber, D.3    Pickar, D.4
  • 8
    • 0345035480 scopus 로고    scopus 로고
    • Evidence for opiate-activated NMDA processes masking opiate analgesia in rats
    • Celerier E., Laulin J., Larcher A., Le Moal M., Simonnet G. Evidence for opiate-activated NMDA processes masking opiate analgesia in rats. Brain Res. 847:1999;18-25.
    • (1999) Brain Res , vol.847 , pp. 18-25
    • Celerier, E.1    Laulin, J.2    Larcher, A.3    Le Moal, M.4    Simonnet, G.5
  • 10
    • 0024539695 scopus 로고
    • Segmental release of Met-enkephalin-like material from the spinal cord of rats, elicited by noxious thermal stimuli
    • Cesselin F., Bourgoin S., Clot A.M., Hamon M., Le Bars D. Segmental release of Met-enkephalin-like material from the spinal cord of rats, elicited by noxious thermal stimuli. Brain Res. 484:1989;71-77.
    • (1989) Brain Res , vol.484 , pp. 71-77
    • Cesselin, F.1    Bourgoin, S.2    Clot, A.M.3    Hamon, M.4    Le Bars, D.5
  • 11
    • 0029983237 scopus 로고    scopus 로고
    • Remifentanil versus alfentanil: Comparative pharmacokinetics and pharmacodynamics in healthy adult male volunteers
    • Egan T.D., Minto C.F., Hermann D.J., Barr J., Muir K.T., Shafer S.L. Remifentanil versus alfentanil: comparative pharmacokinetics and pharmacodynamics in healthy adult male volunteers. Anesthesiology. 84:1996;821-833.
    • (1996) Anesthesiology , vol.84 , pp. 821-833
    • Egan, T.D.1    Minto, C.F.2    Hermann, D.J.3    Barr, J.4    Muir, K.T.5    Shafer, S.L.6
  • 12
    • 0017317634 scopus 로고
    • Lack of effect of naloxone on pain perception in humans
    • El Sobky A., Dostrovsky J.O., Wall P.D. Lack of effect of naloxone on pain perception in humans. Nature. 263:1976;783-784.
    • (1976) Nature , vol.263 , pp. 783-784
    • El Sobky, A.1    Dostrovsky, J.O.2    Wall, P.D.3
  • 13
    • 0015758661 scopus 로고
    • Disposition of naloxone-7,8,3H in normal and narcotic-dependent men
    • Fishman J., Roffwarg H., Hellman L. Disposition of naloxone-7,8,3H in normal and narcotic-dependent men. J Pharmacol Exp Ther. 187:1973;575-580.
    • (1973) J Pharmacol Exp Ther , vol.187 , pp. 575-580
    • Fishman, J.1    Roffwarg, H.2    Hellman, L.3
  • 14
    • 0036703883 scopus 로고    scopus 로고
    • Sustained morphine exposure induces a spinal dynorphin-dependent enhancement of excitatory transmitter release from primary afferent fibers
    • Gardell L.R., Wang R., Burgess S.E., Ossipov M.H., Vanderah T.W., Malan T.P. Jr., Lai J., Porreca F. Sustained morphine exposure induces a spinal dynorphin-dependent enhancement of excitatory transmitter release from primary afferent fibers. J Neurosci. 22:2002;6747-6755.
    • (2002) J Neurosci , vol.22 , pp. 6747-6755
    • Gardell, L.R.1    Wang, R.2    Burgess, S.E.3    Ossipov, M.H.4    Vanderah, T.W.5    Malan T.P., Jr.6    Lai, J.7    Porreca, F.8
  • 15
    • 0018121518 scopus 로고
    • Placebo analgesia, endorphins, and naloxone
    • Goldstein A., Grevert P. Placebo analgesia, endorphins, and naloxone. Lancet. 2:1978;1385.
    • (1978) Lancet , vol.2 , pp. 1385
    • Goldstein, A.1    Grevert, P.2
  • 16
    • 0021069803 scopus 로고
    • Placebo and naloxone can alter post-surgical pain by separate mechanisms
    • Gracely R.H., Dubner R., Wolskee P.J., Deeter W.R. Placebo and naloxone can alter post-surgical pain by separate mechanisms. Nature. 306:1983;264-265.
    • (1983) Nature , vol.306 , pp. 264-265
    • Gracely, R.H.1    Dubner, R.2    Wolskee, P.J.3    Deeter, W.R.4
  • 17
    • 0018138580 scopus 로고
    • Endorphins: Naloxone fails to alter experimental pain or mood in humans
    • Grevert P., Goldstein A. Endorphins: naloxone fails to alter experimental pain or mood in humans. Science. 199:1978;1093-1095.
    • (1978) Science , vol.199 , pp. 1093-1095
    • Grevert, P.1    Goldstein, A.2
  • 19
    • 0036294426 scopus 로고    scopus 로고
    • Supplementing desflurane-remifentanil anesthesia with small-dose ketamine reduces perioperative opioid analgesic requirements
    • [table]
    • Guignard B., Coste C., Costes H., Sessler D.I., Lebrault C., Morris W., Simonnet G., Chauvin M. Supplementing desflurane-remifentanil anesthesia with small-dose ketamine reduces perioperative opioid analgesic requirements. Anesth Analg. 95:2002;103-108. [table].
    • (2002) Anesth Analg , vol.95 , pp. 103-108
    • Guignard, B.1    Coste, C.2    Costes, H.3    Sessler, D.I.4    Lebrault, C.5    Morris, W.6    Simonnet, G.7    Chauvin, M.8
  • 20
    • 0036233609 scopus 로고    scopus 로고
    • The absence of acute tolerance during remifentanil infusion in volunteers
    • Gustorff B., Nahlik G., Hoerauf K.H., Kress H.G. The absence of acute tolerance during remifentanil infusion in volunteers. Anesth Analg. 94:2002;1223-1228.
    • (2002) Anesth Analg , vol.94 , pp. 1223-1228
    • Gustorff, B.1    Nahlik, G.2    Hoerauf, K.H.3    Kress, H.G.4
  • 21
    • 0033834731 scopus 로고    scopus 로고
    • Neural mechanisms of cutaneous nociceptive pain
    • Koltzenburg M. Neural mechanisms of cutaneous nociceptive pain. Clin J Pain. 16:2000;S131-S138.
    • (2000) Clin J Pain , vol.16
    • Koltzenburg, M.1
  • 22
    • 0028235568 scopus 로고
    • Nociceptor modulated central sensitization causes mechanical hyperalgesia in acute chemogenic and chronic neuropathic pain
    • Koltzenburg M., Torebjörk H.E., Wahren L.K. Nociceptor modulated central sensitization causes mechanical hyperalgesia in acute chemogenic and chronic neuropathic pain. Brain. 117:1994;579-591.
    • (1994) Brain , vol.117 , pp. 579-591
    • Koltzenburg, M.1    Torebjörk, H.E.2    Wahren, L.K.3
  • 23
    • 0034895045 scopus 로고    scopus 로고
    • A new model of electrically evoked pain and hyperalgesia in human skin: The effects of intravenous alfentanil, S(+)-ketamine, and lidocaine
    • Koppert W., Dern S.K., Sittl R., Albrecht S., Schuttler J., Schmelz M. A new model of electrically evoked pain and hyperalgesia in human skin: the effects of intravenous alfentanil, S(+)-ketamine, and lidocaine. Anesthesiology. 95:2001;395-402.
    • (2001) Anesthesiology , vol.95 , pp. 395-402
    • Koppert, W.1    Dern, S.K.2    Sittl, R.3    Albrecht, S.4    Schuttler, J.5    Schmelz, M.6
  • 24
    • 0038787535 scopus 로고    scopus 로고
    • Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans
    • Koppert W, Sittl R, Scheuber K, Alsheimer M, Schmelz M, Schuttler J. Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans. Anesthesiology 2003;99(1):152-9.
    • (2003) Anesthesiology , vol.99 , Issue.1 , pp. 152-159
    • Koppert, W.1    Sittl, R.2    Scheuber, K.3    Alsheimer, M.4    Schmelz, M.5    Schuttler, J.6
  • 25
    • 0037052624 scopus 로고    scopus 로고
    • Potentiation of the excitatory action of NMDA in ventrolateral periaqueductal gray by the mu-opioid receptor agonist, DAMGO
    • Kow L.M., Commons K.G., Ogawa S., Pfaff D.W. Potentiation of the excitatory action of NMDA in ventrolateral periaqueductal gray by the mu-opioid receptor agonist, DAMGO. Brain Res. 935:2002;87-102.
    • (2002) Brain Res , vol.935 , pp. 87-102
    • Kow, L.M.1    Commons, K.G.2    Ogawa, S.3    Pfaff, D.W.4
  • 26
    • 0025868408 scopus 로고
    • Neurogenic hyperalgesia psychophysical studies of underlying mechanisms
    • LaMotte R.H., Shain C.N., Simone D.A., Tsai E.F.P. Neurogenic hyperalgesia psychophysical studies of underlying mechanisms. J Neurophysiol. 66:1991;190-211.
    • (1991) J Neurophysiol , vol.66 , pp. 190-211
    • LaMotte, R.H.1    Shain, C.N.2    Simone, D.A.3    Tsai, E.F.P.4
  • 27
    • 0031937382 scopus 로고    scopus 로고
    • Acute tolerance associated with a single opiate administration: Involvement of N-methyl-D-aspartate-dependent pain facilitatory systems
    • Larcher A., Laulin J.P., Celerier E., Le Moal M., Simonnet G. Acute tolerance associated with a single opiate administration: involvement of N-methyl-D-aspartate-dependent pain facilitatory systems. Neuroscience. 84:1998;583-589.
    • (1998) Neuroscience , vol.84 , pp. 583-589
    • Larcher, A.1    Laulin, J.P.2    Celerier, E.3    Le Moal, M.4    Simonnet, G.5
  • 28
    • 0031814048 scopus 로고    scopus 로고
    • Long-lasting increased pain sensitivity in rat following exposure to heroin for the first time
    • Laulin J.P., Larcher A., Celerier E., Le Moal M., Simonnet G. Long-lasting increased pain sensitivity in rat following exposure to heroin for the first time. Eur J Neurosci. 10:1998;782-785.
    • (1998) Eur J Neurosci , vol.10 , pp. 782-785
    • Laulin, J.P.1    Larcher, A.2    Celerier, E.3    Le Moal, M.4    Simonnet, G.5
  • 29
    • 0036232961 scopus 로고    scopus 로고
    • The role of ketamine in preventing fentanyl-induced hyperalgesia and subsequent acute morphine tolerance
    • [table]
    • Laulin J.P., Maurette P., Corcuff J.B., Rivat C., Chauvin M., Simonnet G. The role of ketamine in preventing fentanyl-induced hyperalgesia and subsequent acute morphine tolerance. Anesth Analg. 94:2002;1263-1269. [table].
    • (2002) Anesth Analg , vol.94 , pp. 1263-1269
    • Laulin, J.P.1    Maurette, P.2    Corcuff, J.B.3    Rivat, C.4    Chauvin, M.5    Simonnet, G.6
  • 30
    • 0023156596 scopus 로고
    • Noxious mechanical stimuli increase the release of Met-enkephalin-like material heterosegmentally in the rat spinal cord
    • Le Bars D., Bourgoin S., Clot A.M., Hamon M., Cesselin F. Noxious mechanical stimuli increase the release of Met-enkephalin-like material heterosegmentally in the rat spinal cord. Brain Res. 402:1987;188-192.
    • (1987) Brain Res , vol.402 , pp. 188-192
    • Le Bars, D.1    Bourgoin, S.2    Clot, A.M.3    Hamon, M.4    Cesselin, F.5
  • 31
    • 0018240415 scopus 로고
    • The mechanism of placebo analgesia
    • Levine J.D., Gordon N.C., Fields H.L. The mechanism of placebo analgesia. Lancet. 2:1978;654-657.
    • (1978) Lancet , vol.2 , pp. 654-657
    • Levine, J.D.1    Gordon, N.C.2    Fields, H.L.3
  • 32
    • 0018741991 scopus 로고
    • Naloxone dose dependently produces analgesia and hyperalgesia in postoperative pain
    • Levine J.D., Gordon N.C., Fields H.L. Naloxone dose dependently produces analgesia and hyperalgesia in postoperative pain. Nature. 278:1979;740-741.
    • (1979) Nature , vol.278 , pp. 740-741
    • Levine, J.D.1    Gordon, N.C.2    Fields, H.L.3
  • 33
    • 0018185529 scopus 로고
    • The narcotic antagonist naloxone enhances clinical pain
    • Levine J.D., Gordon N.C., Jones R.T., Fields H.L. The narcotic antagonist naloxone enhances clinical pain. Nature. 272:1978;826-827.
    • (1978) Nature , vol.272 , pp. 826-827
    • Levine, J.D.1    Gordon, N.C.2    Jones, R.T.3    Fields, H.L.4
  • 34
  • 35
    • 0034950455 scopus 로고    scopus 로고
    • Opioid-induced hyperalgesia and incisional pain
    • Li X., Angst M.S., Clark J.D. Opioid-induced hyperalgesia and incisional pain. Anesth Analg. 93:2001;204-209.
    • (2001) Anesth Analg , vol.93 , pp. 204-209
    • Li, X.1    Angst, M.S.2    Clark, J.D.3
  • 37
    • 0034853835 scopus 로고    scopus 로고
    • Roles of capsaicin-insensitive nociceptors in cutaneous pain and secondary hyperalgesia
    • Magerl W., Fuchs P.N., Meyer R.A., Treede R.D. Roles of capsaicin-insensitive nociceptors in cutaneous pain and secondary hyperalgesia. Brain. 124:2001;1754-1764.
    • (2001) Brain , vol.124 , pp. 1754-1764
    • Magerl, W.1    Fuchs, P.N.2    Meyer, R.A.3    Treede, R.D.4
  • 38
    • 0019995533 scopus 로고
    • The binding spectrum of narcotic analgesic drugs with different agonist and antagonist properties
    • Magnan J., Paterson S.J., Tavani A., Kosterlitz H.W. The binding spectrum of narcotic analgesic drugs with different agonist and antagonist properties. Naunyn Schmiedebergs Arch Pharmacol. 319:1982;197-205.
    • (1982) Naunyn Schmiedebergs Arch Pharmacol , vol.319 , pp. 197-205
    • Magnan, J.1    Paterson, S.J.2    Tavani, A.3    Kosterlitz, H.W.4
  • 39
    • 0037107189 scopus 로고    scopus 로고
    • Chronic morphine induces downregulation of spinal glutamate transporters: Implications in morphine tolerance and abnormal pain sensitivity
    • Mao J., Sung B., Ji R.R., Lim G. Chronic morphine induces downregulation of spinal glutamate transporters: implications in morphine tolerance and abnormal pain sensitivity. J Neurosci. 22:2002;8312-8323.
    • (2002) J Neurosci , vol.22 , pp. 8312-8323
    • Mao, J.1    Sung, B.2    Ji, R.R.3    Lim, G.4
  • 41
    • 0025953580 scopus 로고
    • Mechanically insensitive afferents (Mias) in cutaneous nerves of monkey
    • Meyer R.A., Davis K.D., Cohen R.H., Treede R.D., Campbell J.N. Mechanically insensitive afferents (Mias) in cutaneous nerves of monkey. Brain Res. 561:1991;252-261.
    • (1991) Brain Res , vol.561 , pp. 252-261
    • Meyer, R.A.1    Davis, K.D.2    Cohen, R.H.3    Treede, R.D.4    Campbell, J.N.5
  • 42
    • 0035182654 scopus 로고    scopus 로고
    • Effect of remifentanil on pain and secondary hyperalgesia associated with the heat-capsaicin sensitization model in healthy volunteers
    • Petersen K.L., Jones B., Segredo V., Dahl J.B., Rowbotham M.C. Effect of remifentanil on pain and secondary hyperalgesia associated with the heat-capsaicin sensitization model in healthy volunteers. Anesthesiology. 94:2001;15-20.
    • (2001) Anesthesiology , vol.94 , pp. 15-20
    • Petersen, K.L.1    Jones, B.2    Segredo, V.3    Dahl, J.B.4    Rowbotham, M.C.5
  • 43
    • 0035875701 scopus 로고    scopus 로고
    • Capsaicin responses in heat-sensitive and heat-insensitive A-fiber nociceptors
    • Ringkamp M., Peng Y.B., Wu G., Hartke T.V., Campbell J.N., Meyer R.A. Capsaicin responses in heat-sensitive and heat-insensitive A-fiber nociceptors. J Neurosci. 21:2001;4460-4468.
    • (2001) J Neurosci , vol.21 , pp. 4460-4468
    • Ringkamp, M.1    Peng, Y.B.2    Wu, G.3    Hartke, T.V.4    Campbell, J.N.5    Meyer, R.A.6
  • 44
    • 0036164304 scopus 로고    scopus 로고
    • Fentanyl enhancement of carrageenan-induced long-lasting hyperalgesia in rats: Prevention by the N-methyl-D-aspartate receptor antagonist ketamine
    • Rivat C., Laulin J.P., Corcuff J.B., Celerier E., Pain L., Simonnet G. Fentanyl enhancement of carrageenan-induced long-lasting hyperalgesia in rats: prevention by the N-methyl-D-aspartate receptor antagonist ketamine. Anesthesiology. 96:2002;381-391.
    • (2002) Anesthesiology , vol.96 , pp. 381-391
    • Rivat, C.1    Laulin, J.P.2    Corcuff, J.B.3    Celerier, E.4    Pain, L.5    Simonnet, G.6
  • 46
    • 0033975763 scopus 로고    scopus 로고
    • Encoding of burning pain from capsaicin-treated human skin in two categories of unmyelinated nerve fibres
    • Schmelz M., Schmidt R., Handwerker H.O., Torebjörk H.E. Encoding of burning pain from capsaicin-treated human skin in two categories of unmyelinated nerve fibres. Brain. 123:2000;560-571.
    • (2000) Brain , vol.123 , pp. 560-571
    • Schmelz, M.1    Schmidt, R.2    Handwerker, H.O.3    Torebjörk, H.E.4
  • 48
    • 0037454943 scopus 로고    scopus 로고
    • Opioid-induced hyperalgesia: Abnormal or normal pain?
    • Simonnet G., Rivat C. Opioid-induced hyperalgesia: abnormal or normal pain? NeuroReport. 14:2003;1-7.
    • (2003) NeuroReport , vol.14 , pp. 1-7
    • Simonnet, G.1    Rivat, C.2
  • 49
    • 0026534771 scopus 로고
    • Central changes in processing of mechanoreceptive input in capsaicin-induced secondary hyperalgesia in humans
    • Torebjörk H.E., Lundberg L.E.R., LaMotte R.H. Central changes in processing of mechanoreceptive input in capsaicin-induced secondary hyperalgesia in humans. J Physiol (Lond). 448:1992;765-780.
    • (1992) J Physiol (Lond) , vol.448 , pp. 765-780
    • Torebjörk, H.E.1    Lundberg, L.E.R.2    LaMotte, R.H.3
  • 50
    • 0034555126 scopus 로고    scopus 로고
    • Postsynaptic signaling via the [mu]-opioid receptor: Responses of dorsal horn neurons to exogenous opioids and noxious stimulation
    • Trafton J.A., Abbadie C., Marek K., Basbaum A.I. Postsynaptic signaling via the [mu]-opioid receptor: responses of dorsal horn neurons to exogenous opioids and noxious stimulation. J Neurosci. 20:2000;8578-8584.
    • (2000) J Neurosci , vol.20 , pp. 8578-8584
    • Trafton, J.A.1    Abbadie, C.2    Marek, K.3    Basbaum, A.I.4
  • 51
    • 0031839765 scopus 로고    scopus 로고
    • Rapid development of tolerance to analgesia during remifentanil infusion in humans
    • Vinik H.R., Kissin I. Rapid development of tolerance to analgesia during remifentanil infusion in humans. Anesth Analg. 86:1998;1307-1311.
    • (1998) Anesth Analg , vol.86 , pp. 1307-1311
    • Vinik, H.R.1    Kissin, I.2
  • 52
    • 0033571905 scopus 로고    scopus 로고
    • Functional attributes discriminating mechano-insensitive and mechano-responsive C nociceptors in human skin
    • Weidner C., Schmelz M., Schmidt R., Hansson B., Handwerker H.O., Torebjörk H.E. Functional attributes discriminating mechano-insensitive and mechano-responsive C nociceptors in human skin. J Neurosci. 19:1999;10184-10190.
    • (1999) J Neurosci , vol.19 , pp. 10184-10190
    • Weidner, C.1    Schmelz, M.2    Schmidt, R.3    Hansson, B.4    Handwerker, H.O.5    Torebjörk, H.E.6
  • 54
    • 0032730144 scopus 로고    scopus 로고
    • Secondary hyperalgesia to punctate mechanical stimuli - Central sensitization to A-fibre nociceptor input
    • Ziegler E.A., Magerl W., Meyer R.A., Treede R.D. Secondary hyperalgesia to punctate mechanical stimuli - central sensitization to A-fibre nociceptor input. Brain. 122:1999;2245-2257.
    • (1999) Brain , vol.122 , pp. 2245-2257
    • Ziegler, E.A.1    Magerl, W.2    Meyer, R.A.3    Treede, R.D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.