Specificity of G Protein-Coupled Receptor Kinase 6-Mediated Phosphorylation and Regulation of Single-Cell M3 Muscarinic Acetylcholine Receptor Signaling

Molecular Pharmacology

Volumn 64, Issue 5, 2003, Pages 1059-1068

  Willets, Jonathon M ^a   Mistry, Rajendra ^a   Nahorski, Stefan R ^a   Challiss, R A John ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CASEIN KINASE IALPHA; G PROTEIN COUPLED RECEPTOR KINASE; G PROTEIN COUPLED RECEPTOR KINASE 2; G PROTEIN COUPLED RECEPTOR KINASE 3; G PROTEIN COUPLED RECEPTOR KINASE 5; G PROTEIN COUPLED RECEPTOR KINASE 6; INOSITOL 1,4,5 TRISPHOSPHATE; MUSCARINIC M3 RECEPTOR; PHOSPHOLIPASE C; PHOSPHOTRANSFERASE; PLECKSTRIN; PROTEIN KINASE P60; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL STRAIN; CELL STRAIN SH SY5Y; CONTROLLED STUDY; DESENSITIZATION; ENZYME SPECIFICITY; HUMAN; HUMAN CELL; NEUROBLASTOMA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RECEPTOR DOWN REGULATION; REGULATORY MECHANISM; WILD TYPE;

ATROPINE; BETA-ADRENERGIC RECEPTOR KINASE; CELL LINE; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DRUG INTERACTIONS; HUMANS; MUSCARINIC AGONISTS; MUSCARINIC ANTAGONISTS; PHOSPHORYLATION; PROTEIN KINASE C; PROTEIN-SERINE-THREONINE KINASES; RECEPTOR, MUSCARINIC M3; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY;

EID: 0142148103     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.64.5.1059     Document Type: Article

References (41)

1. Aiyar N, Disa J, Dang K, Pronin AN, Benovic JL, and Nambi P (2000) Involvement of G protein-coupled receptor kinase-6 in desensitization of CGRP receptors. Eur J Pharmacol 403:1-7.
2. Benovic JL, Pike LJ, Cerione RA, Staniszewski C, Yoshimasa T, Codina J, Caron MG, and Lefkowitz RJ (1985) Phosphorylation of the mammalian β-adrenergic receptor by cyclic AMP-dependent protein kinase. J Biol Chem 260:7094-7101.
3. 2 receptor in vivo phosphorylation sites and their role in receptor function. J Biol Chem 276:40431-40440.
4. Brown BL, Albano JDM, Ekins RP, Sgherzi AM, and Tampion W (1971) A simple and sensitive saturation assay method for the measurement of adenosine 3′,5′-cyclic monephosphate. Biochem J 121:561-562.
5. q/11-coupled receptor by casein kinase. J Biol Chem 275:19667-19675.
6. q/11 in SH-SY5Y human neuroblastoma cells. Br J Pharmacol 134:257-264.
7. q/11 by an RGS domain in the G protein-coupled receptor kinase, GRK2. J Biol Chem 274:34483-34492.
8. Challiss RAJ, Batty IH, and Nahorski SR (1988) Mass measurements of inositol-1, 4, 5-trisphosphate in rat cerebral cortex using a radioreceptor assay: effects of neurotransmitters and depolarization. Biochem Biophys Res Commun 157:684-691.
9. Chuang TT, LeVine H III, and DeBlasi A (1995) Phosphorylation and activation of β-adrenergic receptor kinase by protein kinase C. J Biol Chem 270:18660-18665.
10. 2-adrenergic receptor. Mol Pharmacol 36:343-348.
11. Cong M, Perry SJ, Lin F-T, Fraser ID, Hu LA, Chen W, Pitcher JA, Scott JD, and Lefkowitz RJ (2001) Regulation of membrane targeting of the G protein-coupled receptor kinase 2 by protein kinase A and its anchoring protein AKAP79. J Biol Chem 276:15192-15199.
12. DebBurman SK, Kunapuli P, Benovic JL, and Hosey MM (1995) Agonist-dependent phosphorylation of human muscarinic receptor in Spodoptera frugiperda insect cell membranes by G protein-coupled receptor kinases. Mol Pharmacol 47:224-233.
13. 1B adrenergic receptor. J Biol Chem 271:5049-5058.
14. 2-adrenergic receptor via phospho-Tyr-350, phosphorylates G-protein-linked receptor kinase 2 and mediates-induced receptor desensitization. J Biol Chem 276:13240-13247.
15. Ferguson SSG (2001) Evolving concepts in G protein-coupled receptor endocytosis: the role of receptor desensitization and signaling. Pharmacol Rev 53:1-24.
16. Fong AM, Premont RT, Richardson RM, Yu Y-RA, Lefkowitz RJ, and Patel DD (2002) Defective lymphocyte chemotaxis in β-arrestin2- and GRK6-deficient mice. Proc Natl Acad Sci USA 99:7478-7483.
17. Freedman NJ, Ament AS, Oppermann M, Stoffel RH, Exum ST, and Lefkowitz RJ (1997) Phosphorylation and desensitization of human endothelin A and B receptors: evidence for G protein-coupled receptor kinase specificity. J Biol Chem 272:17734-17743.
18. Ghadessy RS, Willets JM, and Kelly E (2003) G protein-coupled receptor kinase 6 (GRK6) selectively regulates secretin receptor responsiveness in NG108-15 cells. Br J Pharmacol 138:660-670.
19. 2+ mobilization patterns. Science (Wash DC) 284:1527-1530.
20. Krupnick JG and Benovic JL (1998) The role of receptor kinases and arrestins in G protein-coupled receptor regulation. Ann Rev Pharmacol Toxicol 38:289-319.
21. 2+-signaling in a human neuroblastoma revealed by cellular differentiation. Br J Pharmacol 126:1559-1566.
22. 2 receptor desensitization. Mol Pharmacol 51:991-998.
23. Mundell SJ, Matharu AL, Pula G, Holman D, Roberts PJ, and Kelly E (2002) Metabotropic glutamate receptor 1 internalization induced by muscarinic acetylcholine receptor activation: differential dependency of internalization of splice variants on nonvisual arrestins. Mol Pharmacol 61:1114-1123.
24. 3 production following G-protein-coupled-receptor activation. Biochem J 356:137-142.
25. Nash MS, Young KW, Challiss RAJ, and Nahorski SR (2001b) Intracellular signalling. Receptor-specific messenger oscillations. Nature (Lond) 413:381-382.
26. Oppermann M, Freedman NJ, Alexander RW, and Lefkowitz RJ (1996) Phosphorylation of the type 1A angiotensin II receptor by G protein-coupled receptor kinases and protein kinase C. J Biol Chem 271:13266-13272.
27. Pitcher JA, Lohse MJ, Codina J, Caron MG, and Lefkowitz RJ (1992) Desensitization of the isolated β2-adrenergic receptor by β-adrenergic receptor kinase, cAMP receptor kinase and protein kinase C occurs via distinct molecular mechanisms. Biochemistry 31:3193-3197.
28. Pronin AN and Benovic JL (1997) Regulation of the G protein-coupled receptor kinase GRK5 by protein kinase C. J Biol Chem 272:3806-3812.
29. Pitcher JA, Freedman NJ, and Lefkowitz RJ (1998) G protein-coupled receptor kinases. Ann Rev Biochem 67:653-692.
30. q. Mol Pharmacol 57:826-831.
31. Shetzline MA, Walker JK, Valenzano KJ, and Premont RT (2002) Vasoactive intestinal polypeptide type-1 receptor regulation. Desensitization, phosphorylation and sequestration. J Biol Chem 277:25519-25526.
32. Tobin AB and Nahorski SR (1993) Rapid agonist-mediated phosphorylation of m3-muscarinic receptors revealed by immunoprecipitation. J Biol Chem 268:9817-9823.
33. Tobin AB, Totty NF, Sterlin AE, and Nahorski SR (1997) Stimulus-dependent phosphorylation of G-protein-coupled receptors by casein kinase 1α. J Biol Chem 272:20844-20849.
34. +-and carbachol-evoked noradrenaline release from the human neuroblastoma SH-SY5Y. Biochem J 297:407-413.
35. 2 receptors. Am J Physiol 277:C859-C869.
36. Willars GB, Nahorski SR, and Challiss RAJ (1998) Differential regulation of muscarinic acetylcholine receptor-sensitive polyphosphoinositide pools and consequences for signaling in human neuroblastoma cells. J Biol Chem 273:5037-5046.
37. 3 muscarinic acetylcholine receptor in human SH-SY5Y cells. Mol Pharmacol 60:321-330.
38. 3 muscarinic acetylcholine receptor phosphorylation and desensitization in human SH-SY5Y neuroblastoma cells. J Biol Chem 277:15523-15529.
39. Willets JM and Kelly E (2001b) Desensitization of endogenously expressed δ-opioid receptors: no evidence for involvement of G protein-coupled receptor kinase 2. Eur J Pharmacol 431:133-141.
40. 2 adenosine receptor desensitization following antisense-induced suppression of G protein-coupled receptor kinase 2 expression. J Neurochem 73:1781-1789.
41. 3-muscarinic receptor and their role in receptor regulation. J Biol Chem 275:9026-9034.