Dopamine and uric acid act as antioxidants in the repair of DNA radicals: Implications in Parkinson's disease

Free Radical Research

Volumn 37, Issue 10, 2003, Pages 1131-1136

  Anderson, Robert F ^a   Harris, Tracy A ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

DNA radicals; Dopamine; Parkinson's disease; Uric acid

Indexed keywords

ANTIOXIDANT; DNA; DOPAMINE; FREE RADICAL; PLASMID DNA; URIC ACID;

ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DNA DETERMINATION; DNA REPAIR; DNA STRAND BREAKAGE; GAMMA RADIATION; OXIDATION REDUCTION POTENTIAL; OXIDATIVE STRESS; PARKINSON DISEASE; PULSE RADIOLYSIS;

ANIMALS; ANTIOXIDANTS; BRAIN; DNA; DNA DAMAGE; DNA REPAIR; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, RADIATION; FREE RADICALS; HUMANS; LIGHT; MODELS, CHEMICAL; OXYGEN; PARKINSON DISEASE; PLASMIDS; REACTIVE OXYGEN SPECIES; URIC ACID;

EID: 0142125713     PISSN: 10715762     EISSN: None     Source Type: Journal    
DOI: 10.1080/10715760310001604134     Document Type: Article

References (34)

1. Halliwell, B. (1992) "Reactive oxygen species and the central nervous system", J. Neurochem. 59, 1609-1623.
2. Zhang, J., Perry, G., Smith, M.A., Robertson, D., Olson, S.J., Graham, D.G. and Montine, T.J. (1999) "Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons", Am. J. Pathol. 154, 1423-1429.
3. Ozawa, T., Hayakawa, M., Katsumata, K., Yoneda, M., Ikebe, S. and Mizuno, Y. (1997) "Fragile mitochondrial DNA: The missing link in the apoptotic neuronal cell death in Parkinson's disease" Biochem. Biophys. Res. Commun. 235, 158-161.
4. Hornykiewicz, O. (1998) "Biochemical aspects of Parkinson's disease", Neurology 51(Suppl. 2), S2-S9.
5. Church, W.H. and Ward, VL. (1994) "Uric acid is reduced in the substantia nigra in Parkinson's disease: effect on dopamine oxidation", Brain Res. Bull. 33, 419-425.
6. Yoritaka, A., Hattori, N., Uchida, K., Tanaka, M., Stadtman, E.R. and Mizuno, Y. (1996) "Immunohistochemical detection of 4-hydroxynonenal protein aducts in Parkinson disease", Proc. Natl Acad. Sci. USA 93, 2696-2701.
7. Alam, Z.I., Daniel, S.E., Lee, A.J., Marsden, D.C., Jenner, P. and Halliwell, B.A. (1997) "A generalised increase in protein carbonyls in the brain in Parkinson's but not incidental Lewy body disease", J. Neurochem. 69, 1326-1329.
8. Alam, Z.I., Jenner, A., Daniel, S.E., Lees, A.J., Cairns, N., Marsden, D.C., Jenner, P. and Halliwell, B. (1997) "Oxidative damage in the Parkinson brain: an apparent selective increase in 8-hydroxyguanine levels in substantia. nigra", J. Neurochem. 69,1196-1203.
9. Jenner, P. and Olanow, C.W. (1998) "Understanding cell death in Parkinson's disease", Ann. Neurol. 44, S72-S84.
10. de la Torre, M.R., Casado, A., Lopez-Fernandez, M.E., Carrascosa, D., Casado, M.C., Venarucci, D. and Venarucci, V (1996) "Human aging brain disorders: role of antioxidant enzymes", Neurochem. Res. 21, 885-888.
11. Perry, T.L., Godin, D.V. and Hansen, S. (1982) "Parkinson's disease: a disorder due to nigral glutathione deficiency?", Neurosci. Lett. 33, 305-310.
12. Cadenas, E. and Davies, K.J.A. (2000) "Mitochondrial free radical generation, oxidative stress, and aging", Free Radic. Biol. Med. 29,222-230.
13. Smythies, J. and Galzigna, L. (1998) "The oxidative metabolism of catecholamines in the brain: a review", Biochim. Biophys. Acta 1380,159-162.
14. Davis, J.W., Grandinetti, A., Waslien, C.I., Ross, G.W., White, L.R. and Morens, D.M. (1996) "Observations on serum uric acid levels and the risk of idiopathic Parkinson's disease", Am. J. Epidemiol. 144,480-484.
15. Ames, B.N., Cathcart, R., Schwiers, E. and Hochstein, P. (1981) "Uric acid provides an antioxiclant defense in humans against oxidant-and radical-caused aging and cancer: a hypothesis", Proc. Natl Acad. Sci. USA 78, 6858-6862.
16. Cohen, A.M., Aberdroth, R.E. and Hochstein, P. (1984) "Inhibition of free-radical induced DNA damage by uric acid", FEBS Lett. 174, 147-150.
17. 2-reactive species in oxygen toxicity in biology", J. Biol. Chem. 265, 13589-13594.
18. Halliwell, B. and Gutteridge, J.M.C. (1990) "Role of free radicals and catalytic metal ions in human disease: an overview", Methods Enzymol. 186,1-85.
19. Halliwell, B. and Aruoma, O.I. (1991) "DNA damage by oxygen-derived species. Its mechanism and measurement in mammalian systems", FEBS Lett. 281, 9-19.
20. Anderson, R.E, Amarasinghe, C., Fisher, L.J., Mak, W.B. and Packer, R.E. (2000) "Reduction in free-radical-induced DNA strand breaks and base damage through fast chemical repair by flavonoids", Free Radic. Res. 33, 91-103.
21. •OH radical-induced strand breaks and base damage through fast chemical repair of DNA radicals", Carcinogenesis 22, 1189-1193.
22. Eldrup, E., Mogensen, P, Jacobsen, J., Pakkenberg, H. and Christensen, N. (1995) "CSF and plasma concentrations of free norepinephrine, dopamme, 3,4-dihydroxyphenylacetic acid (DOPAC), 3,4-dihydroxyphenylalanine (DOPA), and epinephrine in Parkinson's disease" Acta Neurol. Scand. 92, 116-121.
23. van Hemmen, J.J. and Meuling, W.J.A. (1975) "Inactivation of biologically active DNA by γ-ray-induced superoxide radicals and their dismutation products singlet oxygen and hydrogen peroxide", Biochim. Biophys. Acta 402, 133-141.
24. -) in aqueous solution", J. Phys. Chem. Ref. Data 17, 513-886.
25. Hodgkins, PS., Fairman, M.P. and O'Neill, R (1996) "Rejoining of gamma-radiation-induced single-strand breaks in plasmid DNA by human cell extracts: dependence on the concentration of the hydroxyl radical scavenger, tris", Radiat. Res. 145, 24-30.
26. Krokan, H.E., Standal, R. and Slupphaug, G. (1997) "DNA glycosylases in the base excision repair of DNA", Biochem. J. 325,1-16.
27. Anderson, R.E, Denny, W.A., Li, W., Packer, J.E., Tercel, M. and Wilson, W.R. (1997) "Pulse radiolysis studies on the fragmentation of arylmethyl quaternary nitrogen mustards by one-electron reduction in aqueous solution", J. Phys. Chem. A 101, 9704-9709.
28. Steenken, S. and Neta, P. (1982) "One-electron redox potentials of phenols. Hydroxy- and aminophenols and related compounds of biological interest", J. Phys. Chem. 86, 3661-3667.
29. Simic, M.G. and Jovanovic, S.V. (1989) "Antioxidant mechanisms of uric acid", J. Am. Chem. Soc. 111, 5778-5782.
30. Steenken, S. and Jovanovic, S.V. (1997) "How easily oxidizable is DNA? One-electron reduction potentials of adenosine and guanosine radicals in aqueous solution", J. Am. Chem. Soc. 119, 617-618.
31. Schulte-Frohlinde, D., Behrens, G. and Onal, A. (1986) "Lifetime of peroxyl radicals of poly(U), poly(A) and single- and double-stranded DNA and the rate of their reaction with thiols", Int. J. Radiat. Biol. 50, 103-110.
32. Rice, M.E. (2000) "Ascorbate regulation and its neuroprotective role in the brain", Trends Neurosci. 23, 209-216.
33. Williams, N.H. and Yandell, J.K. (1982) "Outer-sphere electron-transfer reactions of ascorbate anions", Aust. J. Chem. 35,1133-1144.
34. • radical-induced damage on DNA", Redox Report 6, 197-199.