Analysis of Intragraft Gene and Protein Expression of the Costimulatory Molecules, CD80, CD86 and CD154, in Orthotopic Liver Transplant Recipients

American Journal of Transplantation

Volumn 3, Issue 11, 2003, Pages 1363-1368

  Bartlett, Adam S R ^a   McCall, John L ^a,b   Ameratunga, Rohan ^b   Yeong, Mee Ling ^b,c   Gane, Ed ^b   Munn, Stephen R ^b  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b AUCKLAND CITY HOSPITAL   (New Zealand)

^c Diagnostic Medlab ^*  (New Zealand)

Author keywords

Acute cellular rejection; CD40 antigens; CD40 ligand; Costimulation; Graft rejection; Liver transplantation

Indexed keywords

B7 ANTIGEN; CD40 LIGAND; CD86 ANTIGEN;

ARTICLE; CELL STIMULATION; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; GENE EXPRESSION; GRAFT SURVIVAL; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; ISCHEMIA; LIVER BIOPSY; LIVER TRANSPLANTATION; PROTEIN EXPRESSION; REPERFUSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCORING SYSTEM;

ANTIGENS, CD; ANTIGENS, CD80; ANTIGENS, CD86; BIOPSY; CD40 LIGAND; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER TRANSPLANTATION; MEMBRANE GLYCOPROTEINS; REPERFUSION INJURY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TIME FACTORS;

EID: 0142090744     PISSN: 16006135     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1600-6135.2003.00259.x     Document Type: Article

References (49)

1. Wells AD, Li XC, Li Y et al. Requirements for T cell apoptosis in the induction of peripheral transplantation tolerance. Nat Med 1999; 5: 1303-1307.
2. Schwartz R. Models of T cell anergy: is there a common molecular mechanism? J Exp Med 1996; 184: 1-8.
3. Kirk AD, Harlan DM, Armstrong NN et al. CTLA4Ig and anti-CD40 ligand prevent renal allograft rejection in primates. Proc Natl Acad Sci U S A 1997; 94: 8789-8794.
4. Larsen CP, Elwood ET, Alexander DZ et al. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature 1996; 381: 434-438.
5. Denton MD, Reul RM, Dharnidharka VR, Fang JC, Ganz P, Briscoe DM. Central role of CD40/CD40 ligand (CD154) interactions in transplant rejection. Pediatr Transplant 1998; 2: 6-15.
6. Larsen CP, Alexander DZ, Hollenbaugh D et al. CD40-gp39 interactions play a critical role during allograft rejection. Transplantation 1996; 61: 4-9.
7. Zheng XX, Schachter AD, Vasconcellos L et al. Increased CD40 ligand gene expression during human renal and murine islet allograft rejection. Transplantation 1998; 65: 1512-1515.
8. Reul RM, Fang JC, Denton MD et al. CD40 and CD40 Ligand are coexpressed on microvessels in vivo in human cardiac allograft rejection. Transplantation 1997; 64: 1765-1774.
9. Gaweco AS, Wiesner RH, Yong S et al. CD40L expression in human liver allogafts during chronic ductopenic rejection. Liver Transpl Surg 1999; 5: 1-7.
10. Gaweco AS, Mitchell BL, Lucas BA, McClatchey KD, Van Thiel DH. CD40 expression on graft infiltrates and parenchymal CD154 (CD40L) induction in human chronic renal allograft rejection. Kidney Int 1999; 55: 1543-1552.
11. Gaweco AS, Wiesner RH, Yong S et al. Kupffer cell expression of CD40L (CD154) in human chronic liver allograft rejection. Transplant Proc 1999; 31: 560-561.
12. Bartlett A, McCall J, Ameratunga R, Munn S. The kinetics of CD154 (CD40L) expression in peripheral blood mononuclear cells of healthy subjects in liver allograft recipients and X-linked hyper-IgM syndrome. Clin Transplant 2000; 14: 520-528.
13. Demetrius AJ, Batts KP, Dhillon AP et al. Banff Schema for grading liver allograft rejection: an international consensus document. Hepatology 1997; 25: 658-663.
14. Chomczynski P, Sacchi N. Single step method of RNA isolation by acid Guanidinuim Thiocyanate-Phenol-Choloforn extraction. Analytic Biochem 1987; 162: 156-159.
15. Biancone L, Segoloni G, Turello E et al. Expression of inducible lymphocyte costimulatory molecules in human renal allograft. Nephrol Dial Transplant 1998; 13: 716-722.
16. Hancock WW, Sayegh MH, Zheng XG, Peach R, Linsley PS, Turka LA. Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vasculaized murine cardiac allograft rejection. Proc Natl Acad Sci U S A 1996; 93: 13967-13972.
17. Ohashi Y, Okazaki H, Sato T, Miura S, Amada N, Yamaguchi M. Function of CD40/CD40L in peritubular capillary of renal allograft rejection. Transplant Proc 2001; 33: 407-408.
18. Afford SC, Randhawa S, Eliopoulos AG, Hubscher SG, Young LS, Adams DH. CD40 activation induces apoptosis in cultered human hepatocytes via induction of cell surface Fas ligand expression and amplifies Fas mediated hepatocyte death during allograft rejection. J Exp Med 1999; 189: 441-446.
19. van Rijen MM, Kuijf ML, Metselaar HJ et al. CD154 is expressed during treatment with calcineurin inhibitors after organ transplantation. Transplantation 2002; 73: 1666-1672.
20. Gauchat JF, Henchoz S, Mazzei G et al. Induction of human IgE synthesis in B cells by mast cells and basophils. Nature 1993; 365: 340-343.
21. Graf D, Korthauer U, Mages HW, Senger G, Kroczek RA. Cloning of TRAP, a ligand for CD40 on human T cells. Eur J Immunol 1992; 22: 3191-3194.
22. Carbone E, Ruggiero G, Terrazzano G et al. A new mechanism of NK cell cytotoxicity activation: the CD40-CD40 ligand interaction. J Exp Med 1997; 185: 2053-2060.
23. van Kooten C, Bancherau J. Functions of CD40 on B cells, dendritic cells and other cells. Curr Opin Immunol 1997; 9: 330-337.
24. Henn V, Slupsky JR, Grafe M et al. CD40 ligand on activated platelets an inflammatory reaction of endothelial cells. Nature 1998; 391: 591-594.
25. Mach F, Schonbeck U, Sukhova GK et al. Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: Implications for CD40-CD40 ligand signaling in atherosclerosis. Proc Nat Acad Sci U S A 1997; 94: 1931-36.
26. van Kooten C, Gerritsma JS, Paape ME, van Es LA, Banchereau J, Daha MR. Possible role for CD40-CD40L in the regulation of interstitial infiltration in the kidney. Kidney Int 1997; 51: 711-721.
27. Bartlett AS, McCall JL, Ameratunga R et al. Costimulatory blockade prevents early rejection, promotes lymphocyte apoptosis, and inhibits the upregulation of intragraft interleukin-6 in an orthotopic liver transplant model in the rat. Liver Transplant 2002; 8: 458-468.
28. Smiley ST, Csizmadia V, Gao W, Turka LA, Hancock WW. Differential effects of cyclosporine A, methylprednisolone, mycophenolate and rapamycin on CD154 induction and requiremnent for NFkB. Transplantation 2000; 70: 415-419.
29. Fuleihan R, Ramesh N, Horner A et al. Cyclosporin A inhibits CD40 ligand expression in T lymphocytes. J Clin Invest 1994; 93: 1315-1320.
30. Flanagan WM, Corthesy B, Bram RJ, Crabtree GR. Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A. Nature 1991; 352: 803.
31. Tsytsykova A, Tsitsikov E, Geha R. The CD40L promoter contains nuclear factor of activated T cells-binding motifs which require AP-1 binding for activation of transcription. J Biol Chem 1996; 271: 3763.
32. Shoker A, Shoker A, George D, Yang H, Baltzan M, Heightened CD40 ligand gene expression in peripheral CD4+ T cells from patients with kidney allograft rejection. Transplantation 2000; 70: 497-505.
33. Armitage RJ, Fanslow WC, Strockbine L et al. Molecular and biological characterisation of a murine ligand for CD40. Nature 1992; 357: 80-82.
34. Lane P, Traunecker A, Hubele S, Inui S, Lanzavecchia A, Grey D. Activated human T cells express a ligand for the human B cell-associated antigen CD40 which participates in T cell-dependent activation of B lymphocytes. Eur J Immunol 1992; 22: 2573-2578.
35. Hermann P, Blanchard D, de Saint-Vis B et al. Expression of a 32-kDa ligand for the CD40 antigen on activated human T lymphocytes. Eur J Immunol 1993; 23: 961-964.
36. Ludewig B, Henn V, Schroder JM, Graf D, Kroczek RA. Induction, regulation, and function of soluble TRAP (CD40 ligand) during interaction of primary CD4+ CD45RA+ T cells with dendritic cells. Eur J Immunol 1996; 26: 3137-3143.
37. Noelle RJ, Roy M, Shepherd DM, Stamenovic I, Ledbetter JA, Aruffo A. A 39-kDa protein on activated helper T cells inds CD40 and transduces the signal for cognate activation on B cells. Proc Nat Acad Sci U S A 1992; 89: 6550-6554.
38. Lenschow D, Walunas T, Bluestone J. CD28/B7 system of T cell costimulation. Annu Rev Immunol 1996; 12: 233-258.
39. Roy M, Aruffo A, Ledbetter J, Linsley P, Kehry M, Noelle R. Studies on the interdependence of GP39 and B7 expression and function during antigen-specific immune responses. Eur J Immunol 1995; 25: 596-603.
40. Hackett C, Dickler H. Immunologic tolerance for immune system-mediated diseases. J Allergy Clin Immunol 1999; 103: 362-370.
41. Yang Y, Wilson J. CD40-ligand dependant T cell activation: requirement of B7-CD28 signalling through CD40. Science 1996; 273: 1862.
42. Durie FH, Foy TM, Masters SR, Laman JD, Noelle RJ. The role of CD40 in the regulation of humoral and cell mediated immunity. Immunol Today 1994; 15: 406-411.
43. Ranheim E, Kipps T. Activated T cells induce expression of B7/BB1 on normal or leukaemic B cells through a C40 dependent signal. J Exp Med 1993; 177: 925-935.
44. Jaiswal AI, Dubey C, Swain SL, Croft M. Regulation of CD40 ligand expression on naive CD4 T cells: a role for TCR but not co-stimulatory signals. Int Immunol 1996; 8: 275-285.
45. Elwood ET, Larsen CT, Cho HR et al. Prolonged acceptance of concordant and discordant xenografts with combined CD40 and CD28 pathway blockade. Transplantation 1998; 65: 1422-1428.
46. Sun H, Subbotin V, Chen C et al. Prevention of chronic rejection in mouse aortic allografts by combined treatment with CTLA4Ig and anti-CD40 Ligand monoclonal antibody. Transplantation 1997; 64: 1838-1856.
47. Tang A, Judge TA, Nickoloff BJ, Turka LA. Suppression of murine allergic contact dermatitis by CTLA4-Ig: tolerance induction of Th2 responses required additional blockade of CD40-ligand. J Immunol 1996; 157: 117.
48. Matzinger P. Tolerance, danger, and the extended family. Annu Rev Immunol 1994; 12: 991-1045.
49. Gallucci S, Lolkema M, Matzinger P. Natural adjuvants: endogenous activators of dendritic cells. Nat Med 1999; 5: 1249-1255.