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Volumn 14, Issue 5, 2003, Pages 533-537

Fibroblast growth factors: Key players in epithelial morphogenesis, repair and cytoprotection

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR 1; FIBROBLAST GROWTH FACTOR 10; FIBROBLAST GROWTH FACTOR 2; FIBROBLAST GROWTH FACTOR 3; FIBROBLAST GROWTH FACTOR RECEPTOR 2; FIBROBLAST GROWTH FACTOR RECEPTOR 4; KERATINOCYTE GROWTH FACTOR; REACTIVE OXYGEN METABOLITE;

EID: 0142090636     PISSN: 09581669     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.copbio.2003.08.003     Document Type: Review
Times cited : (69)

References (49)
  • 1
    • 0035081241 scopus 로고    scopus 로고
    • Fibroblast growth factors
    • reviews 3005
    • Ornitz DM, Itoh N: Fibroblast growth factors. Genome Biol 2001, 2: reviews 3005.
    • (2001) Genome Biol , vol.2
    • Ornitz, D.M.1    Itoh, N.2
  • 2
    • 0027344852 scopus 로고
    • Structural and functional diversity in the FGF receptor multigene family
    • Johnson D.E., Williams L.T. Structural and functional diversity in the FGF receptor multigene family. Adv. Cancer Res. 60:1993;1-41.
    • (1993) Adv. Cancer Res. , vol.60 , pp. 1-41
    • Johnson, D.E.1    Williams, L.T.2
  • 3
    • 0026736833 scopus 로고
    • The FGF family of growth factors and oncogenes
    • Basilico C., Moscatelli D. The FGF family of growth factors and oncogenes. Adv. Cancer Res. 59:1992;115-165.
    • (1992) Adv. Cancer Res. , vol.59 , pp. 115-165
    • Basilico, C.1    Moscatelli, D.2
  • 4
    • 0344109562 scopus 로고    scopus 로고
    • Keratinocyte growth factor: A unique player in epithelial repair processes
    • Werner S. Keratinocyte growth factor: a unique player in epithelial repair processes. Cytokine Growth Factor Rev. 9:1998;153-165.
    • (1998) Cytokine Growth Factor Rev. , vol.9 , pp. 153-165
    • Werner, S.1
  • 6
    • 0038676258 scopus 로고    scopus 로고
    • Regulation of wound healing by growth factors and cytokines
    • Werner S., Grose R. Regulation of wound healing by growth factors and cytokines. Phys. Rev. 83:2003;835-870.
    • (2003) Phys. Rev. , vol.83 , pp. 835-870
    • Werner, S.1    Grose, R.2
  • 7
    • 0002058462 scopus 로고    scopus 로고
    • Modulation of wound repair by members of the fibroblast growth factor family
    • Edited by RAF Clark: Plenum Press: New York
    • Abraham JA, Klagsbrun M: Modulation of wound repair by members of the fibroblast growth factor family. In The Molecular and Cellular Biology of Wound Repair, edn 2. Edited by RAF Clark: Plenum Press: New York; 1996:195-248.
    • (1996) The Molecular and Cellular Biology of Wound Repair, Edn 2. , pp. 195-248
    • Abraham, J.A.1    Klagsbrun, M.2
  • 8
    • 0032510806 scopus 로고    scopus 로고
    • Neuronal defects and delayed wound healing in mice lacking fibroblast growth factor 2
    • Ortega S., Ittmann M., Tsang S.H., Ehrlich M., Basilico C. Neuronal defects and delayed wound healing in mice lacking fibroblast growth factor 2. Proc. Natl. Acad. Sci. USA. 95:1998;5672-5677.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 5672-5677
    • Ortega, S.1    Ittmann, M.2    Tsang, S.H.3    Ehrlich, M.4    Basilico, C.5
  • 9
    • 0033995557 scopus 로고    scopus 로고
    • Compensation by fibroblast growth factor 1 (FGF1) does not account for the mild phenotypic defects observed in FGF2 null mice
    • Miller D.L., Ortega S., Bashayan O., Basch R., Basilico C. Compensation by fibroblast growth factor 1 (FGF1) does not account for the mild phenotypic defects observed in FGF2 null mice. Mol. Cell. Biol. 20:2000;2260-2268.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 2260-2268
    • Miller, D.L.1    Ortega, S.2    Bashayan, O.3    Basch, R.4    Basilico, C.5
  • 10
    • 0036939722 scopus 로고    scopus 로고
    • Fibroblast growth factors and neuroprotection
    • Alzheimer C., Werner S. Fibroblast growth factors and neuroprotection. Adv. Exp. Med. Biol. 513:2002;335-351.
    • (2002) Adv. Exp. Med. Biol. , vol.513 , pp. 335-351
    • Alzheimer, C.1    Werner, S.2
  • 12
    • 0030821282 scopus 로고    scopus 로고
    • A role for FGF-6 in skeletal muscle regeneration
    • Floss T., Arnold H.H., Braun T. A role for FGF-6 in skeletal muscle regeneration. Genes Dev. 11:1997;2040-2051.
    • (1997) Genes Dev. , vol.11 , pp. 2040-2051
    • Floss, T.1    Arnold, H.H.2    Braun, T.3
  • 13
    • 0032557548 scopus 로고    scopus 로고
    • Characterization of recombinant human fibroblast growth factor (FGF)-10 reveals functional similarities with keratinocyte growth factor (FGF-7)
    • Igarashi M., Finch P.W., Aaronson S.A. Characterization of recombinant human fibroblast growth factor (FGF)-10 reveals functional similarities with keratinocyte growth factor (FGF-7). J. Biol. Chem. 273:1998;13230-13235.
    • (1998) J. Biol. Chem. , vol.273 , pp. 13230-13235
    • Igarashi, M.1    Finch, P.W.2    Aaronson, S.A.3
  • 14
    • 0035895835 scopus 로고    scopus 로고
    • Identification of a novel fibroblast growth factor, FGF-22, preferentially expressed in the inner root sheath of the hair follicle
    • Nakatake Y., Hoshikawa M., Asaki T., Kassai Y., Itoh N. Identification of a novel fibroblast growth factor, FGF-22, preferentially expressed in the inner root sheath of the hair follicle. Biochim. Biophys. Acta. 1517:2001;460-463.
    • (2001) Biochim. Biophys. Acta , vol.1517 , pp. 460-463
    • Nakatake, Y.1    Hoshikawa, M.2    Asaki, T.3    Kassai, Y.4    Itoh, N.5
  • 15
    • 0032574824 scopus 로고    scopus 로고
    • Targeted disruption of fibroblast growth factor (FGF) receptor 2 suggests a role for FGF signaling in pregastrulation mammalian development
    • Arman E., Haffner-Krausz R., Chen Y., Heath J.K., Lonai P. Targeted disruption of fibroblast growth factor (FGF) receptor 2 suggests a role for FGF signaling in pregastrulation mammalian development. Proc. Natl. Acad. Sci. USA. 95:1998;5082-5087.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 5082-5087
    • Arman, E.1    Haffner-Krausz, R.2    Chen, Y.3    Heath, J.K.4    Lonai, P.5
  • 16
    • 0033961133 scopus 로고    scopus 로고
    • An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis
    • This paper describes the phenotype of FGFR2-IIIb knockout mice. Agenesis and dysgenesis of several organs were observed, demonstrating that FGFR2-IIIb is crucial for epithelial morphogenesis
    • De Moerlooze L., Spencer-Dene B., Revest J., Hajihosseini M., Rosewell I., Dickson C. An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis. Development. 127:2000;483-492 This paper describes the phenotype of FGFR2-IIIb knockout mice. Agenesis and dysgenesis of several organs were observed, demonstrating that FGFR2-IIIb is crucial for epithelial morphogenesis.
    • (2000) Development , vol.127 , pp. 483-492
    • De Moerlooze, L.1    Spencer-Dene, B.2    Revest, J.3    Hajihosseini, M.4    Rosewell, I.5    Dickson, C.6
  • 17
    • 0035281514 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 2-IIIb acts upstream of Shh and Fgf4 and is required for limb bud maintenance but not for the induction of Fgf8, Fgf10, Msx1 or Bmp4
    • Revest J.M., Spencer-Dene B., Kerr K., De Moerlooze L., Rosewell I., Dickson C. Fibroblast growth factor receptor 2-IIIb acts upstream of Shh and Fgf4 and is required for limb bud maintenance but not for the induction of Fgf8, Fgf10, Msx1 or Bmp4. Dev. Biol. 231:2001;47-62.
    • (2001) Dev. Biol. , vol.231 , pp. 47-62
    • Revest, J.M.1    Spencer-Dene, B.2    Kerr, K.3    De Moerlooze, L.4    Rosewell, I.5    Dickson, C.6
  • 18
    • 0035881543 scopus 로고    scopus 로고
    • Development of the thymus requires signaling through the fibroblast growth factor receptor R2-IIIb
    • Revest J.M., Suniara R.K., Kerr K., Owen J.J., Dickson C. Development of the thymus requires signaling through the fibroblast growth factor receptor R2-IIIb. J. Immunol. 167:2001;1954-1961.
    • (2001) J. Immunol. , vol.167 , pp. 1954-1961
    • Revest, J.M.1    Suniara, R.K.2    Kerr, K.3    Owen, J.J.4    Dickson, C.5
  • 20
    • 0037309058 scopus 로고    scopus 로고
    • The IIIb isoform of fibroblast growth factor receptor 2 is required for proper growth and branching of pancreatic ductal epithelium but not for differentiation of exocrine or endocrine cells
    • Pulkkinen M.A., Spencer-Dene B., Dickson C., Otonkoski T. The IIIb isoform of fibroblast growth factor receptor 2 is required for proper growth and branching of pancreatic ductal epithelium but not for differentiation of exocrine or endocrine cells. Mech. Dev. 120:2003;167-175.
    • (2003) Mech. Dev. , vol.120 , pp. 167-175
    • Pulkkinen, M.A.1    Spencer-Dene, B.2    Dickson, C.3    Otonkoski, T.4
  • 21
    • 0032532479 scopus 로고    scopus 로고
    • Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless
    • Min H., Danilenko D.M., Scully S.A., Bolon B., Ring B.D., Tarpley J.E., DeRose M., Simonet W.S. Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless. Genes Dev. 12:1998;3156-3161.
    • (1998) Genes Dev. , vol.12 , pp. 3156-3161
    • Min, H.1    Danilenko, D.M.2    Scully, S.A.3    Bolon, B.4    Ring, B.D.5    Tarpley, J.E.6    DeRose, M.7    Simonet, W.S.8
  • 25
    • 0030028984 scopus 로고    scopus 로고
    • Keratinocyte growth factor is required for hair development but not for wound healing
    • Guo L., Degenstein L., Fuchs E. Keratinocyte growth factor is required for hair development but not for wound healing. Genes Dev. 10:1996;165-175.
    • (1996) Genes Dev. , vol.10 , pp. 165-175
    • Guo, L.1    Degenstein, L.2    Fuchs, E.3
  • 27
    • 0027500633 scopus 로고
    • Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear
    • Mansour S.L., Goddard J.M., Capecchi M.R. Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear. Development. 117:1993;13-28.
    • (1993) Development , vol.117 , pp. 13-28
    • Mansour, S.L.1    Goddard, J.M.2    Capecchi, M.R.3
  • 30
    • 0030786165 scopus 로고    scopus 로고
    • Mouse fibroblast growth factor 10: CDNA cloning, protein characterization, and regulation of mRNA expression
    • Beer H.D., Florence C., Dammeier J., McGuire L., Werner S., Duan D.R. Mouse fibroblast growth factor 10: cDNA cloning, protein characterization, and regulation of mRNA expression. Oncogene. 15:1997;2211-2218.
    • (1997) Oncogene , vol.15 , pp. 2211-2218
    • Beer, H.D.1    Florence, C.2    Dammeier, J.3    McGuire, L.4    Werner, S.5    Duan, D.R.6
  • 31
    • 0037177385 scopus 로고    scopus 로고
    • A role for skin γδ T cells in wound repair
    • Wound healing studies in mice lacking γδ TCR-bearing dendritic epidermal T cells revealed a crucial role of these cells in re-epithelialization, most likely due to their production of FGF-7 and FGF-10
    • Jameson J., Ugarte K., Chen N., Yachi P., Fuchs E., Boismenu R., Havran W.L. A role for skin γδ T cells in wound repair. Science. 296:2002;747-749 Wound healing studies in mice lacking γδ TCR-bearing dendritic epidermal T cells revealed a crucial role of these cells in re-epithelialization, most likely due to their production of FGF-7 and FGF-10.
    • (2002) Science , vol.296 , pp. 747-749
    • Jameson, J.1    Ugarte, K.2    Chen, N.3    Yachi, P.4    Fuchs, E.5    Boismenu, R.6    Havran, W.L.7
  • 32
    • 0028117098 scopus 로고
    • Modulation of epithelial cell growth by intraepithelial γδ T cells
    • Boismenu R., Havran W.L. Modulation of epithelial cell growth by intraepithelial γδ T cells. Science. 266:1994;1253-1255.
    • (1994) Science , vol.266 , pp. 1253-1255
    • Boismenu, R.1    Havran, W.L.2
  • 33
    • 0042203636 scopus 로고    scopus 로고
    • Fibroblast growth factor 22 and its potential role during skin development and repair
    • Beyer T.A., Werner S., Dickson C., Grose R. Fibroblast growth factor 22 and its potential role during skin development and repair. Exp. Cell. Res. 287:2003;228-236.
    • (2003) Exp. Cell. Res. , vol.287 , pp. 228-236
    • Beyer, T.A.1    Werner, S.2    Dickson, C.3    Grose, R.4
  • 34
    • 0030023110 scopus 로고    scopus 로고
    • Increased expression of keratinocyte growth factor messenger RNA associated with inflammatory bowel disease
    • Finch P.W., Pricolo V., Wu A., Finkelstein S.D. Increased expression of keratinocyte growth factor messenger RNA associated with inflammatory bowel disease. Gastroenterology. 110:1996;441-451.
    • (1996) Gastroenterology , vol.110 , pp. 441-451
    • Finch, P.W.1    Pricolo, V.2    Wu, A.3    Finkelstein, S.D.4
  • 36
    • 0037195101 scopus 로고    scopus 로고
    • Protection of the intestinal mucosa by intra-epithelial γδ T cells
    • Using a dextran sulfate sodium induced mouse model of colitis, the authors demonstrate increased mucosal injury and delayed tissue repair in FGF-7-deficient mice. Delayed repair was also reported in mice lacking FGF-7 producing γδ TCR-bearing dendritic epidermal T cells
    • Chen Y., Chou K., Fuchs E., Havran W.L., Boismenu R. Protection of the intestinal mucosa by intra-epithelial γδ T cells. Proc. Natl. Acad. Sci. USA. 99:2002;14338-14343 Using a dextran sulfate sodium induced mouse model of colitis, the authors demonstrate increased mucosal injury and delayed tissue repair in FGF-7-deficient mice. Delayed repair was also reported in mice lacking FGF-7 producing γδ TCR-bearing dendritic epidermal T cells.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 14338-14343
    • Chen, Y.1    Chou, K.2    Fuchs, E.3    Havran, W.L.4    Boismenu, R.5
  • 37
    • 0042804872 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor signalling is crucial for liver homeostasis and repair
    • By expression of a dominant-negative FGF receptor mutant in hepatocytes of transgenic mice, a crucial role of FGF receptor signalling in hepatocyte proliferation after partial hepatectomy was observed. This is the first in vivo evidence for a function of FGFs in liver repair
    • Steiling H., Wüstefeld T., Bugnon P., Brauchle M., Fässler R., Teupser D., Thiery J., Gordon J.I., Trautwein C., Werner S. Fibroblast growth factor receptor signalling is crucial for liver homeostasis and repair. Oncogene. 22:2003;4380-4388 By expression of a dominant-negative FGF receptor mutant in hepatocytes of transgenic mice, a crucial role of FGF receptor signalling in hepatocyte proliferation after partial hepatectomy was observed. This is the first in vivo evidence for a function of FGFs in liver repair.
    • (2003) Oncogene , vol.22 , pp. 4380-4388
    • Steiling, H.1    Wüstefeld, T.2    Bugnon, P.3    Brauchle, M.4    Fässler, R.5    Teupser, D.6    Thiery, J.7    Gordon, J.I.8    Trautwein, C.9    Werner, S.10
  • 38
    • 0029102375 scopus 로고
    • Expression of fibroblast growth factor receptors flg and bek during hepatic ontogenesis and regeneration in the rat
    • Hu Z., Evarts R.P., Fujio K., Marsden E.R., Thorgeirsson S.S. Expression of fibroblast growth factor receptors flg and bek during hepatic ontogenesis and regeneration in the rat. Cell. Growth Differ. 6:1995;1019-1025.
    • (1995) Cell. Growth Differ. , vol.6 , pp. 1019-1025
    • Hu, Z.1    Evarts, R.P.2    Fujio, K.3    Marsden, E.R.4    Thorgeirsson, S.S.5
  • 39
    • 0034685916 scopus 로고    scopus 로고
    • Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4
    • Yu C., Wang F., Kan M., Jin C., Jones R.B., Weinstein M., Deng C.X., McKeehan W.L. Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4. J. Biol. Chem. 275:2000;15482-15489.
    • (2000) J. Biol. Chem. , vol.275 , pp. 15482-15489
    • Yu, C.1    Wang, F.2    Kan, M.3    Jin, C.4    Jones, R.B.5    Weinstein, M.6    Deng, C.X.7    McKeehan, W.L.8
  • 40
    • 0036898019 scopus 로고    scopus 로고
    • Increased carbon tetrachloride-induced liver injury and fibrosis in FGFR4-deficient mice
    • Yu C., Wang F., Jin C., Wu X., Chan W.K., McKeehan W.L. Increased carbon tetrachloride-induced liver injury and fibrosis in FGFR4-deficient mice. Am. J. Pathol. 161:2002;2003-2010.
    • (2002) Am. J. Pathol. , vol.161 , pp. 2003-2010
    • Yu, C.1    Wang, F.2    Jin, C.3    Wu, X.4    Chan, W.K.5    McKeehan, W.L.6
  • 41
    • 0033079839 scopus 로고    scopus 로고
    • Keratinocyte growth factor-2 accelerates wound healing in incisional wounds
    • Jimenez P.A., Rampy M.A. Keratinocyte growth factor-2 accelerates wound healing in incisional wounds. J. Surg. Res. 81:1999;238-242.
    • (1999) J. Surg. Res. , vol.81 , pp. 238-242
    • Jimenez, P.A.1    Rampy, M.A.2
  • 42
    • 0035677239 scopus 로고    scopus 로고
    • Randomized trial of topically applied repifermin (recombinant human keratinocyte growth factor-2) to accelerate wound healing in venous ulcers
    • This clinical study describes a beneficial effect of FGF-10 for the treatment of human venous ulcers
    • Robson M.C., Phillips T.J., Falanga V., Odenheimer D.J., Parish L.C., Jensen J.L., Steed D.L. Randomized trial of topically applied repifermin (recombinant human keratinocyte growth factor-2) to accelerate wound healing in venous ulcers. Wound Repair Regen. 9:2001;347-352 This clinical study describes a beneficial effect of FGF-10 for the treatment of human venous ulcers.
    • (2001) Wound Repair Regen. , vol.9 , pp. 347-352
    • Robson, M.C.1    Phillips, T.J.2    Falanga, V.3    Odenheimer, D.J.4    Parish, L.C.5    Jensen, J.L.6    Steed, D.L.7
  • 43
    • 0037097583 scopus 로고    scopus 로고
    • Protection from thymic epithelial cell injury by keratinocyte growth factor: A new approach to improve thymic and peripheral T-cell reconstitution after bone marrow transplantation
    • In a murine bone marrow transplantation model, thymic injury and prolonged immune deficiency were prevented by pre-treatment with FGF-7
    • Min D., Taylor P.A., Panoskaltsis-Mortari A., Chung B., Danilenko D.M., Farrell C., Lacey D.L., Blazar B.R., Weinberg K.I. Protection from thymic epithelial cell injury by keratinocyte growth factor: a new approach to improve thymic and peripheral T-cell reconstitution after bone marrow transplantation. Blood. 99:2002;4592-4600 In a murine bone marrow transplantation model, thymic injury and prolonged immune deficiency were prevented by pre-treatment with FGF-7.
    • (2002) Blood , vol.99 , pp. 4592-4600
    • Min, D.1    Taylor, P.A.2    Panoskaltsis-Mortari, A.3    Chung, B.4    Danilenko, D.M.5    Farrell, C.6    Lacey, D.L.7    Blazar, B.R.8    Weinberg, K.I.9
  • 44
    • 0037100314 scopus 로고    scopus 로고
    • Keratinocyte growth factor preserves normal thymopoiesis and thymic microenvironment during experimental graft-versus-host disease
    • After bone marrow transplantation in mice, FGF-7 averted graft-versus-host disease-related injury of thymic epithelial cells
    • Rossi S., Blazar B.R., Farrell C.L., Danilenko D.M., Lacey D.L., Weinberg K.I., Krenger W., Hollander G.A. Keratinocyte growth factor preserves normal thymopoiesis and thymic microenvironment during experimental graft-versus-host disease. Blood. 100:2002;682-691 After bone marrow transplantation in mice, FGF-7 averted graft-versus-host disease-related injury of thymic epithelial cells.
    • (2002) Blood , vol.100 , pp. 682-691
    • Rossi, S.1    Blazar, B.R.2    Farrell, C.L.3    Danilenko, D.M.4    Lacey, D.L.5    Weinberg, K.I.6    Krenger, W.7    Hollander, G.A.8
  • 45
    • 0036360966 scopus 로고    scopus 로고
    • The effects of keratinocyte growth factor in preclinical models of mucositis
    • Using a mouse model of intestinal epithelial injury, the authors demonstrate a potent cytoprotective effect of FGF-7 for intestinal epithelial cells in vivo, suggesting the use of FGF-7 for the treatment of mucositis in cancer patients
    • Farrell C.L., Rex K.L., Chen J.N., Bready J.V., DiPalma C.R., Kaufman S.A., Rattan A., Scully S., Lacey D.L. The effects of keratinocyte growth factor in preclinical models of mucositis. Cell Prolif. 35(Suppl 1):2002;78-85 Using a mouse model of intestinal epithelial injury, the authors demonstrate a potent cytoprotective effect of FGF-7 for intestinal epithelial cells in vivo, suggesting the use of FGF-7 for the treatment of mucositis in cancer patients.
    • (2002) Cell Prolif. , vol.35 , Issue.SUPPL. 1 , pp. 78-85
    • Farrell, C.L.1    Rex, K.L.2    Chen, J.N.3    Bready, J.V.4    DiPalma, C.R.5    Kaufman, S.A.6    Rattan, A.7    Scully, S.8    Lacey, D.L.9
  • 46
    • 0037609493 scopus 로고    scopus 로고
    • Inducible expression of keratinocyte growth factor (KGF) in mice inhibits lung epithelial cell death induced by hyperoxia
    • By inducible expression of FGF-7 and a dominant-negative Akt mutant in the lung of transgenic mice, the authors show that FGF-7 can protect lung epithelial cells from hyperoxia via activation of the antiapoptotic Akt signalling axis
    • Ray P., Devaux Y., Stolz D.B., Yarlagadda M., Watkins S.C., Lu Y., Chen L., Yang X., Ray A. Inducible expression of keratinocyte growth factor (KGF) in mice inhibits lung epithelial cell death induced by hyperoxia. Proc. Natl. Acad. Sci. USA. 100:2003;6098-6103 By inducible expression of FGF-7 and a dominant-negative Akt mutant in the lung of transgenic mice, the authors show that FGF-7 can protect lung epithelial cells from hyperoxia via activation of the antiapoptotic Akt signalling axis.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 6098-6103
    • Ray, P.1    Devaux, Y.2    Stolz, D.B.3    Yarlagadda, M.4    Watkins, S.C.5    Lu, Y.6    Chen, L.7    Yang, X.8    Ray, A.9
  • 47
    • 0030903157 scopus 로고    scopus 로고
    • The human homologue of a bovine non-selenium glutathione peroxidase is a novel keratinocyte growth factor-regulated gene
    • Frank S., Munz B., Werner S. The human homologue of a bovine non-selenium glutathione peroxidase is a novel keratinocyte growth factor-regulated gene. Oncogene. 14:1997;915-921.
    • (1997) Oncogene , vol.14 , pp. 915-921
    • Frank, S.1    Munz, B.2    Werner, S.3
  • 48
    • 0030803334 scopus 로고    scopus 로고
    • A novel type of glutathione peroxidase: Expression and regulation during wound repair
    • Munz B., Frank S., Hubner G., Olsen E., Werner S. A novel type of glutathione peroxidase: expression and regulation during wound repair. Biochem. J. 326:1997;579-585.
    • (1997) Biochem. J. , vol.326 , pp. 579-585
    • Munz, B.1    Frank, S.2    Hubner, G.3    Olsen, E.4    Werner, S.5
  • 49
    • 0036318224 scopus 로고    scopus 로고
    • Nrf2 transcription factor, a novel target of keratinocyte growth factor action which regulates gene expression and inflammation in the healing skin wound
    • The identification of the Nrf2 transcription factor as a target of FGF-7 in keratinocytes suggests a crucial role for Nrf2 in the cytoprotective effect of FGF-7. A function of this transcription factor in wound healing is demonstrated
    • Braun S., Hanselmann C., Gassmann M.G., auf dem Keller U., Born-Berclaz C., Chan K., Kan Y.W., Werner S. Nrf2 transcription factor, a novel target of keratinocyte growth factor action which regulates gene expression and inflammation in the healing skin wound. Mol. Cell. Biol. 22:2002;5492-5505 The identification of the Nrf2 transcription factor as a target of FGF-7 in keratinocytes suggests a crucial role for Nrf2 in the cytoprotective effect of FGF-7. A function of this transcription factor in wound healing is demonstrated.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 5492-5505
    • Braun, S.1    Hanselmann, C.2    Gassmann, M.G.3    Auf Dem Keller, U.4    Born-Berclaz, C.5    Chan, K.6    Kan, Y.W.7    Werner, S.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.