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In a murine bone marrow transplantation model, thymic injury and prolonged immune deficiency were prevented by pre-treatment with FGF-7
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After bone marrow transplantation in mice, FGF-7 averted graft-versus-host disease-related injury of thymic epithelial cells
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Rossi S., Blazar B.R., Farrell C.L., Danilenko D.M., Lacey D.L., Weinberg K.I., Krenger W., Hollander G.A. Keratinocyte growth factor preserves normal thymopoiesis and thymic microenvironment during experimental graft-versus-host disease. Blood. 100:2002;682-691 After bone marrow transplantation in mice, FGF-7 averted graft-versus-host disease-related injury of thymic epithelial cells.
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Braun S., Hanselmann C., Gassmann M.G., auf dem Keller U., Born-Berclaz C., Chan K., Kan Y.W., Werner S. Nrf2 transcription factor, a novel target of keratinocyte growth factor action which regulates gene expression and inflammation in the healing skin wound. Mol. Cell. Biol. 22:2002;5492-5505 The identification of the Nrf2 transcription factor as a target of FGF-7 in keratinocytes suggests a crucial role for Nrf2 in the cytoprotective effect of FGF-7. A function of this transcription factor in wound healing is demonstrated.
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