Determinants of low HDL levels in familial combined hyperlipidemia

Journal of Lipid Research

Volumn 44, Issue 8, 2003, Pages 1536-1544

  Soro, Aino ^a   Jauhiainen, Matti ^b   Ehnholm, Christian ^b   Taskinen, Marja Riitta ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b BIOMEDICUM HELSINKI   (Finland)

Author keywords

Cholesteryl ester transfer protein; HDL2 cholesterol; Hepatic lipase; Insulin resistance; Lipoprotein lipase; Phospholipid transfer protein; Triglycerides

Indexed keywords

APOLIPOPROTEIN A1; CHOLESTEROL; CHOLESTEROL ESTER TRANSFER PROTEIN; HEPARIN; HIGH DENSITY LIPOPROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPOPROTEIN LIPASE; LIVER TRIACYLGLYCEROL LIPASE; PHOSPHOLIPID TRANSFER PROTEIN; TRIACYLGLYCEROL;

ADULT; ARTICLE; BODY MASS; CORRELATION ANALYSIS; ENZYME ACTIVITY; FAMILIAL DISEASE; FAMILIAL HYPERLIPEMIA; FEMALE; HUMAN; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL;

ADULT; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CHOLESTEROL ESTER TRANSFER PROTEINS; CHOLESTEROL, HDL; FEMALE; FINLAND; GLYCOPROTEINS; HUMANS; HYPERLIPIDEMIA, FAMILIAL COMBINED; LIPASE; LIPOLYSIS; LIVER; MALE; MEMBRANE PROTEINS; MIDDLE AGED; PHOSPHOLIPID TRANSFER PROTEINS;

EID: 0142074278     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: 10.1194/jlr.M300069-JLR200     Document Type: Article

References (78)

1. Goldstein, J. L., H. G. Schrott, W. R. Hazzard, E. L. Bierman, and A. G. Motulsky. 1973. Hyperlipidemia in coronary heart disease. II. Genetic analysis of lipid levels in 176 families and delineation of a new inherited disorder, combined hyperlipidemia. J. Clin. Invest. 52: 1544-1568.
2. Grundy, S. M., A. Chait, and J. D. Brunzell. 1987. Familial combined hyperlipidemia workshop. Arteriosclerosis. 7: 203-207.
3. Genest, J. J., S. S. Martin-Munley, J. R. McNamara, J. M. Ordovas, J. Jenner, R. H. Myers, S. R. Silberman, P. W. Wilson, D. N. Salem, and E. J. Schaefer. 1992. Familial lipoprotein disorders in patients with premature coronary artery disease. Circulation. 85: 2025-2033.
4. Nikkilä, E. A., and A. Aro. 1973. Family study of serum lipids and lipoproteins in coronary heart disease. Lancet. 1: 954-958.
5. Castro Cabezas, M., T. W. de Bruin, H. Jansen, L. A. Kock, W. Kortlandt, and D. W. Erkelens. 1993. Impaired chylomicron remnant clearance in familial combined hyperlipidemia. Arterioscler. Thromb. 13: 804-814.
6. de Graaf, J., and A. F. Stalenhoef. 1998. Defects of lipoprotein metabolism in familial combined hyperlipidaemia. Curr. Opin. Lipidol. 9: 189-196.
7. Hunt, S. C., L. L. Wu, P. N. Hopkins, B. M. Stults, H. Kuida, M. E. Ramirez, J-M. Lalouel, and R. R. Williams. 1989. Apolipoprotein, low density lipoprotein subfraction, and insulin associations with familial combined hyperlipidemia. Study of Utah patients with familial dyslipidemic hypertension. Arteriosclerosis. 9: 335-344.
8. Bredie, S. J. H., J. J. T. Cees, P. Smits, and A. F. H. Stalenhoef. 1997. Nonobese patients with familial combined hyperlipidemia are insulin resistant compared with their nonaffected relatives. Arterioscler. Thromb. Vasc. Biol. 17: 1465-1471.
9. Vakkilainen, J., K. V. K. Porkka, I. Nuotio, P. Pajukanta, L. Suurinkeroinen, K. Ylitalo, J. S. A. Viikari, C. Ehnholm, and M-R. Taskinen. 1998. Glucose intolerance in familial combined hyperlipidaemia. Eur. J. Clin. Invest. 28: 24-32.
10. Pihlajamäki, J., L. Karjalainen, P. Karhapää, I. Vauhkonen, and M. Laakso. 2000. Impaired free fatty acid suppression during hyperinsulinemia is a characteristic finding in familial combined hyperlipidemia but insulin resistance is observed only in hypertriglyceridemic patients. Arterioscler. Thromb. Vasc. Biol. 20: 164-170.
11. Barter, P. J., and K. A. Rye. 1996. High density lipoproteins and coronary heart disease. Atherosclerosis. 121: 1-12.
12. Stein, O., and Y. Stein. 1999. Atheroprotective mechanisms of HDL. Atherosclerosis. 144: 285-301.
13. Rye, K. A., M. A. Clay, and P. J. Barter. 1999. Remodelling of high density lipoproteins by plasma factors. Atherosclerosis. 145: 227-238.
14. von Eckardstein, A., J. R. Nofer, and G. Assmann. 2001. High density lipoproteins and arteriosclerosis. Role of cholesterol efflux and reverse cholesterol transport. Arterioscler. Thromb. Vasc. Biol. 21: 13-27.
15. van Tol, A. 2002. Phospholipid transfer protein. Curr. Opin. Lipidol. 13: 135-139.
16. Jiang, X. C., C. Bruce, J. Mar, M. Lin, Y. Ji, O. L. Francone, and A. R. Tall. 1999. Targeted mutation of plasma phospholipid transfer protein gene markedly reduces high-density lipoprotein levels. J. Clin. Invest. 103: 907-914.
17. Qin, S., K. Kawano, C. Bruce, M. Lin, C. Bisgaier, A. R. Tall, and X. Jiang. 2000. Phospholipid transfer protein gene knock-out mice have low high density lipoprotein levels, due to hypercatabolism, and accumulate apoA-IV-rich lamellar lipoproteins. J. Lipid Res. 41: 269-276.
18. Hopkins, G. J., and P. J. Barter. 1986. Role of triglyceride-rich lipoproteins and hepatic lipase in determining the particle size and composition of high density lipoproteins. J. Lipid Res. 27: 1265-1277.
19. Clay, M. A., H. H. Newnham, and P. J. Barter. 1991. Hepatic lipase promotes a loss of apolipoprotein A-I from triglyceride-enriched human high density lipoproteins during incubation in vitro. Arterioscler: Thromb. 11: 415-422.
20. Barrans, A., X. Collet, R. Barbaras, B. Jaspard, J. Manent, C. Vieu, H. Chap, and B. Perret. 1994. Hepatic lipase induces the formation of pre-beta 1 high density lipoprotein (HDL) from triacylglycerol-rich HDL2. A study comparing liver perfusion to in vitro incubation with lipases. J. Biol. Chem. 269: 11572-11577.
21. Newnham, H. H., G. J. Hopkins, S. Devlin, and P. J. Barter. 1990. Lipoprotein lipase prevents the hepatic lipase-induced reduction in particle size of high density lipoproteins during incubation of human plasma. Atherosclerosis. 82: 167-176.
22. Santamarina-Fojo, S., C. Haudenschild, and M. Amar. 1998. The role of hepatic lipase in lipoprotein metabolism and atherosclerosis. Curr. Opin. Lipidol. 9: 211-219.
23. Kee, P., K. A. Rye, J. L. Taylor, P. H. Barrett, and P. J. Barter. 2002. Metabolism of apoA-I as lipid-free protein or as component of discoidal and spherical reconstituted HDLs: studies in wild-type and hepatic lipase transgenic rabbits. Arterioscler. Thromb. Vasc. Biol. 22: 1912-1917.
24. Porkka, K. V. K., I. Nuotio, P. Pajukanta, C. Ehnholm, L. Suurinkeroinen, M. Syvänne, T. Lehtimäki, A. T. Lahdenkari, S. Lahdenpera, K. Ylitalo, M. Antikainen, M. Perola, O. T. Raitakari, P. Kovanen, J. S. A. Viikari, L. Peltonen, and M. R. Taskinen. 1997. Phenotype expression in familial combined hyperlipidaemia. Atherosclerosis. 133: 245-253.
25. Vartiainen, E., P. Puska, P. Jousilahti, H. J. Korhonen, J. Tuomilehto, and A. Nissinen. 1994. Twenty-year trends in coronary risk factors in north Karelia and in other areas of Finland. Int. J. Epidemiol. 23: 495-504.
26. Vartiainen, E., P. Jousilahti, G. Alfthan, J. Sundvall, P. Pietinen, and P. Puska. 2000. Cardiovascular risk factor changes in Finland, 1972-1997. Int. J. Epidemiol. 29: 49-56.
27. Parra, H. J., H. Mezdour, N. Ghalim, J. M. Bard, and J. C. Fruchart. 1990. Differential electroimmunoassay of human LpA-I lipoprotein particles on ready-to-use plates. Clin. Chem. 36: 1431-1435.
28. Taskinen, M. R., T. Kuusi, E. Helve, E. A. Nikkila, and H. Yki-Jarvinen. 1988. Insulin therapy induces antiatherogenic changes of serum lipoproteins in noninsulin-dependent diabetes. Arteriosclerosis. 8: 168-177.
29. Vakkilainen, J., M. Jauhiainen, K. Ylitalo, I. O. Nuotio, J. S. A. Viikari, C. Ehnholm, and M-R. Taskinen. 2002. LDL particle size in familial combined hyperlipidemia: effects of serum lipids, lipoprotein-modifying enzymes, and lipid transfer proteins. J. Lipid Res. 43: 598-603.
30. Damen, J., J. Regts, and G. Scherphof. 1982. Transfer of [14C]phosphatidylcholine between liposomes and human plasma high density lipoprotein. Partial purification of a transfer-stimulating plasma factor using a rapid transfer assay. Biochim. Biophys. Acta. 712: 444-452.
31. Jauhiainen, M., J. Metso, R. Pahlman, S. Blomqvist, A. van Tol, and C. Ehnholm. 1993. Human plasma phospholipid transfer protein causes high density lipoprotein conversion. J. Biol. Chem. 268: 4032-4036.
32. Tahvanainen, E., M. Jauhiainen, H. Funke, E. Vartiainen, J. Sundvall, and C. Ehnholm. 1999. Serum phospholipid transfer protein activity and genetic variation of the PLTP gene. Atherosclerosis. 146: 107-115.
33. Matthews, D. R., J. P. Hosker, A. S. Rudenski, B. A. Naylor, D. F. Treacher, and R. C. Turner. 1985. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 28: 412-419.
34. Groener, J. E., R. W. Pelton, and G. M. Kostner. 1986. Improved estimation of cholesteryl ester transfer/exchange activity in serum or plasma. Clin. Chem. 32: 283-286.
35. Huttunen, J. K., C. Ehnholm, P. K. Kinnunen, and E. A. Nikkila. 1975. An immunochemical method for the selective measurement of two triglyceride lipases in human postheparin plasma. Clin. Chim. Acta. 63: 335-347.
36. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. 2001. Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA. 285: 2486-2497.
37. Glantz, S., and B. Slinker. 1990. Primer of Applied Regression and Analysis of Variance. McGraw-Hill, Inc. New York, NY.
38. Brunzell, J. D., J. J. Albers, A. Chait, S. M. Grundy, E. Groszek, and G. B. McDonald. 1983. Plasma lipoproteins in familial combined hyperlipidemia and monogenic familial hypertriglyceridemia. J. Lipid Res. 24: 147-155.
39. Ribalta, J., A. E. La Ville, J. C. Vallve, J. Girona, and L. Masana. 1998. Evidence against alterations in lecithin:cholesterol acyltransferase (LCAT) activity in familial combined hyperlipidemia. Atheriosclerosis. 138: 383-389.
40. McNeely, M. J., K. L. Edwards, S. M. Marcovina, J. D. Brunzell, A. G. Motulsky, and M. A. Austin. 2001. Lipoprotein and apolipoprotein abnormalities in familial combined hyperlipidemia: a 20-year prospective study. Atherosclerosis. 159: 471-481.
41. Castro Cabezas, M., T. W. de Bruin, H. W. de Valk, C. C. Shoulders, H. Jansen, and D. Willem-Erkelens. 1993. Impaired fatty acid metabolism in familial combined hyperlipidemia. A mechanism associating hepatic apolipoprotein B overproduction and insulin resistance. J. Clin. Invest. 92: 160-168.
42. Tall, A. R. 1995. Plasma cholesteryl ester transfer protein and high-density lipoproteins: new insights from molecular genetic studies. J. Intern. Med. 237: 5-12.
43. Tahvanainen, E., M. Syvanne, M. H. Frick, S. Murtomaki-Repo, M. Antikainen, Y. A. Kesaniemi, H. Kauma, A. Pasternak, M. R. Taskinen, and C. Ehnholm. 1998. Association of variation in hepatic lipase activity with promoter variation in the hepatic lipase gene. The LOCAT Study Investigators. J. Clin. Invest. 101: 956-960.
44. Kuusi, T., C. Ehnholm, J. Viikari, R. Harkonen, E. Vartiainen, P. Puska, and M. R. Taskinen. 1989. Postheparin plasma lipoprotein and hepatic lipase are determinants of hypo- and hyperalphalipoproteinemia. J. Lipid Res. 30: 1117-1126.
45. Katzel, L. I., P. J. Coon, M. J. Busby, S. O. Gottlieb, R. M. Krauss, and A. P. Goldberg. 1992. Reduced HDL2 cholesterol subspecies and elevated postheparin hepatic lipase activity in older men with abdominal obesity and asymptomatic myocardial ischemia. Arterioscler. Thromb. 12: 814-823.
46. Zambon, A., S. S. Deeb, J. E. Hokanson, B. G. Brown, and J. D. Brunzell. 1998. Common variants in the promoter of the hepatic lipase gene are associated with lower levels of hepatic lipase activity, buoyant LDL, and higher HDL2 cholesterol. Arterioscler. Thromb. Vasc. Biol. 18: 1723-1729.
47. Jansen, H., A. J. Verhoeven, L. Weeks, J. J. Kastelein, D. J. Halley, A. van den Ouweland, J. W. Jukema, J. C. Seidell, and J. C. Birkenhager. 1997. Common C-to-T substitution at position -480 of the hepatic lipase promoter associated with a lowered lipase activity in coronary artery disease patients. Arterioscler. Thromb. Vasc. Biol. 17: 2837-2842.
48. Rashid, S., P. H. Barrett, K. D. Uffelman, T. Watanabe, K. Adeli, and G. F. Lewis. 2002. Lipolytically modified triglyceride-enriched HDLs are rapidly cleared from the circulation. Arterioscler. Thromb. Vasc. Biol. 22: 483-487.
49. Lamarche, B., K. D. Uffelman, A. Carpentier J. S. Cohn, G. Steiner, P. H. Barrett, and G. F. Lewis. 1999. Triglyceride enrichment of HDL enhances in vivo metabolic clearance of HDL apo A-I in healthy men. J. Clin. Invest. 103: 1191-1199.
50. van der Kallen, C., C. Voors-Pette, F. Bouwman, H. Keizer, J. Lu, R. van de Hulst, R. Bianchi, M. Janssen, E. Keulen, W. Boeckx, J. Rotter, and T. de Bruin. 2002. Evidence of insulin resistant lipid metabolism in adipose tissue in familial combined hyperlipidemia, but not type 2 diabetes mellitus. Atherosclerosis. 164: 337-346.
51. Ji, Z. S., H. L. Dichek, R. D. Miranda, and R. W. Mahley. 1997. Heparan sulfate proteoglycans participate in hepatic lipase and apolipoprotein E-mediated binding and uptake of plasma lipoproteins, including high density lipoproteins. J. Biol. Chem. 272: 31285-31292.
52. Lambert, G., M. B. Chase, K. Dugi, A. Bensadoun, H. B. Brewer, Jr., and S. Santamarina-Fojo. 1999. Hepatic lipase promotes the selective uptake of high density lipoprotein-cholesteryl esters via the scavenger receptor B1. J. Lipid Res. 40: 1294-1303.
53. Allayee, H., K. M. Dominguez, B. E. Aouizerat, R. M. Krauss, J. I. Rotter, J. Lu, R. M. Cantor, T. W. de Bruin, and A. J. Lusis. 2000. Contribution of the hepatic lipase gene to the atherogenic lipoprotein phenotype in familial combined hyperlipidemia. J. Lipid Res. 41: 245-252.
54. Hoffer, M. J., H. Snieder, S. J. Bredie, P. N. Demacker, J. J. Kastelein, R. R. Frants, and A. F. Stalenhoef. 2000. The V73M mutation in the hepatic lipase gene is associated with elevated cholesterol levels in four Dutch pedigrees with familial combined hyperlipidemia. Atherosclerosis. 151: 443-450.
55. Pihlajamäki, J., L. Karjalainen, P. Karhapää, I. Vauhkonen, M-R. Taskinen, S. S. Deeb, and M. Laakso. 2000. G-250A substitution in promoter of hepatic lipase gene is associated with dyslipidemia and insulin resistance in healthy control subjects and in members of families with familial combined hyperlipidemia. Arterioscler. Thromb. Vasc. Biol. 20: 1789-1795.
56. Pajukanta, P., K. V. K. Porkka, M. Antikainen, M-R. Taskinen, M. Perola, S. Murtomäki-Repo, S. Ehnholm, I. Nuotio, L. Suurinkeroinen, A-T. Lahdenkari, A-C. Syvänen, J. S. A. Viikari, C. Ehnholm, and L. Peltonen. 1997. No evidence of linkage between familial combined hyperlipidemia and genes encoding lipolytic enzymes in Finnish families. Arterioscler. Thromb. Vasc. Biol. 17: 841-850.
57. Pajukanta, P., J. D. Terwilliger, M. Perola, T. Hiekkalinna, I. Nuotio, P. Ellonen, M. Parkkonen, J. Hartiala, K. Ylitalo, J. Pihlajamäki, K. Porkka, M. Laakso, J. Viikari, C. Ehnholm, M-R. Taskinen, and L. Peltonen. 1999. Genomewide scan for familial combined hyperlipidemia genes in Finnish families, suggesting multiple susceptibility loci influencing triglyceride, cholesterol and apolipoprotein B levels. Am. J. Hum. Genet. 64: 1453-1463.
58. Soro, A., P. Pajukanta, H. E. Lilja, K. Ylitalo, J. S. A. Viikari, M-R. Taskinen, and L. Peltonen. 2002. Genome scans provide evidence for low-HDL-C loci on 8q23, 16q24.1-24.2, and 20q13.11 in Finnish families. Am. J. Hum. Genet. 70: 1333-1340.
59. Pajukanta, P., H. Allayee, K. L. Krass, A. Kuraishy, A. Soro, H. E. Lilja, R. Mar, M. R. Taskinen, I. Nuotio, M. Laakso, J. I. Rotter, T. W. De Bruin, R. M. Cantor, A. J. Lusis, and L. Peltonen. 2003. Combined analysis of genome scans of Dutch and Finnish families reveals a susceptibility locus for high-density lipoprotein cholesterol on chromosome 16q. Am. J. Hum. Genet. 72: 903-917.
60. Carr, M. C., A. F. Ayyobi, S. J. Murdoch, S. S. Deeb, and J. D. Brunzell. 2002. Contribution of hepatic lipase, lipoprotein lipase, and cholesteryl ester transfer protein to LDL and HDL heterogeneity in healthy women. Arterioscler. Thromb. Vasc. Biol. 22: 667-673.
61. Pajukanta P., I. Nuotio, J. D. Terwilliger, K. V. Porkka, K. Ylitalo, J. Pihlajamaki, A. J. Suomalainen, A. C. Syvanen, T. Lehtimaki, J. S. Viikari, M. Laakso, M. R. Taskinen, C. Ehnholm, and L. Peltonen. 1998. Linkage of familial combined hyperlipidaemia to chromosome 1q21-q23. Nat. Genet. 18: 369-373
62. Aouizerat, B. E., H. Allayee, R. M. Cantor, G. M. Dallinga-Thie, C. D. Lanning, T. W. A. de Bruin, A. J. Lusis, and J. I. Rotter. 1999. Linkage of a candidate gene locus to familial combined hyperlipidemia: lecithin:cholesterol acyltransferase on 16q. Arterioscler. Thromb. Vasc. Biol. 19: 2730-2736.
63. Aouizerat, B. E., H. Allayee, R. M. Cantor, R. C. Davis, C. D. Lanning, P. Z. Wen, G. M. Dallinga-Thie, T. W. A. de Bruin, J. I. Rotter, and A. J. Lusis. 1999. A genome scan for familial combined hyperlipidemia reveals evidence of linkage with a locus on chromosome 11. Am. J. Hum. Genet. 65: 397-412.
64. Cederberg, A., L. M. Gronning, B. Ahren, K. Tasken, P. Carlsson, and S. Enerback. 2001. FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance. Cell. 106: 563-573.
65. Murdoch, S. J., M. C. Carr, J. E. Hokanson, J. D. Brunzell, and J. J. Albers. 2000. PLTP activity in premenopausal women. Relationship with lipoprotein lipase, HDL, LDL, body fat, and insulin resistance. J. Lipid Res. 41: 237-244.
66. Cheung, M. C., G. Wolfbauer, B. G. Brown, and J. J. Albers. 1999. Relationship between plasma phospholipid transfer protein activity and HDL subclasses among patients with low HDL and cardiovascular disease. Atherosclerosis. 142: 201-205.
67. Rye, K. A., M. Jauhiainen, P. J. Barter, and C. Ehnholm. 1998. Triglyceride-enrichment of high density lipoproteins enhances their remodelling by phospholipid transfer protein. J. Lipid Res. 39: 613-622.
68. Patsch, J. R., S. Prasad, A. M. Gotto, Jr., and W. Patsch. 1987. High density lipoprotein2. Relationship of the plasma levels of this lipoprotein species to its composition, to the magnitude of postprandial lipemia, and to the activities of lipoprotein lipase and hepatic lipase. J. Clin. Invest. 80: 341-347.
69. McPherson, R., C. J. Mann, A. R. Tall, M. Hogue, L. Martin, R. W. Milne, and Y. L. Marcel. 1991. Plasma concentrations of cholesteryl ester transfer protein in hyperlipoproteinemia. Relation to cholesteryl ester transfer protein activity and other lipoprotein variables. Arterioscler. Thromb. 11: 797-804.
70. Riemens, S., A. van Tol, W. Sluiter, and R. Dullaart. 1998. Elevated plasma cholesteryl ester transfer in NIDDM: relationships with apolipoprotein B-containing lipoproteins and phospholipid transfer protein. Atherosclerosis. 140: 71-79.
71. Tato, F., G. L. Vega, A. R. Tall, and S. M. Grundy. 1995. Relation between cholesterol ester transfer protein activities and lipoprotein cholesterol in patients with hypercholesterolemia and combined hyperlipidemia. Arterioscler. Thromb. Vasc. Biol. 15: 112-120.
72. Murakami, T., S. Michelagnoli, R. Longhi, G. Gianfranceschi, F. Pazzucconi, L. Calabresi, C. R. Sirtori, and G. Franceschini. 1995. Triglycerides are major determinants of cholesterol esterification/transfer and HDL remodeling in human plasma. Arterioscler. Thromb. Vasc. Biol. 15: 1819-1828.
73. Babirak, S. P., B. G. Brown, and J. D. Brunzell. 1992. Familial combined hyperlipidemia and abnormal lipoprotein lipase. Arterioscler. Thromb. 12: 1176-1183.
74. Reymer, P. W. A., B. E. Groenemeyer, E. Gagné, L. Miao, E. E. G. Appelman, J. C. Seidel, D. Kromhout, S. M. Bivjoet, K. van de Oever, T. Bruin, M. R. Hayden, and J. J. P. Kastelein. 1995. A frequently occurring mutation in the lipoprotein lipase gene (Asn291Ser) contributes to the expression of familial combined hyperlipidemia. Hum. Mol. Genet. 4: 1543-1549.
75. Reynisdottir, S., B. Angelin, D. Langin, H. Lithell, M. Eriksson, C. Holm, and P. Arner. 1997. Adipose tissue lipoprotein lipase and hormone-sensitive lipase-contrasting findings in familial combined hyperlipidemia and insulin resistance syndrome. Arterioscler. Thromb. Vasc. Biol. 17: 2287-2292.
76. Austin, M. A., J. D. Brunzell, W. L. Fitch, and R. M. Krauss. 1990. Inheritance of low density lipoprotein subclass patterns in familial combined hyperlipidemia. Arteriosclerosis. 10: 520-530.
77. Hokanson, J. E., R. M. Krauss, J. J. Albers, M. A. Austin, and J. D. Brunzell. 1995. LDL physical and chemical properties in familial combined hyperlipidemia. Arterioscler. Thromb. Vasc. Biol. 15: 452-459.
78. Bredie, S. J. H., L. A. Kiemeney, A. F. J. de Haan, P. N. M. Demacker, and A. F. H. Stalenhoef. 1996. Inherited susceptibility determines the distribution of dense low-density lipoprotein subfraction profiles in familial combined hyperlipidemia. Am. J. Hum. Genet. 58: 812-822.