Hyperphagia induced by direct administration of midazolam into the parabrachial nucleus of the rat

European Journal of Pharmacology

Volumn 313, Issue 1-2, 1996, Pages 1-9

  Higgs, Suzanne ^a   Cooper, Steven J ^a  

^a DURHAM UNIVERSITY   (United Kingdom)

Author keywords

Benzodiazepine; Brain stem; Hyperphagia; Palatability; Parabrachial nucleus; Rat

Indexed keywords

BENZODIAZEPINE RECEPTOR; BENZODIAZEPINE RECEPTOR BLOCKING AGENT; BENZODIAZEPINE RECEPTOR STIMULATING AGENT; FLUMAZENIL; MIDAZOLAM;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FOOD INTAKE; HYPERPHAGIA; INJECTION SITE; INTRACEREBRAL DRUG ADMINISTRATION; LOCOMOTION; MALE; NONHUMAN; PARABRACHIAL NUCLEUS; PRIORITY JOURNAL; RAT;

EID: 0030579095     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(96)00446-3     Document Type: Article

References (31)

1. Berridge, K.C., 1988, Brainstem systems mediate the enhancement of palatability by chlordiazepoxide, Brain Res. 447, 262.
2. Berridge, K.C. and S. Pecina, 1995, Benzodiazepines, appetite and taste palatability, Neurosci. Biobehav. Rev. 19, 121.
3. Berridge, K.C. and D. Treit, 1986, Chlordiazepoxide directly enhances positive ingestive reactions in rats, Pharmacol. Biochem. Behav. 24, 217.
4. Cooper, S.J., 1980, Benzodiazepines as appetite enhancing compounds, Appetite 1, 7.
5. Cooper, S.J., 1989, Benzodiazepine receptor-mediated enhancement and inhibition of taste reactivity, food choice and intake, Ann. NY Acad. Sci. 575, 321.
6. Cooper, S.J. and A.E. Green, 1993, The benzodiazepine receptor partial agonist bretazenil (Ro 16-6028) and Ro 17-1812, affect saccharin preference and aversions in the rat, Brain Res. 59, 144.
7. Cooper, S.J. and S.E. Greenwood, 1992, The β-carboline abecarnil, a novel agonist at central benzodiazepine receptors influences saccharin and salt preference in the rat, Brain Res. 59, 144.
8. Cooper, S.J. and S. Higgs, 1994, Neuropharmacology of appetite and taste preferences, in: Appetite Neural and Behavioural Bases, ed. C R. Legg and D.A Booth (OUP, Oxford) 212.
9. Cooper, S.J. and W.R. Moores, 1985, Chlordiazepoxide-induced hyperphagia in non-food deprived rats: effects of Ro 15-1788, CGS 8216 and ZK 93 426, Eur. J. Pharmacol. 12, 39.
10. Cooper, S.J. and R.E. Yerbury, 1988, Clonazepam selectively increases saccharin ingestion in a two-choice test, Brain Res. 89, 462.
11. Cooper, S.J., D.J. Barber, D.B. Gilbert and W.R. Moores, 1985, Benzodiazepine receptor ligands and the consumption of a highly palatable diet in non-deprived male rats, Psychopharmacology 86, 348.
12. Cooper, S.J., R.E. Yerbury, J.C. Neill and A. Desa, 1987, Partial agonists acting at benzodiazepine receptors can be differentiated in tests of ingestional behaviour, Physiol. Behav. 41, 247.
13. File, S.E., 1981, Rapid development of tolerance to the sedative effects of lorazepam and triazolam in rats, Psychopharmacology 73, 240.
14. Flynn, F.W., H.J. Grill, J. Schulkin and R. Norgren, 1991, Central gustatory lesions: 2. Effects on sodium appetite, taste aversion learning and feeding behaviors, Behav. Neurosci. 105, 944.
15. Flynn, F.W., H.J. Grill, G.J. Schwartz and R. Norgren, 1991, Central gustatory lesions: 1. Preference and taste reactivity tests, Behav. Neurosci. 105, 933.
16. Higgs, S. and S.J. Cooper, 1996, Increased food intake following injection of the benzodiazepine receptor agonist midazolam into the IVth ventricle, Pharmacol. Biochem. Behav. (in press).
17. Higgs, S., D.B. Gilbert, N.M. Barnes and S.J. Cooper, 1993, Possible brainstem mediation of benzodiazepine-induced hyperphagia, Appetite 21, 183 (abstract).
18. A/benzodiazepine receptor heterogeneity: neurophysiological implications, Neuropharmacology 34, 245.
19. Krukoff, T.L., K.H. Harris and J.H. Jhamandas, 1993, Efferent projections from the parabrachial nucleus demonstrated with the anterograde tracer phaseolus vulgaris leucoagglutinin, Brain Res. Bull. 30, 163.
20. Myers, R.D., 1966, Injection of solutions into cerebral tissue: relation between volume and diffusion, Physiol. Behav. 1, 171.
21. Norgren, R., 1976, Taste pathways to hypothalamus and amygdala, J. Comp. Neurol. 166, 17.
22. Norgren, R., 1978, Projections from the nucleus of the solitary tract in the rat, Neuroscience 3, 207.
23. Norgren, R. and C.M. Leonard, 1973, Ascending central gustatory pathways, J. Comp. Neurol. 150, 217.
24. Paxinos, G. and C. Watson, 1982, The Rat Brain in Stereotaxic Coordinates (Academic Press, New York).
25. Pfaffmann, C., 1982, Taste: a model of incentive motivation, in: Physiological Mechanisms of Motivation, ed. D.W. Pfaff (Springer Verlag, New York) 61.
26. Roache, J.D. and J.E. Zabik, 1986, Effects of benzodiazepines on taste aversions in a two-bottle choice paradigm, Pharmacol. Biochem. Behav. 25, 431.
27. Saper, C.B. and A.D. Loewy, 1980, Efferent connections of the parabrachial nucleus in the rat. Brain Res. 197, 291.
28. A receptor and benzodiazepine receptors in the brain shown by monoclonal antibodies, Nature 314, 168.
29. Spector, A.C., 1995, Gustatory function in the parabrachial nuclei: implications from lesion studies in rats, Rev. Neurosci. 6, 143.
30. Spector, A.C., H.J. Grill and R. Norgren, 1993, Concentration-dependent licking of sucrose and sodium chloride in rats with parabrachial gustatory lesions, Physiol. Behav. 53, 277.
31. Spector, A.C., G. Scalera, H.J. Grill and R. Norgren, 1995, Gustatory detection thresholds after parabrachial nuclei lesions in rats, Behav. Neurosci. 109, 939.