Methyl palmoxirate increases eating behavior and brain Fos-like immunoreactivity in rats

Brain Research

Volumn 781, Issue 1-2, 1998, Pages 8-14

  Horn, Charles C ^a,b,c   Friedman, Mark I ^b  

^a KANSAS STATE UNIVERSITY   (United States)

^b MONELL CHEMICAL SENSES CENTER   (United States)

^c Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

c Fos; Feeding behavior; Food intake; Hunger; Metabolism; Methyl palmoxirate; Rat

Indexed keywords

FATTY ACID; ORAL ANTIDIABETIC AGENT; PALMOXIRIC ACID METHYL ESTER;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA POSTREMA; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; FATTY ACID OXIDATION; FEEDING BEHAVIOR; FOOD INTAKE; FOREBRAIN; HYPOTHALAMUS; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; MALE; NERVE TRACT; NONHUMAN; ONCOGENE C FOS; ORAL DRUG ADMINISTRATION; PARABRACHIAL NUCLEUS; PRIORITY JOURNAL; RAT; RHOMBENCEPHALON; SENSORY NERVE; SOLITARY TRACT NUCLEUS; STRIA TERMINALIS; THALAMUS MIDLINE NUCLEUS;

ANIMALS; BRAIN; EPOXY COMPOUNDS; FEEDING BEHAVIOR; HYPOGLYCEMIC AGENTS; IMMUNOHISTOCHEMISTRY; MALE; NEURONS; PROPIONATES; PROSENCEPHALON; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, SPRAGUE-DAWLEY; RHOMBENCEPHALON;

EID: 0032545670     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)01143-8     Document Type: Article

References (35)

1. Bauche F., Sabourault D., Giudicelli Y., Nordmann J., Nordmann R. 2-Mercaptoacetate administration depresses the β-oxidation pathway through an inhibition of long-chain acyl-CoA dehydrogenase activity. Biochem. J. 196:1981;803-809.
2. Bauche F., Sabourault D., Giudicelli Y., Nordmann J., Nordmann R. Inhibition in vitro of acyl-CoA dehydrogenases by 2-mercaptoacetate in rat liver mitochondria. Biochem. J. 215:1983;457-464.
3. Beverly J.L., Meguid M.M., Yang Z.-J., Yue M.-X., Fetterman B.L. Metabolic influences on satiety in rats receiving parenteral nutrition. Am. J. Physiol. 266:1994;R381-R386. Regulatory Integrative Comp. Physiol. 35.
4. Cechetto D.F. Central representation of visceral function. Fed. Proc. 46:1987;17-23.
5. Emond M.H., Weingarten H.P. Fos-like immunoreactivity in vagal and hypoglossal nuclei in different feeding states: a quantitative study. Physiol. Behav. 58:1995;459-465.
6. Fraser K.A., Davison J.S. Meal-induced c-fos expression in brain stem is not dependent on cholecystokinin release. Am. J. Physiol. 265:1993;R235-R239. Regulatory Integrative Comp. Physiol. 34.
7. Fraser K.A., Raizada E., Davison J.S. Oral-pharyngeal-esophageal and gastric cues contribute to meal-induced c-fos expression. Am. J. Physiol. 268:1995;R223-R230. Regulatory Integrative Comp. Physiol. 37.
8. Friedman M.I., Ramirez I., Bowden C.R., Tordoff M.G. Fuel partitioning and food intake: role for mitochondrial fatty acid transport. Am. J. Physiol. 258:1990;R216-R221. Regulatory Integrative Comp. Physiol. 27.
9. Friedman M.I., Tordoff M.G. Fatty acid oxidation and glucose utilization interact to control food intake in rats. Am. J. Physiol. 251:1986;R840-R845. Regulatory Integrative Comp. Physiol. 20.
10. Friedman M.I., Tordoff M.G., Ramirez I. Integrated metabolic control of food intake. Brain Res. Bull. 17:1986;855-859.
11. Hoffman G.E., Smith M.S., Fitzsimmons M.D. Detecting steroidal effects on immediate early gene expression in the hypothalamus. Neuroprotocols. 1:1992;52-66.
12. Horn C.C., Friedman M.I. Diet-related increases in food intake and brain Fos-like immunoreactivity (Fos-li) after treatment with 2,5-anhydro-D-mannitol (2,5-AM). FASEB J. 10:1996;A823.
13. Kiorpes T.C., Hoerr D., Ho W., Weaner L.E., Inman M.G., Tutwiler G.F. Identification of 2-tetradecylglycidyl coenzyme A as the active form of methyl 2-tetradecylglycidate (methyl palmoxirate) and its characterization as an irreversible, active site-directed inhibitor of carnitine palmitoyltransferase A in isolated rat liver mitochondria. J. Biol. Chem. 259:1984;9750-9755.
14. Langhans W., Scharrer E. Evidence for a vagally mediated satiety signal derived from hepatic fatty acid oxidation. J. Auton. Nerv. Syst. 18:1987;13-18.
15. R.A. Leslie, D.J.M. Reynolds, I.N.C. Lawes, Central connections of the nuclei of the vagus nerve, in: S. Ritter, R.C. Ritter, C.D. Barnes (Eds.), Neuroanatomy and Physiology of Abdominal Vagal Afferents, CRC, Boca Raton, 1992, pp. 81-98.
16. Norgen R., Smith G.P. Central distribution of subdiaphragmatic vagal branches in the rat. J. Comp. Neurol. 273:1988;207-223.
17. Olson B.R., Freilino M., Hoffman G.E., Stricker E.M., Sved A.F., Verbalis J.G. c-Fos expression in rat brain and brainstem nuclei in response to treatments that alter food intake and gastric motility. Mol. Cell. Neurosci. 4:1993;93-106.
18. G. Paxinos, C. Watson, The Rat Brain in Stereotaxic Coordinates, 2nd ed., Academic Press, New York, 1986.
19. Rawson N.E., Friedman M.I. Phosphate loading prevents the decrease in ATP and increase in food intake produced by 2,5-anhydro-D-mannitol. Am. J. Physiol. 266:1994;R1792-R1796. Regulatory Integrative Comp. Physiol. 35.
20. Rawson N.E., Ulrich P.M., Friedman M.I. Fatty acid oxidation modulates the eating response to the fructose analogue 2,5-anhydro-D-mannitol. Am. J. Physiol. 271:1996;R144-R148. Regulatory Integrative Comp. Physiol. 40.
21. Reed D.R., Tordoff M.G., Friedman M.I. Enhanced acceptance and metabolism of fats by rats fed a high-fat diet. Am. J. Physiol. 261:1991;R1084-R1088. Regulatory Integrative Comp. Physiol. 30.
22. Ricardo J.A., Koh E.T. Anatomical evidence of direct projections from the nucleus of the solitary tract to the hypothalamus, amygdala, and other forebrain structures in the rat. Brain Res. 153:1978;1-26.
23. Ritter S., Dinh T.T. 2-Mercaptoacetate and 2-deoxy-D-glucose induce Fos-like immunoreactivity in rat brain. Brain Res. 641:1994;111-120.
24. Ritter S., Dinh T.T., Friedman M.I. Induction of Fos-like immunoreactivity (Fos-li) and stimulation of feeding by 2,5-anhydro-D-mannitol (2,5-AM) require the vague nerve. Brain Res. 646:1994;53-64.
25. Ritter S., Taylor J.S. Capsaicin abolishes lipoprivic but not glucoprivic feeding in rats. Am. J. Physiol. 256:1989;R1232-R1239. Regulatory Integrative Comp. Physiol. 25.
26. Ritter S., Taylor J.S. Vagal sensory neurons are required for lipoprivic but not glucoprivic feeding in rats. Am. J. Physiol. 258:1990;R1395-R1401. Regulatory Integrative Comp. Physiol. 27.
27. Sagar S.M., Sharp F.R., Curran T. Expression of c-fos protein in brain: metabolic mapping at the cellular level. Science. 240:1988;1328-1331.
28. Shapiro R.E., Miselis R.R. The central neural connections of the area postrema of the rat. J. Comp. Neurol. 234:1985;344-364.
29. Sharp F.R., Sagar S.M., Hicks K., Lowenstein D., Hisanaga K. c-fos mRNA, Fos, Fos-related antigen induction by hypertonic saline and stress. J. Neurosci. 11:1991;2321-2331.
30. Scharrer E.C., Langhans W. Control of food intake by fatty acid oxidation. Am. J. Physiol. 250:1986;R1003-R1006. Regulatory Integrative Comp. Physiol. 19.
31. Smith G.P., Epstein A.N. Increased feeding in response to decreased glucose utilization in the rat and monkey. Am. J. Physiol. 217:1969;1083-1087.
32. Tordoff M.G., Flynn F.W., Grill H.J., Friedman M.I. Contribution of fat metabolism to 'glucoprivic' feeding produced by fourth ventricular 5-thio-D-glucose. Brain Res. 445:1988;216-221.
33. Tutwiler G.F., Ho W., Mohrbacher R.J. 2-Tetradecylglycidic acid. Methods Enzymol. 72:1981;533-551.
34. Van der Kooy D., Koda L.Y., McGinty J.F., Gerfen C.R., Bloom F.E. The organization of projections from the cortex, amygdala, and hypothalamus to the nucleus of the solitary tract in rat. J. Comp. Neurol. 224:1984;1-24.
35. Watson R.E. Jr., Wiegand S.J., Clough R.W., Hoffman G.E. Use of cryoprotectant to maintain long-term peptide immunoreactivity and tissue morphology. Peptides. 7:1986;155-159.