Characterization of Binary Mixtures Consisting of Cross-Linked High Amylose Starch and Hydroxypropylmethylcellulose Used in the Preparation of Controlled Release Tablets

Pharmaceutical Development and Technology

Volumn 8, Issue 4, 2003, Pages 335-348

  Rahmouni, Miloud ^a,b   Lenaerts, Vincent ^e   Massuelle, Danielle ^c   Doelker, Eric ^c   Johnson, Marc ^d   Leroux, Jean Christophe ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b Labopharm Inc   (Canada)

^c UNIVERSITY OF GENEVA   (Switzerland)

^d Texture Technologies Corp   (United States)

^e NONE

Author keywords

Compaction behavior; Controlled released; Cross linked starch; Direct compression; Enzymatic degradation; Hydroxypropylmethylcellulose

Indexed keywords

AMYLOSE; CONTRAMID; CROSSLINKED AMYLOSE STARCH; DICLOFENAC; EXCIPIENT; HYDROXYPROPYLMETHYLCELLULOSE; PREDNISONE; PSEUDOEPHEDRINE; STARCH; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED DRUG RELEASE; CROSS LINKING; DRUG MIXTURE; DRUG SOLUBILITY; ENZYME DEGRADATION; GEL; HYDROLYSIS; PARTICLE SIZE; PRIORITY JOURNAL; TABLET COMPRESSION; TABLET MANUFACTURE;

AMYLOSE; CHEMISTRY, PHARMACEUTICAL; COMPRESSIVE STRENGTH; CROSS-LINKING REAGENTS; DELAYED-ACTION PREPARATIONS; DRUG COMPOUNDING; ENZYMES; GELS; METHYLCELLULOSE; PERMEABILITY; SOLUBILITY; TABLETS;

EID: 0142031043     PISSN: 10837450     EISSN: None     Source Type: Journal    
DOI: 10.1081/PDT-120024687     Document Type: Article

References (26)

1. Lenaerts, V.; Dumoulin, Y.; Mateescu, M.A. Controlled release of theophylline from CLA tablets. J. Control. Release 1991, 15, 39-46.
2. Rahmouni, M.; Lenaerts, V.; Massuelle, D.; Doelker, D.; Leroux, J.-C. Influence of physical parameters and lubricants on the compaction properties of granulated and non-granulated cross-linked high amylose starch. Chem. Pharm. Bull. 2002, 50 (9), 1155-1162.
3. Moussa, I.S.; Lenaerts, V.; Cartilier, L.H. Effect of some physical parameters on the swelling properties of cross-linked amylose matrices. Int. J. Pharm. 1998, 173, 35-41.
4. Rahmouni, M.; Lenaerts, V.; Leroux, J.-C. Solute transport ccross cross-linked high amylose starch (Contramid®) hydrogels. 27th Proc. Int. Symp. Control. Release Bioact. Mater., Paris, July 7-13, 2000; Controlled released society, 2000; 724-725.
5. Rahmouni, M.; Chouinard, F.; Nekka, F.; Lenaerts, V.; Leroux, J.-C. Enzymatic degradation of cross-linked high amylose starch tablets and its effect on in vitro release of sodium diclofenac. Eur. J. Pharm. Biopharm. 2001, 51, 191-198.
6. Ford, J.L.; Rubinstein, M.H.; Hogan, J.E. Formulation of sustained release promethazine hydrochloride tablets using hydroxypropylmethylcellulose matrices. Int. J. Pharm. 1985, 24, 327-338.
7. Ford, J.L.; Rubinstein, M.H.; Hogan, J.E. Dissolution of a poorly water soluble drug, indomethacin, from hydroxypropylmethylcellulose controlled release tablets. J. Pharm. Pharmacol. 1985, 37, 33P-39P.
8. Ford, J.L.; Rubinstein, M.H.; McCaul, F.; Hogan, J.E.; Edgar, P.J. Importance of drug type, tablet shape and added diluents on drug release kinetics from hydroxypropylmethylcellulose matrix tablets. Int. J. Pharm. 1987, 40, 223-234.
9. Ranga Rao, K.V.; Padmalatha Devi, K.; Buri, P. Influence of molecular size and water solubility of the solute on its release from swelling and erosion controlled polymeric matrices. J. Control. Release 1990, 12, 133-141.
10. Victoria Velasco, M.; Ford, J.L.; Rowe, P.; Rajabi Siahboomi, A.R. Influence of drug:hydroxypropylmethylcellulose ratio, drug and polymer particle size and compression force on the release of diclofenac sodium from HPMC tablets. J. Control. Release 1999, 57, 75-85.
11. Buri, P.; Doelker, E. Formulation des comprimés à libération prolongée. II. Matrices hydrophiles. Pharm. Acta Helv. 1980, 55, 189-197.
12. Alderman, D.A. A review of cellulose ethers in hydrophilic matrices for oral controlled-release dosage forms. Int. J. Pharm. Technol. Prod. Manuf. 1984, 5 (3), 1-9.
13. Doelker, E. Cellulose derivatives. In Hydrogels in Medicine and Pharmacy; Peppas, N.A., Ed.; Polymers, CRS Press: Boca Raton, 1987; Vol. 2, 115-160.
14. Carr, R.L. Evaluating flow properties of solids. Chem. Eng. 1965, 72, 163-168.
15. Rime, A.F.; Lescure, F.; Mordier, D.; Gurny, R.; Doelker, E. A new high performance data acquisition system interfacing an instrumented tablet machine to a microcomputer. Acta Pharm. Technol. 1990, 36, 264-268.
16. Doelker, E. Assessment of powder compaction. In Powder Technology and Pharmaceutical Processes; Chulia, D., Deleuil, M., Pourcelot, Y., Eds.; Elsevier: Amsterdam, 1994; 403-471.
17. Armstrong, N.A.; Haines-Nutt, R.F. Elastic recovery and surface area changes in compacted powder systems. J. Pharm. Pharmacol. 1972, 24, 135P-136P.
18. Heckel, R.W. An analysis of powder compaction phenomena. Trans. Metall. Soc. AIME 1961, 221, 1001-1008.
19. Moore, J.W.; Flanner, H.H. Mathematical comparison of curves with an emphasis on in-vitro dissolution profiles. Pharm. Technol. 1996, 20 (6), 64-74.
20. FDA, Center for Drug Evaluation and Research, Guidance for Industry. Modified Release Solid Oral Dosage Forms; Scale-Up and Post-Approval Changes: Chemistry, Manufacturing and Controls, In Vitro Dissolution Testing, and In Vivo Bioequivalence Documentation; www.FDA-gov/cder/guidance/1214fnl.pdf; September 1997.
21. Amidon, G.E.; Augsburger, L.L.; Brittain, H.G.; Byrn, S.R.; Fox, C.D.; Peck, G.E.; Wurster, D.E. Physical test methods for powder flow characterization of pharmaceutical materials: a review of methods. Pharmacop. Forum 1999, 25, 8298-8305.
22. Hancock, B.C.; Carlson, G.T.; Ladipo, D.D.; Langdon, B.A.; Mullarney, M.P. The powder flow and compact mechanical properties of two recently developed matrix-forming polymers. J. Pharm. Pharmacol. 2001, 53, 1193-1199.
23. Staniforth, J.N.; Baichwal, A.R.; Hart, J.P.; Heng, P.W.S. Effect of addition of water on the rheological and mechanical properties of microcrystalline celluloses. Int. J. Pharm. 1988, 41, 231-236.
24. Chowhan, Z.T. Role of binder in moisture-induced hardness increase in compressed tablets and its effect on in vitro disintegration and dissolution. J. Pharm. Sci. 1980, 69, 1-4.
25. Le Bail, P.; Morin, F.G.; Marchessault, R.H. Characterization of cross linked high amylose starch excipient. Int. J. Biol. Macromol. 1999, 26, 193-200.
26. Rajabi-Siahboomi, A.R.; Bowtell, R.W.; Mansfield, P.; Hendersen, A.; Davies, M.C.; Melia, C.D. Structure and behaviour in hydrophilic matrix sustained release dosage forms: 2. NMR-imaging studies of dimensional changes in the gel layer and core of HPMC tablets undergoing hydration. J. Control. Release 1994, 31, 121-128.