Enzymatic degradation of cross-linked high amylose starch tablets and its effect on in vitro release of sodium diclofenac

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 51, Issue 3, 2001, Pages 191-198

  Rahmouni, M ^a   Chouinard, F ^b   Nekka, F ^a   Lenaerts, V ^b   Leroux, J C ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b Labopharm Inc   (Canada)

Author keywords

Amylose; Contramid; Controlled release; Cross linked starch; Enzymatic degradation; Amylase

Indexed keywords

AMYLASE; AMYLOSE; BUFFER; CONTRAMID; DICLOFENAC; ENZYME; HYDROXYPROPYLMETHYLCELLULOSE; MACROGOL; PHOSPHATE; POLYMER; POLYOX WSR 303; POLYVINYL ALCOHOL; STARCH; UNCLASSIFIED DRUG;

APPARATUS; ARTICLE; COMPRESSION; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; CROSS LINKING; DEGRADATION; DIFFUSION; DISSOLUTION; DRUG RELEASE; EROSION; FORCE; GRAVIMETRY; HYDROLYSIS; IN VITRO STUDY; IONIC STRENGTH; KINETICS; PH; PHYSICAL CHEMISTRY; SIMULATION; SOLUTION AND SOLUBILITY; STOMACH JUICE; TABLET;

ALPHA-AMYLASE; AMYLOSE; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DICLOFENAC; ENZYME STABILITY; GASTRIC ACID; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; METHYLCELLULOSE; MODELS, BIOLOGICAL; OSMOLAR CONCENTRATION; POLYVINYL ALCOHOL; PRESSURE; TABLETS; TIME;

EID: 0035021203     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0939-6411(01)00127-8     Document Type: Article

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