Loss of hemolysin expression in Staphylococcus aureus agr mutants correlates with selective survival during mixed infections in murine abscesses and wounds

FEMS Immunology and Medical Microbiology

Volumn 38, Issue 1, 2003, Pages 23-28

  Schwan, William R ^a,b   Langhorne, Michael H ^b,c   Ritchie, Heather D ^b   Stover, C Kendall ^b,d  

^a UNIVERSITY OF WISCONSIN LA CROSSE   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

^c Chiron Corporation   (United States)

^d PFIZER INC   (United States)

Author keywords

Abscess; Hemolytic; Staphylococcus aureus; Wound

Indexed keywords

HEMOLYSIN;

ABSCESS; AGRC GENE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL COUNT; BACTERIAL STRAIN; CONTROLLED STUDY; GENE; GENE EXPRESSION; GENE MUTATION; INOCULATION; LIVER; MIXED INFECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STAPHYLOCOCCUS AUREUS; SURVIVAL; WILD TYPE; WOUND INFECTION;

EID: 0142029151     PISSN: 09288244     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-8244(03)00098-1     Document Type: Article

References (25)

1. Jarvis W.R., Martone W.J. Predominant pathogens in hospital infections. J. Antimicrob. Chemother. 29:(Suppl. A):1992;19-24.
2. Thornsberry C. Epidemiology of staphylococcal infections - a USA perspective. J. Chemother. 6:(Suppl. 2):1994;61-65.
3. Menestrina G., Serra M.D., Prevost G. Mode of action of beta-barrel pore-forming toxins of the staphylococcal alpha-hemolysin family. Toxicon. 39:2001;1661-1672.
4. Kehoe M., Duncan J., Foster T., Fairweather N., Dougan G. Cloning, expression, and mapping of the Staphylococcus aureus alpha-hemolysin determinant in Escherichia coli K-12. Infect. Immun. 41:1983;1105-1111.
5. Taubler J.H., Kapral F.A., Mudd F. Role of α-toxin in lesion formation by Staphylococcus aureus on sutures subcutaneously implanted in mice. J. Bacteriol. 86:1963;51-57.
6. O-Reilly M., de Azavedo J.C.S., Kennedy S., Foster T.J. Inactivation of the alpha-hemolysin gene of Staphylococcus aureus 8325-4 by site-directed mutagenesis and studies on the expression of its haemolysins. Microb. Pathog. 1:1986;125-138.
7. Ji Y., Marra A., Rosenberg M., Woodnutt G. Regulated antisense RNA eliminates alpha-toxin virulence in Staphylococcus aureus infection. J. Bacteriol. 181:1999;6585-6590.
8. Kapral F.A. Factors involved in experimental staphylococcal peritonitis. Ann. N.Y. Acad. Sci. 128:1965;259-273.
9. Kinsman, O., Jonsson, P., Haraldsson, I., Lindberg, M., Arbuthnott, J. P. and Wadstrom, T. (1981) Decreased virulence of α-hemolysin negative and coagulase-negative mutants of Staphylococcus aureus in experimental infections in mice. In: Staphylococci and Utaphylococcal Infections, Zbl Bakt. Suppl. 10 (Jeljaszewicz, J., Ed.). Gustav Fischer Verlag, Stuttgart.
10. McElroy M.C., Harty H.R., Hosfrod G.E., Boylan G.M., Pittet J.F., Foster T.J. Alpha-toxin damages the air-blood barrier of the lung in a rat model of Staphylococcus aureus-induced pneumonia. Infect. Immun. 67:1999;5541-5544.
11. Hasegawa N., San Clemente C.L. Virulence and immunity of Staphylococcus aureus BB and certain deficient mutants. Infect. Immun. 22:1978;473-479.
12. Kimura K. Mechanism of staphylococcal infection by various mutants originating from Staphylococcus aureus No. 248. II. Comparison of the virulence of 248 α-H and 248 β-H in intraperitoneal infection of mice. Jpn. J. Bacteriol. 26:1971;1-8.
13. O'Callaghan R.J., Callegan M.C., Moreau J.M., Green L.C., Foster T.J., Hartford O.M., Engel L.S., Hill J.M. Specific roles of alpha-toxin and beta-toxin during Staphylococcus aureus corneal infection. Infect. Immun. 65:1997;1571-1578.
14. Gemmell C.G. Staphylococcal scalded skin syndrome. J. Med. Microbiol. 43:1995;318-327.
15. Coulter S.N., Schwan W.R., Ng E.Y.W., Langhorne M.H., Ritchie H.D., Westbrock-Wadman S., Hufnagle W.O., Folger K.R., Bayer A.S., Stover C.K. Staphylococcus aureus genetic loci impacting growth and survival in multiple infection environments. Mol. Microbiol. 30:1998;393-404.
16. Novick, R. (1990) The Staphylococcus as a molecular genetic system. In: Molecular Biology of the Staphylococci (Novick, R.P., Ed.), pp. 1-40. VCH Publishers, New York.
17. Rescei P., Kreiswirth B., O'Reilly M., Schlievert P., Bruss A., Novick R.P. regulation of exoprotein gene expression in Staphylococcus aureus by agr. Mol. Gen. Genet. 202:1986;58-61.
18. Behnke D., Gerlach D. Cloning and expression in Escherichia coli, Bacillus subtilis, and Streptococcus sanguis, of a gene for staphylokinase - a bacterial plasminogen activator. Mol. Gen. Genet. 210:1987;528-534.
19. Vasishta R., Saxena M., Chhibber S. Contribution of silver ion replacement to the pathogenicity of Pseudomonas aeruginosa with special reference to burn sepsis. Folia Microbiol. 36:1991;498-501.
20. Devriese L.A., Nzuambe D., Godard C. Identification and characteristics of staphylococci isolated from lesions and normal skin of horses. Vet. Microbiol. 10:1985;269-277.
21. Dajcs J.J., Austin M.S., Sloop G.D., Moreau J.M., Hume E.B., Thompson H.W., McAleese F.M., Foster T.J., O'Callaghan R.J. Corneal pathogenesis of Staphylococcus aureus strain Newman. Invest. Ophthalmol. Vis. Sci. 43:2002;1109-1115.
22. Goerke C., Campana S., Bayer M.G., Doring G., Botzenhart K., Wolz C. Direct quantitative transcript analysis of the agr regulon of Staphylococcus aureus during human infection in comparison to the expression profile in vitro. Infect. Immun. 68:2000;1304-1311.
23. Henriksen B.M., Albrektsen S.B., Simper L.B., Gutschik E. Soft tissue infections from drug abuse. A clinical and microbiological review of 145 cases. Acta Orthop. Scand. 65:1994;625-628.
24. Somerville G.A., Beres S.B., Fitzgerald J.R., DeLeo F.R., Cole R.L., Hoff J.S., Musser J.M. In vitro serial passage of Staphylococcus aureus: changes in physiology, virulence factor production, and agr nucleotide sequence. J. Bacteriol. 184:2002;1430-1437.
25. McNamara P.J., Iandolo J.J. Genetic instability of the global regulator explains the phenotype of then xpr mutation in Staphylococcus aureus KSI9051. J. Bacteriol. 180:1998;2609-2615.