Propranolol Cytotoxicity in Rat and Human Lung In Vitro

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 25, Issue 7, 2003, Pages 509-515

  Kastelova, Antonia ^a   Dimova, S ^b   Nemery, B ^b  

^a INSTITUTE OF PHYSIOLOGY   (Bulgaria)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

A549 cell line; Alveolar macrophages; Lung toxicity in vitro; Propranolol; Type II pneumocytes

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; AMIODARONE; AMPHETAMINE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CHLORPROMAZINE; IMIPRAMINE; LACTATE DEHYDROGENASE; LOCAL ANESTHETIC AGENT; PROPANOL;

ADENOCARCINOMA; ANIMAL CELL; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER; LUNG; LUNG ALVEOLUS CELL TYPE 2; LUNG ALVEOLUS MACROPHAGE; LUNG TOXICITY; MALE; MAMMAL; MITOCHONDRION; NONHUMAN; RAT;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; LUNG; MACROPHAGES, ALVEOLAR; MALE; PROPRANOLOL; RATS; RATS, WISTAR; TIME FACTORS;

EID: 0142027050     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: 10.1358/mf.2003.25.7.778088     Document Type: Article

References (43)

1. Dunn, T.L., Gerber, M.J., Shen, A.S., Fernandez, E., Iseman, M. D., Cherniak, R.M. The effect of topical ophtalmic instillation of timolol and betaxolol on lung function in asthmatic subjects. Am Rev Resp Dis 1986, 133: 265-8.
2. Akoun, G., Milleron, B., Mayaud, C., Tholoniat, D. Provocation test couled with bronchoalveolar lavagein diagnosis of propranolol-induced hypersensitivity pneumonitis. Am Rev Respir Dis 1989, 139: 247-9.
3. Masubuchi, Y., Hosokawa, S., Horie, T. et al. Cytochrome P-450 isozymes involved in propranolol metabolism in human liver microsomes. The role of CYP2D6 as ring-hydroxylase and CYPIA2 as N-desisopropylase. Drug Metab Dispos 1994, 22(6): 909-15.
4. Narimatsu, S., Arai, T., Watanabe, T. et al. Covalent binding of a reactive metabolite derived from propranolol and its active metabolite 4-hydroxypropranolol to hepatic microsomal protein of the rat. Chem Res Toxicol 1997, 10(3): 289-95.
5. Hinson, J.A., Roberts, D.W. Role of covalent and noncovalent interactions in cell toxicity: Effect on proteins. Annu Rev Pharmacol Toxicol 1992, 32: 471-510.
6. Nedelcheva, V., Gut, I. P450 in the rat and man: Methods of investigation, substrate specificities and relevance to cancer. Xenobiotica 1994, 24(12): 1151-75.
7. Speirs, S.J., Murray, S., Davies, D.S., Biola Mabadaje, A.F., Boobis, A.R. Debrisoquine oxidation phenotype and susceptibility to lung cancer. Brit J Clin Pharmacol 1990, 29: 101-9.
8. Robiano, L., Martelli, A., Allavena, A., Mazzei, M., Gazzaniga, G. M., Brambilla, G. Formation of the N-nitrozo derivates of six β -adrenergic-blocking agents and their genotoxic effects in rat and human hepatocytes. Cancer Res 1991, 51((): 2273-9.
9. Ono, Y., Wu, X., Noda, A. et al. β-Adrenoceptor antagonistic actions and mutagenicities of R(+)- and S(-)- enantiomers of desisopropylpropranolol and its N-acetyl conjugate. Biol Pharm Bull 1997, 20(1): 61-5.
10. Maura, A., Carlo, P., Ricci, R., Cavanna, M., Brambilla, G. Absence of DNA damage in mice and rats given high doses of five β-adrenergic blocking agents. Arzneimittelforschung 1985, 35(8): 1236-8.
11. Wasserman, B., Block, E.R. Prevention of acute paraquat toxicity in rats by superoxide dismutase. Aviat Space Envir Med 1978, 49(6): 805-9.
12. Schuller, H.M., Porter, B., Richert, A. β-Adrenergic modulation of NNK-induced lung carcinogenesis in hamsters. J Cancer Res Clin Oncol 2000, 126(11): 624-30.
13. Smith, D.M., Smith, S. The fibrogenic response of adult rat lung to continuous propranolol treatment. Histol Histopathol 1988, 3(3): 291-9.
14. Petit, K.P., Nielsen, H.C. Chronic in utero β-blockade alters fetal lung development. Dev Pharmacol Ther 1992, 19(2-3): 131-40.
15. Kai, H., Isohama, Y., Takaki, K. et al. Both β1- and β2- adrenoceptors are involved in mediating phosphatidylcholine secretion in rat type II pneumocytes culture. Eur J Pharmacol 1992, 212(1): 101-3.
16. Chen, M., Brown, L.A. Histamine stimulation of surfactant secretion from rat type pneumocytes. Am J Physiol 1990, 2.58(4 Pt 1): L195-200.
17. Finney, R.E., Nudelman, E., White, T. et al. Pharmacological inhibition of phosphatidylcholine biosynthesis is associated with induction of phosphatidylinositol accumulation and cytolysis of neoplastic cell lines. Cancer Res 2000, 60(18): 5204-13.
18. Hirafuji, M., Sakakibara, M., Endo, T. et al. Biological effects of disel exhaust particles (DEP) on tissues and cells isolated from respiratory tracts of guinea pigs. Res Commun Mol Pathol Pharmacol 1995, 90(2): 221-33.
19. Gu, Y., Seidel, A. Influence of salbutamol and isoproterenol on the production of TNF and reactive oxigen species by bovine alveolar macrophages and calcitriol differentiated HL-60cells. Immunopharmacol Immunotoxicol 1996, 18(1): 115-28.
20. Vestal, R.E., Kornhauser, D.M., Shand, D.G. Active uptake of propranolol by isolated rabbit alveolar microphages and its inhibition by other basic amines. J Pharmacol Exp Ther 1980, 214(1): 106-11.
21. Fabisiak, J.P., Vesell E.S., Rannels, D.E. Interactions of β-adrenergic antagonists with isolated rat alveolar type II pneumocytes. II. Receptor-independent accumulation of β-adrenergic antagonists and other cationic amphophilic drugs in lamellar bodies. J Pharmacol Exp Ther 1987, 241(2): 728-35.
22. Richards, R.J., Davies, N., Atkins, J., Oreffo, V. Isolation, biochemical characterization, and culture of lung type II cells of the rat. Lung 1987, 165: 143-58.
23. Hoet, P.H., Lewis, C.P., Dinsdale, D., Demedts, M., Nemery, B. Putrescine uptake in hamster lung slices and primary cultures of type II pneumocytes. Am J Physiol 1995, 269: L681-89.
24. Hoet, P.H., Lewis, C.P., Demeds, M., Nemery, B. Putrescine and paraquat uptake in human lung slices and isolated type II pneumocytes. Biochem Pharmacol 1994, 48: 517-24.
25. Vassault, A. Lactate dehydrogenase. I. UV-method with pyruvate and NADH. In: Methods of Enzymatic Analysis. Bergmeyer, H.U. (Ed.). Verlag Chemie: Weinheim 1983, 118-26.
26. Mosmann, T. Rapid colorimetric assay for cellular growth and survival. Application to proliferation and cytotoxicity assays. J Immunol Methods 1983, 65: 55-63.
27. Newman, J.M., DiMaria, C.A., Rattigan, S. et al. Relationship of MTT reduction to stimulants of muscle metabolism. Chem Biol Interact 2000, 128(2): 127-40.
28. Saldias, F., Lecuona, E., Friedman, E. Modulation of liquid clearance by isoproterenol in rat lungs. Am J Physiol 1998, 274 (5 pt 1): L694-701.
29. Itoh, H., Jingu, Y., Numakami, K., Sarute, T. Effects of β-blocking agents on the release of various enzymes in muscular tissues. Kitasato Arch Exp Med 1993, 65 (Suppl.): 57-63.
30. Bandyopadhyay, S., Klaunung, J.E., Somani, P. Cytotoxic interaction of cardioactive cationic amphiphilic compounds in primary rat hepatocytes in culture. Hapatology 1990, 12(1): 48-58.
31. Yue, T.L., Wang, X., Gu, J.L., Ruffolo, R.R. Jr., Freuerstein, G.Z. Carvedilol prevents low-density lipoprotein (LDL)-enhanced monocyte adhesion to endothelial cells by inhibition of LDL oxidation. Eur J Pharmacol 1995, 294(2-3): 585-91.
32. He, S.Y. Methamphetamine-induced toxicity in cultured adult rat cardiomyocytes. Nippon Hoigaku Zasshi 1995, 49(3): 175-86.
33. Kramer, J.H., Mak, I.T., Freedman, A.M., Weglicki, W.B. Propranolol reduces anoxia/reoxygenation-mediated injury of adult myocytes through an anti-radical mechanism. J Mol Cell Cardiol 1991, 23(11): 1231-44.
34. Mcginnity, D.F., Parker, A.J., Soars, M., Riley, R.J. Automated definition of the enzymology of drug oxidation by the major human drug metabolizing cytochrome P450s. Drug Metabol Disp 2000, 28: 1327-34.
35. Schwarze, P.E., Johnsen, N.M., Samuelsen, J.T. et al. The use of isolated lung cells in in vitro pulmonary toxicology: Studies of DNA damage, apoptosis and alteration of gene expression. Cent Eur J Public Health 1996, (Suppl. 4): 6-10.
36. Foster, K.A., Oster, C.G., Mayer, M.M., Avery, M.L., Audus, K.L. Characterization of the A549 cell line as a type II pulmonary epithelial cell model for drug metabolism. Exp Cell Res 1998, 243: 359-66.
37. Hukkanen, J., Lassila, A., Peiverinta, K. et al. Induction and regulation of xenobiotic-metabolizing cytochrome P450s in human A549 lung adenocarcinoma cell line. Am J Respir Cell Mol Biol 2000, 22: 360-6.
38. Boyd, M.R., Grydel, J.J., Minchin, R.F. Metabolic activation as abasic of organ-selective toxicity. Clin Exp Pharmacol Physiol 1983, 19: 87-9.
39. Masubuchi, Y., Narimatsu, S., Hosokawa, S., Suzuki, T. Role of the CYP2D subfamily in metabolism-dependent covalent binding of propranolol to liver microsomal protein in rats. Biochem Pharmacol 1994, 48(10): 1891-8.
40. Narimatsu, S., Watanabe, T., Masubuchi, Y. et al. Characterization of a chemically reactive propranolol metabolite that binds to microsomal proteins of rat liver. Chem Res Toxicol 1995, 8(5): 721-8.
41. Kastelova, A., Stoytchev, T. Effect of propranolol, pindolol and atenolol on drug-metabolizing enzyme systems after single administration in rats. Compt Rend Acad Bulg Sci 1993, 46(7): 119-22.
42. Kastelova, A., Yanev, S. Propranolol as an inhibitor of some cytochrome P-450 dependent monoxygenase activities in native and in induced rat liver microsomes. Methods Find Exp Clin Pharmacol 2002, 24(4): 189-94.
43. Horwitz, L.D., Wallner, J.S., Decker D.E., Buxser, S.E. Efficacy of lipid soluble, membrane-protective agents against hydrogen peroxide cytotoxicity in cardiac myocyte. Free Radic Biol Med 1996, 21(6): 743-53.