The development of a manufacturing route for the GPIIb/IIIa receptor antagonist SB-214857-A. Part 1: Synthesis of the key intermediate 2,3,4,5-tetrahydro-4-methyl-3-oxo-1H-1,4-benzodiazepine-2-acetic acid methyl ester, SB-235349

Organic Process Research and Development

Volumn 7, Issue 5, 2003, Pages 655-662

  Andrews, Ian P ^a   Atkins, Richard J ^a   Breen, Gary F ^a   Carey, John S ^a   Forth, Michael A ^a   Morgan, David O ^a   Shamji, Amin ^a   Share, Andrew C ^a   Smith, Stephen A C ^a   Walsgrove, Timothy C ^a   Wells, Andrew S ^a,b  

^a GLAXOSMITHKLINE   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,4,5 TETRAHYDRO 4 METHYL 3 OXO 1H 1,4 BENZODIAZEPIN 2 ACETIC ACID METHYL ESTER; ACETIC ACID DERIVATIVE; ANILINE; BENZODIAZEPINE DERIVATIVE; BENZYL ALCOHOL; DICARBOXYLIC ACID DERIVATIVE; FIBRINOGEN RECEPTOR ANTAGONIST; LOTRAFIBAN; METHYLAMINE; NITRO DERIVATIVE; QUINAZOLINE; SB 235349; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL BOND; DRUG STRUCTURE; DRUG SYNTHESIS; REDUCTION;

EID: 0141993867     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op034024c     Document Type: Article

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