A new and convergent synthesis of (2S)-7-(4,4′-bipiperidinylcarbonyl)-2,3,4,5-tetrahydro-4-methyl-3-oxo-1H- 1,4-benzodiazepine-2-acetic acid using a palladium-catalysed aminocarbonylation reaction

Organic Process Research and Development

Volumn 3, Issue 1, 1999, Pages 60-63

  Etridge, Stephen K ^a   Hayes, Jerome F ^a   Walsgrove, Timothy C ^a   Wells, Andrew S ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0033482620     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op980068n     Document Type: Article

References (5)

1. Nichols, A. J.; Vasko, J. A.; Koster, P. F.; Valocik, R. E.; Samanen, J. M. GPIIb/IIIa Antagonists as Novel M Drugs: Potential Therapeutic Agents. In Cellular Adhesion: Molecular Definition to Therapeutic Potential: Metcalf, B. W., Dalton, B. J., Poste, G., Eds.; Plenum Press: New York, 1994; pp 213-237.
2. (a) Bondinell, W. E.; Callahan, J. F.; Huffman, W. F.; Keenan, R. M.; Ku, T. W.; Newlander, K. A.; Samanen, J. M.; Uzinskas, I. N. Patent WO 9414776, 7 July 1994; CAN 123:112082.
3. (b) Miller, W. H.; Ku, T. W.; Ali, F. E.; Bondinell, W. E.; Calvo, R. R.; Davis, L. D.; Erhard, K. F.; Hall, L. B.; Huffman, W. F.; Keenan, R. M.; Kwon, C.; Newlander, K. A.; Ross, S. T.; Samanen, J. M.; Takata, D. T. and Yuan, C.-K. Tetrahedron Lett. 1995, 36, 9433.
4. An alternative route using an intermolecular fluoride displacement reaction where no racemization is detected has recently been disclosed: Thomas, W. K.; Fadia, E. A.; Bondinell, W. E.; Erhard, K. F.; Huffman, W. F.; Venslavsky, J. W.; Yuan, C.-C.-K. Tetrahedron Lett. 1997, 38, 3131.
5. Unpublished results.