Plasma triglycerides: An overlooked biomarker of hepatotoxicity in the rat

Comparative Clinical Pathology

Volumn 12, Issue 2, 2003, Pages 95-101

  Provost, Jean Pierre ^a,b   Hanton, G ^a   Le Net, J L ^a  

^a PFIZER INC   (United States)

^b Centre de Recherche   (France)

Author keywords

Biomarkers; Hepatotoxicity; Liver toxicity; Plasma chemistry; Plasma lipids; Preclinical safety assessment; Rat; Triglycerides

Indexed keywords

BIOLOGICAL MARKER; CHLORPROMAZINE; ETHIONINE; FORMIC ACID DERIVATIVE; GALACTOSAMINE; LIPID; PIRINIXIC ACID; RIFAMPICIN; THIOACETAMIDE; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD CHEMISTRY; BLOOD SAMPLING; BODY WEIGHT; CLINICAL FEATURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; HISTOPATHOLOGY; LIPOLYSIS; LIVER BIOPSY; LIVER NECROSIS; LIVER TOXICITY; MALE; NONHUMAN; RAT; RELIABILITY; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 0141926524     PISSN: 16185641     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00580-003-0483-1     Document Type: Article

References (50)

1. Amacher DE, Shomaker SJ, Burkkardt JE (1998) The relationship among microsomal enzyme induction, liver weight and histological change in rat toxicology studies. Food Chem Toxicol 36:831-839
2. Animal Clinical Chemistry Association (ACCA, UK) (1988) Assessment of hepatic function and damage in animal species. J Appl Toxicol 8:249-254
3. Cantafora A, Yan CC, Sun Y et al. (1994) Effects of taurine on microsomal enzyme activities involved in liver lipid metabolism of Wistar rats. In: Huxtable R, Michalk DV, eds. Taurine in health and desease. New York, Plenum Press, 99-110
4. Carpuso A (1991) Drugs affecting triglycerides. Cardiology 78:218-225
5. Cattley RC, Popp JA (2002) Liver. In: Haschek WM, Rousseaux CG, Wallig MA, eds: Handbook of toxicologic pathology. San Diego, Academic Press, 187-222
6. Cohen AJ (1981) Review of the hepatic responses to hypolipidaemic drugs in rodents and assessment of its toxicological significance to man. Fd Comest Toxicol 19:585-605
7. Danni O, Brando C, Burdino E et al. (1986) A model for monitoring changes in liver function. Res Commun Chem Pathol Pharmacol 54:395-403
8. De Oliveira JR, Rosa JL, Ambroisio S et al. (1992) Effect of galactosamine on hepatic carbohydrate metabolism: protective role of fructose 1,6-biphosphate. Hepatology 15:1147-1153
9. Farag MM, Hassib AT (1993) Elevation of serum triacylglycerol concentration in association with hepatic microsomal enzyme induction after treatment with phenylbutazone and diclofenac sodium in rats. Clin Sci (Colch) 84:387-390
10. Fariss MW, Lippman HR, Mumaw VR et al. (1997) Cholesteryl hemisuccinate treatment protects rodents from the toxic effects of acetaminophen, adriamycin, carbon tetrachloride, chloroform and galactosamine. Toxicol Lett 90:133-144
11. Farombi EO, Akinloye O, Akinmoladum CO et al. (1999) Hepatic drug metabolizing enzyme induction and serum triacylglycerol elevation in rats treated with chlordiazepoxide, griseofulvin, rifampicin and phenytoin. Clin Chim Acta 289:1-10
12. Franke H, Zimmermann T, Dargel R (1985) Changes in intra- and extrahepatic VLDL in the rat following acute injury by thioacetamide. A morphometric study. Wirchows Arch B Cell Pathol Mol Pathol 48:277-288
13. Fujii T (1997) Toxicological correlation between changes in blood biochemical parameters and liver histopathological findings. J Toxicol Sci 22:161-183
14. Godinho AF, Silva MA (1995) Effects of misoprostol on circulating HDL-cholesterol, total cholesterol, triglycerides and their relationship with hepatic microsomal function. Pharmacol Toxicol 77:255-258
15. Handler JA, Kossor DC, Goldstein RS (1994) Assessment of hepatobiliary function in vivo and ex vivo in the rat. J Pharmacol Toxicol Meth 31:11-19
16. Hunter AL, Holscher MA, Neal RA (1977) Thioacetamide-induced hepatic necrosis. I. Involvement of the mixed-function oxidase enzyme system. J Pharmacol Exp Ther 200:439-448
17. Jung W, Gebhardt R, Robenek H (1985) Primary culture of rat hepatocytes as a model system of canalicular development, biliary secretion and intrahepatic cholestasis. Virchows Arch (Cell Pathol) 49:349-363
18. Keppler D, Lesch R, Reutter W et al. (1968) Experimental hepatitis induced by D-galactosamine. Exp Mol Pathol 9:279-290
19. Knodell RG (1975) Effects of chlorpromazine on bilirubin metabolism and biliary secretion in the rat. Gastroenterology 69:965-972
20. Kondoh M, Aoki Y, Ogawa Z et al. (1989) Effect of chlorpromazine on transmigration of mitochondrial aspartate aminotransferase in rat liver. Kitasato Arch Exp Med 62:181-186
21. Krupp MN, Hoover KW, Valentine JJ (1989) Effects of doxazosin and other antihypertensives on serum lipid levels and lipoprotein lipase in the C57BR/cdj mouse. J Cardiovasc Pharmacol 13 (Suppl 2): S11-S19
22. Loeb WF (1997) Clinical biochemistry of laboratory rodents and rabbits. In: Kaneko JJ, Harvey JW, Bruss ML, eds. Clinical biochemistry of domestic animals. San Diego, Academic Press, 845-855
23. Ma X, Stoffregen DA, Wheelock G et al. (1997) Discordant hepatic expression of the cell division control enzyme p34cdc2 kinase, proliferating cell nuclear antigen, p53 tumour suppressor protein and p21waf1 cyclin-dependent kinase inhibitory protein after WY14,643 9([4-chloro-6-(2,3-xyldino)-2-pyrimidinylthio] acetic acid) dosing to rats. Mol Pharmacol 51:69-78
24. Mae T, Hosoe K, Yamamoto T et al. (1998) Effect of a new rifampicin derivative, rifalazil, on liver microsomal enzyme induction in rat and dog. Xenobiotica 28:759-766
25. Magdalou J, Totis M, Boiteux-Antoine AF et al. (1988) Effect of 1-benzylimidazole on cytochrome P450 induction and on the activities of epoxide hydrolases and UDP-glucuronosyltransferases in rat liver. Biochem Pharmacol 37:3297-3304
26. Mangipudy RS, Chanda S, Mehendale HM (1995) Hepatocellular regeneration: key to thioacetamide autoprotection. Pharmacol Toxicol 77:182-188
27. Mason MM (1998) The role of factors that regulate the synthesis and secretion of very-low-density lipoprotein by hepatocytes. Crit Rev Clin Lab Sci 35:461-487
28. Moody DE, Reddy JK, Azarnoff DL (1984) Peroxisome-associated enzymes and serum lipids in tumour-bearing rats treated with peroxisome-proliferating agents. Biochem Pharmacol 33:2591-2597
29. Noguchi M, Tanaka K, Kuwamura Y et al. (1993) Toxicokinetics of phenobarbital in rats with DL-ethionine-induced liver injury. J Toxicol Sci 18:245-255
30. Oesch F, Arand M, Strolin Benedetti M et al. (1996) Inducing properties of rifampicin and rifabutin for selected enzyme activities of the cytochrome P450 and UDP-glucuronosyltransferase superfamilies in the female rat liver. J Antimicrob Chemother 37:1111-1119
31. Piriou A, Maissiat R, Jacqueson A (1987) Ultrastructural changes in the parenchymal liver cells of rats treated with high doses of rifampicin. Br J Exp Pathol 68:201-207
32. Piriou A, Warnet JM, Jacqueson A (1979) Fatty liver induced by high doses of rifampicin in the rat: possible relation with an inhibition of RNA polymerase in eukaryotic cells. Arch Toxicol Suppl 2:333-337
33. Posin G, Vialle-Valentin C, Berthewene F (1990) Alteration of high density lipoproteins induced by hormones in man and rat. In: Malmendier et al., eds. Hypercholesterolemia, hypocholesterolemia, hyperthyroidism. New York, Plenum Press, 147-154
34. Poullain MG, Vacher D, Cezard JP et al. (1989) Serum lipids in the rat refed after starving. Influence of the molecular form of nitrogen-protein, peptides or free amino-acids. Metabol Clin Exp 38:740-744
35. Qarawi AA, Ali BH, Abbel-Gayoum AGA (2000) Plasma and hepatic profiles in furazolidone-treated rats. Exp Toxicol Pathol 52:364-366
36. Ramaiah SK, Soni MG, Bucci TJ et al. (1998) Diet restriction enhances compensatory liver tissue repair and survival following administration of a lethal dose of thioacetamide. Toxicol Appl Pharmacol 150:12-21
37. Rees KR, Tarlow MJ (1967) The hepatotoxic action of allyl formate. Biochem J 104:757-761
38. Rumsby PC, Davies MJ, Price RJ et al. (1994) Effects of some peroxisome proliferators on transforming growth factor II/mannose-6-phosphate receptor gene expression in rat liver. Carcinogenesis 15:419-421
39. Sato A, Watanabe K, Fukuzumi H et al. (1991) Effect of simvastatin (MK-733) on plasma triacylglycerol levels in rats. Biochem Pharmacol 41:1163-1172
40. Sodhi CP, Rana S, Metha S et al. (1997) Study of oxidative-stress in rifampicin-induced hepatic injury in growing rats with and without protein-energy malnutrition. Hum Exp Toxicol 16:315-321
41. Steele R (1982) Role of 3-ethylthiopropionate in ethionine metabolism and toxicity in rats. J Nutr 112:118-125
42. Stonard MD (1988) Relationship between biochemical and morphometric changes in the liver after administration of chemicals which cause liver enlargement in rodents and dogs. J Clin Chem Clin Biochem 26:498-499
43. Tennant BC (1999) Assessment of hepatic function. In: Loeb WF, Quimby FW, eds. Clinical biochemistry of laboratory animals. London, Taylor & Francis, 501-517
44. Terada M, Mizuhashi F, Murata K (1999) Mepanipyrim, a new fungicide, inhibits intracellular transport of very low density lipoprotein in rat hepatocytes. Toxicol Appl Pharmacol 154:1-11
45. Timbrell JA (1998) Biochemical mechanisms of toxicity. In: Timbrell JA, ed. Principles of biochemical toxicology. London, Taylor & Francis, 285-383
46. Travlos GS, Morris RW, Elwell MR et al. (1996) Frequency and relationship of clinical chemistry and liver and kidney histopathology findings in 13-week toxicity studies in rats. Toxicology 107:17-29
47. Varas SM, Oliveros LB, Gimenez MS (1999) Lipids in rat liver submitted to acute and chronic hyperthyroidism. Horm Metab Res 31:514-518
48. Waterfield CJ, Turton JA, Scales MDC, Timbrell JA (1993) Investigations into the effects of various hepatotoxic compounds on urinary and liver taurine levels in rats. Arch Toxicol 67:244-254
49. Weingand K, Brown G, Hall R et al. (1996) Harmonization of animal clinical pathology testing in toxicity and safety studies. Fund Appl Toxicol 29:198-201
50. Zimmermann T, Franke H, Dargel R (1985) Biochemical and substructural studies on hepatic and serum lipoprotein metabolism after liver injury induced by thioacetamide in rats. Exp Pathol 28:225-233