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Volumn 51, Issue 1, 1997, Pages 69-78

Discordant hepatic expression of the cell division control enzyme p34(cdc2) kinase, proliferating cell nuclear antigen, p53 tumor suppressor protein, and p21(Waf1) cyclin-dependent kinase inhibitory protein after WY14,643 ([4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid) dosing to rats

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOGEN; CINCHONA ALKALOID; CORN OIL; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLINE; CYTOCHROME P450; LIVER PROTEIN; PEROXISOME PROLIFERATOR; PIRINIXIC ACID; PROTEIN KINASE; PROTEIN P21; PROTEIN P53;

EID: 0031026197     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.51.1.69     Document Type: Article
Times cited : (18)

References (40)
  • 1
    • 0025033793 scopus 로고
    • Cell cycle control in eukaryotes: Molecular mechanisms of cdc2 activation
    • Draetta, G. Cell cycle control in eukaryotes: molecular mechanisms of cdc2 activation. Trends. Biochem. Sci. 15:378-383 (1990).
    • (1990) Trends. Biochem. Sci. , vol.15 , pp. 378-383
    • Draetta, G.1
  • 2
    • 0028145285 scopus 로고
    • Expression and activation of CDKs (1 and 2) and cyclins in the cell cycle progression during liver regeneration
    • Loyer, P., D. Glaise, S. Cariou, G. Baffet, L. Meijer, and C. Guguen-Guillouzo. Expression and activation of CDKs (1 and 2) and cyclins in the cell cycle progression during liver regeneration. J. Biol. Chem. 269:2491-2500 (1994).
    • (1994) J. Biol. Chem. , vol.269 , pp. 2491-2500
    • Loyer, P.1    Glaise, D.2    Cariou, S.3    Baffet, G.4    Meijer, L.5    Guguen-Guillouzo, C.6
  • 3
    • 0026027660 scopus 로고
    • Differential phosphorylation of vertebrate p34cdc2 kinase at the G1/S and G2/M transitions of the cell cycle: Identification of major phosphorylation sites
    • Krek, W., and E. A. Nigg. Differential phosphorylation of vertebrate p34cdc2 kinase at the G1/S and G2/M transitions of the cell cycle: identification of major phosphorylation sites. EMBO J. 10:305-316 (1991).
    • (1991) EMBO J. , vol.10 , pp. 305-316
    • Krek, W.1    Nigg, E.A.2
  • 4
    • 0023443586 scopus 로고
    • Interactions between cdc13+ and cdc2+ in control of mitosis in fission yeast: Dissociation of the G1 and G2 roles of the cdc2+ protein kinase
    • Booher, R., and D. Beach. Interactions between cdc13+ and cdc2+ in control of mitosis in fission yeast: dissociation of the G1 and G2 roles of the cdc2+ protein kinase. EMBO J. 6:3441-3447 (1987).
    • (1987) EMBO J. , vol.6 , pp. 3441-3447
    • Booher, R.1    Beach, D.2
  • 7
    • 0025775739 scopus 로고
    • Hepatocyte proliferation in stepwise development of experimental liver cell cancer
    • Farber E Hepatocyte proliferation in stepwise development of experimental liver cell cancer. Dig. Dis. Sci. 36:973-978 (1991).
    • (1991) Dig. Dis. Sci. , vol.36 , pp. 973-978
    • Farber, E.1
  • 9
    • 0026342471 scopus 로고
    • The Carcinogenic Potency Database: Analyses of 4000 chronic animal cancer experiments published in the general literature and by the U.S. National Cancer Institute/National Toxicology Program
    • Gold L. S., T. H. Sloan, N. B. Manley, G. B. Garfinkel, E. S. Hudes, L. Rohrbach, and B. N. Ames. The Carcinogenic Potency Database: analyses of 4000 chronic animal cancer experiments published in the general literature and by the U.S. National Cancer Institute/National Toxicology Program. Environ. Health Perspect. 96:11-15 (1991).
    • (1991) Environ. Health Perspect. , vol.96 , pp. 11-15
    • Gold, L.S.1    Sloan, T.H.2    Manley, N.B.3    Garfinkel, G.B.4    Hudes, E.S.5    Rohrbach, L.6    Ames, B.N.7
  • 10
    • 0020963049 scopus 로고
    • Chemical carcinogens without mutagenic activity: Peroxisome proliferators as a prototype
    • Reddy, J. K., D. G. Scarpelli, V. Subbarao, and N. D. Lalwani. Chemical carcinogens without mutagenic activity: peroxisome proliferators as a prototype. Toxicol. Pathol. 11:172-180 (1983).
    • (1983) Toxicol. Pathol. , vol.11 , pp. 172-180
    • Reddy, J.K.1    Scarpelli, D.G.2    Subbarao, V.3    Lalwani, N.D.4
  • 11
    • 0021051308 scopus 로고
    • Carcinogenesis by hepatic peroxisome proliferators: Evaluation of the risk of hypolipidemic drugs and industrial plasticizers to humans
    • Reddy, J. K., and N. D. Lalwani. Carcinogenesis by hepatic peroxisome proliferators: evaluation of the risk of hypolipidemic drugs and industrial plasticizers to humans. Crit. Rev. Toxicol. 12:1-58 (1983).
    • (1983) Crit. Rev. Toxicol. , vol.12 , pp. 1-58
    • Reddy, J.K.1    Lalwani, N.D.2
  • 12
    • 0024314929 scopus 로고
    • Differences between the promoting activities of the peroxisome proliferator WY-14,643 and phenobarbital in rat liver
    • Cattley, R. C., and J. A. Popp. Differences between the promoting activities of the peroxisome proliferator WY-14,643 and phenobarbital in rat liver. Cancer Res. 49:3246-3251 (1989).
    • (1989) Cancer Res. , vol.49 , pp. 3246-3251
    • Cattley, R.C.1    Popp, J.A.2
  • 13
    • 0026730908 scopus 로고
    • The peroxisome proliferator-activated receptor mediates the induction of CYP4A6, a cytochrome P450 fatty acid β-hydroxylase, by clofibric acid
    • Muerhoff, A. S., K. J. Griffin, and E. F. Johnson. The peroxisome proliferator-activated receptor mediates the induction of CYP4A6, a cytochrome P450 fatty acid β-hydroxylase, by clofibric acid. J. Biol. Chem. 267:19051-19053 (1992).
    • (1992) J. Biol. Chem. , vol.267 , pp. 19051-19053
    • Muerhoff, A.S.1    Griffin, K.J.2    Johnson, E.F.3
  • 14
    • 0026522195 scopus 로고
    • The dioxin and peroxisome proliferator-activated receptors in search of endogenous ligands
    • Poellinger, L., M. Gottlicher, and J.-A. Gustafsson. The dioxin and peroxisome proliferator-activated receptors in search of endogenous ligands. Trends Pharmacol. Sci. 13:241-245 (1992).
    • (1992) Trends Pharmacol. Sci. , vol.13 , pp. 241-245
    • Poellinger, L.1    Gottlicher, M.2    Gustafsson, J.-A.3
  • 15
    • 0027185097 scopus 로고
    • The human estrogen receptor structural gene contains a DNA sequence that binds activated mouse and human Ah receptors: A possible mechanism of estrogen receptor regulation by 2,3,7,8-tetrachlorodibenzo-p-dioxin
    • White, T. E. K., and T. A. Gasiewicz. The human estrogen receptor structural gene contains a DNA sequence that binds activated mouse and human Ah receptors: a possible mechanism of estrogen receptor regulation by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Biochem. Biophys. Res. Commun. 193:956-962 (1993).
    • (1993) Biochem. Biophys. Res. Commun. , vol.193 , pp. 956-962
    • White, T.E.K.1    Gasiewicz, T.A.2
  • 16
    • 0029067225 scopus 로고
    • Signaling cross-talk between peroxisome proliferator-activated receptor/retinoid X receptor and estrogen receptor through estrogen response elements
    • Keller, H., F. Givel, M. Perroud, and W. Wahli. Signaling cross-talk between peroxisome proliferator-activated receptor/retinoid X receptor and estrogen receptor through estrogen response elements. Mol. Endocrinol. 9:794-804 (1995).
    • (1995) Mol. Endocrinol. , vol.9 , pp. 794-804
    • Keller, H.1    Givel, F.2    Perroud, M.3    Wahli, W.4
  • 17
    • 0027053666 scopus 로고
    • Protein tyrosine phosphorylation as an indicator of 2,3,7,8-tetrachloro-p-dioxin exposure in vivo and in vitro
    • Ma, X., N. A. Mufti, and J. G. Babish. Protein tyrosine phosphorylation as an indicator of 2,3,7,8-tetrachloro-p-dioxin exposure in vivo and in vitro. Biochem. Biophys. Res. Commun. 189:59-65 (1992).
    • (1992) Biochem. Biophys. Res. Commun. , vol.189 , pp. 59-65
    • Ma, X.1    Mufti, N.A.2    Babish, J.G.3
  • 19
    • 0024241608 scopus 로고
    • Relationship of hepatic peroxisome proliferation and replicative DNA synthesis to the hepatocarcinogenicity of the peroxisome proliferators di-(2-ethylhexyl)-phthalate and [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid (WY-14,643) in rats
    • Marsman, D. S., R. C. Cattley, J. G. Conway, and J. A. Popp. Relationship of hepatic peroxisome proliferation and replicative DNA synthesis to the hepatocarcinogenicity of the peroxisome proliferators di-(2-ethylhexyl)-phthalate and [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid (WY-14,643) in rats. Cancer Res. 48:6739-6744 (1988).
    • (1988) Cancer Res. , vol.48 , pp. 6739-6744
    • Marsman, D.S.1    Cattley, R.C.2    Conway, J.G.3    Popp, J.A.4
  • 20
    • 0027742265 scopus 로고
    • Acute 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure results in enhanced tyrosylphosphorylation, and expression of murine hepatic cyclin dependent kinases
    • Ma, X., and J. G. Babish. Acute 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure results in enhanced tyrosylphosphorylation, and expression of murine hepatic cyclin dependent kinases. Biochem. Biophys. Res. Commun. 197: 1070-1077 (1993).
    • (1993) Biochem. Biophys. Res. Commun. , vol.197 , pp. 1070-1077
    • Ma, X.1    Babish, J.G.2
  • 21
    • 0009482260 scopus 로고
    • Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets, procedure and some applications
    • Towbin, H., T. Staehelin, and J. Gordon. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets, procedure and some applications. Proc. Natl. Acad. Sci. USA 76:4350-4354 (1979).
    • (1979) Proc. Natl. Acad. Sci. USA , vol.76 , pp. 4350-4354
    • Towbin, H.1    Staehelin, T.2    Gordon, J.3
  • 22
    • 0024236331 scopus 로고
    • The molecular biology of cytochrome P450s
    • Gonzalez, F. J. The molecular biology of cytochrome P450s. Pharmacol. Rev. 40:243-288 (1989).
    • (1989) Pharmacol. Rev. , vol.40 , pp. 243-288
    • Gonzalez, F.J.1
  • 23
    • 0023301988 scopus 로고
    • Molecular cloning of cDNA coding for rat proliferating cell nuclear antigen (PCNA)/cyclin
    • Matsumoto, K., T. Moriuchi, T. Koji, and P. K. Nakane. Molecular cloning of cDNA coding for rat proliferating cell nuclear antigen (PCNA)/cyclin. EMBO J. 6:637-642 (1987).
    • (1987) EMBO J. , vol.6 , pp. 637-642
    • Matsumoto, K.1    Moriuchi, T.2    Koji, T.3    Nakane, P.K.4
  • 25
    • 0023091627 scopus 로고
    • Cyclin/ PCNA is the auxiliary protein of DNA polymerase-delta
    • Bravo, R., R. Frank, P. A. Blundell, and H. Macdonald-Bravo. Cyclin/ PCNA is the auxiliary protein of DNA polymerase-delta. Nature (Lond.) 326:515-517 (1987).
    • (1987) Nature (Lond.) , vol.326 , pp. 515-517
    • Bravo, R.1    Frank, R.2    Blundell, P.A.3    Macdonald-Bravo, H.4
  • 26
    • 0027477757 scopus 로고
    • Toxicological and pathological applications of proliferating cell nuclear antigen (PCNA): A novel endogenous marker for cell prolifer-ation
    • Dietrich, D. R. Toxicological and pathological applications of proliferating cell nuclear antigen (PCNA): a novel endogenous marker for cell prolifer-ation. Crit. Rev. Toxicol. 23:77-109 (1993).
    • (1993) Crit. Rev. Toxicol. , vol.23 , pp. 77-109
    • Dietrich, D.R.1
  • 27
    • 0028089002 scopus 로고
    • Elevated expression and activity of mitotic regulatory proteins in human papillomavirus-immortalized keratinocytes
    • Steinmann, K. E., X. F. Pei, H. Stoppler, and R. Schlegel. Elevated expression and activity of mitotic regulatory proteins in human papillomavirus-immortalized keratinocytes. Oncogene 9:387-394 (1994).
    • (1994) Oncogene , vol.9 , pp. 387-394
    • Steinmann, K.E.1    Pei, X.F.2    Stoppler, H.3    Schlegel, R.4
  • 28
    • 0027339198 scopus 로고
    • Increased expression of p34cdc2 and its kinase activity in human gastric and colonic carcinomas
    • Yasui, W., A. Ayhan, Y. Kitadai, K. Nishimura, H. Yokozaki, H. Ho, and E. Tahara. Increased expression of p34cdc2 and its kinase activity in human gastric and colonic carcinomas. Int. J. Cancer 53:36-41 (1993).
    • (1993) Int. J. Cancer , vol.53 , pp. 36-41
    • Yasui, W.1    Ayhan, A.2    Kitadai, Y.3    Nishimura, K.4    Yokozaki, H.5    Ho, H.6    Tahara, E.7
  • 29
    • 0027530449 scopus 로고
    • Redundant cyclin overexpression and gene amplification in breast cancer cells
    • Keyomarsi, K., and A. B. Pardee. Redundant cyclin overexpression and gene amplification in breast cancer cells. Proc. Natl. Acad. Sci. USA 90:1112-1116 (1993).
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 1112-1116
    • Keyomarsi, K.1    Pardee, A.B.2
  • 30
    • 0028940722 scopus 로고
    • Cell cycle regulators and cancer
    • Kamb, A. Cell cycle regulators and cancer. Trends Genet. 11:136-140 (1995).
    • (1995) Trends Genet. , vol.11 , pp. 136-140
    • Kamb, A.1
  • 32
    • 0026589723 scopus 로고
    • Mitogenic stimulation of hepatocellular proliferation in rodents following 1,4-dichlorobenzene administration
    • Eldridge, S. R., T. L. Goldsworthy, J. A. Popp, and B. E. Butterworth. Mitogenic stimulation of hepatocellular proliferation in rodents following 1,4-dichlorobenzene administration. Carcinogenesis 13:409-415 (1992).
    • (1992) Carcinogenesis , vol.13 , pp. 409-415
    • Eldridge, S.R.1    Goldsworthy, T.L.2    Popp, J.A.3    Butterworth, B.E.4
  • 34
    • 0028213828 scopus 로고
    • Dose-response relationships in mice following subchronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin: CYP1A1, CYP1A2, estrogen receptor, and protein tyrosine phosphorylation
    • DeVito, M. J., X. Ma, J. G. Babish, M. Menache, and L. S. Birnbaum. Dose-response relationships in mice following subchronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin: CYP1A1, CYP1A2, estrogen receptor, and protein tyrosine phosphorylation. Toxicol. Appl. Pharmacol. 124: 82-90 (1994).
    • (1994) Toxicol. Appl. Pharmacol. , vol.124 , pp. 82-90
    • DeVito, M.J.1    Ma, X.2    Babish, J.G.3    Menache, M.4    Birnbaum, L.S.5
  • 35
    • 0028093471 scopus 로고
    • How important is the protein phosphorylation pathway in the toxic expression of dioxin-type chemicals?
    • Matsumura, F. How important is the protein phosphorylation pathway in the toxic expression of dioxin-type chemicals? Biochem. Pharmacol. 48: 215-224 (1994).
    • (1994) Biochem. Pharmacol. , vol.48 , pp. 215-224
    • Matsumura, F.1
  • 36
    • 0027946715 scopus 로고
    • Proliferating cell nuclear antigen bound to DNA synthesis sites: Phosphorylation and association with cyclin D1 and cyclin A
    • Prosperi, E., A. I. Scovassi, L. A. Stivala, and L. Bianchi. Proliferating cell nuclear antigen bound to DNA synthesis sites: phosphorylation and association with cyclin D1 and cyclin A. Exp. Cell Res. 215:257-262 (1994).
    • (1994) Exp. Cell Res. , vol.215 , pp. 257-262
    • Prosperi, E.1    Scovassi, A.I.2    Stivala, L.A.3    Bianchi, L.4
  • 37
    • 0027768579 scopus 로고
    • Braking the cycle
    • Hunter, T. Braking the cycle. Cell 75:839-841 (1993).
    • (1993) Cell , vol.75 , pp. 839-841
    • Hunter, T.1
  • 38
    • 0028352434 scopus 로고
    • Waf1 Inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA
    • Waf1 Inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Nature (Lond.) 369:574-578 (1994).
    • (1994) Nature (Lond.) , vol.369 , pp. 574-578
    • Waga, S.1    Marsman, D.S.2    Beach, D.3    Stillman, B.4
  • 39
    • 0028339548 scopus 로고
    • Apoptosis and chemical carcinogenesis
    • Marsman, D. S., and J. D. Barrett. Apoptosis and chemical carcinogenesis. Risk Anal. 14:321-326 (1994).
    • (1994) Risk Anal. , vol.14 , pp. 321-326
    • Marsman, D.S.1    Barrett, J.D.2
  • 40
    • 0026631269 scopus 로고
    • Contrasting hepatocyte peroxisome proliferation, lipofuscin accumulation and cell turnover for the hepatocarcinogens Wy- 14,643 and clofibric acid
    • Marsman, D. S., T. L. Goldsworthy, and J. A. Popp. Contrasting hepatocyte peroxisome proliferation, lipofuscin accumulation and cell turnover for the hepatocarcinogens Wy-14,643 and clofibric acid. Carcinogenesis 13:1011-1017 (1992).
    • (1992) Carcinogenesis , vol.13 , pp. 1011-1017
    • Marsman, D.S.1    Goldsworthy, T.L.2    Popp, J.A.3


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