Discordant hepatic expression of the cell division control enzyme p34(cdc2) kinase, proliferating cell nuclear antigen, p53 tumor suppressor protein, and p21(Waf1) cyclin-dependent kinase inhibitory protein after WY14,643 ([4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid) dosing to rats

Molecular Pharmacology

Volumn 51, Issue 1, 1997, Pages 69-78

  Ma, Xinfang ^a   Stoffregen, Dana A ^b   Wheelock, Geoffrey D ^a   Rininger, Joseph A ^a   Babish, John G ^a,b  

^a Paracelsian Inc   (United States)

^b Department of Obstetrics Gynecology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOGEN; CINCHONA ALKALOID; CORN OIL; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLINE; CYTOCHROME P450; LIVER PROTEIN; PEROXISOME PROLIFERATOR; PIRINIXIC ACID; PROTEIN KINASE; PROTEIN P21; PROTEIN P53;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CYCLE; CELL DIVISION; CELL PROLIFERATION; CONTROLLED STUDY; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; INTRAPERITONEAL DRUG ADMINISTRATION; LIVER CARCINOGENESIS; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE;

EID: 0031026197     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.51.1.69     Document Type: Article

References (40)

1. Draetta, G. Cell cycle control in eukaryotes: molecular mechanisms of cdc2 activation. Trends. Biochem. Sci. 15:378-383 (1990).
2. Loyer, P., D. Glaise, S. Cariou, G. Baffet, L. Meijer, and C. Guguen-Guillouzo. Expression and activation of CDKs (1 and 2) and cyclins in the cell cycle progression during liver regeneration. J. Biol. Chem. 269:2491-2500 (1994).
3. Krek, W., and E. A. Nigg. Differential phosphorylation of vertebrate p34cdc2 kinase at the G1/S and G2/M transitions of the cell cycle: identification of major phosphorylation sites. EMBO J. 10:305-316 (1991).
4. Booher, R., and D. Beach. Interactions between cdc13+ and cdc2+ in control of mitosis in fission yeast: dissociation of the G1 and G2 roles of the cdc2+ protein kinase. EMBO J. 6:3441-3447 (1987).
5. Bischoff, J. R., P. N. Friedman, D. R. Marshak, C. Prives, and D. Beach. Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2. Proc. Natl. Acad. Sci. USA 87:4766-4770 (1990).
6. Xiong Y., G. J. Hannon, H. Zhang, D. Casso, R. Kobayashi, and D. Beach. p21 is a universal inhibitor of cyclin kinases. Nature (Lond.) 366:701-704 (1993).
7. Farber E Hepatocyte proliferation in stepwise development of experimental liver cell cancer. Dig. Dis. Sci. 36:973-978 (1991).
8. Goldsworthy, T. L., K. T. Morgan, J. A. Popp, and B. E. Butterworth. Chemically-induced cell proliferation. CIIT. Act. 10:1-7 (1990).
9. Gold L. S., T. H. Sloan, N. B. Manley, G. B. Garfinkel, E. S. Hudes, L. Rohrbach, and B. N. Ames. The Carcinogenic Potency Database: analyses of 4000 chronic animal cancer experiments published in the general literature and by the U.S. National Cancer Institute/National Toxicology Program. Environ. Health Perspect. 96:11-15 (1991).
10. Reddy, J. K., D. G. Scarpelli, V. Subbarao, and N. D. Lalwani. Chemical carcinogens without mutagenic activity: peroxisome proliferators as a prototype. Toxicol. Pathol. 11:172-180 (1983).
11. Reddy, J. K., and N. D. Lalwani. Carcinogenesis by hepatic peroxisome proliferators: evaluation of the risk of hypolipidemic drugs and industrial plasticizers to humans. Crit. Rev. Toxicol. 12:1-58 (1983).
12. Cattley, R. C., and J. A. Popp. Differences between the promoting activities of the peroxisome proliferator WY-14,643 and phenobarbital in rat liver. Cancer Res. 49:3246-3251 (1989).
13. Muerhoff, A. S., K. J. Griffin, and E. F. Johnson. The peroxisome proliferator-activated receptor mediates the induction of CYP4A6, a cytochrome P450 fatty acid β-hydroxylase, by clofibric acid. J. Biol. Chem. 267:19051-19053 (1992).
14. Poellinger, L., M. Gottlicher, and J.-A. Gustafsson. The dioxin and peroxisome proliferator-activated receptors in search of endogenous ligands. Trends Pharmacol. Sci. 13:241-245 (1992).
15. White, T. E. K., and T. A. Gasiewicz. The human estrogen receptor structural gene contains a DNA sequence that binds activated mouse and human Ah receptors: a possible mechanism of estrogen receptor regulation by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Biochem. Biophys. Res. Commun. 193:956-962 (1993).
16. Keller, H., F. Givel, M. Perroud, and W. Wahli. Signaling cross-talk between peroxisome proliferator-activated receptor/retinoid X receptor and estrogen receptor through estrogen response elements. Mol. Endocrinol. 9:794-804 (1995).
17. Ma, X., N. A. Mufti, and J. G. Babish. Protein tyrosine phosphorylation as an indicator of 2,3,7,8-tetrachloro-p-dioxin exposure in vivo and in vitro. Biochem. Biophys. Res. Commun. 189:59-65 (1992).
18. 3H]thymidine and Salmonella mutagenesis assays. Cancer Res. 40:36-41 (1980).
19. Marsman, D. S., R. C. Cattley, J. G. Conway, and J. A. Popp. Relationship of hepatic peroxisome proliferation and replicative DNA synthesis to the hepatocarcinogenicity of the peroxisome proliferators di-(2-ethylhexyl)-phthalate and [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid (WY-14,643) in rats. Cancer Res. 48:6739-6744 (1988).
20. Ma, X., and J. G. Babish. Acute 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure results in enhanced tyrosylphosphorylation, and expression of murine hepatic cyclin dependent kinases. Biochem. Biophys. Res. Commun. 197: 1070-1077 (1993).
21. Towbin, H., T. Staehelin, and J. Gordon. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets, procedure and some applications. Proc. Natl. Acad. Sci. USA 76:4350-4354 (1979).
22. Gonzalez, F. J. The molecular biology of cytochrome P450s. Pharmacol. Rev. 40:243-288 (1989).
23. Matsumoto, K., T. Moriuchi, T. Koji, and P. K. Nakane. Molecular cloning of cDNA coding for rat proliferating cell nuclear antigen (PCNA)/cyclin. EMBO J. 6:637-642 (1987).
24. El-Deiry, W. S., J. W. Harper, P. M. O'Conner, V. E. Velculescu, C. E. Canman, J. Jackman, J. A. Pietenpol, M. Burrell, D. E. Hill, Y. Wang, K. G. Wiman, W. E. Mercer, M. B. Kastan, K. W. Kohn, S. E. Elledge, K. W. Kinzler, and B. Vogelstein. Waf1/Cip1 is induced in p53 mediated G1 arrest and apoptosis. Cancer Res. 54:1169-1174 (1994).
25. Bravo, R., R. Frank, P. A. Blundell, and H. Macdonald-Bravo. Cyclin/ PCNA is the auxiliary protein of DNA polymerase-delta. Nature (Lond.) 326:515-517 (1987).
26. Dietrich, D. R. Toxicological and pathological applications of proliferating cell nuclear antigen (PCNA): a novel endogenous marker for cell prolifer-ation. Crit. Rev. Toxicol. 23:77-109 (1993).
27. Steinmann, K. E., X. F. Pei, H. Stoppler, and R. Schlegel. Elevated expression and activity of mitotic regulatory proteins in human papillomavirus-immortalized keratinocytes. Oncogene 9:387-394 (1994).
28. Yasui, W., A. Ayhan, Y. Kitadai, K. Nishimura, H. Yokozaki, H. Ho, and E. Tahara. Increased expression of p34cdc2 and its kinase activity in human gastric and colonic carcinomas. Int. J. Cancer 53:36-41 (1993).
29. Keyomarsi, K., and A. B. Pardee. Redundant cyclin overexpression and gene amplification in breast cancer cells. Proc. Natl. Acad. Sci. USA 90:1112-1116 (1993).
30. Kamb, A. Cell cycle regulators and cancer. Trends Genet. 11:136-140 (1995).
31. Biegel, L. B., M. E. Hurtt, S. R. Frame, M. Applegate, J. C. O'connor, and J. C. Cook. Comparison of the effects of Wyeth-14,643 in Crl:CD BR and Fisher-344 rats. Fundam. Appl. Toxicol. 19:590-597 (1992).
32. Eldridge, S. R., T. L. Goldsworthy, J. A. Popp, and B. E. Butterworth. Mitogenic stimulation of hepatocellular proliferation in rodents following 1,4-dichlorobenzene administration. Carcinogenesis 13:409-415 (1992).
33. 3H-thymidine incorporation and neurogenesis. J. Neurosci. 13:2930-2938 (1993).
34. DeVito, M. J., X. Ma, J. G. Babish, M. Menache, and L. S. Birnbaum. Dose-response relationships in mice following subchronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin: CYP1A1, CYP1A2, estrogen receptor, and protein tyrosine phosphorylation. Toxicol. Appl. Pharmacol. 124: 82-90 (1994).
35. Matsumura, F. How important is the protein phosphorylation pathway in the toxic expression of dioxin-type chemicals? Biochem. Pharmacol. 48: 215-224 (1994).
36. Prosperi, E., A. I. Scovassi, L. A. Stivala, and L. Bianchi. Proliferating cell nuclear antigen bound to DNA synthesis sites: phosphorylation and association with cyclin D1 and cyclin A. Exp. Cell Res. 215:257-262 (1994).
37. Hunter, T. Braking the cycle. Cell 75:839-841 (1993).
38. Waf1 Inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Nature (Lond.) 369:574-578 (1994).
39. Marsman, D. S., and J. D. Barrett. Apoptosis and chemical carcinogenesis. Risk Anal. 14:321-326 (1994).
40. Marsman, D. S., T. L. Goldsworthy, and J. A. Popp. Contrasting hepatocyte peroxisome proliferation, lipofuscin accumulation and cell turnover for the hepatocarcinogens Wy-14,643 and clofibric acid. Carcinogenesis 13:1011-1017 (1992).