Telomerase activity, apoptosis and cell cycle progression in ataxia telangiectasia lymphocytes expressing TCL1

British Journal of Cancer

Volumn 89, Issue 6, 2003, Pages 1091-1095

  Gabellini, C ^a   Antonelli, A ^b   Petrinelli, P ^b   Biroccio, A ^a   Marcucci, L ^b   Nigro, G ^b   Russo, G ^c   Zupi, G ^a   Elli, R ^b,d  

^a REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c LABORATORIO DI PATOLOGIA VASCOLARE   (Italy)

^d POLICLINICO UMBERTO I   (Italy)

Author keywords

Apoptosis; Ataxia telangiectasia; Cell cycle; TCL1; Telomere

Indexed keywords

ETOPOSIDE; TELOMERASE;

APOPTOSIS; ARTICLE; ATAXIA TELANGIECTASIA; CANCER SUSCEPTIBILITY; CELL CYCLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME STABILITY; GENE EXPRESSION; HUMAN; HUMAN CELL; LYMPHOCYTE; LYMPHOCYTE COUNT; METAPHASE; ONCOGENE; PRIORITY JOURNAL; TELOMERE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; ATAXIA TELANGIECTASIA; CELL CYCLE; CELL TRANSFORMATION, NEOPLASTIC; CHROMOSOMES, HUMAN, PAIR 14; CLONE CELLS; DNA-BINDING PROTEINS; ETOPOSIDE; GENE EXPRESSION REGULATION; HUMANS; PRELEUKEMIA; PROTO-ONCOGENE PROTEINS; T-LYMPHOCYTES; TELOMERASE; TELOMERE; TRANSCRIPTION FACTORS; TRANSLOCATION, GENETIC;

EID: 0141921837     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6601213     Document Type: Article

References (38)

1. Bebb DG, Warrington PJ, de Jong G, Yu Z, Moffat JA, Skov K, Spacey S, Gelmon K, Glickman BW (2001) Radiation induced apoptosis in ataxia telangiectasia homozygote, heterozygote and normal cells. Mutat Res 476: 13-20
2. Bichi R, Shinton SA, Martin ES, Koval A, Calin GA, Cesari R, Russo G, Hardy RR, Croce CM (2002) Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression. Proc Natl Acad Sci USA 99: 6955-6960
3. Biroccio A, Amodei S, Benassi B, Scarsella M, Cianciulli A, Mottolese M, Del Bufalo D, Leonetti C, Zupi G (2002) Reconstitution of hTERT restores tumorigenicity in melanoma-derived c-Myc low-expressing clones. Oncogene 21: 3011-3019
4. Blasco MA (2002) Telomerase beyond telomeres. Nat Rev Cancer 2: 627-633
5. Brennan P, Babbage JW, Burgering BM, Groner B, Reif K, Cantrell DA (1997) Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F. Immunity 7: 679-689
6. Duchaud E, Ridet A, Stoppa-Lyonnet D, Janin N, Moustacchi E, Rosselli F (1996) Deregulated apoptosis in ataxia telangiectasia: association with clinical stigmata and radiosensitivity. Cancer Res 56: 1400-1404
7. Fears S, Chakrabarti SR, Nucifora G, Rowley JD (2002) Differential expression of TCL1 during pre-B-cell acute lymphoblastic leukemia progression. Cancer Genet Cytogenet 135: 110-119
8. Ferraro C, Quemeneur L, Fournel S, Prigent AF, Revillard JP, Bonnefoy-Berard N (2000) The topoisomerase inhibitors camptothecin and etoposide induce a CD95-independent apoptosis of activated peripheral lymphocytes. Cell Death Differ 7: 197-206
9. Gilad S, Khosravi R, Shkedy D, Uziel T, Ziv Y, Savitsky K, Rotman G, Smith S, Chessa L, Jorgensen TJ, Harnik R, Frydman M, Sanal O, Portnoi S, Goldwicz Z, Jaspers NG, Gatti RA, Lenoir G, Lavin MF, Tatsumi K, Wegner RD, Shiloh Y, Bar-Shira A (1996) Predominance of null mutations in ataxia-telangiectasia. Hum Mol Genet 5: 433-439
10. Greenwell PW, Kronmal SL, Porter SE, Gassenhuber J, Obermaier B, Petes TD (1995) TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene. Cell 82: 823-829
11. Gritti C, Dastot H, Soulier J, Janin A, Daniel MT, Madani A, Grimber G, Briand P, Sigaux F, Stern MH (1998) Transgenic mice for MTCP1 develop T-cell prolymphocytic leukemia. Blood 92: 368-373
12. Harley CB, Futcher AB, Greider CW (1990) Telomeres shorten during ageing of human fibroblasts. Nature 345: 458-460
13. Hoyer KK, French SW, Turner DE, Nguyen MT, Renard M, Malone CS, Knoetig S, Qi CF, Su TT, Cheroutre H, Wall R, Rawlings DJ, Morse III HC, Teitell MA (2002) Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma. Proc Natl Acad Sci USA 99: 14392-14397
14. Kang SS, Kwon J, Kwon DJ, Do SI (1999) Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunit. J Biol Chem 274: 13085-13090
15. Kunstle G, Laine J, Pierron G, Kagami Si S, Nakajima H, Hoh F, Roumestand C, Stern MH, Noguchi M (2002) Identification of Akt association and oligomerization domains of the Akt kinase coactivator TCL1. Mol Cell Biol 22: 1513-1525
16. Laine J, Kunstle G, Obata T, Sha M, Noguchi M (2000) The protooncogene TCL1 is an Akt kinase coactivator. Mol Cell 6: 395-407
17. Lauder A, Castellanos A, Weston K (2001) c-Myb transcription is activated by protein kinase B (PKB) following interleukin 2 stimulation of T cells and is required for PKB-mediated protection from apoptosis. Mol Cell Biol 21: 5797-5805
18. Metcalfe JA, Parkhill J, Campbell L, Stacey M, Biggs P, Byrd PJ, Taylor AM (1996) Accelerated telomere shortening in ataxia telangiectasia. Nat Genet 13: 350-353
19. Meyn MS (1999) Ataxia-telangiectasia, cancer and the pathobiology of the ATM gene. Clin Genet 55: 289-304
20. Narducci MG, Pescarmona E, Lazzeri C, Signoretti S, Lavinia AM, Remotti D, Scala E, Baroni CD, Stoppacciaro A, Croce CM, Russo G (2000) Regulation of TCL1 expression in B- and T-cell lymphomas and reactive lymphoid tissues. Cancer Res 60: 2095-2100
21. Narducci MG, Virgilio L, Isobe M, Stoppacciaro A, Elli R, Fiorilli M, Carbonari M, Antonelli A, Chessa L, Croce CM, Russo G (1995) TCL1 oncogene activation in preleukemic T cells from a case of ataxia-telangiectasia. Blood 86: 2358-2364
22. Nicholson KM, Anderson NG (2002) The protein kinase B/Akt signalling pathway in human malignancy. Cell Signal 14: 381-395
23. Pandita TK (2002) ATM function and telomere stability. Oncogene 21: 611-618
24. Pandita TK, Dhar S (2000) Influence of ATM function on interactions between telomeres and nuclear matrix. Radiat Res 154: 133-139
25. Pandita TK, Pathak S, Geard CR (1995) Chromosome end associations, telomeres and telomerase activity in ataxia telangiectasia cells. Cytogenet Cell Genet 71: 86-93
26. Pekarsky Y, Hallas C, Isobe M, Russo G, Croce CM (1999) Abnormalities at 14q32.1 in T cell malignancies involve two oncogenes. Proc Natl Acad Sci USA 96:2949-2951
27. Pekarsky Y, Koval A, Hallas C, Bichi R, Tresini M, Malstrom S, Russo G, Tsichlis P, Croce CM (2000) Tell enhances Akt kinase activity and mediates its nuclear translocation. Proc Natl Acad Sci USA 97: 3028-3033
28. Petrinelli P, Elli R, Marcucci L, Barbieri C, Ambra R, Antonelli A (1996) VP16 hypersensitivity and increased faulty recombination in ataxia telangiectasia lymphocytes characterized by the tandem translocation t(14;14)(q11;q32). Carcinogenesis 17: 203-207
29. Petrinelli P, Elli R, Marcucci L, Tabolacci E, Barbieri C, Antonelli A (2001) Telomeric associations and chromosome instability in ataxia telangiectasia T cells characterized by TCL1 expression. Cancer Genet Cytogenet 125: 46-51
30. Shiloh Y, Kastan MB (2001) ATM: genome stability, neuronal development, and cancer cross paths. Adv Cancer Res 83: 209-254
31. Sinkule JA (1984) Etoposide: a semisynthetic epipodophyllotoxin. Chemistry, pharmacology, pharmacokinetics, adverse effects and use as an antineoplastic agent. Pharmacotherapy 4: 61-73
32. Smith GC, d'Adda di Fagagna F, Lakin ND, Jackson SP (1999) Cleavage and inactivation of ATM during apoptosis. Mol Cell Biol 19: 6076-6084
33. Stern MH, Soulier J, Rosenzwajg M, Nakahara K, Canki-Klain N, Aurias A, Sigaux F, Kirsch IR (1993) MTCP-1: a novel gene on the human chromosome Xq28 translocated to the T cell receptor alpha/delta locus in mature T cell proliferations. Oncogene 8: 2475-2483
34. Taylor AM, Metcalfe JA, Thick J, Mak YF (1996) Leukemia and lymphoma in ataxia telangiectasia. Blood 87: 423-438
35. Virgilio L, Lazzeri C, Bichi R, Nibu K, Narducci MG, Russo G, Rothstein JL, Croce CM (1998) Deregulated expression of TCL1 causes T cell leukemia in mice. Proc Natl Acad Sci USA 95: 3885-3889
36. Virgilio L, Narducci MG, Isobe M, Billips LG, Cooper MD, Croce CM, Russo G (1994) Identification of the TCL1 gene involved in T-cell malignancies. Proc Natl Acad Sci USA 91: 12530-12534
37. Wood LD, Halvorsen TL, Dhar S, Baur JA, Pandita RK, Wright WE, Hande MP, Calaf G, Hei TK, Levine F, Shay JW, Wang JJ, Pandita TK (2001) Characterization of ataxia telangiectasia fibroblasts with extended life-span through telomerase expression. Oncogene 20: 278-288
38. Zhu J, Wang H, Bishop JM, Blackburn EH (1999) Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening. Proc Natl Acad Sci USA 96: 3723-3728