NGF and BNDF: A leading role in sensorineural hearing loss. Preliminary data;Nerve growth factor e brain derived neurotrophic factor: Un possibile ruolo eziopatogenico nell'ipoacusia neurosensoriale. Dati preliminari

Annali dell'Istituto Superiore di Sanita

Volumn 39, Issue 2, 2003, Pages 189-194

  Salvinelli, Fabrizio ^a   Antonelli, Alessia ^b   Stampachiacchiere, Barbara ^b   Bianchi Di Castelbianco, Federico ^c   Casale, Manuele ^a   D'Ascanio, Luca ^a   Greco, Fabio ^a   Aloe, Luigi ^b  

^a UNIVERSITY CAMPUS BIO MEDICO   (Italy)

^b CNR   (Italy)

^c Istituto di Ortofonologia   (Italy)

Author keywords

BDNF; Hearing; Inner ear; Neurotrophins; NGF; Sensorineural hearing loss

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; NERVE GROWTH FACTOR; NEUROTROPHIN;

ADOLESCENT; ADULT; ARTICLE; AUDITORY SYSTEM; CELL SURVIVAL; CLINICAL ARTICLE; CONTROLLED STUDY; HEARING; HUMAN; INNER EAR; NERVE CELL; PERCEPTION DEAFNESS; PERIPHERAL NERVOUS SYSTEM; PROTEIN BLOOD LEVEL; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN STRUCTURE; SCHOOL CHILD;

ADOLESCENT; ADULT; BRAIN-DERIVED NEUROTROPHIC FACTOR; CASE-CONTROL STUDIES; CHILD; FEMALE; HEARING LOSS, SENSORINEURAL; HUMANS; MALE; MIDDLE AGED; NERVE GROWTH FACTOR;

EID: 0141892157     PISSN: 00212571     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Willems PJ. Mechanisms of disease: genetic causes of hearing loss. N Engl J Med 2000;342:1101-9.
2. Steel KP. Science, medicine, and the future. New interventions in hearing impairment. BMJ 2000;320:622-5.
3. Glorig A, Davis H. Age, nose and hearing loss. Ann Otol 1961;70:556-71.
4. Rosenhall U. Presbyacusis-hearing loss in old age. Lakartidningen 2001;98:2802-6.
5. Mohr PE, Feldman JJ, Dunbar JL, McConkey-Robbins A, Niparko JK, Rittenhouse RK, Skinner MW. The societal costs of severe to profound hearing loss in the United States. Int J Technol Assess Health Care 2000 Autumn;16(4):1120-35.
6. Paparella MM. Review of sensorineural hearing loss. Am J Otol 1984;5(4):311-4.
7. Apfel SC, Kessler JA, Adomato BT, Litchy WJ, Sanders C, Rask CA. Recombinant human nerve growth factor in the treatment of diabetic polineuropathy. Neurol 1998;51:695-702.
8. Qun LX, Pirvola U, Saarma M, Ylikosky J. Neurotrophic factors in the auditory periphery. Ann NY Acad Sci 1999;884:292-304.
9. Agerman K, Hjerling-Leffler J, Blanchard MP, Scarfone E, Canlon B, Nosrat C, Ernfors P. BDNF gene replacement reveals multiple mechanisms for establishing neurotrophin specificity during sensory nervous system development. Development 2003;130(8):1479-91.
10. Levi-Montalcini R The nerve growth factor 35 years later. Science 1987;4:1154-62.
11. Aloe L, Tirassa P, Bracci-Laudiero L. Nerve growth factor in neurological and non-neurological diseases: basic findings and emerging pharmacological prospectives. Curr Pharm Des 2001; 7:113-23.
12. Salvinelli F, Casale M, Greco F, Trivelli M, Di Peco V, Amendola T, Antonelli A, Stampachiacchiere B, Aloe L. Nerve growth factor serum level is reduced in patients with sensorineural hearing impairment: possible clinical implications. J Biol Regul Homeost Agents 2002;16(3):176-80.
13. Weskamp G, Otten U. An enzyme-linked immunoassay for nerve growth factor (NGF): a tool for studying regulatory mechanisms involved in NGF production in brain and peripheral tissues. J Neurochem 1987;48:1779-86.
14. Aloe L. Nerve growth factor and neuroimmune responses: basic and clinical observations. Arch Physiol Biochem 2001;109(4):354-6.
15. Marzella PL, Gillespie LN. Role of trophic factors in the development, survival and repair of primary auditory neurons. Clin Exp Pharmacol Physiol 2002;29(0-6):363-71.
16. Malgrange B, Rigo JM, Van de Water TR, Staecker H, Moonen G, Lefebvre PP. Growth factor therapy to the damaged inner ear: clinical prospects. Int J Pediatr Otorhinolaryngol 1999;49:19-25.
17. Vega JA, San Jose I, Cabo R, Rodriguez S, Represa J. Trks and P75 genes are differentially expressed in the inner ear of human embryos. What may Trks and p75 null mutant mice suggest on human development? Neurosci Lett 1999;272:103-6.
18. Shoji F, Miller AL, Mitchell A, Yamasoba T, Altschuler RA, Miller JM. Differential protective effects of neurotrophins in the attenuation of noise-induced hair cell loss. Hear Res 2000;146(1-2):134-42.
19. Dugan LL, Creedon DJ, Johnson EM Jr, Holtzman DM. Rapid suppression of free radical formation by nerve growth factor involves the mitogen-activated protein kinase pathway. Proc Natl Acad Sci USA 1997;94(8):4086-91.
20. Gabaizadeh R, Staecker H, Liu W, Van De Water TR. BDNF protection of auditory neurons from cisplatin involves changes in intracellular levels of both reactive oxygen species and glutathione. Brain Res Mol Brain Res 1997;50:71-8.
21. Staecker H, Gabaizadeh R, Federoff H, Van De Water TR. Brain-derived neurotrophic factor gene therapy prevents spiral ganglion degeneration after hair cell loss. Otolaryngol Head Neck Surg 1998;119(1):7-13.
22. Nakao N, Kokaia Z, Odin P, Lindvall O. Protective effects of BDNF and NT-3 but not PDGF against hypoglycemic injury to cultured striatal neurons. Exp Neurol 1995;131(1):1-10.
23. Zheng JL, Gao WQ. Differential damage to auditory neurons and hair cells by ototoxins and neuroprotection by specific neurotrophins in rat cochlear organotypic cultures. Eur J Neurosci 1996;8(9):1897-905.
24. Kuang R, Hever G, Zajic G, Yan Q, Collins F, Louis JC, Keithley E, Magal E. Glial cell line-derived neurotrophic factor. Potential for otoprotection. Ann NY Acad Sci 199928;884:270-91.
25. Ruan RS, Leong SK, Mark I, Yeoh KH. Effects of BDNF and NT-3 on hair cell survival in guinea pig cochlea damaged by kanamycin treatment. Neuroreport 19993;10(10):2067-71.
26. Aloe L, Skaper SD, Leon A, Levi-Montalcini R. Nerve growth factor and autoimmune diseases. Autoimmunity 1994;19(2):141-50.
27. Lambiase A, Manni L, Bonini S, Rama P, Micera A, Aloe L. Nerve growth factor promotes corneal healing: structural, biochemical, and molecular analyses of rat and human corneas. Invest Ophthalmol Vis Sci 2000;41(5):1063-9.
28. Bernabei R, Landi F, Bonini S, Onder G, Lambiase A, Pola R, Aloe L. Effect of topical application of nerve-growth factor on pressure ulcers. Lancet 1999;354(9175):307.